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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphorothioic acid, O,O-diethyl O-(2-isopropyl-6-methyl-4-pyrimidinyl) ester

RTECS #

TF3325000

CAS #

333-41-5; 65863-03-8

Updated

June 2017

Molecular Weight

304.38

Molecular Formula

C12H21N2O3PS

Synonyms

4-Pyrimidinol, 2-isopropyl-6-methyl-, O-ester with O,O-diethyl phosphorothioate
Antigal
Bassadinon
Basudin S
Compass
Dacutox
Dassitox
Dazzel
Delzinon
Diazinon
Diazinon (ACGIH)
Diazinone
Dicid
Diethyl 4-(2-isopropyl-6-methylpyrimidinyl)phosphorothionate
Dimpylate
Dizictol
Drawizon
Dyzol
ENT 19,507
Exodin
Flytrol
G 301
G-24480
Galesan
Garden Tox
Geigy 24480
Isopropylmethylpyrimidyl diethyl thiophosphate
Knox Out 2FM
Knox Out Yellow Jacket Contorl
NCI-C08673
Neocidol
Neodinon
Nipsan
Nucidol
O,O-Diaethyl-O-(2-isopropyl-4-methyl)-6-pyrimidyl-thionophosphat (German)
O,O-Diaethyl-O-(2-isopropyl-4-methyl-pyrimidin-6-yl)-monothiophosphat (German)
O,O-Diethyl O-(2-isopropyl-4-methyl-6-pyrimidyl) thionophosphate
O,O-Diethyl O-(2-isopropyl-6-methyl-4-pyrimidinyl) phosphorothioate
O,O-Diethyl O-6-methyl-2-isopropyl-4-pyrimidinyl phosphorothioate
O,O-Diethyl-O-(2-isopropyl-4-methyl-6-pyrimidinyl)-phosphorothioate
O,O-Diethyl-O-(2-isopropyl-4-methyl-6-pyrimidyl)phosphorothioate
O,O-Diethyl-O-(2-isopropyl-4-methyl-pyrimidin-6-yl)-monothiofosfaat (Dutch)
O,O-Dietil-O-(2-isopropil-4-metil-pirimidin-6-il)-monotiofosfato (Italian)
O-2-Isopropyl-4-methylpyrimidyl-O,O-diethyl phosphorothioate
Oleodiazinon
OMS 469
Optimizer
Phosphorothioate, O,O-diethyl O-6-(2-isopropyl-4-methylpyrimidyl)
PT 265
Sarolex
Srolex
Terminator
Thiophosphate de O,O-diethyle et de O-2-isopropyl-4-methyl-6-pyrimidyle (French)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg severeCIGET* -,-,1977
skin /rabbit 500 mg open irritation test moderateCIGET* -,-,1977

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human500 µg/LTSITAQ 18,1490,1976
Cytogenetic Analysislung/hamster100 mg/L/27HMUREAV 66,277,1979
Cytogenetic Analysissperm/human500 µmol/L/1HREPTED 25,455,2008
DNA Damagesperm/human6.238 mmol/L/1HREPTED 25,455,2008
DNA Damageintraperitoneal/rat10014 µg/kgTXCYAC 253,8,2008
DNA Damageintraperitoneal/mouse8.12 mg/kg/1DTOXID9 78,426,2004
DNA Damageoral/rabbit161.04 mg/kg/1Y- intermittentTXCYAC 307,109,2013
DNA inhibitionmultiple/other fish640 µg/LSTEVA8 76,63,1988
micronucleus testlymphocyte/human4 mg/LMUREAV 388,27,1997
micronucleus testovary/hamster52.7 mg/L/24H (-enzymatic activation step)MUREAV 582,116,2005
micronucleus testovary/hamster94 mg/L/3H (+enzymatic activation step)MUREAV 582,116,2005
micronucleus testoral/rat560 mg/kg/4W- intermittentPYTOEY 18,499,2011
morphological transformembryo/rat11 µg/plateJJATDK 1,190,1981
mutation in mammalian somatic cellslymphocyte/mouse60 mg/LEMMUEG 12,85,1988
other mutation test systemslymphocyte/human500 µg/LBIHAA2 38(Pt1),344,1971
other mutation test systemsmultiple/other fish1060 µg/LSTEVA8 76,63,1988
sister chromatid exchangemultiple/other fish540 pmol/LMUREAV 118,61,1983
sister chromatid exchangelymphocyte/rat20 mg/L/2HMUREAV 472,85,2000
sperm morphologysperm/human50 µmol/L/1HREPTED 22,508,2006

