Phosphoric acid, tri-o-tolyl ester
RTECS #
TD0350000
CAS #
Updated
March 2019
Molecular Weight
368.39
Molecular Formula
C21H21O4P
Synonyms
o-Cresyl phosphate
o-Tolyl phosphate
o-Trikresylphosphate (German)
Phosflex 179C
Phosphoric acid, tri-o-cresyl ester
Phosphoric acid, tris(2-methylphenyl) ester
TOCP
TOFK
TOTP
Tri 2-methylphenyl phosphate
Tri-2-tolyl phosphate
Tri-o-cresyl phosphate
Tri-o-cresyl-phosphate
Triorthocresyl phosphate
Triorthocresyl phosphate (ACGIH:OSHA)
Tri-o-tolyl phosphate
Tri-o-totyl phosphate
Tris(o-cresyl)-phosphate
Tris(o-methylphenyl)phosphate
Tris(o-tolyl)-phosphate
Trojkrezylu fosforan (Polish)
o-Tolyl phosphate
o-Trikresylphosphate (German)
Phosflex 179C
Phosphoric acid, tri-o-cresyl ester
Phosphoric acid, tris(2-methylphenyl) ester
TOCP
TOFK
TOTP
Tri 2-methylphenyl phosphate
Tri-2-tolyl phosphate
Tri-o-cresyl phosphate
Tri-o-cresyl-phosphate
Triorthocresyl phosphate
Triorthocresyl phosphate (ACGIH:OSHA)
Tri-o-tolyl phosphate
Tri-o-totyl phosphate
Tris(o-cresyl)-phosphate
Tris(o-methylphenyl)phosphate
Tris(o-tolyl)-phosphate
Trojkrezylu fosforan (Polish)
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| DNA Damage | oral/rat | 500 mg/kg/10D-continuous | CRNGDP 14,2039,1993 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | 1500 mg/kg (10D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | TXAPA9 89,64,1987 |
| oral/rat | 2100 mg/kg (14D pregnant) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | TXAPA9 107,35,1991 |
| oral/rat | 450 mg/kg (3D male) | Reproductive: Other effects on male | TXAPA9 89,64,1987 |
| oral/rat | 3150 mg/kg (21D male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | TXAPA9 89,64,1987 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Hamster, ovary | Inhibitor Concentration (20 percent kill): 9.4 µmol/L/24H | Endocrine: Estrogenic | TXCYAC 314,76,2013 |
| In Vitro/Hamster, ovary | Inhibitor Concentration (20 percent kill): 11 µmol/L/24H | Endocrine: Other changes | TXCYAC 314,76,2013 |
| In Vitro/Human, neuroblastoma | Inhibitor Concentration Low: 0.2 mmol/L/24H | In Vitro Toxicity Studies: Cell morphology: overgrowth of cell appendixes etc. In Vitro Toxicity Studies: Other assays | TXCYAC 310,92,2013 |
| intramuscular/rabbit | lowest published lethal dose: 135 mg/kg | AEPPAE 171,439,1933 | |
| intraperitoneal/chicken | lethal dose (50 percent kill): 500 mg/kg | EQSFAP 3,173,1974 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 1960 mg/kg | TXAPA9 2,495,1960 | |
| intraperitoneal/rabbit | lowest published lethal dose: 100 mg/kg | Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Behavioral: Tremor Lung, Thorax, or Respiration: Other changes | AEPPAE 168,473,1932 |
| intraperitoneal/rat | lethal dose (50 percent kill): 2500 mg/kg | APCRAW 4,117,1961 | |
| intraperitoneal/rat | lowest published toxic dose: 10 mg/kg | Liver: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | TXAPA9 179,119,2002 |
| intraperitoneal/rat | lowest published toxic dose: 100 mg/kg | Liver: Other changes Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | TOXID9 72,315,2003 |
| intraperitoneal/rat | lowest published toxic dose: 100 mg/kg | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases Biochemical: Metabolism (intermediary): Lipids including transport | JTEHF8 67,583,2004 |
| intratracheal/chicken | lowest published toxic dose: 750 mg/kg | Spinal Cord: Other degenerative changes Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral: Ataxia | TOLED5 210,276,2012 |
| intravenous/chicken | lowest published toxic dose: 40 mg/kg | Behavioral: Ataxia Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TOLED5 143,65,2003 |
| intravenous/rabbit | lowest published lethal dose: 100 mg/kg | Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Kidney, Ureter, and Bladder: Other changes in urine composition | AEPPAE 168,473,1932 |
| oral/chicken | lowest published toxic dose: 800 mg/kg | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOLED5 136,143,2002 |
| oral/chicken | lowest published toxic dose: 1600 mg/kg | Brain and Coverings: Other degenerative changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOLED5 136,143,2002 |
