Quinoline
RTECS #
VA9275000
CAS #
Updated
December 2017
Molecular Weight
129.17
Molecular Formula
C9H7N
Synonyms
1-Azanaphthalene
1-Benzazine
B-500
Benzo(b)pyridine
Chinoleine
Chinolin (Czech)
Chinoline
Leucol
Leukol
USAF EK-218
1-Benzazine
B-500
Benzo(b)pyridine
Chinoleine
Chinolin (Czech)
Chinoline
Leucol
Leukol
USAF EK-218
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
skin /rabbit | 100 mg/24H | moderate | 85JCAE -,848,1986 |
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
Cytogenetic Analysis | embryo/non-mammalian species | 460 mmol/L/10M-continuous | CHROAU 56,289,1976 |
Cytogenetic Analysis | ovary/hamster | 500 µg/L | ENMUDM 7,1,1985 |
Cytogenetic Analysis | lung/hamster | 100 mg/L | ATSUDG 4,41,1980 |
DNA adduct | /Escherichia coli | 30 µmol/L | MUREAV 89,95,1981 |
DNA Damage | liver/rat | 1 mmol/L | SinJF# 26OCT1982 |
micronucleus test | intraperitoneal/mouse | 50 mg/kg | TCMUD8 9,111,1989 |
micronucleus test | intraperitoneal/rat | 75 mg/kg | MUREAV 583,133,2005 |
micronucleus test | oral/rat | 75 mg/kg | MUREAV 583,133,2005 |
micronucleus test | oral/rat | 420 mg/kg/14D | MUREAV 780-781,2,2015 |
morphological transform | fibroblast/mouse | 0.0001 pph/21D (-enzymatic activation step) | EMMUEG 37,231,2001 |
mutation in mammalian somatic cells | lymphocyte/mouse | 700 mg/L | EMMUEG 12,85,1988 |
mutation in mammalian somatic cells | intraperitoneal/mouse | 200 mg/kg/4D-continuous | MUREAV 412,161,1998 |
mutation in microorganisms | ovary/hamster | 80 µmol/L (+enzymatic activation step) | ENMUDM 4,395,1982 |
mutation in microorganisms | /Salmonella typhimurium | 313 µg/plate/20M (+enzymatic activation step) | MUTAEX 20,217,2005 |
mutation in microorganisms | /Salmonella typhimurium | 313 µg/plate/48H (+enzymatic activation step) | MUTAEX 20,217,2005 |
mutation in microorganisms | /Salmonella typhimurium | 25 µg/plate (-enzymatic activation step) | MUREAV 174,247,1986 |
other mutation test systems | other cell types/human | 313 µmol/L | TIVIEQ 29,1425,2015 |
other mutation test systems | intraperitoneal/mouse | 100 mg/kg | MUREAV 747,164,2012 |
other mutation test systems | embryo/non-mammalian species | 460 mmol/L/10M-continuous | CHROAU 56,289,1976 |
other mutation test systems | liver/rat | 500 µmol/L | CBINA8 29,257,1980 |
sister chromatid exchange | ovary/hamster | 110 µg/L | ENMUDM 7,1,1985 |
Unscheduled DNA Synthesis | liver/rat | 100 µmol/L | MUREAV 221,263,1989 |
Tumorigenic Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
intraperitoneal/mouse | lowest published toxic dose: 9042 µg/kg/15D- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors Blood: Lymphoma including Hodgkin's disease | JJCREP 78,139,1987 |
oral/mouse | lowest published toxic dose: 50 gm/kg/30W- continuous | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Tumors | GANNA2 68,785,1977 |
oral/rat | lowest published toxic dose: 7770 mg/kg/37W- continuous | Tumorigenic: Neoplastic by RTECS criteria Liver: Tumors | CNREA8 36,329,1976 |
oral/rat | toxic dose: 23 gm/kg/30W- continuous | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Tumors | GANNA2 68,785,1977 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/rat | lethal dose (50 percent kill): 331 mg/kg | 85JCAE -,848,1986 | |
oral/rat | lowest published lethal dose: 331 mg/kg | MUREAV 747,164,2012 | |
skin/rabbit | lethal dose (50 percent kill): 540 µL/kg | AMIHBC 4,119,1951 | |
subcutaneous/frog | lowest published lethal dose: 150 mg/kg | HBAMAK 4,1289,1935 | |
subcutaneous/rabbit | lowest published lethal dose: 200 mg/kg | HBAMAK 4,1289,1935 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/rat | lowest published toxic dose: 840 mg/kg/14D- intermittent | Liver: Tumors | MUREAV 780-781,2,2015 |
oral/rat | lowest published toxic dose: 1680 mg/kg/14D- intermittent | Liver: Changes in liver weight | MUREAV 780-781,2,2015 |
Reviews
Organization | Standard | Reference |
---|---|---|
TOXICOLOGY REVIEW | MUREAV 567,347,2004 | |
TOXICOLOGY REVIEW | MUREAV 578,88,2005 | |
TOXICOLOGY REVIEW | MUREAV 588,88,2005 | |
TOXICOLOGY REVIEW | MUREAV 627,10,2007 | |
TOXICOLOGY REVIEW | MUREAV 590,1,2005 | |
TOXICOLOGY REVIEW | MUTAEX 26,223,2011 | |
TOXICOLOGY REVIEW | MUREAV 721,27,2011 | |
TOXICOLOGY REVIEW | MUREAV 783,19,2015 | |
TOXICOLOGY REVIEW | FCTOD7 94,93,2016 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Occupational Exposure Limit-RUSSIA | time-weighted average 0.1 mg/m3, short term exposure limit 0.5 mg/m3, JUN2003 |
NIOSH Documentation and Surveillance
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health