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Registry of Toxic Effects of Chemical Substances (RTECS)

Phenol, pentachloro-

RTECS #

SM6300000

CAS #

87-86-5

Updated

April 2017

Molecular Weight

266.32

Molecular Formula

C6HCl5O

Synonyms

1-Hydroxypentachlorobenzene
2,3,4,5,6-Pentachlorophenol
AD 73
Chem-Penta
Chem-Tol
Chlon
Chlorophen
CM 613
CP 1309
Dow pentachlorophenol DP-2 antimicrobial
Dowicide 7
Dowicide EC-7
Durotox
EP 30
Fungifen
Grundier arbezol
Lauxtol
Lauxtol A
Liroprem
MB 333
NCI-C54933
NCI-C55378
NCI-C56655
PCP
PCP (pesticide)
Penchlorol
Penta
Penta ready
Penta WR
Pentachloorfenol (Dutch)
Pentachlorofenol
Pentachlorofenolo
Pentachlorophenol
Pentachlorophenol (ACGIH:OSHA)
Pentachlorophenol, DP-2
Pentachlorophenol, EC-7
Pentachlorophenol, technical-grade
Pentachlorphenol
Pentachlorphenol (German)
Pentaclorofenolo (Italian)
Pentacon
Penta-kil
Penwar
Peratox
Permacide
Permagard
Permasan
Permatox DP-2
Permatox penta
Permite
Pol Nu
Pole topper fluid
Preventol P
RCRA waste number U242
Santophen 20
Thompson's wood fix
Weedone
Witophen P
Woodtreat A

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 µL/24H mildNTIS** OTS0546023
skin /rabbit 10 mg/24H open irritation test mildAIHAAP 23,95,1962

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster80 mg/LEMMUEG 10(Suppl 10),1,1987
Cytogenetic Analysisfibroblast/hamster300 mg/L (-enzymatic activation step)HBPTO* 2,1491,2001
DNA adductoral/rat6000 mg/kg/8WFCTOD7 74,28,2014
DNA DamageAscites tumor/human50 mg/L/2HFCTOD7 42,1323,2004
DNA Damagemultiple/non-mammalian species100 µg/L/2HMUREAV 605,78,2006
DNA Damagefibroblast/human1 mmol/L/1H (+enzymatic activation step)MUREAV 701,103,2010
DNA Damagelymphocyte/human0.75 mmol/L/1H (+enzymatic activation step)MUREAV 701,103,2010
DNA Damagefibroblast/hamster1.5 mmol/L/1H (+enzymatic activation step)MUREAV 701,103,2010
DNA Damageliver/human1.35 mmol/L/1H (+enzymatic activation step)MUREAV 701,103,2010
DNA DamageHeLa cell/human1.35 mmol/L/1H (+enzymatic activation step)MUREAV 701,103,2010
DNA Damagemultiple/other insects25 µg/L/24HMUREAV 758,41,2013
DNA Damagemultiple/other insects25 µg/L/96H-continuousMUREAV 758,41,2013
gene conversion and mitotic recombination/Saccharomyes cerevisiae190 µmol/LIARCCD 10,161,1974
micronucleus testmultiple/non-mammalian species10 µg/L/24HMUREAV 605,78,2006
morphological transformembryo/hamster100 mg/LAETODY 1,241,1980
morphological transformfibroblast/mouse0.01 mg/L/21D (-enzymatic activation step)EMMUEG 37,231,2001
mutation in microorganisms/Other microorganisms40 mg/LHBPTO* 2,1491,2001
mutation in microorganisms/Salmonella typhimurium40 nmol/plate (-enzymatic activation step)AIDZAC 10,305,1982
mutation in microorganisms/Saccharomyes cerevisiae400 mg/L (-enzymatic activation step)EVSRBT 12,325,1978
other mutation test systemsoral/mouse30 mg/kgMUREAV 343,157,1995
other mutation test systems/Other microorganisms10 mg/LEESADV 13,7,1987
sister chromatid exchangeovary/hamster3 mg/LEMMUEG 10(Suppl 10),1,1987
specific locus testintraperitoneal/mouse50 mg/kgEVSRBT 12,325,1978
specific locus testmultiple/other fish5 µg/L/10D-continuousMUREAV 609,92,2006

