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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphorothioic acid, O,O-diethyl O-(p-nitrophenyl) ester

RTECS #

TF4550000

CAS #

56-38-2; 8057-70-3; 11111-91-4; 110616-89-2

Updated

April 2017

Molecular Weight

291.28

Molecular Formula

C10H14NO5PS

Synonyms

AATP
Alkron
Alleron
American cyanamid 3422
Aphamite
Aralo
B 404
Bay 1605
BAY E-605
Bayer E-605
Bladan F
Compound 3422
Diethyl 4-nitrophenyl phosphorothionate
Diethyl para-nitrophenol thiophosphate
Diethyl p-nitrophenyl phosphorothionate
Diethyl p-nitrophenyl thionophosphate
Diethyl p-nitrophenyl thiophosphate
Diethylparathion
Dietil tiofosfato de p-nitrofenila (Portuguese)
Drexel parathion 8E
E 605
E 605 F
E 605 forte
Ekatin WF & WF ULV
Ekatox
ENT 15,108
Ethyl parathion
Etilon
Etylparation (Czech)
Folidol
Folidol E
Folidol E605
Folidol oil
Fosferno
Fosfex
Fostern
Gearphos
Kolphos
Lethalaire G-54
Lirothion
Murfos
NCI-C00226
Niran
Niran E-4
Nitrostigmin (German)
Nitrostigmine
NIUIF-100
Nourithion
O,O-Diaethyl-O-(4-nitro-phenyl)-monothiophosphat (German)
O,O-Diethyl O-(p-nitrophenyl) phosphorothioate
O,O-Diethyl O-4-nitrophenyl thiophosphate
O,O-Diethyl O-p-nitrophenyl thiophosphate
O,O-Diethyl-O-(4-nitro-fenil)-monothiofosfaat (Dutch)
O,O-Diethyl-O-(4-nitrophenyl) phosphorothioate
O,O-Diethyl-O-(p-nitrophenyl)thionophosphate
O,O-Diethyl-O-p-nitrofenylester kyseliny thiofosforecne (Czech)
O,O-Dietil-O-(4-nitro-fenil)-monotiofosfato (Italian)
O,O-Dietyl-O-p-nitrofenyltiofosfat (Czech)
Oleofos 20
Oleoparaphene
Oleoparathion
OMS 19
Orthophos
Pacol
Panthion
Paradust
Paramar 50
Paraphos
Parathene
Parathion
Parathion (ACGIH:OSHA)
Parathion-aethyl (German)
Parathion-ethyl
Parawet
Penncap E
Pestox plus
Pethion
Phenol, p-nitro-, O-ester with O,O-diethylphosphorothioate
Phoskil
Phosphemol
Phosphenol
Phosphorothioic acid, O,O-diethyl O-(4-nitrophenyl) ester
Phosphostigmine
RB
RCRA waste number P089
Rhodiasol
Rhodiatox
Selephos
SNP
Soprathion
Stabilized ethyl parathion
Super Rodiatox
T-47
Thiofos
Thiomex
Thiophos
Thiophos 3422
Thiophosphate de O,O-diethyle et de O-(4-nitrophenyle) (French)
Vitrex

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageoral/rat10 mg/kg/28D- intermittentMUREAV 53,175,1978
DNA Damageintraperitoneal/rat3 µg/kgMUREAV 53,175,1978
DNA Damageoral/mouse20 mg/kg/28D- intermittentMUREAV 53,175,1978
DNA Damageintraperitoneal/mouse3 µg/kgMUREAV 53,175,1978
DNA Damagelymphocyte/rat10 µmol/L/16HJAPTO* 23,23,2003
DNA Damagelymphocyte/mouse10 µmol/L/16HJAPTO* 23,23,2003
mutation in microorganisms/Salmonella typhimurium1 mg/plate (+enzymatic activation step)ENMUDM 5(Suppl 1),3,1983
mutation in microorganisms/Salmonella typhimurium500 µg/plate (-enzymatic activation step)JTEHD6 16,403,1985
sister chromatid exchangeovary/hamster300 µmol/LJTEHD6 8,939,1981
sister chromatid exchangelymphocyte/human200 µg/LMUREAV 102,89,1982
Unscheduled DNA Synthesisfibroblast/human10 µmol/LNTIS** PB268-647

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 3 mg/kg (11D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)AEHLAU 16,805,1968
intraperitoneal/rat 3 mg/kg (11D pregnant)Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Other effects on female

