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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphoric acid, tributyl ester

RTECS #

TC7700000

CAS #

126-73-8

Updated

April 2017

Molecular Weight

266.36

Molecular Formula

C12H27O4P

Synonyms

Butyl phosphate, tri-
Celluphos 4
MCS 2495
TBP
Tributilfosfato (Italian)
Tributyl phosphate
Tributyl phosphate (ACGIH:OSHA)
Tributyle (phosphate de) (French)
Tributylfosfaat (Dutch)
Tributylfosfat (Czech)
Tributylphosphat (German)
Tri-n-butyl phosphate

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg severeAJOPAA 29,1363,1946
eye /rabbit 100 mg mildHPV341 -,-,2001
skin /guinea pig 10%/24H mildHPV341 -,-,2001
skin /human 75%/3HHPV341 -,-,2001
skin /human 50%/24HHPV341 -,-,2001
skin /rabbit 500 mg severeHPV341 -,-,2001
skin /rabbit 10%HPV341 -,-,2001
skin /rabbit 10 mg/24H open irritation testJIHTAB 26,269,1944

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium500 µg/plate (+/-enzymatic activation step)GISAAA 51(9),81,1986

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 7500 mg/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
NTIS** OTS0529384
oral/rat 43770 mg/kg (multigeneration)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)FAATDF 40,90,1997
oral/rat 4350 mg/kg (6-15D pregnant)Reproductive: Other effects on femaleHPV341 -,-,2001
oral/rat 1375 mg/kg (7-17D pregnant)Reproductive: Other effects on femaleHPV341 -,-,2001
oral/rat 5500 mg/kg (7-17D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
HPV341 -,-,2001
oral/rabbit 3250 mg/kg (6-18D pregnant)Reproductive: Other effects on femaleHPV341 -,-,2001
oral/rabbit 10075 mg/kg (6-18D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
HPV341 -,-,2001

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 229 gm/kg/78W- continuousTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
TOXID9 36(1 Pt2),174,1997
oral/mouse lowest published toxic dose: 64800 mg/kg/72W- intermittentTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HPV341 -,-,2001
oral/rat lowest published toxic dose: 263 gm/kg/2Y- continuousTumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
TOXID9 36(1 Pt2),174,1997
oral/rat lowest published toxic dose: 23520 mg/kg/2Y- intermittentTumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HPV341 -,-,2001

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Hamster, ovary Inhibitor Concentration (20 percent kill): 22 µmol/L/24HEndocrine: Other changesTXCYAC 314,76,2013
inhalation/cat Lowest published lethal concentration: 24510 mg/m3/5HLung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis
EDWU** -,-,1937
inhalation/cat Lowest published lethal concentration: 24510 mg/m3/5HHPV341 -,-,2001
inhalation/mouse lethal concentration (50 percent kill): 1300 mg/m3GTPZAB 15(8),30,1971
inhalation/rat lowest published toxic concentration: 1500 mg/m3/6HLung, Thorax, or Respiration: Other changes

Skin: After topical application: Primary irritation
HPV341 -,-,2001
inhalation/rat lethal concentration (50 percent kill): >42000 mg/m3/6HHPV341 -,-,2001
inhalation/rat lethal concentration (50 percent kill): 28000 mg/m3/1HHPV341 -,-,2001
intraperitoneal/mouse lowest published toxic dose: 100 mg/kgBrain and Coverings: Other degenerative changesTOLED5 135,89,2002
intraperitoneal/mouse lethal dose (50 percent kill): 158.5 mg/kgHPV341 -,-,2001
intraperitoneal/rat lethal dose (50 percent kill): 251 mg/kgGTPZAB 15(8),30,1971
intraperitoneal/rat lowest published lethal dose: 800 mg/kgHPV341 -,-,2001
intravenous/rat lowest published lethal dose: 100 mg/kgBehavioral: General anesthetic

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes
NATUAS 179,154,1957
intravenous/rat lowest published lethal dose: 100 mg/kgHPV341 -,-,2001
oral/chicken lethal dose (50 percent kill): 1500 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
TIHEEC 6,415,1990
oral/chicken lethal dose (50 percent kill): 1500 mg/kgHPV341 -,-,2001
oral/mammal (species unspecified) lethal dose (50 percent kill): 1189 mg/kgGISAAA 39(4),86,1974
oral/mouse lethal dose (50 percent kill): 900 mg/kgHPV341 -,-,2001
oral/rat lethal dose (50 percent kill): 1390 mg/kgHPV341 -,-,2001
skin/guinea pig lowest published lethal dose: 9700 mg/kgHPV341 -,-,2001
skin/rabbit lethal dose (50 percent kill): >3100 mg/kgHPV341 -,-,2001
subcutaneous/mouse lethal dose (50 percent kill): 764 mg/kgJKXXAF #72-18000
subcutaneous/mouse lowest published lethal dose: 3000 mg/kgHPV341 -,-,2001
unreported route/mouse lethal dose (50 percent kill): 1200 mg/kgGISAAA 33(7),100,1968
unreported route/rat lethal dose (50 percent kill): 1400 mg/kgGISAAA 33(7),100,1968

