1,3-Propanediol, 2-bromo-2-nitro-

RTECS #
TY3385000
CAS #
52-51-7
See: NMAM or OSHA Methods
Updated
March 2019
Molecular Weight
200.01
Molecular Formula
C3H6BrNO4
Synonyms
2-Bromo-2-nitro-1,3-propanediol
2-Bromo-2-nitropropan-1,3-diol
2-Bromo-2-nitropropane-1,3-diol
2-Bronopol
beta-Bromo-beta-nitrotrimethyleneglycol
Bronidiol
Bronocot
Bronopol
Bronopolu (Polish)
Bronosol
Bronotak

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 5 mgJSCCA5 29,3,1978
skin /human 10 mg moderateJSCCA5 29,3,1978
skin /rabbit 500 mg/24H mildJEPTDQ 4(4),47,1980
skin /rabbit 80 mg moderateJEPTDQ 4(4),47,1980
skin /rat 0.2%VCVGK* -,194,1994

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rabbit 1040 mg/kg (7-19D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
FEREAC 67,78459,2002

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, leukemia cells Inhibitor Concentration (25 percent kill): 4 mg/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 30,318,2015
In Vitro/Human, leukemia cells Inhibitor Concentration Low: 4 mg/L/48HImmunological Including Allergic: Increase in cellular immune responseTIVIEQ 30,318,2015
In Vitro/Human, leukemia cells Inhibitor Concentration Low: 4 mg/L/24HBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationTIVIEQ 30,318,2015
In Vitro/Human, lymphocyte Inhibitor Concentration (30 percent kill): 6 mg/L/45HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.TIVIEQ 29,901,2015
In Vitro/Human, lymphocyte Inhibitor Concentration (50 percent kill): 2 mg/L/45HIn Vitro Toxicity Studies: Other assaysTIVIEQ 29,901,2015
inhalation/rat lethal concentration (50 percent kill): >5 gm/m3/4HFEREAC 70,67906,2005
inhalation/rat lowest published toxic concentration: 5 mg/m3/6HEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Dyspnea
FEREAC 67,78459,2002
inhalation/rat lethal concentration (50 percent kill): >5 gm/m3/6HPEMNDP 9,103,1991
inhalation/rat lethal concentration (50 percent kill): 800 mg/m3/4HVCVGK* -,193,1994
intraperitoneal/mouse lethal dose (50 percent kill): 32.8 mg/kgGastrointestinal: PeritonitisVCVGK* -,193,1994
intraperitoneal/mouse lethal dose (50 percent kill): 15500 µg/kgKHFZAN 11(1),73,1977
intraperitoneal/rat lethal dose (50 percent kill): 22 mg/kgGastrointestinal: PeritonitisVCVGK* -,193,1994
intraperitoneal/rat lethal dose (50 percent kill): 26 mg/kgJSCCA5 29,3,1978
intravenous/mouse lethal dose (50 percent kill): 48 mg/kgIYKEDH 8,680,1977
intravenous/rat lethal dose (50 percent kill): 37400 µg/kgIYKEDH 8,680,1977
oral/Dog lethal dose (50 percent kill): 250 mg/kg28ZEAL 5,30,1976
oral/mouse lethal dose (50 percent kill): 194 mg/kgLung, Thorax, or Respiration: Other changes

Gastrointestinal: Gastritis
VCVGK* -,193,1994
oral/mouse lethal dose (50 percent kill): 270 mg/kgPEMNDP 9,103,1991
oral/rabbit lethal dose (50 percent kill): 190 mg/kgLung, Thorax, or Respiration: Other changes

Gastrointestinal: Gastritis
VCVGK* -,193,1994
oral/rat lethal dose (50 percent kill): 267 mg/kgLung, Thorax, or Respiration: Other changes

Gastrointestinal: Gastritis
VCVGK* -,193,1994
oral/rat lowest published toxic dose: 80 mg/kgBehavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Changes in structure or function of salivary glands
FEREAC 67,78459,2002
oral/rat lethal dose (50 percent kill): 254 mg/kgBehavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression

Blood: Changes in spleen
FEREAC 67,78459,2002
oral/rat lethal dose (50 percent kill): 342 mg/kgBehavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Changes in structure or function of salivary glands
FEREAC 67,78459,2002
oral/rat lethal dose (50 percent kill): 180 mg/kg28ZEAL 5,30,1976
skin/mouse lethal dose (50 percent kill): 4750 mg/kgIYKEDH 8,680,1977
skin/rabbit lowest published toxic dose: 250 mg/kg/8HSkin: After topical application: Primary irritationVCVGK* -,194,1994
skin/rabbit lethal dose (50 percent kill): >2000 mg/kgFEREAC 67,78459,2002
skin/rat lowest published toxic dose: >2000 mg/kg/24HLung, Thorax, or Respiration: Dyspnea

Skin: After topical application: Primary irritation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 67,78459,2002
skin/rat lethal dose (50 percent kill): 64 mg/kgFEREAC 70,67906,2005
subcutaneous/mouse lethal dose (50 percent kill): 116 mg/kgIYKEDH 8,680,1977
subcutaneous/rat lethal dose (50 percent kill): 200 mg/kgLung, Thorax, or Respiration: Other changes

Gastrointestinal: Gastritis
VCVGK* -,193,1994
subcutaneous/rat lethal dose (50 percent kill): 170 mg/kgBehavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair
KSRNAM 8,1029,1974

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 1800 mg/kg/90D- intermittentGastrointestinal: Nausea or vomitingVCVGK* -,194,1994
oral/Dog lowest published toxic dose: 1820 mg/kg/13W- intermittentGastrointestinal: Nausea or vomitingFEREAC 67,78459,2002
oral/rat lowest published toxic dose: 1800 mg/kg/90D- intermittentGastrointestinal: Other changesFEREAC 70,67906,2005
oral/rat lowest published toxic dose: 7200 mg/kg/90D- intermittentLung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,194,1994
oral/rat lowest published toxic dose: 29120 mg/kg/104W- continuousGastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Ulceration or bleeding from stomach

Kidney, Ureter, and Bladder: Hematuria
FEREAC 67,78459,2002
oral/rat lowest published toxic dose: 116480 mg/kg/104W- continuousKidney, Ureter, and Bladder: Changes primarily in glomeruli

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FEREAC 67,78459,2002
oral/rat lowest published toxic dose: 7280 mg/kg/13W- intermittentLung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FEREAC 67,78459,2002
skin/rabbit lowest published toxic dose: 450 mg/kg/90D- intermittentSkin: After topical application: Primary irritationFEREAC 70,67906,2005

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWJACTDZ 3(3),139,1984
TOXICOLOGY REVIEWRTOPDW 61,1,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,165,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 3 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X1235; Number of Industries 1; Total Number of Facilities 117; Number of Occupations 5; Total Number of Employees Exposed 5176; Total Number of Female Employees Exposed 4904

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Page last reviewed: November 16, 2018