Propane, 1,2-epoxy-3-phenoxy-
RTECS #
TZ3675000
CAS #
Updated
December 2018
Molecular Weight
150.19
Molecular Formula
C9H10O2
Synonyms
(Phenoxymethyl)oxirane
1,2-Epoxy-3-phenoxypropane
2,3-Epoxypropylphenyl ether
3-Phenoxy-1,2-epoxypropane
Ageflex PGE
Benzene, (2,3-epoxypropoxy)-
Ether, 2,3-epoxypropyl phenyl
Ether, phenylglycidyl
Fenyl-glycidylether (Czech)
Glycidyl phenyl ether
Heloxy WC-63
Oxirane, (phenoxymethyl)-
PGE (OSHA)
Phenol glycidyl ether
Phenol-glycidaether (German)
Phenoxypropene oxide
Phenoxypropylene oxide
Phenyl 2,3-epoxypropyl ether
Phenyl glycidyl ether
Phenyl glycidyl ether (ACGIH:OSHA)
Phenylglycydyl ether
1,2-Epoxy-3-phenoxypropane
2,3-Epoxypropylphenyl ether
3-Phenoxy-1,2-epoxypropane
Ageflex PGE
Benzene, (2,3-epoxypropoxy)-
Ether, 2,3-epoxypropyl phenyl
Ether, phenylglycidyl
Fenyl-glycidylether (Czech)
Glycidyl phenyl ether
Heloxy WC-63
Oxirane, (phenoxymethyl)-
PGE (OSHA)
Phenol glycidyl ether
Phenol-glycidaether (German)
Phenoxypropene oxide
Phenoxypropylene oxide
Phenyl 2,3-epoxypropyl ether
Phenyl glycidyl ether
Phenyl glycidyl ether (ACGIH:OSHA)
Phenylglycydyl ether
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 111 mg | mild | AMIHAB 14,250,1956 |
| eye /rabbit | 250 µg/24H | severe | 85JCAE -,776,1986 |
| skin /rabbit | 10 mg/24H open irritation test | severe | AMIHBC 10,61,1954 |
| skin /rabbit | 20 mg/24H | moderate | 85JCAE -,776,1986 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| DNA Damage | /Escherichia coli | 1 µmol/L | ARTODN 46,277,1980 |
| host-mediated assay | Salmonella typhimurium/mouse | 2500 mg/kg | MUREAV 67,9,1979 |
| morphological transform | embryo/hamster | 6250 µg/L | MUREAV 67,9,1979 |
| mutation in microorganisms | /Klebsiella pneumoniae | 100 µmol/L (-enzymatic activation step) | MUREAV 89,269,1981 |
| mutation in microorganisms | /Salmonella typhimurium | 33 µg/plate (+enzymatic activation step) | MUREAV 172,105,1986 |
| mutation in microorganisms | /Salmonella typhimurium | 500 µg/plate (-enzymatic activation step) | MUREAV 67,9,1979 |
| mutation in microorganisms | /Escherichia coli | 20 µmol/L (-enzymatic activation step) | ARTODN 46,277,1980 |
| other mutation test systems | /Escherichia coli | 300 µmol/L | MUREAV 231,205,1990 |
| sister chromatid exchange | lung/hamster | 400 µmol/L | MUREAV 249,55,1991 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | 11 ppm/6H (19D male) | Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) | TXAPA9 64,204,1982 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lowest published toxic concentration: 12 ppm/6H/2Y- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Olfaction: Tumors | AJPAA4 111,140,1983 |
| inhalation/rat | lowest published toxic concentration: 1092 mg/kg/2Y- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Olfaction: Tumors | TOXID9 72,27,2003 |
| inhalation/rat | lowest published toxic concentration: 728 mg/kg/2Y- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Olfaction: Tumors | TOXID9 72,27,2003 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | lethal concentration (50 percent kill): >100 ppm/4H | Lung, Thorax, or Respiration: Acute pulmonary edema | AMIHAB 14,250,1956 |
| inhalation/rat | lethal concentration (50 percent kill): >100 ppm/8H | Lung, Thorax, or Respiration: Acute pulmonary edema | AMIHAB 14,250,1956 |
| oral/mouse | lethal dose (50 percent kill): 1400 mg/kg | Brain and Coverings: Recordings from specific areas of CNS Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia | AMIHAB 14,250,1956 |
| oral/rat | lethal dose (50 percent kill): 3850 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Change in motor activity (specific assay) Behavioral: Ataxia | AMIHAB 14,250,1956 |
| skin/rabbit | lethal dose (50 percent kill): 1500 µL/kg | AMIHBC 10,61,1954 | |