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lowest published toxic concentration: 13600 mg/m3/5H/17W- intermittentLiver: Liver function tests impairedGTPZAB 15(8),30,1971
inhalation/rabbit lowest published toxic concentration: 13.6 mg/kg/16W- continuousLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HPV341 -,,2001
inhalation/rat lowest published toxic concentration: 500 mg/m3/6H/30D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0535406
inhalation/rat lowest published toxic concentration: 13.6 mg/m3/16W- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseHPV341 -,,2001
inhalation/rat lowest published toxic concentration: 15 gm/m3/4W- intermittentEndocrine: Other changesGISAAA 55(12),56,1990
oral/mouse lowest published toxic dose: 109 gm/kg/91D- continuousKidney, Ureter, and Bladder: Changes in bladder weight

Related to Chronic Data: Changes in testicular weight

Related to Chronic Data: Changes in uterine weight
JTSCDR 5,270,1980
oral/mouse lowest published toxic dose: 33600 mg/kg/28D- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0526409
oral/mouse lowest published toxic dose: 21000 mg/kg/4W- continuousLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV341 -,,2001
oral/mouse lowest published toxic dose: 84000 mg/kg/4W- continuousLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV341 -,,2001
oral/rabbit lowest published toxic dose: 7000 mg/kg/7D- continuousKidney, Ureter, and Bladder: ProteinuriaHPV341 -,,2001
oral/rabbit lowest published toxic dose: 5200 mg/kg/13D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV341 -,,2001
oral/rat lowest published toxic dose: 27 gm/kg/90D- continuousKidney, Ureter, and Bladder: Other changes

Blood: Change in clotting factors

Blood: Changes in erythrocyte (RBC) count
TOXID9 5,97,1985
oral/rat lowest published toxic dose: 12600 mg/kg/10W- continuousKidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 40,247,1997
oral/rat lowest published toxic dose: 18900 mg/kg/9W- continuousLiver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 13,29,1982
oral/rat lowest published toxic dose: 5880 µL/kg/4D- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerveDCTODJ 6,363,1983
oral/rat lowest published toxic dose: 6825 mg/kg/13W- continuousKidney, Ureter, and Bladder: Other changesHPV341 -,,2001
oral/rat lowest published toxic dose: 34125 mg/kg/13W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes

Blood: Normocytic anemia
HPV341 -,,2001
oral/rat lowest published toxic dose: 13500 mg/kg/90D- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV341 -,,2001
oral/rat lowest published toxic dose: 5600 mg/kg/2W- continuousLiver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Normocytic anemia
HPV341 -,,2001
oral/rat lowest published toxic dose: 1400 mg/kg/7D- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Renal function tests depressed

Kidney, Ureter, and Bladder: Changes in kidney weight
HPV341 -,,2001

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 5 mg/m3 (inhal, vapor)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 5 mg/m3DTLVS* 3,262,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.2 ppm (2.2 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 2.5 mg/m3;KZW 5 mg/m3, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.2 ppm (2.2 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.2 ppm (2.5 mg/m3), carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.2 ppm (2.5 mg/m3), short term exposure limit 0.4 ppm (5 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 0.2 ppm (2.5 mg/m3), C3 Carcinogen, FEB2006
Occupational Exposure Limit-GERMANYMAK 1 ppm (11 mg/m3), skin, 2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.2 ppm (2.5 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.2 ppm (2.5 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.2 ppm (2.5 mg/m3);short term exposure limit 0.4 ppm (5 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.2 ppm (2.2 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.2 ppm (2.5 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,2 ppm (2,18 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.5 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.2 ppm (2.5 mg/m3), KZG-week 0.8 ppm (10 mg/m3), carc 3, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 5 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 5 mg/m3;short term exposure limit 5 mg/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 5 mg/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 5 mg/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 5 mg/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 5 mg/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TRIBUTYL PHOSPHATE-air10H time-weighted average 0.2 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 73730; Number of Industries 79; Total Number of Facilities 4810; Number of Occupations 75; Total Number of Employees Exposed 109402; Total Number of Female Employees Exposed 19015
National Occupational Hazard Survey 1974Hazard Code 73730; Number of Industries 25; Total Number of Facilities 1209; Number of Occupations 30; Total Number of Employees Exposed 30555

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Tributyl phosphate, 5034
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