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/mouse 0.15 mg/m3 (122D prior to copulation)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Other postnatal measures or effects
VCVGK* -,258,1994
oral/rat 50 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on newborn: Sex ratio

Reproductive: Specific developmental abnormalities: Musculoskeletal system
HBPTO* 2,1496,2001
oral/rat 5 gm/kg (26W male/26W prior to copulation/0-20D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects to embryo or fetus
HBPTO* 2,1496,2001
oral/rat 800 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
IJTOFN 20,353,2001
oral/rat 3300 mg/kg (multigeneration)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Germ cell effects (in offspring)
IJTOFN 21,301,2002
oral/rat 6600 mg/kg (multigeneration)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
IJTOFN 21,301,2002
oral/rat 60 mg/kg (9D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)DABBBA 37,1184,1976
oral/rat 50 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemTXAPA9 28,151,1974
oral/rat 4 gm/kg (77D pre-28D after birth)Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TXAPA9 41,138,1977
oral/rat 120 mg/kg (8-11D pregnant)Reproductive: Specific developmental abnormalities: HomeostasisTXAPA9 28,151,1974
oral/man 124 mg/kg (multigeneration)Reproductive: Effects on newborn: Delayed effectsJRPFA4 113,95,1998
subcutaneous/mouse 450 mg/kg (6-14D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathNTIS** PB223-160
unreported route/rat 5 mg/kg (8D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects
VCVGK* -,249,1994
unreported route/rat 5 mg/kg (9D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects
VCVGK* -,249,1994
unreported route/rat 5 mg/kg (10D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects
VCVGK* -,249,1994
unreported route/rat 5 mg/kg (11D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects
VCVGK* -,249,1994
unreported route/rat 5 mg/kg (12D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects
VCVGK* -,249,1994
unreported route/rat 5 mg/kg (13D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects
VCVGK* -,249,1994

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 8652 mg/kg/103W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Endocrine: Adrenal cortex tumors
NTIS** PB89-216536/AS
oral/mouse lowest published toxic dose: 17304 mg/kg/103W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** PB89-216536/AS
oral/mouse lowest published toxic dose: 51912 mg/kg/103W- continuousTumorigenic: Neoplastic by RTECS criteria

Endocrine: Adrenal cortex tumors

Blood: Tumors
NTIS** PB89-216536/AS
oral/mouse lowest published toxic dose: 17304 mg/kg/103W- continuousTumorigenic: Neoplastic by RTECS criteria

Blood: Tumors
NTIS** PB89-216536/AS
oral/mouse lowest published toxic dose: 8736 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors
NTPTR* NTP-TR-349,1989
oral/rat lowest published toxic dose: 21840 mg/kg/52W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors
NTIS** PB99-152878
oral/rat lowest published toxic dose: 21.9 gm/kg/1Y- continuousTumorigenic: Neoplastic by RTECS criteriaHBPTO* 2,1489,2001
subcutaneous/mouse lowest published toxic dose: 46 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
NTIS** PB223-159

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Chicken, neurons Inhibitor Concentration (50 percent kill): 119 µmol/L/21HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,653,1993
In Vitro/Chicken, neurons Inhibitor Concentration (10 percent kill): 38 µmol/L/21HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,653,1993
In Vitro/Chicken, neurons Inhibitor Concentration (50 percent kill): 47 µmol/L/20HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 7,653,1993
In Vitro/Chicken, neurons Inhibitor Concentration (10 percent kill): 33 µmol/L/20HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 7,653,1993
In Vitro/Human, endocrine tumor Inhibitor Concentration Low: 0.4 µmol/L/48HEndocrine: Other changesTXCYAC 282,146,2011
In Vitro/Human, endocrine tumor Inhibitor Concentration Low: 3.4 µmol/L/48HEndocrine: Other changes

