Potassium chloride
RTECS #
TS8050000
CAS #
Updated
March 2019
Molecular Weight
74.55
Molecular Formula
ClK
Synonyms
Chlorid draselny (Czech)
Chloropotassuril
Dipotassium dichloride
Emplets potassium chloride
Enseal
Kalitabs
Kaochlor
Kaon-Cl
Kaon-Cl 10
Kaon-Cl TABS
Kay ciel
K-Dur
K-Lor
Klor-Con
Klotrix
K-Lyte/Cl
K-Predne-dome
Monopotassium chloride
Muriate of potash
Pfiklor
Potassium monochloride
Potavescent
Rekawan
Slow K
Super K
Super K (salt)
Tripotassium trichloride
Chloropotassuril
Dipotassium dichloride
Emplets potassium chloride
Enseal
Kalitabs
Kaochlor
Kaon-Cl
Kaon-Cl 10
Kaon-Cl TABS
Kay ciel
K-Dur
K-Lor
Klor-Con
Klotrix
K-Lyte/Cl
K-Predne-dome
Monopotassium chloride
Muriate of potash
Pfiklor
Potassium monochloride
Potavescent
Rekawan
Slow K
Super K
Super K (salt)
Tripotassium trichloride
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
eye /rabbit | 500 mg/24H | mild | 28ZPAK -,8,1972 |
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
Cytogenetic Analysis | lung/hamster | 12 gm/L | FCTOD7 22,501,1984 |
Cytogenetic Analysis | ovary/hamster | 140 mmol/L | MUREAV 189,15,1987 |
DNA Damage | ovary/hamster | 260 mmol/L | MUREAV 189,15,1987 |
DNA Damage | leukocyte/human | 1 mmol/L/2H | EMMUEG 42,144,2003 |
gene conversion and mitotic recombination | /Saccharomyes cerevisiae | 400 mmol/L | MUTAEX 1,21,1986 |
mutation in microorganisms | /Salmonella typhimurium | 100 µg/plate (+/-enzymatic activation step) | NTPTB* APR1982 |
mutation in microorganisms | /Saccharomyes cerevisiae | 2500 mmol/L (-enzymatic activation step) | GENRA8 37,173,1981 |
mutation in microorganisms | lymphocyte/mouse | 2048 mg/L (+enzymatic activation step) | EMMUEG 12(Suppl 13),37,1988 |
sex chromosome loss and nondisjunction | /Saccharomyes cerevisiae | 300 mmol/L | MUTAEX 1,21,1986 |
sister chromatid exchange | ovary/hamster | 180 mmol/L | MUREAV 189,15,1987 |
Unscheduled DNA Synthesis | oral/rat | 1500 µg/kg | JJCREP 80,424,1989 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
In Vitro/Chicken, neurons | Inhibitor Concentration (50 percent kill): 129798 µmol/L/21H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 7,653,1993 |
In Vitro/Chicken, neurons | Inhibitor Concentration (10 percent kill): 38748 µmol/L/21H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 7,653,1993 |
In Vitro/Chicken, neurons | Inhibitor Concentration (50 percent kill): 97249 µmol/L/20H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 7,653,1993 |
In Vitro/Chicken, neurons | Inhibitor Concentration (10 percent kill): 24440 µmol/L/20H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 7,653,1993 |
In Vitro/hqb | Inhibitor Concentration Low: 80 mmol/L | Vascular: Contraction (isolated tissue) | JOETD7 189,99,2016 |
In Vitro/Human, melanoma | Inhibitor Concentration Low: 60 µmol/L | Gastrointestinal: Contraction (isolated tissue) | FTRPAE 83,1286,2012 |
In Vitro/jzx | Inhibitor Concentration (50 percent kill): 5592.89 mg/L/48H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 25,1989,2011 |
In Vitro/Mouse, fibroblast | Inhibitor Concentration (50 percent kill): 50.5 mmol/L/48H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 27,1357,2013 |
In Vitro/oga | Inhibitor Concentration Low: 15 mmol/L | Vascular: Contraction (isolated tissue) | PYTOEY 23,793,2016 |
In Vitro/ozx | Inhibitor Concentration Low: 40 mmol/L | Vascular: Contraction (isolated tissue) | TIVIEQ 27,627,2013 |
In Vitro/paa | Inhibitor Concentration Low: 22.0 mmol/L/44H | In Vitro Toxicity Studies: Other assays | TIVIEQ 27,1416,2013 |
In Vitro/pha | Inhibitor Concentration Low: 60 mmol/L | Vascular: Contraction (isolated tissue) | JOETD7 134,50,2011 |
In Vitro/pzx | Inhibitor Concentration Low: 60 µmol/L | Nutritional and Gross Metabolic: Changes in: Ca | FTRPAE 82,988,2011 |
In Vitro/pzx | Inhibitor Concentration Low: 30 mmol/L | Vascular: Contraction (isolated tissue) | TXAPA9 245,203,2010 |
In Vitro/Rat, endocrine tumor | Inhibitor Concentration Low: 100 mmol/L/20S | Nutritional and Gross Metabolic: Changes in: Ca | NRTXDN 33,255,2012 |
