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Registry of Toxic Effects of Chemical Substances (RTECS)

Silver(I) nitrate (1:1)

RTECS #

VW4725000

CAS #

7761-88-8

Updated

December 2016

Molecular Weight

169.88

Molecular Formula

NO3·Ag

Synonyms

Lunar caustic
Nitrate d'argent (French)
Nitric acid, silver(1+) salt
Silbernitrat
Silver nitrate
Silver(1+) nitrate

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 1 mg severeAROPAW 25,839,1941
eye /rabbit 10 mg moderateTXAPA9 55,501,1980
skin /man 1%CODEDG 61,120,2009

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA adductovary/hamster1 mg/L/24HTOLED5 222,55,2013
DNA inhibitionlymphocyte/human76 µmol/LIAAAAM 79,83,1986
DNA inhibitionintraperitoneal/mouse20 gm/kgARGEAR 51,605,1981
micronucleus testovary/hamster5 mg/L/24HTOLED5 222,55,2013
morphological transformembryo/hamster60 µmol/LCNREA8 39,193,1979
sex chromosome loss and nondisjunction/Saccharomyes cerevisiae140 ppbANYAA9 407,186,1983

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intratesticular/rat 3398 µg/kg (1D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JRPFA4 7,21,1964
intratesticular/rat 400 mg/kg (1D male)Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)FESTAS 24,884,1973
intratesticular/Dog 20 mg/kg (1D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductAEFTAA 6,349,1975
oral/rat 28560 mg/kg (17W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)GTPZAB 27(12),33,1983
subcutaneous/rat 13590 µg/kg (1D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductJRPFA4 7,21,1964
subcutaneous/mouse 13590 µg/kg (30D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JRPFA4 7,21,1964
subcutaneous/Dog 50 mg/kg (1D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductFESTAS 24,884,1973

Tumorigenic Data and References

Route/OrganismDoseEffectReference
skin/mouse lowest published toxic dose: 15 gm/kg/19W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
NCIMAV 10,489,1963

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Hamster, ovary Inhibitor Concentration Low: 5 mg/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TOLED5 222,55,2013
In Vitro/Hamster, ovary Inhibitor Concentration Low: 10 mg/L/24HIn Vitro Toxicity Studies: Apoptosis in vitroTOLED5 222,55,2013
In Vitro/Hamster, ovary Inhibitor Concentration (50 percent kill): 10 mg/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TOLED5 222,55,2013
In Vitro/Human, bone marrow Inhibitor Concentration Low: 0.015 mmol/LIn Vitro Toxicity Studies: Cell Viability (cell death), unspecified assayTIVIEQ 27,739,2013
In Vitro/Human, erythrocytes Inhibitor Concentration Low: 200 µg/mL/2HIn Vitro Toxicity Studies: Hemolysis in vitroFCTOD7 67,80,2014
In Vitro/Human, liver Inhibitor Concentration Low: 2 mg/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TOLED5 201,92,2011
In Vitro/Human, liver Inhibitor Concentration (50 percent kill): 8 mg/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TOLED5 201,92,2011
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 1.24 mg/L/24HIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,2013,2013
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 2.96 mg/L/24HIn Vitro Toxicity Studies: Cell Viability (cell death), unspecified assayTIVIEQ 27,2013,2013
In Vitro/Human, lung Inhibitor Concentration (50 percent kill): 2.5 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXCYAC 305,20,2013
In Vitro/Human, lung Inhibitor Concentration Low: 1 µmol/L/24HIn Vitro Toxicity Studies: Other assaysTXCYAC 305,20,2013
In Vitro/Human, skin Inhibitor Concentration Low: 40 mg/well/3MIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 28,616,2014
In Vitro/Mouse, macrophage Inhibitor Concentration Low: 4.51 mg/mL/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXCYAC 328,84,2015
In Vitro/Non-mammalian species, liver Inhibitor Concentration (50 percent kill): 2.4 gm/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXAPA9 272,519,2013
In Vitro/phaInhibitor Concentration Low: 20 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 27,305,2013
In Vitro/phaInhibitor Concentration Low: 5 µmol/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TIVIEQ 27,305,2013
In Vitro/phaInhibitor Concentration Low: 7.5 µmol/L/5DIn Vitro Toxicity Studies: Cell growth: Colony formationTIVIEQ 27,305,2013
In Vitro/ppb Inhibitor Concentration Low: 0.02 mmol/L/1HIn Vitro Toxicity Studies: Hemolysis in vitroTIVIEQ 27,739,2013
In Vitro/qpbInhibitor Concentration Low: 0.02 mmol/L/1HIn Vitro Toxicity Studies: Hemolysis in vitroTIVIEQ 27,739,2013
intraperitoneal/guinea pig lowest published lethal dose: 216 mg/kgAEHLAU 11,201,1965
intraperitoneal/mouse lethal dose (50 percent kill): 17 mg/kgGTPZAB 27(12),33,1983
intraperitoneal/rat lethal dose (50 percent kill): 83 mg/kgGTPZAB 27(12),33,1983
intratracheal/mouse lowest published toxic dose: 400 µg/kgBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationTXCYAC 328,84,2015
intrauterine/woman lowest published lethal dose: 140 mg/kgHBTME* -,809,2007
intravenous/rabbit lowest published lethal dose: 8800 µg/kgEQSSDX 1,1,1975
oral/Dog lowest published lethal dose: 20 mg/kgHBAMAK 4,1289,1935
oral/guinea pig lethal dose (50 percent kill): 473 mg/kgBehavioral: Tetany

