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Registry of Toxic Effects of Chemical Substances (RTECS)

Potassium nitrate

RTECS #

TT3700000

CAS #

7757-79-1

Updated

March 2016

Molecular Weight

179.31

Molecular Formula

KNO3·K

Synonyms

Collo-Bo
Kaliumnitrat (German)
Niter
Nitre
Nitric acid, potassium salt
Saltpeter
Vicknite

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
gene conversion and mitotic recombination/Escherichia coli5 pphJGMIAN 8,45,1953

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 22 gm/kg (1-22D pregnant)Reproductive: Effects on fertility: Other measures of fertilityJANSAG 15,1291,1956
oral/rat 598 mg/kg (1-22D preg/5D after birth)Reproductive: Effects on newborn: BehavioralAPHHDU 74,69,1989
oral/rabbit 6505 mg/kg (23-27D pregnant)Reproductive: Effects on fertility: AbortionSOVEA7 27,246,1974
oral/guinea pig 15 gm/kg (24W prior to copulation)Reproductive: Effects on newborn: StillbirthTXAPA9 12,179,1968
oral/guinea pig 1670 gm/kg (29W prior to copulation)Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Other effects to embryo or fetus
TXAPA9 12,179,1968

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intravenous/cat lowest published lethal dose: 100 mg/kgHBAMAK 4,1289,1935
oral/rabbit lethal dose (50 percent kill): 1901 mg/kgSOVEA7 27,246,1974
oral/rat lethal dose (50 percent kill): 3540 mg/kgLung, Thorax, or Respiration: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVN5* -,49,1993
oral/rat lowest published toxic dose: 10 mg/kgBlood: Methemoglobinemia- Carboxhemoglobinemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVN5* -,49,1993
oral/rat lethal dose (50 percent kill): 3750 mg/kgNYKZAU 81,469,1983

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 36 gm/kg/90D- intermittentGastrointestinal: Other changesBECTA6 60,185,1998
oral/rat lowest published toxic dose: 2250 mg/kg/150D- intermittentEndocrine: Thyroid weight (goiter)

Endocrine: Evidence of thyroid hypofunction

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 147,27,2004

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 94,325,2010
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 94,325,2010
International Agency for Research on Cancer (IARC)Cancer Review:Group 2AIMEMDT 94,325,2010
TOXICOLOGY REVIEWTXAPA9 243,180,2010

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,318,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 80350; Number of Industries 67; Total Number of Facilities 4503; Number of Occupations 65; Total Number of Employees Exposed 66562; Total Number of Female Employees Exposed 26088
National Occupational Hazard Survey 1974Hazard Code 80350; Number of Industries 67; Total Number of Facilities 4730; Number of Occupations 53; Total Number of Employees Exposed 36204

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8804
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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