Potassium pyrosulfite

RTECS #

TT4920000

CAS #

16731-55-8
See: NMAM or OSHA Methods

Updated

December 2011

Molecular Weight

222.32

Molecular Formula

O₅S₂·K₂

Synonyms

Dipotassium disulfite
Dipotassium metabisulfite
Disulfurous acid, dipotassium salt (9CI)
Potassium disulfite
Potassium metabisulfite
Pyrosulfurous acid, dipotassium salt

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	lymphocyte/human	25 mg/L/24H	EMMUEG 49,276,2008
Cytogenetic Analysis	intraperitoneal/rat	150 mg/kg	EMMUEG 49,276,2008
micronucleus test	lymphocyte/human	25 mg/L/24H	EMMUEG 49,276,2008
sister chromatid exchange	lymphocyte/human	25 mg/L/24H	EMMUEG 49,276,2008
Unscheduled DNA Synthesis	oral/rat	400 mg/kg	JJCREP 80,424,1989

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	35 gm/kg (49D prior to copulation/1-21D pregnant)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	CRSBAW 172,470,1978

Reviews

Organization	Standard	Reference
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 54,131,1992
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Inadequate Evidence	IMEMDT 54,131,1992
International Agency for Research on Cancer (IARC)	Cancer Review:Group 3	IMEMDT 54,131,1992
TOXICOLOGY REVIEW		IJTOFN 22,63,2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Occupational Exposure Survey 1983	Hazard Code 82177; Number of Industries 34; Total Number of Facilities 4265; Number of Occupations 45; Total Number of Employees Exposed 33335; Total Number of Female Employees Exposed 10193
National Occupational Hazard Survey 1974	Hazard Code 82177; Number of Industries 17; Total Number of Facilities 1935; Number of Occupations 13; Total Number of Employees Exposed 5348

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Inconclusive: In vitro SCE-nonhuman
EPA TSCA Section 8(b) CHEMICAL INVENTORY

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health