| oral/chicken | lowest published toxic dose: 1600 mg/kg | Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Behavioral: Ataxia | TOLED5 136,143,2002 |
| oral/chicken | lethal dose (50 percent kill): 500 mg/kg | EQSFAP 3,173,1974 | |
| oral/chicken | lowest published toxic dose: 750 mg/kg | Peripheral Nerve and Sensation: Structural change in nerve or sheath Nutritional and Gross Metabolic: Changes in: Ca Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | JPETAB 239,597,1986 |
| oral/chicken | lowest published toxic dose: 360 mg/kg | Spinal Cord: Demyelination Spinal Cord: Other degenerative changes | HBPTO* 2,989,2001 |
| oral/chicken | lowest published toxic dose: 200 mg/kg | Peripheral Nerve and Sensation: Structural change in nerve or sheath Behavioral: Ataxia Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases | NRTXDN 9,539,1988 |
| oral/chicken | lowest published toxic dose: 10 mg/kg | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | NRTXDN 6,79,1985 |
| oral/chicken | lowest published toxic dose: 200 mg/kg | Peripheral Nerve and Sensation: Structural change in nerve or sheath Behavioral: Muscle weakness Biochemical: Metabolism (intermediary): Other | ENVRAL 60,290,1993 |
| oral/chicken | lowest published toxic dose: 50 mg/kg | Peripheral Nerve and Sensation: Structural change in nerve or sheath Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) | TAEHC* 110IV,122,1990 |
| oral/chicken | lowest published toxic dose: 750 mg/kg | Brain and Coverings: Other degenerative changes Spinal Cord: Other degenerative changes Peripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia | TXCYAC 223,127,2006 |
| oral/chicken | lowest published toxic dose: 750 mg/kg | Brain and Coverings: Other degenerative changes Spinal Cord: Other degenerative changes Behavioral: Ataxia | TXCYAC 239,45,2007 |
| oral/chicken | lowest published toxic dose: 750 mg/kg | Brain and Coverings: Other degenerative changes Behavioral: Ataxia Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | TXCYAC 252,56,2008 |
| oral/chicken | lowest published toxic dose: 750 mg/kg | Peripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TXCYAC 258,94,2009 |
| oral/chicken | lowest published toxic dose: 500 mg/kg | Behavioral: Ataxia Nutritional and Gross Metabolic: Changes in: Ca Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | HETOEA 27,247,2008 |
| oral/chicken | lowest published toxic dose: 750 mg/kg | Peripheral Nerve and Sensation: Structural change in nerve or sheath | TXCYAC 262,258,2009 |
| oral/chicken | lowest published toxic dose: 500 mg/kg | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic: Changes in: Ca Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | TOLED5 192,238,2010 |
| oral/chicken | lowest published toxic dose: 500 mg/kg | Spinal Cord: Other degenerative changes Behavioral: Ataxia Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | TXCYAC 302,88,2012 |
| oral/domestic bird | lowest published toxic dose: 375 mg/kg | Peripheral Nerve and Sensation: Structural change in nerve or sheath Biochemical: Metabolism (intermediary): Other proteins | TXCYAC 191,25,2003 |
| oral/mammal (species unspecified) | lethal dose (50 percent kill): 400 mg/kg | GISAAA 39(4),86,1974 | |
| oral/mouse | lethal dose (50 percent kill): 900 mg/kg | Gastrointestinal: Hypermotility, diarrhea Skin and Appendages: Other: Hair Behavioral: Muscle weakness | TXAPA9 7,227,1965 |
| oral/rabbit | lowest published lethal dose: 100 mg/kg | Behavioral: Muscle weakness Gastrointestinal: Hypermotility, diarrhea Kidney, Ureter, and Bladder: Interstitial nephritis | AEPPAE 168,473,1932 |
| oral/rat | lethal dose (50 percent kill): 1160 mg/kg | TOXID9 4,55,1984 | |
| oral/rat | lowest published toxic dose: 840 mg/kg | Spinal Cord: Other degenerative changes Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Peripheral Nerve and Sensation: Structural change in nerve or sheath | TAEHC* 110IV,122,1990 |
| skin/cat | lethal dose (50 percent kill): 1500 mg/kg | Eye: Miosis (pupilliary constriction) Behavioral: Muscle weakness Gastrointestinal: Hypermotility, diarrhea | NTOTDY 5,431,1983 |
| skin/rabbit | lethal dose (50 percent kill): >3700 mg/kg | TXAPA9 41,291,1977 | |