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AEHLAU 16,805,1968
intraperitoneal/rat 3500 µg/kg (11D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)AEHLAU 16,805,1968
intraperitoneal/rat 980 µg/kg (9D pregnant)Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
AJOGAH 96,1148,1966
oral/rat 360 µg/kg (2-22D preg/15D after birth)Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Other postnatal measures or effects
TOLED5 3,11,1979
oral/rat 2304 µg/kg (16D prior to copulation)Reproductive: Maternal effects: Uterus, cervix, vaginaTOERD9 3,279,1981
oral/rat 22 mg/kg (1-22D pregnant)Reproductive: Effects on newborn: Biochemical and metabolicJJATDK 9,401,1989
subcutaneous/rat 6 mg/kg (13-16D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)PWPSA8 16,141,1973
subcutaneous/rat 9800 µg/kg (7-13D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathOYYAA2 6,667,1972

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 1260 mg/kg/80W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Adrenal cortex tumors
NCITR* NCI-TR-70,1979

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, skin Inhibitor Concentration (50 percent kill): 14.6 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 27,1347,2013
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 14.2 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 27,1347,2013
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 7.28 mg/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,1347,2013
In Vitro/mtbInhibitor Concentration (50 percent kill): 36 µmol/LIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TOLED5 207,182,2011
In Vitro/mtbInhibitor Concentration (50 percent kill): 54 µmol/LIn Vitro Toxicity Studies: Other assaysTOLED5 207,182,2011
In Vitro/mtbInhibitor Concentration (50 percent kill): 0.14 mmol/L/48HIn Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc.TXCYAC 314,135,2013
In Vitro/mtbInhibitor Concentration (50 percent kill): 0.12 mmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXCYAC 314,135,2013
In Vitro/mtbInhibitor Concentration (50 percent kill): 0.083 mmol/L/72HIn Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc.TXCYAC 314,135,2013
In Vitro/mtbInhibitor Concentration (50 percent kill): 0.16 mmol/L/72HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXCYAC 314,135,2013
In Vitro/mtbInhibitor Concentration (50 percent kill): 0.24 mmol/L/72HIn Vitro Toxicity Studies: Cell differentiationTXCYAC 314,135,2013
In Vitro/paaInhibitor Concentration Low: 5.18 µmol/L/44HIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,1416,2013
In Vitro/Rat, endocrine tumor Inhibitor Concentration (50 percent kill): 4.13 µmol/L/20MIn Vitro Toxicity Studies: Other assaysNRTXDN 43,110,2014
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): 2.10 mg/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,1347,2013
inhalation/Dog Lethal concentration: >37130 µg/m3/4HBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseNTIS** AD-A041-973
inhalation/guinea pig Lowest published lethal concentration: 14 mg/m3/2HAMIHBC 5,44,1952
inhalation/mouse Lowest published lethal concentration: 15 mg/m385GMAT -,52,1982
inhalation/rabbit Lowest published lethal concentration: 50 mg/m3/2HAMIHBC 5,44,1952
inhalation/rat lethal concentration (50 percent kill): 84 mg/m3/4HBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
NTIS** AD-A041-973
intramuscular/domestic animal lowest published lethal dose: 20 mg/kgEye: Miosis (pupilliary constriction)

Behavioral: Muscle weakness

Behavioral: Rigidity (includes catalepsy)
MRLR** #269,1954
intramuscular/mouse lethal dose (50 percent kill): 7200 µg/kgAEPPAE 237,211,1959
intramuscular/rat lethal dose (50 percent kill): 6 mg/kgJCINAO 37,350,1958
intraperitoneal/cat lethal dose (50 percent kill): 3 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression
JPETAB 95,79,1949
intraperitoneal/chicken lethal dose (50 percent kill): 2500 µg/kgEQSFAP 3,173,1974
intraperitoneal/Dog lethal dose (50 percent kill): 12 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression
JPETAB 95,79,1949
intraperitoneal/guinea pig lethal dose (50 percent kill): 12 mg/kgARZNAD 5,626,1955
intraperitoneal/mouse lethal dose (50 percent kill): 3 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseJAFCAU 11,91,1963
intraperitoneal/mouse lowest published toxic dose: 10 mg/kgBehavioral: TremorTXAPA9 227,42,2008
intraperitoneal/rat lowest published toxic dose: 1660.3 µg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTXCYAC 253,8,2008
intraperitoneal/rat lethal dose (50 percent kill): 2 mg/kgAPCRAW 4,117,1961
intraperitoneal/rat lowest published toxic dose: 2 mg/kgBrain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 66,314,2002
intratracheal/human lowest published lethal dose: 714 µg/kgSKEZAP 9,1,1968
intratracheal/rat lethal dose (50 percent kill): 6200 µg/kgJJATDK 19,133,1999
intravenous/cat lethal dose (50 percent kill): 3 mg/kgEye: Lacrimation

