Propane, 1-nitro-

RTECS #

TZ5075000

CAS #

108-03-2
See: NMAM or OSHA Methods

Updated

December 2015

Molecular Weight

89.11

Molecular Formula

C₃H₇NO₂

Synonyms

1-Nitropropane
1-Nitropropane (ACGIH:OSHA)
1-NP

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /human	150 ppm/15M		JIHTAB 28,262,1946

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
sister chromatid exchange	ovary/hamster	74 mg/L/24H (-enzymatic activation step)	MUREAV 515,181,2002
Unscheduled DNA Synthesis	liver/rat	1 µmol/L	MUREAV 221,263,1989

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/guinea pig	Lowest published lethal concentration: 5000 ppm/3H		JIHTAB 22,315,1940
inhalation/human	lowest published toxic concentration: 150 ppm	Eye: Conjunctiva irritation	JIHTAB 28,262,1946
inhalation/rabbit	lethal concentration (50 percent kill): 5000 ppm/3H		85JCAE -,404,1986
inhalation/rat	lethal concentration (50 percent kill): 3100 ppm/8H		NPIRI* 1,91,1974
intraperitoneal/mouse	lethal dose (50 percent kill): 250 mg/kg		KHFZAN 10(6),53,1976
intraperitoneal/rat	lowest published lethal dose: 550 mg/kg	Blood: Methemoglobinemia- Carboxhemoglobinemia	BSPLA9 (4),131,1972
oral/mouse	lethal dose (50 percent kill): 800 mg/kg	Behavioral: General anesthetic Behavioral: Tremor Behavioral: Excitement	GISAAA 32(9),9,1967
oral/rabbit	lowest published lethal dose: 250 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory stimulation	JIHTAB 22,315,1940
oral/rat	lethal dose (50 percent kill): 455 mg/kg		NPIRI* 1,91,1974
skin/rabbit	Lethal dose: >2 gm/kg		NTIS** OTS0556802

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	lowest published toxic dose: 2800 mg/kg/4W- continuous	Behavioral: Ataxia Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0556802

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 25 ppm	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		MUREAV 705,184,2010
TOXICOLOGY REVIEW		MUREAV 786-788,14,2015

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 25 ppm (90 mg/m³)	DTLVS* 3,188,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 25 ppm (91 mg/m³), Carcinogen, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 25 ppm (92 mg/m³);KZW 25 ppm (92 mg/m³), skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 25 ppm (92 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 5 ppm (18 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 25 ppm (92 mg/m³), short term exposure limit 40 ppm (150 mg/m³), skin, NOV2011
Occupational Exposure Limit-FRANCE	VME 25 ppm (90 mg/m³), FEB2006
Occupational Exposure Limit-GERMANY	MAK 25 ppm (92 mg/m³), 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 10 mg/m³, Skin, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 5 ppm (18 mg/m³), NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 25 ppm (90 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 25 ppm (90 mg/m³);short term exposure limit 35 ppm (135 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 25 ppm (91 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 20 ppm (70 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 25 ppm (91 mg/m³), JUL2005
Occupational Exposure Limit-SWEDEN	time-weighted average 5 ppm (18 mg/m³), ceiling concentration 10 ppm (35 mg/m³), JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 25 ppm (90 mg/m³), KZG-week 100 ppm (360 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 90 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 25 ppm (90 mg/m³), JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 25 ppm (90 mg/m³), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 25 ppm (90 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 25 ppm (90 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 25 ppm (90 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 25 ppm (90 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1-NITROPROPANE-air	10H time-weighted average 25 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 51100; Number of Industries 19; Total Number of Facilities 2539; Number of Occupations 26; Total Number of Employees Exposed 21537; Total Number of Female Employees Exposed 1311
National Occupational Hazard Survey 1974	Hazard Code 51100; Number of Industries 20; Total Number of Facilities 1155; Number of Occupations 31; Total Number of Employees Exposed 9874

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #46

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health