| subcutaneous/mouse | lethal dose (50 percent kill): 760 mg/kg | Autonomic Nervous System: Smooth muscle relaxant (mechanism undefined, spasmolytic) | ARZNAD 15,1355,1965 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lowest published toxic concentration: 5 ppm/6H/90D- intermittent | Skin and Appendages: Other: Hair | JTEHD6 3,859,1977 |
| inhalation/rat | lowest published toxic concentration: 728 mg/kg/2Y- intermittent | Olfaction: Other olfaction effects | TOXID9 72,27,2003 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.1 ppm (skin, sen) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed animal carcinogen | DTLVS* TLV/BEI,2013 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 47,237,1989 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 71,1525,1999 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 71,1525,1999 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 2B | IMEMDT 71,1525,1999 |
| TOXICOLOGY REVIEW | AJOGAH 113,130,1972 | |
| TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
| TOXICOLOGY REVIEW | MUREAV 654,114,2008 | |
| TOXICOLOGY REVIEW | MUTAEX 25,3,2010 | |
| TOXICOLOGY REVIEW | FCTOD7 55,596,2013 | |
| TOXICOLOGY REVIEW | MUREAV 802,1,2016 | |
| TOXICOLOGY REVIEW | RTOPDW 55,43,2009 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 10 ppm (62 mg/m3) | DTLVS* 3,206,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 1 ppm (6.1 mg/m3), JUL2008 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 0.1 ppm (0.6 mg/m3), Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 0.1 ppm (0.6 mg/m3), skin, carc, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 0.5 ppm (3.1 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 1 ppm (6 mg/m3), C2 Carcinogen, FEB2006 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 0.1 ppm (0.6 mg/m3), short term exposure limit 1 ppm (5 mg/m3), skin, sen, NOV2011 | |
| Occupational Exposure Limit-JAPAN | 2B carc, MAY2012 | |
| Occupational Exposure Limit-KOREA | time-weighted average 1 ppm (6 mg/m3), 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 10 ppm (60 mg/m3) (skin), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 1 ppm (6.1 mg/m3), skin, sen, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 1 ppm (5 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 0.1 ppm (0.61 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 0.6 mg/m3, MAC(short term exposure limit) 3 mg/m3, JAN1999 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 10 ppm (60 mg/m3);short term exposure limit 15 ppm (90 mg/m3), Sen, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 1 ppm (6 mg/m3), carc 2, skin, sen, JAN2011 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 10 ppm (62 mg/m3), JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 10 ppm (60 mg/m3), JAN1993 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 10 ppm (60 mg/m3) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 10 ppm (60 mg/m3) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 10 ppm (60 mg/m3) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 10 ppm (60 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHENYL GLYCIDYL ETHER-air | Carcinogen ceiling concentration 1 ppm/15M | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 57280; Number of Industries 15; Total Number of Facilities 355; Number of Occupations 18; Total Number of Employees Exposed 10551; Total Number of Female Employees Exposed 4108 | |
| National Occupational Hazard Survey 1974 | Hazard Code 57280; Number of Industries 13; Total Number of Facilities 434; Number of Occupations 12; Total Number of Employees Exposed 8533 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA GENETOX PROGRAM 1988, Positive: SHE-focus assay | |
| EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE | FEREAC 47,26992,82 |
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NIOSH Analytical Method, 1994: Phenyl glycidyl ether, 1619 | |
| NIOSH CURRENT INTELLIGENCE BULLETIN 29, 1978 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health