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 100 mg/kg (11D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemAEHLAU 16,805,1968
intraperitoneal/rat 150 mg/kg (11D pregnant)Reproductive: Other effects on female

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
AEHLAU 16,805,1968
intraperitoneal/rat 200 mg/kg (11D pregnant)Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
AEHLAU 16,805,1968
intraperitoneal/mouse 8.12 mg/kg (1D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Other effects on male
TOXID9 78,426,2004
oral/rat 26400 µg/kg (12-15D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemJFMAAQ 54,452,1967
oral/rat 45 mg/kg (8-12D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemJFMAAQ 54,452,1967
oral/rat 63500 µg/kg (10D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)JFMAAQ 54,452,1967
oral/mouse 3960 µg/kg (1-22D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Delayed effects
JTEHD6 3,989,1977
oral/mouse 189 mg/kg (1-21D pregnant)Reproductive: Specific developmental abnormalities: Endocrine systemJEPTDQ 2(2),357,1978
oral/mouse 3780 µg/kg (1-21D pregnant)Reproductive: Effects on newborn: Biochemical and metabolicJEPTDQ 2(2),357,1978
oral/mouse 210 µg/kg (1-21D pregnant)Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system

Reproductive: Effects on newborn: Delayed effects
JEPTDQ 4(5-6),53,1980
oral/mouse 189 mg/kg (1-21D pregnant)Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)JEPTDQ 4(5-6),53,1980
oral/rabbit 130 mg/kg (6-18D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)NNGADV 14,113,1989
oral/pig 570 mg/kg (1-16W pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
32OAAP -,253,1973
subcutaneous/rat 4 mg/kg (15-18D pregnant)Reproductive: Other developmental abnormalities

Reproductive: Effects on newborn: Other postnatal measures or effects
NETEEC 37,23,2013

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, erythrocytes Inhibitor Concentration (50 percent kill): 87 µmol/L/72HIn Vitro Toxicity Studies: Other assaysTOLED5 196S,S325,2010
In Vitro/Human, fibroblast Inhibitor Concentration (50 percent kill): 7.5 µmol/L/72HIn Vitro Toxicity Studies: Other assaysTOLED5 196S,S325,2010
In Vitro/jpcInhibitor Concentration (50 percent kill): 30 µmol/L/72HIn Vitro Toxicity Studies: Other assaysTOLED5 196S,S325,2010
In Vitro/paaInhibitor Concentration Low: 10 µmol/L/24HIn Vitro Toxicity Studies: Other assays