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation
JAMAAP 144,104,1950
intravenous/Dog lethal dose (50 percent kill): 12 mg/kgEye: Lacrimation

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation
JAMAAP 144,104,1950
intravenous/mouse lethal dose (50 percent kill): 13 mg/kgENTOX* ,706,2005
intravenous/rat lethal dose (50 percent kill): 3800 µg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterasesCJBPAZ 34,197,1956
oral/cat lethal dose (50 percent kill): 0.93 mg/kgENTOX* -,331,2005
oral/chicken lethal dose (50 percent kill): 10 mg/kgEQSFAP 3,173,1974
oral/Dog lethal dose (50 percent kill): 3 mg/kgSPEADM 78-1,33,1978
oral/domestic animal lowest published lethal dose: 100 mg/kgBehavioral: Excitement

Behavioral: Rigidity (includes catalepsy)

Lung, Thorax, or Respiration: Dyspnea
MRLR** #269,1954
oral/duck lethal dose (50 percent kill): 2100 µg/kgDOEAAH 35,25,1979
oral/guinea pig lethal dose (50 percent kill): 8 mg/kgARZNAD 5,626,1955
oral/horse, donkey lethal dose (50 percent kill): 5 mg/kg85DPAN -,-,1971/1976
oral/human lowest published lethal dose: 171 µg/kgCMEP** -,1,1956
oral/human lethal dose (50 percent kill): 3 mg/kg85JFAN A311,1986
oral/mammal (species unspecified) lethal dose (50 percent kill): 49 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
NTIS** PB288-416
oral/man lowest published toxic dose: 2143 mg/kgBehavioral: Coma

Cardiac: Pulse rate decreased with fall in BP

Vascular: Shock
NEURAI 31,603,1981
oral/man lowest published toxic dose: 214 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Change in motor activity (specific assay)

Behavioral: Coma
JNNPAU 56,1135,1993
oral/man lowest published toxic dose: 429 µg/kg/4D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTXAPA9 14,603,1969
oral/mouse lethal dose (50 percent kill): 5 mg/kgABCHA6 30,181,1966
oral/mouse lowest published toxic dose: 4 mg/kgImmunological Including Allergic: Decreased immune responseJTEHF8 68,2187,2005
oral/pigeon lethal dose (50 percent kill): 1330 µg/kgASTTA8 (680),157,1979
oral/quail lethal dose (50 percent kill): 4040 µg/kgPCBPBS 7,28,1977
oral/quail lowest published toxic dose: 5 mg/kgEndocrine: Change in LHCBCPAI 83C,451,1986
oral/quail lowest published lethal dose: 10 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Eye: Lacrimation

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
CBCPAI 83C,451,1986
oral/rabbit lethal dose (50 percent kill): 10 mg/kgENTOX* -,331,2005
oral/rat lowest published toxic dose: 0.35 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTXAPA9 210,142,2006
oral/rat lowest published toxic dose: 0.35 mg/kgBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXAPA9 210,142,2006
oral/rat lowest published lethal dose: 0.5 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTXAPA9 210,142,2006
oral/rat lethal dose (50 percent kill): 2 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTXAPA9 11,546,1967
oral/rat lowest published lethal dose: 0.5 mg/kgBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 72,308,2003
oral/rat lethal dose (50 percent kill): 9 mg/kgBehavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Respiratory stimulation

Endocrine: Hyperglycemia
TPKVAL 7,122,1965
oral/wild bird lethal dose (50 percent kill): 1330 µg/kgASTTA8 (680),157,1979
oral/woman lowest published lethal dose: 2350 µL/kgBehavioral: Coma

Cardiac: Pulse rate increased without fall in BP

Lung, Thorax, or Respiration: Respiratory depression
HETOEA 17,587,1998
oral/woman lowest published toxic dose: 2 mL/kgEye: Miosis (pupilliary constriction)

Behavioral: Muscle weakness

Behavioral: Coma
JTCTDW 31,497,1993
oral/woman lowest published toxic dose: 5670 µg/kgEye: Mydriasis (pupilliary dilation)

