Potassium chloride

RTECS #

TS8050000

CAS #

7447-40-7; 12599-00-7; 59217-68-4
See: NMAM or OSHA Methods

Updated

March 2019

Molecular Weight

74.55

Molecular Formula

ClK

Synonyms

Chlorid draselny (Czech)
Chloropotassuril
Dipotassium dichloride
Emplets potassium chloride
Enseal
Kalitabs
Kaochlor
Kaon-Cl
Kaon-Cl 10
Kaon-Cl TABS
Kay ciel
K-Dur
K-Lor
Klor-Con
Klotrix
K-Lyte/Cl
K-Predne-dome
Monopotassium chloride
Muriate of potash
Pfiklor
Potassium monochloride
Potavescent
Rekawan
Slow K
Super K
Super K (salt)
Tripotassium trichloride

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	500 mg/24H	mild	28ZPAK -,8,1972

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	lung/hamster	12 gm/L	FCTOD7 22,501,1984
Cytogenetic Analysis	ovary/hamster	140 mmol/L	MUREAV 189,15,1987
DNA Damage	ovary/hamster	260 mmol/L	MUREAV 189,15,1987
DNA Damage	leukocyte/human	1 mmol/L/2H	EMMUEG 42,144,2003
gene conversion and mitotic recombination	/Saccharomyes cerevisiae	400 mmol/L	MUTAEX 1,21,1986
mutation in microorganisms	/Salmonella typhimurium	100 µg/plate (+/-enzymatic activation step)	NTPTB* APR1982
mutation in microorganisms	/Saccharomyes cerevisiae	2500 mmol/L (-enzymatic activation step)	GENRA8 37,173,1981
mutation in microorganisms	lymphocyte/mouse	2048 mg/L (+enzymatic activation step)	EMMUEG 12(Suppl 13),37,1988
sex chromosome loss and nondisjunction	/Saccharomyes cerevisiae	300 mmol/L	MUTAEX 1,21,1986
sister chromatid exchange	ovary/hamster	180 mmol/L	MUREAV 189,15,1987
Unscheduled DNA Synthesis	oral/rat	1500 µg/kg	JJCREP 80,424,1989

