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Registry of Toxic Effects of Chemical Substances (RTECS)

Propane, 1-nitro-

RTECS #

TZ5075000

CAS #

108-03-2

Updated

December 2015

Molecular Weight

89.11

Molecular Formula

C3H7NO2

Synonyms

1-Nitropropane
1-Nitropropane (ACGIH:OSHA)
1-NP

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /human 150 ppm/15MJIHTAB 28,262,1946

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
sister chromatid exchangeovary/hamster74 mg/L/24H (-enzymatic activation step)MUREAV 515,181,2002
Unscheduled DNA Synthesisliver/rat1 µmol/LMUREAV 221,263,1989

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig Lowest published lethal concentration: 5000 ppm/3HJIHTAB 22,315,1940
inhalation/human lowest published toxic concentration: 150 ppmEye: Conjunctiva irritationJIHTAB 28,262,1946
inhalation/rabbit lethal concentration (50 percent kill): 5000 ppm/3H85JCAE -,404,1986
inhalation/rat lethal concentration (50 percent kill): 3100 ppm/8HNPIRI* 1,91,1974
intraperitoneal/mouse lethal dose (50 percent kill): 250 mg/kgKHFZAN 10(6),53,1976
intraperitoneal/rat lowest published lethal dose: 550 mg/kgBlood: Methemoglobinemia- CarboxhemoglobinemiaBSPLA9 (4),131,1972
oral/mouse lethal dose (50 percent kill): 800 mg/kgBehavioral: General anesthetic

Behavioral: Tremor

Behavioral: Excitement
GISAAA 32(9),9,1967
oral/rabbit lowest published lethal dose: 250 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation
JIHTAB 22,315,1940
oral/rat lethal dose (50 percent kill): 455 mg/kgNPIRI* 1,91,1974
skin/rabbit Lethal dose: >2 gm/kgNTIS** OTS0556802

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 2800 mg/kg/4W- continuousBehavioral: Ataxia

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0556802

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 25 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 705,184,2010
TOXICOLOGY REVIEWMUREAV 786-788,14,2015

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 25 ppm (90 mg/m3)DTLVS* 3,188,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 25 ppm (91 mg/m3), Carcinogen, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 25 ppm (92 mg/m3);KZW 25 ppm (92 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 25 ppm (92 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 ppm (18 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 25 ppm (92 mg/m3), short term exposure limit 40 ppm (150 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 25 ppm (90 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 25 ppm (92 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 10 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 5 ppm (18 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 25 ppm (90 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 25 ppm (90 mg/m3);short term exposure limit 35 ppm (135 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 25 ppm (91 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 20 ppm (70 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 25 ppm (91 mg/m3), JUL2005
Occupational Exposure Limit-SWEDENtime-weighted average 5 ppm (18 mg/m3), ceiling concentration 10 ppm (35 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 25 ppm (90 mg/m3), KZG-week 100 ppm (360 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 90 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 25 ppm (90 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 25 ppm (90 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 25 ppm (90 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 25 ppm (90 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 25 ppm (90 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 25 ppm (90 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1-NITROPROPANE-air10H time-weighted average 25 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 51100; Number of Industries 19; Total Number of Facilities 2539; Number of Occupations 26; Total Number of Employees Exposed 21537; Total Number of Female Employees Exposed 1311
National Occupational Hazard Survey 1974Hazard Code 51100; Number of Industries 20; Total Number of Facilities 1155; Number of Occupations 31; Total Number of Employees Exposed 9874

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #46
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