In Vitro Toxicity Studies: Other assays

Biochemical: Metabolism (intermediary): Effect on cyclic nucleotides
TXCYAC 282,146,2011
In Vitro/Human, kidney tumor Inhibitor Concentration (50 percent kill): 67.9 mg/LIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.TIVIEQ 27,1347,2013
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 420 mg/LIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.TIVIEQ 27,1347,2013
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 13.9 mg/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,1347,2013
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 60.4 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXAPA9 266,335,2013
In Vitro/Human, monocyte Inhibitor Concentration (20 percent kill): 31 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TOLED5 199,51,2010
In Vitro/Human, monocyte Inhibitor Concentration (20 percent kill): 31 µmol/L/2HIn Vitro Toxicity Studies: Other assaysTOLED5 199,51,2010
In Vitro/Human, neuroblastoma Inhibitor Concentration Low: 1.9 µmol/L/4MIn Vitro Toxicity Studies: Membrane currentsTXAPA9 245,191,2010
In Vitro/Human, neuroblastoma Inhibitor Concentration (50 percent kill): 65 µmol/L/15MIn Vitro Toxicity Studies: Other assaysTXAPA9 245,191,2010
In Vitro/Human, neuroblastoma Inhibitor Concentration (50 percent kill): 860 µmol/L/60MBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTXAPA9 245,191,2010
In Vitro/Human, skin Inhibitor Concentration (50 percent kill): 0.679 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 27,1347,2013
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 19.1 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 27,1347,2013
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 23.1 mg/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,1347,2013
In Vitro/Non-mammalian species, fibroblast Inhibitor Concentration (50 percent kill): 0.24 mmol/L/24HIn Vitro Toxicity Studies: Cell countingTIVIEQ 7,537,1993
In Vitro/paaInhibitor Concentration Low: 0.357 µmol/L/44HIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,1416,2013
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): 22.1 mg/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,1347,2013
inhalation/mouse lethal concentration (50 percent kill): 225 mg/m3Behavioral: Excitement

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea
GTPZAB 13(9),58,1969
inhalation/mouse lethal concentration (50 percent kill): 225 mg/m3Cardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,248,1994
inhalation/rat lethal concentration (50 percent kill): 335 mg/m3Cardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,248,1994
inhalation/rat lethal concentration (50 percent kill): 200 mg/m3HBPTO* 2,1229,2001
inhalation/rat lethal concentration (50 percent kill): 355 mg/m3Behavioral: Excitement

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea
GTPZAB 13(9),58,1969
intraperitoneal/mouse lethal dose (50 percent kill): 32 mg/kgARTODN 40,63,1978
intraperitoneal/mouse lowest published toxic dose: 120 mg/kgImmunological Including Allergic: Decrease in humoral immune responseTXCYAC 36,307,1985
intraperitoneal/mouse lowest published lethal dose: 250 mg/kgVCVGK* -,257,1994
intraperitoneal/rabbit lowest published lethal dose: 135 mg/kgHBTXAC 5,123,1959
intraperitoneal/rat lethal dose (50 percent kill): 56 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature increase
BJPCAL 13,20,1958
intraperitoneal/rat lowest published toxic dose: 1.86 mg/kgEndocrine: Other changesTXCYAC 67,107,1991
intraperitoneal/rat lethal dose (50 percent kill): 60 mg/kgHBPTO* 2,1486,2001
intraperitoneal/rat lethal dose (50 percent kill): 56 mg/kgCardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,246,1994
oral/duck lethal dose (50 percent kill): 380 mg/kgHBPTO* 2,1229,2001
oral/gerbil lethal dose (50 percent kill): 294 mg/kgARTODN 40,63,1978
oral/hamster lethal dose (50 percent kill): 168 mg/kgTXAPA9 48,A192,1979
oral/man lowest published lethal dose: 401 mg/kgBehavioral: Change in motor activity (specific assay)

