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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphoric acid, 1,2-dibromo-2,2-dichloroethyl dimethyl ester

RTECS #

TB9450000

CAS #

300-76-5; 53095-31-1

Updated

December 2016

Molecular Weight

380.80

Molecular Formula

C4H7Br2Cl2O4P

Synonyms

1,2-Dibromo-2,2-dichloroethyl dimethyl phosphate
Alvora
Arthodibrom
Bromchlophos
Bromex (insecticide)
Dibrom
Dibromfos
Dimethyl 1,2-dibromo-2,2-dichloroethyl phosphate
Dimethyl-1,2-dibromo-2,2-dichloroethyl phosphate (OSHA)
ENT 24988
Ethanol, 1,2-dibromo-2,2-dichloro-, dimethyl phosphate
Flibol Ex
Fosforan O-1,2-dwubromo-2,2-dwuchloroetylo-O,O-dwumetylowy (Polish)
Hibrom
Naled
Naled (ACGIH)
Naledu (Polish)
O-(1,2-Dibrom-2,2-dichlor-aethyl)-O,O-dimethyl-phosphat (German)
O-(1,2-Dibromo-2,2-dicloro-etil)-O,O-dimetil-fosfato (Italian)
O-(1,2-Dibroom-2,2-dichloor-ethyl)-O,O-dimethyl-fosfaat (Dutch)
O,O-Dimethyl O-2,2-dichloro-1,2-dibromoethyl phosphate
O,O-Dimethyl-O-(1,2-dibrom-2,2-dichlor-aethyl)-phosphat (German)
O,O-Dimethyl-O-(1,2-dibromo-2,2-dichloroethyl)phosphate
OMS 75
Ortho 4355
Phosphate de O,O-dimethyle et de O-(1,2-dibromo-2,2-dichlorethyle) (French)
RE-4355

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /man 42 mg/21D- intermittent open irritation testTXAPA9 21,369,1972
skin /rabbit 500 mg/24H severeTXAPA9 21,369,1972

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium9800 µg/plate (+enzymatic activation step)MUREAV 28,405,1975
mutation in microorganisms/Salmonella typhimurium50 µg/plate (-enzymatic activation step)JAFCAU 29,268,1981
mutation in microorganisms/Bacillus subtilis300 µg/plate (+enzymatic activation step)JAFCAU 29,268,1981

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse Lethal concentration: >1500 mg/m3/6H85JFAN A289,1983
intraperitoneal/mouse lethal dose (50 percent kill): 84 mg/kg85GMAT -,56,1982
intraperitoneal/rat lethal dose (50 percent kill): 35 mg/kgBECTA6 19,113,1978
oral/duck lethal dose (50 percent kill): 52 mg/kgDOEAAH 35,25,1979
oral/mammal (species unspecified) lethal dose (50 percent kill): 430 mg/kgHPBIA9 21,53,1975
oral/mouse lethal dose (50 percent kill): 222 mg/kgEye: Other eye effects

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands
BECTA6 19,113,1978
oral/rat lethal dose (50 percent kill): 92 mg/kgBehavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Hypermotility, diarrhea
ATDAEI 1,90,1990
skin/mouse lethal dose (50 percent kill): 600 mg/kgJPIFAN (8),24,1971
skin/rabbit lethal dose (50 percent kill): 1100 mg/kgENTOX* -,180,2005
skin/rat lethal dose (50 percent kill): 800 mg/kgENTOX* -,180,2005

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 1350 mg/kg/9W- intermittentNutritional and Gross Metabolic: Body temperature decrease

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
RPZHAW 20,463,1969
skin/mouse lowest published toxic dose: 1 pph/3D- intermittentImmunological Including Allergic: Increased immune responseTXCYAC 261,152,2009

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 mg/m3 (inhal, vapor, skin, sen)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWDTTIAF 80,485,1973
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWENTOX* -,180,2005
TOXICOLOGY REVIEWTXAPA9 268,157,2013

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,135,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 3 mg/m3DTLVS* 3,73,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 3 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 3 mg/m3;KZW 12 mg/m3, inhal, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 3 mg/m3, Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 3 mg/m3, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 3 mg/m3, short term exposure limit 6 mg/m3, skin, NOV2011
Occupational Exposure Limit-FRANCEVME 3 mg/m3, Skin, FEB2006
Occupational Exposure Limit-GERMANYMAK 1 mg/m3, inhal, skin, 2011
Occupational Exposure Limit-ICELANDtime-weighted average 3 mg/m3, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 3 mg/m3, skin, 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 3 mg/m3, skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 3 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,1 mg/m3, JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.5 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg/m3, skin, sen, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 3 mg/m3, JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 3 mg/m3, 2003
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 3 mg/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 3 mg/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 3 mg/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 3 mg/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air10H time-weighted average 3 mg/m3 (Sk)NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974Hazard Code 26420; Number of Industries 1; Total Number of Facilities 16; Number of Occupations 1; Total Number of Employees Exposed 16

Status in Federal Agencies

OrganizationReference
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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