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXAPA9 274,372,2014
In Vitro/Rat, endocrine tumor Inhibitor Concentration Low: 30 µmol/L/24HIn Vitro Toxicity Studies: Other assaysNETEEC 34,395,2012
In Vitro/Rat, neurons Inhibitor Concentration Low: 0.5 µmol/L/24HIn Vitro Toxicity Studies: Cell morphology: overgrowth of cell appendixes etc.TXCYAC 318,59,2014
In Vitro/Rat, neurons Inhibitor Concentration Low: 10 µmol/L/1HIn Vitro Toxicity Studies: Other assaysTXCYAC 318,59,2014
In Vitro/Rat, neurons Inhibitor Concentration Low: 10 µmol/L/24HBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTXCYAC 318,59,2014
inhalation/guinea pig lethal concentration (50 percent kill): 5500 mg/m3/4HPSDTAP 15,239,1974
inhalation/mouse lethal concentration (50 percent kill): 1600 mg/m3/4HPSDTAP 15,239,1974
inhalation/rat lethal concentration (50 percent kill): 3.5 gm/m3/4HENTOX* -,785,2005
intramuscular/monkey lowest published toxic dose: 10 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseJOPSEQ 19,455,2005
intramuscular/monkey lowest published toxic dose: 90 mg/kgBehavioral: Somnolence (general depressed activity)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
JOPSEQ 19,455,2005
intramuscular/monkey lowest published toxic dose: 130 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
JOPSEQ 19,455,2005
intraperitoneal/mouse lowest published toxic dose: 30 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases
TXAPA9 205,149,2005
intraperitoneal/mouse lowest published toxic dose: 30 mg/kgBrain and Coverings: Other degenerative changesTOLED5 135,89,2002
intraperitoneal/mouse lowest published toxic dose: 8.12 mg/kgReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)TXAPA9 202,189,2005
intraperitoneal/mouse lethal dose (50 percent kill): 33 mg/kgTXAPA9 2,495,1960
intraperitoneal/mouse lowest published toxic dose: 30 mg/kgBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases
TXAPA9 224,98,2007
intraperitoneal/rat lowest published toxic dose: 6.5 mg/kgKidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOLED5 170,229,2007
intraperitoneal/rat lowest published toxic dose: 65 mg/kgBrain and Coverings: Other degenerative changesTOLED5 170,229,2007
intraperitoneal/rat lowest published toxic dose: 6.5 mg/kgEndocrine: Hyperglycemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases

Biochemical: Metabolism (intermediary): Lipids including transport
TOLED5 182,42,2008
intraperitoneal/rat lowest published toxic dose: 6.5 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases

Biochemical: Metabolism (intermediary): Lipids including transport
TOLED5 182,42,2008
intraperitoneal/rat lethal dose (50 percent kill): 65 mg/kgARZNAD 5,436,1955
intratracheal/rat lethal dose (50 percent kill): 210 mg/kgJJATDK 19,133,1999
intravenous/mouse lethal dose (50 percent kill): 180 mg/kgCSLNX* NX#00023
oral/chicken lethal dose (50 percent kill): 8400 µg/kg85DPAN -,-,1971/1976
oral/domestic bird lowest published toxic dose: 0.5 mg/kgBehavioral: AnalgesiaTOXID9 90,322,2006
oral/duck lethal dose (50 percent kill): 3500 µg/kgDOEAAH 35,25,1979
oral/guinea pig lethal dose (50 percent kill): 250 mg/kg85DPAN -,-,1971/1976
oral/human lowest published toxic dose: 214 mg/kgBehavioral: Change in motor activity (specific assay)

Behavioral: Muscle weakness

Skin and Appendages: Other: Sweating
CTOXAO 12,435,1978
oral/mouse lethal dose (50 percent kill): 17 mg/kgSKEZAP 24,268,1983
oral/pig lethal dose (50 percent kill): 320 mg/kgYKYUA6 31,459,1980
oral/pigeon lethal dose (50 percent kill): 3160 µg/kgASTTA8 (680),157,1979
oral/quail lethal dose (50 percent kill): 4210 µg/kgASTTA8 (680),157,1979
oral/rabbit lethal dose (50 percent kill): 143 mg/kgYKYUA6 31,459,1980
oral/rat lethal dose (50 percent kill): 66 mg/kgDOEAAH 35,25,1979
oral/rat lowest published toxic dose: 1 mg/kgBrain and Coverings: Other degenerative changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 72,306,2003
oral/rat lowest published toxic dose: 15 mg/kgBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXAPA9 205,31,2005
oral/rat lowest published toxic dose: 30 mg/kgBrain and Coverings: Other degenerative changesTXAPA9 205,31,2005
oral/rat lowest published toxic dose: 100 mg/kgEye: Lacrimation