Skin and Appendages: Other: Sweating

Nutritional and Gross Metabolic: Body temperature increase
EESADV 1,343,1977
oral/mouse lethal dose (50 percent kill): 36 mg/kgARTODN 40,63,1978
oral/mouse lethal dose (50 percent kill): 117 mg/kgBehavioral: Somnolence (general depressed activity)TOLED5 29,39,1985
oral/mouse lethal dose (50 percent kill): 30 mg/kgCardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,246,1994
oral/mouse lowest published toxic dose: 30 mg/kgLiver: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TOSCF2 73,26,2003
oral/rabbit lethal dose (50 percent kill): 200 mg/kgCardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,246,1994
oral/rabbit lowest published lethal dose: 70 mg/kgVCVGK* -,249,1994
oral/rabbit lowest published lethal dose: 70 mg/kgBehavioral: Muscle weakness

Vascular: BP elevation not characterized in autonomic section

Kidney, Ureter, and Bladder: Urine volume increased
JPETAB 76,104,1942
oral/rat lethal dose (50 percent kill): 27 mg/kgVascular: BP elevation not characterized in autonomic section

Endocrine: Hyperglycemia

Nutritional and Gross Metabolic: Body temperature increase
JPETAB 76,104,1942
oral/rat lethal dose (50 percent kill): 27 mg/kgCardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,246,1994
oral/rat lowest published toxic dose: 5 mg/kgLiver: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TOSCF2 73,26,2003
oral/rat lethal dose (50 percent kill): 50 mg/kgVCVGK* -,249,1994
skin/rabbit lowest published lethal dose: 40 mg/kgVCVGK* -,249,1994
skin/rabbit lowest published lethal dose: 40 mg/kgBehavioral: Muscle weakness

Vascular: BP elevation not characterized in autonomic section

Kidney, Ureter, and Bladder: Urine volume increased
JPETAB 76,104,1942
skin/rat lethal dose (50 percent kill): 96 mg/kgBehavioral: Excitement

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea
GTPZAB 13(9),58,1969
skin/rat lethal dose (50 percent kill): 26 mg/kgCardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,246,1994
subcutaneous/Dog lowest published lethal dose: 135 mg/kgHBTXAC 5,123,1959
subcutaneous/rabbit lowest published lethal dose: 70 mg/kgBehavioral: Muscle weakness

Vascular: BP elevation not characterized in autonomic section

Kidney, Ureter, and Bladder: Urine volume increased
JPETAB 76,104,1942
subcutaneous/rabbit lowest published lethal dose: 70 mg/kgVCVGK* -,249,1994
subcutaneous/rat lethal dose (50 percent kill): 100 mg/kgCardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,246,1994
Tank with water/Other invertebrate lethal concentration (50 percent kill): 0.92 mg/L/24HTIVIEQ 32,271,1995
Tank with water/Zebrafish lowest published toxic concentration: 50 µg/mL/8HReproductive: Other effects to embryo or fetusTXAPA9 277,183,2014
unreported route/Dog lethal dose (50 percent kill): 70 mg/kgPHPHA6 1,3,1953
unreported route/frog lethal dose (50 percent kill): 36 mg/kgPHPHA6 1,3,1953
unreported route/guinea pig lethal dose (50 percent kill): 100 mg/kgPHPHA6 1,3,1953

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rabbit lowest published toxic concentration: 29 mg/m3/4H/15D- intermittentBrain and Coverings: Other degenerative changes

Liver: Other changes

Blood: Normocytic anemia
VCVGK* -,249,1994
inhalation/rabbit lowest published toxic concentration: 29 mg/m3/4H/60D- intermittentLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Gastrointestinal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,249,1994
inhalation/rat lowest published toxic concentration: 29 mg/m3/4H/60D- intermittentLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Gastrointestinal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,249,1994
inhalation/rat lowest published toxic concentration: 29 mg/m3/4H/15D- intermittentBrain and Coverings: Other degenerative changes