| subcutaneous/cat | lowest published lethal dose: 185 mg/kg | Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral: Ataxia Lung, Thorax, or Respiration: Other changes | JHHBAI 52,39,1933 |
| subcutaneous/chicken | lowest published toxic dose: 60 mg/kg | Spinal Cord: Other degenerative changes Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral: Ataxia | TOLED5 210,276,2012 |
| subcutaneous/Dog | lowest published lethal dose: 100 mg/kg | Behavioral: Muscle weakness Gastrointestinal: Hypermotility, diarrhea Kidney, Ureter, and Bladder: Interstitial nephritis | AEPPAE 168,473,1932 |
| subcutaneous/guinea pig | lowest published lethal dose: 300 mg/kg | Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Kidney, Ureter, and Bladder: Urine volume decreased or anuria Musculoskeletal: Other changes | AEPPAE 168,473,1932 |
| subcutaneous/monkey | lowest published lethal dose: 1 gm/kg | Autonomic Nervous System: Other (direct) parasympathomimetic Behavioral: Food intake (animal) Lung, Thorax, or Respiration: Dyspnea | AEPPAE 165,84,1972 |
| subcutaneous/mouse | lowest published lethal dose: 12500 mg/kg | Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Cyanosis | EDWU** -,-,1937 |
| subcutaneous/mouse | lowest published toxic dose: 10 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Reactivates cholinesterase | TXAPA9 255,214,2011 |
| subcutaneous/rabbit | lowest published lethal dose: 100 mg/kg | Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Kidney, Ureter, and Bladder: Other changes in urine composition | AEPPAE 168,473,1932 |
| unreported route/chicken | lowest published toxic dose: 500 mg/kg | Spinal Cord: Other degenerative changes Peripheral Nerve and Sensation: Structural change in nerve or sheath Behavioral: Ataxia | TOXID9 78,227,2004 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/mouse | lowest published toxic dose: 7 gm/kg/7D- continuous | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Proteases | JEPOEC 17,69,1998 |
| intraperitoneal/rat | lowest published toxic dose: 2800 mg/kg/7D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | DTESD7 11,495,1983 |
| oral/chicken | lowest published toxic dose: 1800 mg/kg/18D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Related to Chronic Data: Changes in testicular weight | TOLED5 37,279,1987 |
| oral/chicken | lowest published toxic dose: 1050 mg/kg/14D- intermittent | Peripheral Nerve and Sensation: Sensory change involving peripheral nerve Behavioral: Change in motor activity (specific assay) Behavioral: Ataxia | TOXID9 42,126,1998 |
| oral/chicken | lowest published toxic dose: 450 mg/kg/90D- continuous | Spinal Cord: Other degenerative changes Behavioral: Ataxia | NTIS** OTS0518529 |
| oral/domestic animal | lowest published toxic dose: 900 mg/kg/26W- intermittent | Brain and Coverings: Other degenerative changes Spinal Cord: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXAPA9 69,417,1983 |
| oral/duck | lowest published toxic dose: 3 gm/kg/30D- intermittent | Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Behavioral: Ataxia | JTEHD6 14,789,1984 |
| oral/mouse | lowest published toxic dose: 4725 mg/kg/21D- intermittent | Liver: Changes in liver weight Nutritional and Gross Metabolic: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOLED5 18(Suppl 1),4,1983 |
| oral/mouse | lowest published toxic dose: 60750 mg/kg/39W- intermittent | Spinal Cord: Other degenerative changes Autonomic Nervous System: Other (direct) parasympathomimetic Behavioral: Ataxia | TXAPA9 79,83,1985 |
| oral/mouse | lowest published toxic dose: 1400 mg/kg/14D- intermittent | Reproductive: Paternal effects: Testes, epididymis, sperm duct | TOLED5 211,54,2012 |
| oral/rabbit | lowest published toxic dose: 1500 mg/kg/3D- intermittent | Peripheral Nerve and Sensation: Structural change in nerve or sheath Autonomic Nervous System: Other (direct) parasympathomimetic | TXAPA9 41,291,1977 |
| oral/rat | lowest published toxic dose: 18900 mg/kg/9W- continuous | Liver: Changes in liver weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood: Changes in erythrocyte (RBC) count | TOLED5 13,29,1982 |