Behavioral: Coma

Lung, Thorax, or Respiration: Dyspnea
ANYAA9 160,383,1969
oral/woman lowest published toxic dose: 10 mL/kgCardiac: Arrythmias (indlucing changes in conduction)JTCTDW 46,758,2008
parenteral/frog lethal dose (50 percent kill): 967 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Altered sleep time (including change in righting reflex)

Lung, Thorax, or Respiration: Other changes
AIPTAK 124,212,1960
skin/duck lethal dose (50 percent kill): 28 mg/kgTXAPA9 47,451,1979
skin/guinea pig lethal dose (50 percent kill): 45 mg/kgENTOX* -,331,2005
skin/human lowest published lethal dose: 7143 µg/kgSKEZAP 9,1,1968
skin/mouse lethal dose (50 percent kill): 19 mg/kgENTOX* -,331,2005
skin/rabbit lethal dose (50 percent kill): 15 mg/kgENTOX* -,331,2005
skin/rat lethal dose (50 percent kill): 6800 µg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement
TXAPA9 2,88,1960
skin/wild bird lethal dose (50 percent kill): 1800 µg/kgTXAPA9 26,154,1973
subcutaneous/guinea pig lethal dose (50 percent kill): 10 mg/kgEye: Lacrimation

Behavioral: Muscle contraction or spasticity

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TPKVAL 7,122,1965
subcutaneous/guinea pig lethal dose (50 percent kill): 10 mg/kgBehavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Respiratory stimulation

Endocrine: Hyperglycemia
TPKVAL 7,122,1965
subcutaneous/guinea pig lowest published toxic dose: 2.5 mg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Urine volume decreased or anuria
TPKVAL 7,122,1965
subcutaneous/mouse lowest published toxic dose: 12.5 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Reactivates cholinesterase
TXAPA9 255,214,2011
subcutaneous/mouse lethal dose (50 percent kill): 10 mg/kgPHARAT 37,729,1982
subcutaneous/rabbit lethal dose (50 percent kill): 30 mg/kgEye: Lacrimation

Behavioral: Muscle contraction or spasticity

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TPKVAL 7,122,1965
subcutaneous/rabbit lethal dose (50 percent kill): 30 mg/kgBehavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Respiratory stimulation

Endocrine: Hyperglycemia
TPKVAL 7,122,1965
subcutaneous/rat lowest published toxic dose: 15 mg/kgBehavioral: Change in motor activity (specific assay)

Biochemical: Metabolism (intermediary): Other
NRTXDN 40,57,2014
subcutaneous/rat lowest published toxic dose: 27 mg/kgBehavioral: Tremor

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TXAPA9 272,608,2013
subcutaneous/rat lethal dose (50 percent kill): 9 mg/kgEye: Lacrimation

Behavioral: Muscle contraction or spasticity

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TPKVAL 7,122,1965
subcutaneous/rat lethal dose (50 percent kill): 9 mg/kgBehavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Respiratory stimulation

Endocrine: Hyperglycemia
TPKVAL 7,122,1965
subcutaneous/rat lowest published toxic dose: 1.8 mg/kgBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXCYAC 239,167,2007
subcutaneous/rat lowest published toxic dose: 18 mg/kgBrain and Coverings: Other degenerative changes

Peripheral Nerve and Sensation: Fasciculations

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXAPA9 219,106,2007
subcutaneous/rat lowest published toxic dose: 6 mg/kgGastrointestinal: Changes in structure or function of salivary glands

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXCYAC 210,135,2005
subcutaneous/rat lowest published toxic dose: 0.63 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseNETEEC 25,599,2003
subcutaneous/rat lowest published toxic dose: 2.1 mg/kgNutritional and Gross Metabolic: Weight loss or decreased weight gainNETEEC 25,599,2003
subcutaneous/rat lowest published lethal dose: 12 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Changes in structure or function of salivary glands
ARTODN 76,650,2002
Tank with water/Lugworm lethal concentration (50 percent kill): 2.7 mg/L/48HAQUTO* 10,235,1987
Tank with water/Zebrafish Lowest published lethal concentration: 10 µmol/L/5DReproductive: Other effects to embryo or fetus

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NETEEC 33,735,2011
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 6 mg/kg30ZDA9 -,323,1971
unreported route/man lowest published lethal dose: 1471 µg/kg85DCAI 2,73,1970
unreported route/mouse lethal dose (50 percent kill): 14500 µg/kgGTPZAB 7(5),38,1963
unreported route/rat lowest published toxic dose: 18 mg/kgBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 60,241,2001
unreported route/rat lowest published toxic dose: 18 mg/kgBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Metabolism (intermediary): Other
TOXID9 60,241,2001
unreported route/rat lowest published toxic dose: 1 mg/kgBrain and Coverings: Other degenerative changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 72,309,2003