Behavioral: Change in motor activity (specific assay)

Gastrointestinal: Changes in structure or function of salivary glands
TOXID9 1,112,2001
oral/rat lowest published toxic dose: 6 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTOSCF2 92,235,2006
oral/rat lowest published toxic dose: 60 mg/kgBehavioral: Ataxia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOSCF2 92,235,2006
oral/wild bird lethal dose (50 percent kill): 2 mg/kgTXAPA9 21,315,1972
skin/mouse lethal dose (50 percent kill): 2750 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseJTEHD6 9,491,1982
skin/pig lethal dose (50 percent kill): 633 mg/kgYKYUA6 31,459,1980
skin/rabbit lethal dose (50 percent kill): 3.6 gm/kgENTOX* -,785,2005
skin/rat lethal dose (50 percent kill): 180 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterasePMJMAQ -,155,1957
subcutaneous/mouse lethal dose (50 percent kill): 58 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Reactivates cholinesteraseOIZAAV 71,6099,1959
subcutaneous/mouse lowest published toxic dose: 50 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Reactivates cholinesterase
TXAPA9 255,214,2011
Tank with water/Zebrafish Lowest published lethal concentration: 30 µmol/L/5DRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNETEEC 33,735,2011
Tank with water/Zebrafish lowest published toxic concentration: 10 µmol/L/5DBehavioral: Change in motor activity (specific assay)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NETEEC 33,735,2011
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 76 mg/kg30ZDA9 -,338,1971
unreported route/rat lowest published toxic dose: 75 mg/kgBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 66,312,2002
unreported route/rat lethal dose (50 percent kill): 250 mg/kgRISHDJ 23,101,1983

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 201 µg/m3/24H/13W- continuousKidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 42(1),6,1977
intraperitoneal/mouse lowest published toxic dose: 40 mg/kg/28D- intermittentBlood: Other changes

Immunological Including Allergic: Decreased immune response

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
TXCYAC 196,173,2004
intraperitoneal/mouse lowest published toxic dose: 500 mg/kg/28D- intermittentBlood: Changes in spleen

Immunological Including Allergic: Decreased immune response

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
TXCYAC 196,173,2004
oral/Dog lowest published toxic dose: 157 mg/kg/12W- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTXAPA9 1,1,1959
oral/Dog lowest published toxic dose: 3395 mg/kg/1Y- continuousBrain and Coverings: Other degenerative changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NNGADV 14,113,1989
oral/Dog lowest published toxic dose: 4900 mg/kg/35W- intermittentGastrointestinal: Other changes

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXAPA9 18,285,1971
oral/Dog lowest published toxic dose: 1200 mg/kg/46W- intermittentBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
JAFCAU 3,1017,1955
oral/domestic animal lowest published toxic dose: 1050 mg/kg/21D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)VHTODE 41,287,1999
oral/mouse lowest published toxic dose: 1620 mg/kg/45D- continuousBlood: Changes in spleen

Blood: Other changes

Immunological Including Allergic: Uncharacterized (multiple organ involvement)
TXCYAC 172,13,2002
oral/mouse lowest published toxic dose: 1.62 gm/kg/45D- intermittentBlood: Hemorrhage

Blood: Changes in spleen

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXCYAC 172,13,2002
oral/mouse lowest published toxic dose: 26280 mg/kg/2Y- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainNNGADV 14,113,1989
oral/mouse lowest published toxic dose: 750 mg/kg/15D- intermittentImmunological Including Allergic: Decrease in cellular immune responseTXCYAC 236,123,2007
oral/pig lowest published toxic dose: 2450 mg/kg/35W- intermittentGastrointestinal: Other changes

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 18,285,1971
oral/rabbit lowest published toxic dose: 161.04 mg/kg/1Y- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases

Biochemical: Metabolism (intermediary): Other
TXCYAC 307,109,2013
oral/rabbit lowest published toxic dose: 322.08 mg/kg/1Y- intermittentKidney, Ureter, and Bladder: Interstitial nephritis

Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXCYAC 307,109,2013
oral/rat lowest published toxic dose: 240 mg/kg/15D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
TOXID9 -,118,2009
oral/rat lowest published toxic dose: 371 mg/kg/14D- continuousBlood: Change in clotting factorsJEPOEC 7(3),67,1987
oral/rat lowest published toxic dose: 28 mg/kg/28W- intermittentLiver: Fatty liver degeneration

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
BECTA6 37,501,1986
oral/rat lowest published toxic dose: 1095 mg/kg/2Y- continuousEndocrine: Changes in thyroid weight

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NNGADV 14,113,1989
oral/rat lowest published toxic dose: 98 mg/kg/28W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
DCTODJ 9,117,1986
oral/rat lowest published toxic dose: 70 mg/kg/1W- intermittentLiver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
TXCYAC 211,197,2005
oral/rat lowest published toxic dose: 280 mg/kg/4W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainETOPFR 22,46,2006
oral/rat lowest published toxic dose: 70 mg/kg/1W- intermittentBlood: Thrombocytopenia

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count
ETOPFR 22,46,2006
oral/rat lowest published toxic dose: 70 mg/kg/1W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterasesETOPFR 22,46,2006
oral/rat lowest published toxic dose: 50 mg/kg/5D- intermittentGastrointestinal: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TOLED5 161,200,2006
oral/rat lowest published toxic dose: 46 mg/kg/92D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
AECTCV 9,637,1980
oral/rat lowest published toxic dose: 560 mg/kg/4W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
FCTOD7 48,2803,2010
oral/rat lowest published toxic dose: 840 mg/kg/8W- intermittentKidney, Ureter, and Bladder: Renal function tests depressed

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Metabolism (intermediary): Lipids including transport
FCTOD7 48,3345,2010
oral/rat lowest published toxic dose: 560 mg/kg/8W- intermittentKidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
FCTOD7 48,3345,2010
oral/rat lowest published toxic dose: 560 mg/kg/4W- intermittentBlood: Changes in erythrocyte (RBC) count

Blood: Changes in platelet count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
PYTOEY 18,499,2011
oral/rat lowest published toxic dose: 86 mg/kg/30D- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXAPA9 54,359,1980
oral/rat lowest published toxic dose: 91 mg/kg/26W- continuousBlood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
JPFCD2 16,1,1981
skin/rabbit lowest published toxic dose: 210 mg/kg/21D- intermittentBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NNGADV 14,113,1989
subcutaneous/rat lowest published toxic dose: 2 mg/kg/4D- intermittentBehavioral: Alteration of classical conditioning

Behavioral: Alteration of operant conditioning

Behavioral: Change in psychophysiological tests
NETEEC 30,38,2008
subcutaneous/rat lowest published toxic dose: 4 mg/kg/4D- intermittentBrain and Coverings: Other degenerative changesNETEEC 37,23,2013
unreported route/rat lowest published toxic dose: 2 mg/kg/4D- intermittentCardiac: Other changes