Liver: Other changes

Blood: Normocytic anemia
VCVGK* -,249,1994
oral/cattle lowest published toxic dose: 2610 mg/kg/23W- continuousEndocrine: Changes in thymus weight

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TXAPA9 52,468,1980
oral/cattle lowest published toxic dose: 2610 mg/kg/160D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TXAPA9 52,468,1980
oral/cattle lowest published toxic dose: 2610 mg/kg/160D- intermittentLung, Thorax, or Respiration: Changes in lung weight

Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 52,468,1980
oral/mouse lowest published toxic dose: 140 mg/kg/14D- intermittentImmunological Including Allergic: Decrease in humoral immune responseHBPTO* 2,1499,2001
oral/mouse lowest published toxic dose: 45 gm/kg/30D- continuousLiver: Changes in liver weight

Endocrine: Changes in spleen weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NTP-TR-349,1989
oral/mouse lowest published toxic dose: 1680 mg/kg/8W- continuousLiver: Changes in liver weight

Immunological Including Allergic: Decrease in humoral immune response

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
FAATDF 2,90,1982
oral/mouse lowest published toxic dose: 10920 mg/kg/26W- continuousLiver: Changes in liver weight

Endocrine: Changes in spleen weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
NTPTR* NTP-TR-349,1989
oral/mouse lowest published toxic dose: 14168 mg/kg/23W- continuousTumorigenic: Facilitates action of known carcinogensCRNGDP 24,1105,2003
oral/mouse lowest published toxic dose: 728 mg/kg/2W- continuousLiver: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
CRNGDP 24,1105,2003
oral/pig lowest published toxic dose: 150 mg/kg/30D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in leukocyte (WBC) count
BECTA6 31,599,1983
oral/rabbit lowest published toxic dose: 195 mg/kg/13D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainIJTOFN 20,345,2001
oral/rabbit lowest published toxic dose: 390 mg/kg/13D- intermittentBehavioral: Food intake (animal)IJTOFN 20,345,2001
oral/rat lowest published toxic dose: 800 mg/kg/10D- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
IJTOFN 20,353,2001
oral/rat lowest published toxic dose: 840 mg/kg/12W- continuousLiver: Changes in liver weight

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXCYAC 2,141,1974
oral/rat lowest published toxic dose: 84 mg/kg/28D- intermittentEndocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOLED5 71,9,1994
oral/rat lowest published toxic dose: 21840 mg/kg/2Y- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
EVSRBT 12,301,1978
oral/rat lowest published toxic dose: 11.76 gm/kg/28W- continuousLiver: Other changesHBPTO* 2,1489,2001
oral/rat lowest published toxic dose: 300 mg/kg/10D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainHBPTO* 2,1496,2001
oral/rat lowest published toxic dose: 8643 mg/kg/201D- continuousReproductive: Maternal effects: Uterus, cervix, vagina

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 2,1496,2001
oral/rat lowest published toxic dose: 2556 mg/kg/142D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVGK* -,249,1994
oral/rat lowest published toxic dose: 2060 mg/kg/57D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVGK* -,249,1994
oral/rat lowest published toxic dose: 3600 mg/kg/120D- intermittentLiver: Hepatitis (hepatocellular necrosis), zonal

Liver: Changes in liver weight

Related to Chronic Data: Changes in ovarian weight
IJTOFN 21,301,2002
oral/rat lowest published toxic dose: 7200 mg/kg/120D- intermittentGastrointestinal: Changes in structure or function of salivary glands

Liver: Other changes

Related to Chronic Data: Changes in uterine weight
IJTOFN 21,301,2002
oral/rat lowest published toxic dose: 1000 mg/kg/100D- intermittentLiver: Other changes

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
IJTOFN 21,301,2002
oral/rat lowest published toxic dose: 6000 mg/kg/100D- intermittentBrain and Coverings: Changes in brain weight