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 200 µg/m3/7H/6W- intermittentBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NTIS** AD-A041-973
inhalation/rat lowest published toxic concentration: 740 µg/m3/7H/6W- intermittentLung, Thorax, or Respiration: Acute pulmonary edema

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NTIS** AD-A041-973
intraperitoneal/mouse lowest published toxic dose: 10 mg/kg/2D- intermittentBehavioral: Sleep

Behavioral: Change in motor activity (specific assay)
TOXID9 -,408,2009
oral/chicken lowest published toxic dose: 1800 µg/kg/18D- intermittentBrain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOLED5 37,279,1987
oral/Dog lowest published toxic dose: 15 mg/kg/6W- intermittentBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NTIS** AD-A041-973
oral/Dog lowest published toxic dose: 145 mg/kg/26W- intermittentBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
JJATDK 14,145,1994
oral/Dog lowest published toxic dose: 7.9 mg/kg/168D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HBPTO* 1,59,2001
oral/duck lowest published toxic dose: 92500 µg/kg/5W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
RREVAH 81,1,1981
oral/human lowest published toxic dose: 4.2 mg/kg/42D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HBPTO* 1,59,2001
oral/mammal (species unspecified) lowest published toxic dose: 1394 mg/kg/30D- continuousBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** PB288-416
oral/mouse lowest published toxic dose: 5.6 mg/kg/14D- continuousBrain and Coverings: Other degenerative changesHBPTO* 2,1026,2001
oral/mouse lowest published toxic dose: 0.75 mg/kg/5D- intermittentImmunological Including Allergic: Decreased immune response

Immunological Including Allergic: Increased immune response
TXCYAC 289,132,2011
oral/mouse lowest published toxic dose: 0.75 mg/kg/5D- intermittentBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation

Immunological Including Allergic: Uncharacterized (multiple organ involvement)
TXCYAC 309,1,2013
oral/pig lowest published toxic dose: 196 mg/kg/49D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseHBPTO* 1,59,2001
oral/rat lowest published toxic dose: 901.6 mg/kg/112W- continuousEndocrine: Adrenal cortex tumorsHBPTO* 1,814,2001
oral/rat lowest published toxic dose: 21.84 mg/kg/84D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseHBPTO* 1,59,2001
oral/rat lowest published toxic dose: 10500 mg/kg/28D- continuousLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
TXAPA9 18,607,1971
oral/rat lowest published toxic dose: 788 mg/kg/15W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 2,523,1960
oral/rat lowest published toxic dose: 234 mg/kg/90D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
ENVRAL 17,1,1978
oral/rat lowest published toxic dose: 182 mg/kg/26W- continuousBlood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
JPFCD2 16,1,1981
subcutaneous/guinea pig lowest published toxic dose: 420 mg/kg/24W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 7,122,1965
subcutaneous/mouse lowest published toxic dose: 12 mg/kg/6D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTXAPA9 25,582,1973
subcutaneous/rabbit lowest published toxic dose: 225 mg/kg/30D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTPKVAL 7,122,1965
subcutaneous/rabbit lowest published toxic dose: 1260 mg/kg/24W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 7,122,1965
subcutaneous/rat lowest published toxic dose: 0.4 mg/kg/4D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
NETEEC 31,390,2009
subcutaneous/rat lowest published toxic dose: 0.4 mg/kg/4D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
NETEEC 31,390,2009
subcutaneous/rat lowest published toxic dose: 22.5 mg/kg/10D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTPKVAL 7,122,1965
subcutaneous/rat lowest published toxic dose: 378 mg/kg/24W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 7,122,1965
subcutaneous/rat lowest published toxic dose: 32500 µg/kg/21D- intermittentBrain and Coverings: Other degenerative changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOLED5 73,33,1994
unreported route/rat lowest published toxic dose: 16 mg/kg/16D- intermittentBrain and Coverings: Other degenerative changes

Reproductive: Specific developmental abnormalities: Central nervous system
HBPTO* 2,1029,2001
unreported route/rat lowest published toxic dose: 0.4 mg/kg/4D- intermittentCardiac: Other changes

