Phthalic acid

RTECS #
TH9625000
CAS #
88-99-3
See: NMAM or OSHA Methods
Updated
July 2015
Molecular Weight
166.14
Molecular Formula
C8H6O4
Synonyms
1,2-Benzenedicarboxylic acid
Acide phtalique (French)
Benzene-1,2-dicarboxylic acid
Kyselina ftalova (Czech)
o-Benzenedicarboxylic acid
o-Dicarboxybenzene
O-Phthalic acid

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Dominant Lethal Testintraperitoneal/mouse200 mg/kg/5D-continuousMUREAV 422,207,1998
sperm morphologyintraperitoneal/mouse100 mg/kgMUREAV 422,207,1998

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 29810 mg/kg (7-16D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TOLED5 93,109,1997

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Non-mammalian species, liver Inhibitor Concentration Low: 0.01 µmol/L/4DIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,84,2013
In Vitro/ptiInhibitor Concentration (50 percent kill): 325 µmol/L/24HIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,1711,2013
intraperitoneal/mouse lethal dose (50 percent kill): 250 mg/kgFCTOD7 41,405,2003
intraperitoneal/mouse lethal dose (50 percent kill): 550 mg/kgBehavioral: Change in motor activity (specific assay)

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Cyanosis
PSEBAA 49,471,1942
oral/mouse lethal dose (50 percent kill): >5000 mg/kgFCTOD7 41,405,2003
oral/mouse lethal dose (50 percent kill): 2530 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Gastrointestinal: Hypermotility, diarrhea
ATDAEI 1,711,1992
rectal/mouse lethal dose (50 percent kill): 510 mg/kgFCTOD7 41,405,2003
unreported route/rat lethal dose (50 percent kill): 1100 mg/kgGISAAA 32(8),12,1967

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 102 mg/kg/26W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)GISAAA 32(8),12,1967

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWBPCT** -,183,1974
TOXICOLOGY REVIEWHTOPA* 1,501,2002

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 59185; Number of Industries 22; Total Number of Facilities 1480; Number of Occupations 27; Total Number of Employees Exposed 19693; Total Number of Female Employees Exposed 2861
National Occupational Hazard Survey 1974Hazard Code 59185; Number of Industries 4; Total Number of Facilities 106; Number of Occupations 8; Total Number of Employees Exposed 2321

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
Page last reviewed: November 16, 2018