In Vitro/Rat, intestinal | Inhibitor Concentration Low: 60 mmol/L | Gastrointestinal: Contraction (isolated tissue) | JOETD7 154,704,2014 |
intraarterial/guinea pig | lowest published lethal dose: 130 mg/kg | AEPPAE 131,171,1928 | |
intracerebral/rat | lowest published toxic dose: 272.7 mg/kg | Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum | TXCYAC 236,42,2007 |
intraperitoneal/guinea pig | lowest published lethal dose: 900 mg/kg | Behavioral: Change in motor activity (specific assay) Behavioral: Coma Lung, Thorax, or Respiration: Other changes | JPETAB 35,1,1929 |
intraperitoneal/mouse | lethal dose (50 percent kill): 620 mg/kg | COREAF 256,1043,1963 | |
intraperitoneal/rat | lethal dose (50 percent kill): 660 mg/kg | ENTOX* -,520,2005 | |
intravenous/guinea pig | lowest published lethal dose: 77 mg/kg | AEPPAE 131,171,1928 | |
intravenous/mouse | lethal dose (50 percent kill): 117 mg/kg | EJTXAZ 8,188,1975 | |
intravenous/rat | lethal dose (50 percent kill): 142 mg/kg | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea | ARZNAD 14,1128,1964 |
intravenous/rat | lethal dose (50 percent kill): 142 mg/kg | ENTOX* -,520,2005 | |
oral/guinea pig | lowest published lethal dose: 2500 mg/kg | Behavioral: Change in motor activity (specific assay) Behavioral: Coma Lung, Thorax, or Respiration: Other changes | JPETAB 35,1,1929 |
oral/infant | lowest published lethal dose: 938 mg/kg/2D | Lung, Thorax, or Respiration: Cyanosis Lung, Thorax, or Respiration: Other changes Nutritional and Gross Metabolic: Changes in: K | JAMAAP 240,1339,1978 |
oral/man | lowest published lethal dose: 20 mg/kg | Cardiac: Arrythmias (indlucing changes in conduction) Gastrointestinal: Nausea or vomiting Blood: Change in clotting factors | LANCAO 2,919,1980 |
oral/man | lowest published toxic dose: 214.29 mg/kg | Gastrointestinal: Hypermotility, diarrhea Gastrointestinal: Nausea or vomiting | JTCTDW 39,641,2001 |
oral/mouse | lethal dose (50 percent kill): 1500 mg/kg | IYKEDH 21,257,1990 | |
oral/rat | lethal dose (50 percent kill): 2600 mg/kg | ENTOX* -,520,2005 | |
oral/woman | lowest published toxic dose: 60 mg/kg | Gastrointestinal: Nausea or vomiting Blood: Change in clotting factors | LANCAO 2,919,1980 |
oral/woman | lowest published toxic dose: 1500 mg/kg | Cardiac: Arrythmias (indlucing changes in conduction) Vascular: BP lowering not characterized in autonomic section | JTCTDW 46,1102,2008 |
parenteral/guinea pig | lowest published lethal dose: 40 mg/kg | AEPPAE 131,171,1928 | |
subcutaneous/frog | lowest published lethal dose: 2120 mg/kg | HBAMAK 4,1289,1935 | |
subcutaneous/guinea pig | lowest published lethal dose: 2550 mg/kg | HBAMAK 4,1289,1935 | |
subcutaneous/pigeon | lowest published lethal dose: 2210 mg/kg | HBAMAK 4,1289,1935 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/rat | lowest published toxic dose: 75.6 gm/kg/6W- continuous | Kidney, Ureter, and Bladder: Urine volume increased | FCTOD7 42,135,2004 |
oral/rat | lowest published toxic dose: 983 gm/kg/78W- continuous | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | FCTOD7 42,135,2004 |
oral/rat | lowest published toxic dose: 1536 gm/kg/130W- continuous | Endocrine: Adrenal cortex hyperplasia | FCTOD7 42,135,2004 |
Reviews
Organization | Standard | Reference |
---|---|---|
TOXICOLOGY REVIEW | INTEAG 15,7,1974 | |
TOXICOLOGY REVIEW | MUREAV 560,101,2004 | |
TOXICOLOGY REVIEW | APHRER 37,1675,2003 | |
TOXICOLOGY REVIEW | ENTOX* -,520,2005 | |
TOXICOLOGY REVIEW | HPCQA4 38,527,2007 | |
TOXICOLOGY REVIEW | HTOPA* 1,595,2002 | |
TOXICOLOGY REVIEW | NBREV* 5,1,1981 | |
TOXICOLOGY REVIEW | NBREV* 11,107,1987 | |
TOXICOLOGY REVIEW | RTOPDW 55,200,2009 | |
TOXICOLOGY REVIEW | RTOPDW 58,395,2010 | |
TOXICOLOGY REVIEW | FCTOD7 111,329,2018 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Occupational Exposure Limit-RUSSIA | short term exposure limit 5 mg/m3, JUN2003 |
NIOSH Documentation and Surveillance
Status in Federal Agencies
Organization | Reference |
---|---|
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health