| oral/rat | lowest published toxic dose: 2800 mg/kg/14D- intermittent | Autonomic Nervous System: Other (direct) parasympathomimetic Reproductive: Paternal effects: Testes, epididymis, sperm duct Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TXAPA9 89,49,1987 |
| oral/rat | lowest published toxic dose: 1575 mg/kg/63D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | TXAPA9 89,49,1987 |
| oral/rat | lowest published toxic dose: 1600 mg/kg/2D- intermittent | Behavioral: Tremor Gastrointestinal: Hypermotility, diarrhea Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TXAPA9 89,49,1987 |
| oral/rat | lowest published toxic dose: 600 mg/kg/3D- intermittent | Behavioral: Tremor Gastrointestinal: Hypermotility, diarrhea Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TXAPA9 89,49,1987 |
| oral/rat | lowest published toxic dose: 1400 mg/kg/14D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct | TXAPA9 89,49,1987 |
| oral/rat | lowest published toxic dose: 2800 mg/kg/14D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TXAPA9 89,49,1987 |
| oral/rat | lowest published toxic dose: 3150 mg/kg/63D- intermittent | Behavioral: Food intake (animal) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | TXAPA9 89,49,1987 |
| oral/rat | lowest published toxic dose: 4725 mg/kg/63D- intermittent | Related to Chronic Data: Changes in testicular weight | TXAPA9 89,49,1987 |
| oral/rat | lowest published toxic dose: 1575 mg/kg/63D- intermittent | Reproductive: Paternal effects: Testes, epididymis, sperm duct | TXAPA9 89,49,1987 |
| oral/rat | lowest published toxic dose: 630 mg/kg/63D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | TXAPA9 89,49,1987 |
| oral/rat | lowest published toxic dose: 4200 mg/kg/63D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | TOXID9 72,305,2003 |
| oral/rat | lowest published toxic dose: 1050 mg/kg/2W- intermittent | Brain and Coverings: Other degenerative changes | TOXID9 72,305,2003 |
| oral/rat | lowest published toxic dose: 4200 mg/kg/48D- intermittent | Blood: Other changes | TOXID9 66,316,2002 |
| oral/rat | lowest published toxic dose: 8400 mg/kg/48D- intermittent | Liver: Liver function tests impaired | TOXID9 66,316,2002 |
| oral/rat | lowest published toxic dose: 2100 mg/kg/48D- intermittent | Liver: Other changes | TOXID9 66,316,2002 |
| oral/rat | lowest published toxic dose: 2.1 gm/kg/63D- intermittent | Peripheral Nerve and Sensation: Structural change in nerve or sheath | TOXID9 90,300,2006 |
| oral/rat | lowest published toxic dose: 1050 mg/kg/49D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | TOPADD 33,378,2005 |
| oral/rat | lowest published toxic dose: 1050 mg/kg/14D- intermittent | Behavioral: Tremor Nutritional and Gross Metabolic: Weight loss or decreased weight gain Nutritional and Gross Metabolic: Dehydration | TOPADD 33,378,2005 |
| oral/rat | lowest published toxic dose: 2100 mg/kg/49D- intermittent | Nutritional and Gross Metabolic: Dehydration Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TOPADD 33,378,2005 |
| oral/rat | lowest published toxic dose: 2100 mg/kg/14D- intermittent | Spinal Cord: Other degenerative changes Behavioral: Tremor Nutritional and Gross Metabolic: Dehydration | TOPADD 33,378,2005 |
| oral/rat | lowest published toxic dose: 4200 mg/kg/49D- intermittent | Spinal Cord: Demyelination Peripheral Nerve and Sensation: Structural change in nerve or sheath Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TOPADD 33,378,2005 |
| oral/rat | lowest published toxic dose: 300 mg/kg/5D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | JTEHF8 67,431,2004 |
| oral/rat | lowest published toxic dose: 2100 mg/kg/14D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JTEHF8 67,431,2004 |
| oral/rat | lowest published toxic dose: 1050 mg/kg/63D- intermittent | Brain and Coverings: Other degenerative changes Spinal Cord: Other degenerative changes Peripheral Nerve and Sensation: Structural change in nerve or sheath | TOXID9 12,468,2008 |
| oral/rat | lowest published toxic dose: 4200 mg/kg/63D- intermittent | Brain and Coverings: Demyelination Brain and Coverings: Other degenerative changes Peripheral Nerve and Sensation: Structural change in nerve or sheath | TOXID9 -,443,2009 |
