2-Propanol, 1-amino-

RTECS #

UA5775000

CAS #

78-96-6
See: NMAM or OSHA Methods

Updated

August 2006

Molecular Weight

75.13

Molecular Formula

C₃H₉NO

Synonyms

1-Amino-2-propanol
1-Aminopropan-2-ol
1-Methyl-2-aminoethanol
2-Hydroxy-1-propylamine
2-Hydroxypropylamine
alpha-Aminoisopropyl alcohol
Isopropanolamine
Mono-iso-propanolamine
Threamine

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	970 µg	severe	UCDS** 5/21/1971
eye /rabbit	250 µg/24H	severe	85JCAE -,683,1986
skin /rabbit	485 mg open irritation test	moderate	UCDS** 5/21/1971
skin /rabbit	500 mg/24H	mild	85JCAE -,683,1986

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
unreported route/rat	280 µg/kg (1D male)	Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)	TLSMA6 140,79,1981

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/mouse	lowest published lethal dose: 250 mg/kg	Behavioral: Excitement	CBCCT* 4,232,1952
oral/rat	lethal dose (50 percent kill): 1715 mg/kg	Behavioral: Somnolence (general depressed activity) Gastrointestinal: Hypermotility, diarrhea Nutritional and Gross Metabolic: Body temperature decrease	GTPZAB 30(7),46,1986
skin/mammal (species unspecified)	lethal dose (50 percent kill): >1 gm/kg		GTPZAB 30(7),46,1986
skin/rabbit	lethal dose (50 percent kill): 1640 µL/kg		UCDS** 5/21/1971

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit-RUSSIA	short term exposure limit 1 mg/m³, Skin, JUN2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Occupational Exposure Survey 1983	Hazard Code 83332; Number of Industries 79; Total Number of Facilities 6922; Number of Occupations 80; Total Number of Employees Exposed 132873; Total Number of Female Employees Exposed 13538
National Occupational Hazard Survey 1974	Hazard Code 83332; Number of Industries 60; Total Number of Facilities 3204; Number of Occupations 59; Total Number of Employees Exposed 51002

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health