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Chicken, neurons	Inhibitor Concentration (50 percent kill): 129798 µmol/L/21H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 7,653,1993
In Vitro/Chicken, neurons	Inhibitor Concentration (10 percent kill): 38748 µmol/L/21H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 7,653,1993
In Vitro/Chicken, neurons	Inhibitor Concentration (50 percent kill): 97249 µmol/L/20H	In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.	TIVIEQ 7,653,1993
In Vitro/Chicken, neurons	Inhibitor Concentration (10 percent kill): 24440 µmol/L/20H	In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.	TIVIEQ 7,653,1993
In Vitro/hqb	Inhibitor Concentration Low: 80 mmol/L	Vascular: Contraction (isolated tissue)	JOETD7 189,99,2016
In Vitro/Human, melanoma	Inhibitor Concentration Low: 60 µmol/L	Gastrointestinal: Contraction (isolated tissue)	FTRPAE 83,1286,2012
In Vitro/jzx	Inhibitor Concentration (50 percent kill): 5592.89 mg/L/48H	In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.	TIVIEQ 25,1989,2011
In Vitro/Mouse, fibroblast	Inhibitor Concentration (50 percent kill): 50.5 mmol/L/48H	In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.	TIVIEQ 27,1357,2013
In Vitro/oga	Inhibitor Concentration Low: 15 mmol/L	Vascular: Contraction (isolated tissue)	PYTOEY 23,793,2016
In Vitro/ozx	Inhibitor Concentration Low: 40 mmol/L	Vascular: Contraction (isolated tissue)	TIVIEQ 27,627,2013
In Vitro/paa	Inhibitor Concentration Low: 22.0 mmol/L/44H	In Vitro Toxicity Studies: Other assays	TIVIEQ 27,1416,2013
In Vitro/pha	Inhibitor Concentration Low: 60 mmol/L	Vascular: Contraction (isolated tissue)	JOETD7 134,50,2011
In Vitro/pzx	Inhibitor Concentration Low: 60 µmol/L	Nutritional and Gross Metabolic: Changes in: Ca	FTRPAE 82,988,2011
In Vitro/pzx	Inhibitor Concentration Low: 30 mmol/L	Vascular: Contraction (isolated tissue)	TXAPA9 245,203,2010
In Vitro/Rat, endocrine tumor	Inhibitor Concentration Low: 100 mmol/L/20S	Nutritional and Gross Metabolic: Changes in: Ca	NRTXDN 33,255,2012
In Vitro/Rat, intestinal	Inhibitor Concentration Low: 60 mmol/L	Gastrointestinal: Contraction (isolated tissue)	JOETD7 154,704,2014
intraarterial/guinea pig	lowest published lethal dose: 130 mg/kg		AEPPAE 131,171,1928
intracerebral/rat	lowest published toxic dose: 272.7 mg/kg	Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum	TXCYAC 236,42,2007
intraperitoneal/guinea pig	lowest published lethal dose: 900 mg/kg	Behavioral: Change in motor activity (specific assay) Behavioral: Coma Lung, Thorax, or Respiration: Other changes	JPETAB 35,1,1929
intraperitoneal/mouse	lethal dose (50 percent kill): 620 mg/kg		COREAF 256,1043,1963
intraperitoneal/rat	lethal dose (50 percent kill): 660 mg/kg		ENTOX* -,520,2005
intravenous/guinea pig	lowest published lethal dose: 77 mg/kg		AEPPAE 131,171,1928
intravenous/mouse	lethal dose (50 percent kill): 117 mg/kg		EJTXAZ 8,188,1975
intravenous/rat	lethal dose (50 percent kill): 142 mg/kg	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea	ARZNAD 14,1128,1964
intravenous/rat	lethal dose (50 percent kill): 142 mg/kg		ENTOX* -,520,2005
oral/guinea pig	lowest published lethal dose: 2500 mg/kg	Behavioral: Change in motor activity (specific assay) Behavioral: Coma Lung, Thorax, or Respiration: Other changes	JPETAB 35,1,1929
oral/infant	lowest published lethal dose: 938 mg/kg/2D	Lung, Thorax, or Respiration: Cyanosis Lung, Thorax, or Respiration: Other changes Nutritional and Gross Metabolic: Changes in: K	JAMAAP 240,1339,1978
oral/man	lowest published lethal dose: 20 mg/kg	Cardiac: Arrythmias (indlucing changes in conduction) Gastrointestinal: Nausea or vomiting Blood: Change in clotting factors	LANCAO 2,919,1980
oral/man	lowest published toxic dose: 214.29 mg/kg	Gastrointestinal: Hypermotility, diarrhea Gastrointestinal: Nausea or vomiting	JTCTDW 39,641,2001
oral/mouse	lethal dose (50 percent kill): 1500 mg/kg		IYKEDH 21,257,1990
oral/rat	lethal dose (50 percent kill): 2600 mg/kg		ENTOX* -,520,2005
oral/woman	lowest published toxic dose: 60 mg/kg	Gastrointestinal: Nausea or vomiting Blood: Change in clotting factors	LANCAO 2,919,1980
oral/woman	lowest published toxic dose: 1500 mg/kg	Cardiac: Arrythmias (indlucing changes in conduction) Vascular: BP lowering not characterized in autonomic section	JTCTDW 46,1102,2008
parenteral/guinea pig	lowest published lethal dose: 40 mg/kg		AEPPAE 131,171,1928
subcutaneous/frog	lowest published lethal dose: 2120 mg/kg		HBAMAK 4,1289,1935
subcutaneous/guinea pig	lowest published lethal dose: 2550 mg/kg		HBAMAK 4,1289,1935
subcutaneous/pigeon	lowest published lethal dose: 2210 mg/kg		HBAMAK 4,1289,1935

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	lowest published toxic dose: 75.6 gm/kg/6W- continuous	Kidney, Ureter, and Bladder: Urine volume increased	FCTOD7 42,135,2004
oral/rat	lowest published toxic dose: 983 gm/kg/78W- continuous	Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)	FCTOD7 42,135,2004
oral/rat	lowest published toxic dose: 1536 gm/kg/130W- continuous	Endocrine: Adrenal cortex hyperplasia	FCTOD7 42,135,2004

Reviews

Organization	Standard	Reference
TOXICOLOGY REVIEW		INTEAG 15,7,1974
TOXICOLOGY REVIEW		MUREAV 560,101,2004
TOXICOLOGY REVIEW		APHRER 37,1675,2003
TOXICOLOGY REVIEW		ENTOX* -,520,2005
TOXICOLOGY REVIEW		HPCQA4 38,527,2007
TOXICOLOGY REVIEW		HTOPA* 1,595,2002
TOXICOLOGY REVIEW		NBREV* 5,1,1981
TOXICOLOGY REVIEW		NBREV* 11,107,1987
TOXICOLOGY REVIEW		RTOPDW 55,200,2009
TOXICOLOGY REVIEW		RTOPDW 58,395,2010
TOXICOLOGY REVIEW		FCTOD7 111,329,2018

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit-RUSSIA	short term exposure limit 5 mg/m³, JUN2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Occupational Exposure Survey 1983	Hazard Code 60360; Number of Industries 147; Total Number of Facilities 16061; Number of Occupations 125; Total Number of Employees Exposed 387624; Total Number of Female Employees Exposed 175287
National Occupational Hazard Survey 1974	Hazard Code 60360; Number of Industries 97; Total Number of Facilities 14471; Number of Occupations 88; Total Number of Employees Exposed 122749

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health