Endocrine: Differential effect of sex or castration on observed toxicity

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOXID9 -,271,2008

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.01 mg/m3 (inhal, vapor, skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 112,84,2015
International Agency for Research on Cancer (IARC)Cancer Review:Human Limited EvidenceIMEMDT 112,84,2015
International Agency for Research on Cancer (IARC)Cancer Review:Group 2AIMEMDT 112,84,2015
TOXICOLOGY REVIEWAQMOAC #73-19,1973
TOXICOLOGY REVIEWRREVAH 46,1,1973
TOXICOLOGY REVIEWCNDQA8 10(3),43,1975
TOXICOLOGY REVIEWDTTIAF 80,485,1973
TOXICOLOGY REVIEWRREVAH 63,1,1976
TOXICOLOGY REVIEWTOLED5 127,29,2002
TOXICOLOGY REVIEWTOLED5 142,207,2003
TOXICOLOGY REVIEWMUREAV 589,208,2005
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWNETOX* 26,531,2005
TOXICOLOGY REVIEWNETOX* 26,573,2005
TOXICOLOGY REVIEWCCATAR 366,1,2006
TOXICOLOGY REVIEWENTOX* -,588,2005
TOXICOLOGY REVIEWENTOX* -,785,2005
TOXICOLOGY REVIEWENTOX* -,306,2005
TOXICOLOGY REVIEWENTOX* -,308,2005
TOXICOLOGY REVIEWJTCTDW 42,579,2004
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWJTEHD6 7,267,2004
TOXICOLOGY REVIEWREPTED 23,260,2007
TOXICOLOGY REVIEWFEREAC 73,29456,2008
TOXICOLOGY REVIEWREPTED 26,1,2008
TOXICOLOGY REVIEWFCTOD7 46,813,2008
TOXICOLOGY REVIEWFEREAC 74,27538,2009
TOXICOLOGY REVIEWFEREAC 73,52607,2008
TOXICOLOGY REVIEWFCTOD7 47,2906,2009
TOXICOLOGY REVIEWMUTAEX 23,271,2008
TOXICOLOGY REVIEWMUTAEX 26,19,2011
TOXICOLOGY REVIEWMUTAEX 26,231,2011
TOXICOLOGY REVIEWREPTED 31,297,2011
TOXICOLOGY REVIEWTXAPA9 258,309,2012
TOXICOLOGY REVIEWMUREAV 760,1,2014
TOXICOLOGY REVIEWTOLED5 209,86,2012
TOXICOLOGY REVIEWNRTXDN 39,158,2013
TOXICOLOGY REVIEWTXCYAC 307,24,2013
TOXICOLOGY REVIEWTXCYAC 307,46,2013
TOXICOLOGY REVIEWTXCYAC 307,89,2013
TOXICOLOGY REVIEWTXCYAC 307,115,2013
TOXICOLOGY REVIEWTXCYAC 307,123,2013
TOXICOLOGY REVIEWTXCYAC 307,136,2013
TOXICOLOGY REVIEWTOLED5 230,85,2014
TOXICOLOGY REVIEWTOLED5 230,434,2014
TOXICOLOGY REVIEWTXAPA9 268,157,2013
TOXICOLOGY REVIEWFCTOD7 83,300,2015
TOXICOLOGY REVIEWMUREAV 802,1,2016

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,109,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.1 mg/m3 (skin)DTLVS* 3,780,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.1 mg/m3;KZW 0.4 mg/m3, inhal, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.01 mg/m3 (vapor, aerosol), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 mg/m3, skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.1 ppm (0.3 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 0.1 mg/m3, Skin, FEB2006
Occupational Exposure Limit-GERMANYMAK 0.1 mg/m3, inhal, 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 0.1 mg/m3, short term exposure limit 0.4 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 mg/m3, skin, NOV2011
Occupational Exposure Limit-INDIAtime-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.1 mg/m3, skin, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.1 mg/m3, skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.1 mg/m3;short term exposure limit 0.3 mg/m3 (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg/m3, skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0.01 mg/m3, JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.2 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg/m3, KZG-week 0.2 mg/m3, inhal, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.1 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIAZINON-air10H time-weighted average 0.1 mg/m3 (Sk)NIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983Hazard Code 23360; Number of Industries 10; Total Number of Facilities 3168; Number of Occupations 18; Total Number of Employees Exposed 39342; Total Number of Female Employees Exposed 3216
National Occupational Hazard Survey 1974Hazard Code 23360; Number of Industries 9; Total Number of Facilities 1268; Number of Occupations 9; Total Number of Employees Exposed 26581

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/97/121107/AS)
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,ratNCITR* NCI-TR-137,1979
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600
On EPA IRIS database
OSHA ANALYTICAL METHOD #ID-62
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