| skin/cat | lowest published toxic dose: 900 mg/kg/90D- intermittent | Behavioral: Ataxia Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TXAPA9 83,126,1986 |
| skin/domestic bird | lowest published toxic dose: 6 gm/kg/10D- intermittent | Spinal Cord: Other degenerative changes | NEZAAQ 52,281,1997 |
| subcutaneous/domestic bird | lowest published toxic dose: 2250 mg/kg/5D- intermittent | Peripheral Nerve and Sensation: Sensory change involving peripheral nerve Behavioral: Ataxia Blood: Other changes | NEZAAQ 47,222,1992 |
| subcutaneous/rat | lowest published toxic dose: 4200 mg/kg/50D- intermittent | Brain and Coverings: Other degenerative changes Peripheral Nerve and Sensation: Structural change in nerve or sheath Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | TOXID9 78,276,2004 |
| subcutaneous/rat | lowest published toxic dose: 2100 mg/kg/50D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | TOXID9 78,276,2004 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.1 mg/m3 (skin) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | CRTXB2 3,289,1975 | |
| TOXICOLOGY REVIEW | IRXPAT 3,219,1964 | |
| TOXICOLOGY REVIEW | CRTXB2 2,365,1973 | |
| TOXICOLOGY REVIEW | CMTVAS 10(3),49,1973 | |
| TOXICOLOGY REVIEW | ARENAA 26,29,1981 | |
| TOXICOLOGY REVIEW | CCATAR 366,1,2006 | |
| TOXICOLOGY REVIEW | ENTOX* -,441,2005 | |
| TOXICOLOGY REVIEW | ENTOX* -,302,2005 | |
| TOXICOLOGY REVIEW | ENTOX* -,308,2005 | |
| TOXICOLOGY REVIEW | NCLNA* 16,503,1998 | |
| TOXICOLOGY REVIEW | NTAPM* -,629,1995 | |
| TOXICOLOGY REVIEW | NTAPM* -,689,1995 | |
| TOXICOLOGY REVIEW | TXCYAC 307,46,2013 | |
| TOXICOLOGY REVIEW | TXAPA9 270,39,2013 | |
| TOXICOLOGY REVIEW | FCTOD7 86,298,2015 | |
| TOXICOLOGY REVIEW | TXCYAC 313,94,2013 | |
| TOXICOLOGY REVIEW | NETEEC 52,248,2015 | |
| TOXICOLOGY REVIEW | VETODR ,197,2018 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 0.1 mg/m3 | DTLVS* 3,271,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.1 mg/m3, JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.1 mg/m3;KZW 0.2 mg/m3, skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 0.1 mg/m3, Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 0.1 mg/m3, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 0.1 mg/m3, Skin, FEB2006 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 0.1 mg/m3, Skin, SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 0.1 mg/m3, NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 0.1 mg/m3, skin, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 0.1 mg/m3;short term exposure limit 0.3 mg/m3, 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.1 mg/m3, skin, JAN2002 | |
| Occupational Exposure Limit-PERU | time-weighted average 0,1 mg/m3, JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 0.1 mg/m3, MAC(short term exposure limit) 0.3 mg/m3, JAN1999 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 0.1 mg/m3, inhal, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.1 mg/m3, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 0.1 mg/m3, JAN1993 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 0.1 mg/m3;short term exposure limit 0.3 mg/m3, OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 0.1 mg/m3 | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 0.1 mg/m3 | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 0.1 mg/m3 | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 0.1 mg/m3 | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TRIORTHOCRESYL PHOSPHATE-air | 10H time-weighted average 0.1 mg/m3 (Sk) | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 74600; Number of Industries 1; Total Number of Facilities 20; Number of Occupations 1; Total Number of Employees Exposed 20; Total Number of Female Employees Exposed 20 | |
| National Occupational Hazard Survey 1974 | Hazard Code 74600; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 1; Total Number of Employees Exposed 14 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE | FEREAC 47,26992,82 |
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NIOSH Analytical Method, 1994: Triorthocresyl phosphate, 5037 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health