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Registry of Toxic Effects of Chemical Substances (RTECS)

Phthalimide, N-((trichloromethyl)thio)-

RTECS #

TI5685000

CAS #

133-07-3; 52306-33-9

Updated

December 2016

Molecular Weight

296.55

Molecular Formula

C9H4Cl3NO2S

Synonyms

1H-Isoindole-1,3(2H)-dione, 2-((trichloromethyl)thio)-
2-((Trichloromethyl)thio)-1H-isoindole-1,3(2H)-dione
Acryptan
Cymoxanil
ENT 26539
Faltex
Folnit
Folpan
Folpel
Folpet
Folpex
Ftalan
Fungitrol II
Intercide TMP
N-(Trichlor-methylthio)-phthalamid (German)
N-(Trichlormethylthio)phthalimide
N-(Trichloromethylmercpato)phthalimide
N-(Trichloromethylthio)phthalimide
Orthophaltan
Phaltan
Phthaltan
SHA 081601
Spolacid
Thiophal
Trichlormethylthioimid kyseliny ftalove (Czech)
Troysan anti-mildew O
Vinicoll

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /human 0.1%/48HCODEDG 17,212,1987

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human15 µg/L/15MMUREAV 53,263,1978
DNA DamageHeLa cell/human1300 nmol/LEMMUEG 17,20,1991
DNA inhibitionother cell types/rat8 mg/LARTODN 45,101,1980
DNA inhibitionlymphocyte/human5 mg/LARTODN 45,101,1980
DNA inhibitionHeLa cell/human1300 nmol/LEMMUEG 17,20,1991
DNA repair/Bacillus subtilis10 µg/discMUREAV 40,19,1976
DNA repair/Escherichia coli4 µg/wellMUREAV 133,161,1984
Dominant Lethal Testoral/rat500 mg/kg/5DFCTXAV 10,363,1972
gene conversion and mitotic recombination/Saccharomyes cerevisiae200 ppmMUREAV 10,533,1970
mutation in mammalian somatic cellslymphocyte/mouse270 µg/LNTIS** PB84-138973
mutation in mammalian somatic cellsovary/hamster250 µg/LENMUDM 3,233,1981
mutation in mammalian somatic cellsovary/hamster0.75 mg/L/10H (-enzymatic activation step)FEREAC 68,10377,2003
mutation in mammalian somatic cellsovary/hamster0.26 mg/L/10H (+enzymatic activation step)FEREAC 68,10377,2003
mutation in mammalian somatic cellsovary/hamster25 mg/L/20H (+enzymatic activation step)FEREAC 68,10377,2003
mutation in microorganisms/Bacillus subtilis50 µg/plate (+/-enzymatic activation step)JAFCAU 29,268,1981
mutation in microorganisms/Salmonella typhimurium16 nmol/plate (+enzymatic activation step)CRNGDP 2,283,1981
mutation in microorganisms/Salmonella typhimurium1 µg/plate (-enzymatic activation step)NTIS** PB268-647
mutation in microorganisms/Escherichia coli5 µg/plate (+/-enzymatic activation step)NTIS** PB268-647
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster2000 ppmJPFCD2 15,867,1980
Unscheduled DNA Synthesisfibroblast/human100 µmol/LNTIS** PB268-647

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/mouse 491 mg/m3/4H (6-13D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathNTIS** PB84-128099
intraperitoneal/rat 500 mg/kg (5D male)Reproductive: Effects on embryo or fetus: Fetal deathFCTXAV 10,363,1972
oral/rat 500 mg/kg (5D male)Reproductive: Effects on embryo or fetus: Fetal deathFCTXAV 10,363,1972
oral/rabbit 488 mg/kg (6-18D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)TXAPA9 13,420,1968
oral/hamster 500 mg/kg (8D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathTXAPA9 16,24,1970
oral/hamster 900 mg/kg (7D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemTXAPA9 16,24,1970
oral/hamster 600 mg/kg (7D pregnant)Reproductive: Specific developmental abnormalities: Central nervous systemTXAPA9 16,24,1970
subcutaneous/mouse 900 mg/kg (6-14D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
NTIS** PB223-160
subcutaneous/mouse 900 mg/kg (6-14D pregnant)Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Urogenital system
NTIS** PB223-160