Endocrine: Differential effect of sex or castration on observed toxicity

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOXID9 -,271,2008
unreported route/rat lowest published toxic dose: 0.8 mg/kg/4D- intermittentBehavioral: AntianxietyTOXID9 12,469,2008
unreported route/rat lowest published toxic dose: 0.4 mg/kg/4D- intermittentBiochemical: Metabolism (intermediary): Lipids including transportTOXID9 -,286,2009
unreported route/rat lowest published toxic dose: 0.8 mg/kg/4D- intermittentBiochemical: Metabolism (intermediary): Lipids including transport

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 -,286,2009
unreported route/rat lowest published toxic dose: 0.4 mg/kg/4D- intermittentBehavioral: Alteration of operant conditioningTOXID9 -,442,2009
unreported route/rat lowest published toxic dose: 0.04 mg/kg/4D- intermittentBehavioral: Change in psychophysiological testsNETEEC 31,242,2009

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.05 mg/m3 (inhal, vapor, skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 30,153,1983
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 30,153,1983
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWANAEA3 35,165,1975
TOXICOLOGY REVIEWAQMOAC #73-19,1973
TOXICOLOGY REVIEWRREVAH 46,1,1973
TOXICOLOGY REVIEWMZUZA8 (8),90,1973
TOXICOLOGY REVIEWCNDQA8 10(3),43,1975
TOXICOLOGY REVIEWECMAAI 14,141,1973
TOXICOLOGY REVIEWDTTIAF 80,485,1973
TOXICOLOGY REVIEWRREVAH 63,1,1976
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWCCATAR 366,1,2006
TOXICOLOGY REVIEWENTOX* -,588,2005
TOXICOLOGY REVIEWENTOX* -,331,2005
TOXICOLOGY REVIEWENTOX* -,306,2005
TOXICOLOGY REVIEWENTOX* -,308,2005
TOXICOLOGY REVIEWJTEHD6 7,1,2004
TOXICOLOGY REVIEWREPTED 23,260,2007
TOXICOLOGY REVIEWFCTOD7 46,813,2008
TOXICOLOGY REVIEWHETOEA 26,321,2007
TOXICOLOGY REVIEWTOLED5 190,107,2009
TOXICOLOGY REVIEWREPTED 31,297,2011
TOXICOLOGY REVIEWNRTXDN 31,562,2010
TOXICOLOGY REVIEWNRTXDN 33,575,2012
TOXICOLOGY REVIEWTOLED5 198,297,2010
TOXICOLOGY REVIEWTOLED5 209,86,2012
TOXICOLOGY REVIEWNRTXDN 42,24,2014
TOXICOLOGY REVIEWNRTXDN 33,1473,2012
TOXICOLOGY REVIEWTXCYAC 307,24,2013
TOXICOLOGY REVIEWTXCYAC 307,42,2013
TOXICOLOGY REVIEWTXCYAC 307,46,2013
TOXICOLOGY REVIEWTXCYAC 307,123,2013
TOXICOLOGY REVIEWTXCYAC 307,136,2013
TOXICOLOGY REVIEWTOLED5 230,85,2014
TOXICOLOGY REVIEWTOLED5 230,434,2014
TOXICOLOGY REVIEWTXAPA9 268,157,2013

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,118,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.1 mg/m3 (skin)DTLVS* 3,195,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.1 mg/m3, inhal, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.05 mg/m3 (vapor, aerosol), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 mg/m3, skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, skin, NOV2011
Occupational Exposure Limit-FRANCEVME 0.1 mg/m3, Skin, FEB2006
Occupational Exposure Limit-GERMANYMAK 0.1 mg/m3, inhal, skin, 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 0.1 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 mg/m3, skin, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.1 mg/m3, skin, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.1 mg/m3, skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.1 mg/m3;short term exposure limit 0.3 mg/m3 (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg/m3, skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.05 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,05 mg/m3, JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.05 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg/m3, inhal, skin, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.11 mg/m3, JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.1 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.1 mg/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.1 mg/m3 (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.1 mg/m3 (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.1 mg/m3 (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PARATHION-air10H time-weighted average 0.05 mg/m3 (Sk)NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974Hazard Code 53920; Number of Industries 1; Total Number of Facilities 43; Number of Occupations 4; Total Number of Employees Exposed 302

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);clear evidence:ratNCITR* NCI-TR-70,1979
NCI Carcinogenesis Bioassay (feed);no evidence:mouseNCITR* NCI-TR-70,1979
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600
On EPA IRIS database
OSHA ANALYTICAL METHOD #ID-62
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