Liver: Hepatitis (hepatocellular necrosis), zonal

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
IJTOFN 21,301,2002
oral/rat lowest published toxic dose: 6000 mg/kg/8W- intermittentLiver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 74,28,2014
subcutaneous/pig lowest published toxic dose: 560 mg/kg/14D- intermittentReproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Maternal effects: Menstrual cycle changes or disorders
REPTED 16,29,2002
unreported route/mouse lowest published toxic dose: 60 mg/kg/3D- intermittentRelated to Chronic Data: Changes in uterine weightTOXID9 54,262,2000

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.5 mg/m3 (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Human Limited EvidenceIMEMDT 41,319,1986
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 53,371,1991
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 71,769,1999
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 20,303,1979
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 53,371,1991
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 53,371,1991
TOXICOLOGY REVIEWSTEVA8 2,305,1974
TOXICOLOGY REVIEWAIHAAP 43,799,1982
TOXICOLOGY REVIEWTOLED5 127,101,2002
TOXICOLOGY REVIEWMUREAV 567,227,2004
TOXICOLOGY REVIEWENTOX* -,567,2005
TOXICOLOGY REVIEWENTOX* -,343,2005
TOXICOLOGY REVIEWJTEHD6 7,1,2004
TOXICOLOGY REVIEWADMOL* 1,85,2006
TOXICOLOGY REVIEWREPTED 23,260,2007
TOXICOLOGY REVIEWREPTED 26,185,2008
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWTPHSDY 29,361,2008
TOXICOLOGY REVIEWFCTOD7 46,813,2008
TOXICOLOGY REVIEWMUREAV 681,80,2009
TOXICOLOGY REVIEWBLREV* 3,71,1989
TOXICOLOGY REVIEWMUREAV 682,94,2009
TOXICOLOGY REVIEWNEUCL* 15,711,1997
TOXICOLOGY REVIEWNBREV* 5,1,1981
TOXICOLOGY REVIEWMUREAV 705,184,2010
TOXICOLOGY REVIEWTOLED5 202,36,2011
TOXICOLOGY REVIEWTXCYAC 307,3,2013
TOXICOLOGY REVIEWTXCYAC 307,123,2013
TOXICOLOGY REVIEWMUREAV 767,67,2016
TOXICOLOGY REVIEWTXCYAC 313,94,2013

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,197,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.5 mg/m3 (skin)DTLVS* 3,198,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.5 mg/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.5 mg/m3, Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.005 ppm (0.05 mg/m3), skin, carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, skin, NOV2011
Occupational Exposure Limit-FRANCEVME 0.5 mg/m3, Skin, C3 Carcinogen, FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 0.001 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.005 ppm (0.05 mg/m3), skin, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.5 mg/m3, skin, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.5 mg/m3, skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.5 mg/m3;short term exposure limit 1.5 mg/m3 (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.5 mg/m3, skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.05 ppm (0.5 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,5 mg/m3, JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 1.5 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.5 mg/m3;short term exposure limit 1.5 mg/m3, Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.005 ppm (0.05 mg/m3), carc 2, inhal, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.06 mg/m3, Skin, 2003
Occupational Exposure Limit-TURKEYtime-weighted average 0.5 mg/m3, Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.5 mg/m3 (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.5 mg/m3 (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.5 mg/m3 (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.5 mg/m3 (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PENTACHLOROPHENOL-air10H time-weighted average 0.5 mg/m3 (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 54160; Number of Industries 29; Total Number of Facilities 2248; Number of Occupations 38; Total Number of Employees Exposed 26806; Total Number of Female Employees Exposed 4191
National Occupational Hazard Survey 1974Hazard Code 54160; Number of Industries 47; Total Number of Facilities 3548; Number of Occupations 42; Total Number of Employees Exposed 29154

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/2001/109106/AS)
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Negative: Host-mediated assay; Mouse spot test
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-forward mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);clear evidence:mouse
NCI Carcinogenesis Studies (feed);equivocal evidence:rat
NIOSH Analytical Method, 1994: Pentachlorophenol, 5512; in blood, 8001; in urine, 8303
On EPA IRIS database
OSHA ANALYTICAL METHOD #39
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