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Registry of Toxic Effects of Chemical Substances (RTECS)

Potassium chloride

RTECS #

TS8050000

CAS #

7447-40-7; 12599-00-7; 59217-68-4

Updated

December 2013

Molecular Weight

74.55

Molecular Formula

ClK

Synonyms

Chlorid draselny (Czech)
Chloropotassuril
Dipotassium dichloride
Emplets potassium chloride
Enseal
Kalitabs
Kaochlor
Kaon-Cl
Kaon-Cl 10
Kaon-Cl TABS
Kay ciel
K-Dur
K-Lor
Klor-Con
Klotrix
K-Lyte/Cl
K-Predne-dome
Monopotassium chloride
Muriate of potash
Pfiklor
Potassium monochloride
Potavescent
Rekawan
Slow K
Super K
Super K (salt)
Tripotassium trichloride

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H mild28ZPAK -,8,1972

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster12 gm/LFCTOD7 22,501,1984
Cytogenetic Analysisovary/hamster140 mmol/LMUREAV 189,15,1987
DNA Damageovary/hamster260 mmol/LMUREAV 189,15,1987
DNA Damageleukocyte/human1 mmol/L/2HEMMUEG 42,144,2003
gene conversion and mitotic recombination/Saccharomyes cerevisiae400 mmol/LMUTAEX 1,21,1986
mutation in microorganisms/Salmonella typhimurium100 µg/plate (+/-enzymatic activation step)NTPTB* APR1982
mutation in microorganisms/Saccharomyes cerevisiae2500 mmol/L (-enzymatic activation step)GENRA8 37,173,1981
mutation in microorganismslymphocyte/mouse2048 mg/L (+enzymatic activation step)EMMUEG 12(Suppl 13),37,1988
sex chromosome loss and nondisjunction/Saccharomyes cerevisiae300 mmol/LMUTAEX 1,21,1986
sister chromatid exchangeovary/hamster180 mmol/LMUREAV 189,15,1987
Unscheduled DNA Synthesisoral/rat1500 µg/kgJJCREP 80,424,1989

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Chicken, neurons Inhibitor Concentration (50 percent kill): 129798 µmol/L/21HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,653,1993
In Vitro/Chicken, neurons Inhibitor Concentration (10 percent kill): 38748 µmol/L/21HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,653,1993
In Vitro/Chicken, neurons Inhibitor Concentration (50 percent kill): 97249 µmol/L/20HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 7,653,1993
In Vitro/Chicken, neurons Inhibitor Concentration (10 percent kill): 24440 µmol/L/20HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 7,653,1993
In Vitro/Human, melanoma Inhibitor Concentration Low: 60 µmol/LGastrointestinal: Contraction (isolated tissue)FTRPAE 83,1286,2012
In Vitro/phaInhibitor Concentration Low: 60 mmol/LVascular: Contraction (isolated tissue)JOETD7 134,50,2011
In Vitro/pzxInhibitor Concentration Low: 60 µmol/LNutritional and Gross Metabolic: Changes in: CaFTRPAE 82,988,2011
In Vitro/pzxInhibitor Concentration Low: 30 mmol/LVascular: Contraction (isolated tissue)TXAPA9 245,203,2010
In Vitro/Rat, endocrine tumor Inhibitor Concentration Low: 100 mmol/L/20SNutritional and Gross Metabolic: Changes in: CaNRTXDN 33,255,2012
intraarterial/guinea pig lowest published lethal dose: 130 mg/kgAEPPAE 131,171,1928
intracerebral/rat lowest published toxic dose: 272.7 mg/kgBiochemical: Neurotransmitters or modulators (putative): Dopamine in striatumTXCYAC 236,42,2007
intraperitoneal/guinea pig lowest published lethal dose: 900 mg/kgBehavioral: Change in motor activity (specific assay)

Behavioral: Coma

Lung, Thorax, or Respiration: Other changes		JPETAB 35,1,1929
intraperitoneal/mouse lethal dose (50 percent kill): 620 mg/kgCOREAF 256,1043,1963
intraperitoneal/rat lethal dose (50 percent kill): 660 mg/kgENTOX* -,520,2005
intravenous/guinea pig lowest published lethal dose: 77 mg/kgAEPPAE 131,171,1928
intravenous/mouse lethal dose (50 percent kill): 117 mg/kgEJTXAZ 8,188,1975
intravenous/rat lethal dose (50 percent kill): 142 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea		ARZNAD 14,1128,1964
intravenous/rat lethal dose (50 percent kill): 142 mg/kgENTOX* -,520,2005
oral/guinea pig lowest published lethal dose: 2500 mg/kgBehavioral: Change in motor activity (specific assay)

Behavioral: Coma

Lung, Thorax, or Respiration: Other changes		JPETAB 35,1,1929
oral/infant lowest published lethal dose: 938 mg/kg/2DLung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Changes in: K		JAMAAP 240,1339,1978
oral/man lowest published lethal dose: 20 mg/kgCardiac: Arrythmias (indlucing changes in conduction)

Gastrointestinal: Nausea or vomiting

Blood: Change in clotting factors		LANCAO 2,919,1980
oral/man lowest published toxic dose: 214.29 mg/kgGastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting		JTCTDW 39,641,2001
oral/mouse lethal dose (50 percent kill): 1500 mg/kgIYKEDH 21,257,1990
oral/rat lethal dose (50 percent kill): 2600 mg/kgENTOX* -,520,2005
oral/woman lowest published toxic dose: 60 mg/kgGastrointestinal: Nausea or vomiting

Blood: Change in clotting factors		LANCAO 2,919,1980
oral/woman lowest published toxic dose: 1500 mg/kgCardiac: Arrythmias (indlucing changes in conduction)

Vascular: BP lowering not characterized in autonomic section		JTCTDW 46,1102,2008
parenteral/guinea pig lowest published lethal dose: 40 mg/kgAEPPAE 131,171,1928
subcutaneous/frog lowest published lethal dose: 2120 mg/kgHBAMAK 4,1289,1935
subcutaneous/guinea pig lowest published lethal dose: 2550 mg/kgHBAMAK 4,1289,1935
subcutaneous/pigeon lowest published lethal dose: 2210 mg/kgHBAMAK 4,1289,1935

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 75.6 gm/kg/6W- continuousKidney, Ureter, and Bladder: Urine volume increasedFCTOD7 42,135,2004
oral/rat lowest published toxic dose: 983 gm/kg/78W- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)FCTOD7 42,135,2004
oral/rat lowest published toxic dose: 1536 gm/kg/130W- continuousEndocrine: Adrenal cortex hyperplasiaFCTOD7 42,135,2004

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWINTEAG 15,7,1974
TOXICOLOGY REVIEWMUREAV 560,101,2004
TOXICOLOGY REVIEWAPHRER 37,1675,2003
TOXICOLOGY REVIEWENTOX* -,520,2005
TOXICOLOGY REVIEWHPCQA4 38,527,2007
TOXICOLOGY REVIEWHTOPA* 1,595,2002
TOXICOLOGY REVIEWNBREV* 5,1,1981
TOXICOLOGY REVIEWNBREV* 11,107,1987

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 60360; Number of Industries 147; Total Number of Facilities 16061; Number of Occupations 125; Total Number of Employees Exposed 387624; Total Number of Female Employees Exposed 175287
National Occupational Hazard Survey 1974Hazard Code 60360; Number of Industries 97; Total Number of Facilities 14471; Number of Occupations 88; Total Number of Employees Exposed 122749

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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