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Hypermotility, diarrhea
GTPZAB 27(12),33,1983
oral/mouse lethal dose (50 percent kill): 50 mg/kgJPPMAB 2,20,1950
oral/rabbit lowest published lethal dose: 800 mg/kgHBAMAK 4,1289,1935
oral/rabbit lethal dose (50 percent kill): 800 mg/kgENTOX* ,17,2005
oral/rat lethal dose (50 percent kill): 1173 mg/kgBehavioral: Tetany

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Hypermotility, diarrhea
GTPZAB 27(12),33,1983
subcutaneous/guinea pig lowest published lethal dose: 62 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea
BMJOAE 2,217,1913
Tank with water/Zebrafish lowest published toxic concentration: 0.1 gm/L/72HReproductive: Other effects to embryo or fetusTXAPA9 272,519,2013
unreported route/human lowest published lethal dose: 140 mg/kgLung, Thorax, or Respiration: Acute pulmonary edema

Liver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
VCVN1* -,83,1998
unreported route/man lowest published lethal dose: 29 mg/kg85DCAI 2,73,1970

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 12 mg/m3/17W- intermittentCardiac: Pulse rate increased without fall in BP

Kidney, Ureter, and Bladder: Urine volume increased

Blood: Changes in erythrocyte (RBC) count
GTPZAB 27(12),33,1983
oral/mouse lowest published toxic dose: 2250 mg/kg/18W- continuousBehavioral: Somnolence (general depressed activity)APTOA6 55,398,1984
oral/mouse lowest published toxic dose: 0.042 mg/kg/1W- intermittentBehavioral: Fluid intake

Kidney, Ureter, and Bladder: Urine volume increased
TXCYAC 186,151,2003
oral/rat lowest published toxic dose: 652 mg/kg/4D- intermittentBiochemical: Metabolism (intermediary): Plasma proteins not involving coagulationTOXID9 72,246,2003
oral/rat lowest published toxic dose: 28560 mg/kg/17W- intermittentCardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
GTPZAB 27(12),33,1983
oral/rat lowest published toxic dose: 14 gm/kg/13W- continuousBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NETOD7 1,275,1979
oral/rat lowest published toxic dose: 0.7 mg/kg/14D- intermittentLiver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Interstitial nephritis

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVN1* -,84,1988
oral/turkey lowest published toxic dose: 113400 mg/kg/18W- continuousCardiac: Cardiomegaly

Cardiac: Changes in heart weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN1* -,84,1988

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.01 mg(Ag)/m3DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWCRTXB2 37,237,2007
TOXICOLOGY REVIEWENTOX* -,17,2005
TOXICOLOGY REVIEWHBTME* ,809,2007

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,335,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.01 mg(Ag)/m3DTLVS* 3,231,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.01 mg(Ag)/m3, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.01 mg(Ag)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.01 mg(Ag)/m3, MAR2002
Occupational Exposure Limit-ECtime-weighted average 0.01 mg(Ag)/m3, FEB2006
Occupational Exposure Limit-FINLANDtime-weighted average 0.01 mg(Ag)/m3, short term exposure limit 0.03 mg/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 0.01 mg(Ag)/m3, FEB2006
Occupational Exposure Limit-GERMANYMAK 0.01 mg(Ag)/m3, inhal, 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 0.01 mg(Ag)/m3, SEP2000
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.01 mg(Ag)/m3, MAY2012
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.01 mg(Ag)/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.01 mg(Ag)/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.01 mg(Ag)/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.5 mg(Ag)/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.01 mg(Ag)/m3, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.01 mg(Ag)/m3, KZG-week 0.02 mg(Ag)/m3, inhal, JAN2011
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.01 mg(Ag)/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.01 mg(Ag)/m3, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 80142; Number of Industries 95; Total Number of Facilities 7884; Number of Occupations 69; Total Number of Employees Exposed 176015; Total Number of Female Employees Exposed 99042
National Occupational Hazard Survey 1974Hazard Code 80142; Number of Industries 76; Total Number of Facilities 3772; Number of Occupations 40; Total Number of Employees Exposed 27982

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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