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 437 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
JJCREP 81,514,1990
subcutaneous/mouse lowest published toxic dose: 1000 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Tumors
NTIS** PB223-159

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): >6 gm/m3/2HTXAPA9 45,320,1978
inhalation/rat lethal concentration (50 percent kill): >5 gm/m3/2HTXAPA9 45,320,1978
inhalation/rat lethal concentration (50 percent kill): >0.48 gm/m3/4HFEREAC 68,1182,2003
intraperitoneal/mouse lethal dose (50 percent kill): 80 mg/kgBehavioral: Convulsions or effect on seizure thresholdABMGAJ 7,502,1961
intraperitoneal/rat lethal dose (50 percent kill): 40 mg/kgENTOX* -,349,2005
intratracheal/rat lowest published toxic dose: 2 mg/kgLung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
FCLPH* 23(Suppl 1),6,2009
oral/mouse lethal dose (50 percent kill): 1546 mg/kgGTPZAB 18(5),50,1974
oral/rabbit lethal dose (50 percent kill): 1115 mg/kgGTPZAB 18(5),50,1974
oral/rat lethal dose (50 percent kill): >5000 mg/kgFEREAC 68,1182,2003
oral/rat lethal dose (50 percent kill): 2636 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Behavioral: Ataxia
NTIS** OTS0533649-9
oral/wild bird lethal dose (50 percent kill): >2.51 mg/kgENTOX* -,349,2005
skin/mouse lowest published lethal dose: 5 gm/kgJACTDZ 9,642,1991
skin/rabbit lethal dose (50 percent kill): >22.6 gm/kgENTOX* -,349,2005
skin/rat lethal dose (50 percent kill): >5000 mg/kgFEREAC 68,1182,2003
unreported route/mouse lethal dose (50 percent kill): 750 mg/kgABMGAJ 1,450,1958
unreported route/rat lethal dose (50 percent kill): >10 gm/kgRREVAH 36,240,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 397082 mg/kg/113W- continuousGastrointestinal: TumorsHBPTO* 1,814,2001
oral/mouse lowest published toxic dose: 109.5 gm/kg/2Y- continuousGastrointestinal: Tumors

Tumorigenic: Tumor types after systemic administration not seen spontaneously
FEREAC 68,10377,2003
oral/rat lowest published toxic dose: 25550 mg/kg/2Y- continuousGastrointestinal: Ulceration or bleeding from stomach

Gastrointestinal: Other changes
FEREAC 68,1182,2003
oral/rat lowest published toxic dose: 45000 mg/kg/90D- continuousBrain and Coverings: Changes in brain weight

Biochemical: Metabolism (intermediary): Other proteins
FEREAC 68,1182,2003
skin/rat lowest published toxic dose: 21 mg/kg/6H/30D- continuousSkin: After topical application: Primary irritationFEREAC 68,1182,2003

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 32,3,1975
TOXICOLOGY REVIEWMUREAV 557,109,2004
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWMUREAV 613,17,2006
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWENTOX* -,349,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWFEREAC 72,41913,2007
TOXICOLOGY REVIEWMUREAV 769,34,2014
TOXICOLOGY REVIEWTXAPA9 268,157,2013

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,121,1998

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M0327; Number of Industries 8; Total Number of Facilities 628; Number of Occupations 21; Total Number of Employees Exposed 10509; Total Number of Female Employees Exposed 1422
National Occupational Hazard Survey 1974Hazard Code M0327; Number of Industries 4; Total Number of Facilities 608; Number of Occupations 8; Total Number of Employees Exposed 1240

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Rodent dominant lethal; B subtilis rec assay
EPA GENETOX PROGRAM 1988, Negative: Host-mediated assay; In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal; TRP reversion
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Weakly Positive: TRP reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database
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