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Registry of Toxic Effects of Chemical Substances (RTECS)

Phenol, nonyl-

RTECS #

SM5600000

CAS #

25154-52-3

Updated

October 2017

Molecular Weight

220.39

Molecular Formula

C15H24O

Synonyms

Hydroxyl No. 253
Monononylphenol
n-Nonylphenol
Nonyl phenol (mixed isomers)
Nonylphenol
Nonylphenol mixture

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 mg open irritation test moderateUCDS** 6/9/1959

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damagemultiple/other insects1 µg/L/24HMUREAV 758,41,2013
DNA Damagemultiple/other insects1 µg/L/96H-continuousMUREAV 758,41,2013
DNA Damageintraperitoneal/mouse250 mg/kg/2WMUREAV 772,14,2014

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 19 gm/kg (21D male/21D pre-13D after birth)Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
REPTED 15,293,2001
oral/rat 154 mg/kg (21D male/21D pre-2W after birth)Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system
REPTED 15,293,2001
oral/rat 4 gm/kg (21D male/21D pre-13D after birth)Reproductive: Specific developmental abnormalities: Gastrointestinal system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
REPTED 15,293,2001
oral/rat 770 mg/kg (21D male/21D pre-2W after birth)Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system
REPTED 15,293,2001
oral/rat 3850 mg/kg (multigeneration))Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system
REPTED 15,293,2001
oral/rat 154 mg/kg (multigeneration))Reproductive: Specific developmental abnormalities: Endocrine systemREPTED 15,293,2001
oral/rat 2 mg/kg (multigeneration))Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Effects on newborn: Biochemical and metabolic
FCTOD7 40,53,2002
oral/rat 2700 mg/kg (15-22D preg/10D after birth)Reproductive: Other effects on female

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
ARTODN 78,97,2004
oral/rat 116.25 mg/kg (7D preg-77D after birth)Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Other postnatal measures or effects

Reproductive: Effects on newborn: Delayed effects
TOXID9 60,29,2001
oral/rat 88.75 mg/kg (1D preg-50D after birth)Reproductive: Effects on newborn: Biochemical and metabolicTOXID9 1,73,2001
oral/rat 97.5 mg/kg (7D preg-64D after birth)Reproductive: Effects on newborn: Biochemical and metabolicTXCYAC 211,207,2005
oral/rat 7000 mg/kg (28D male)Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glandsARTODN 81,77,2007
oral/rat 7000 mg/kg (28D prior to copulation)Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Maternal effects: Menstrual cycle changes or disorders
ARTODN 81,77,2007
oral/rat 27200 mg/kg (1D preg-21D after birth)Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Delayed effects
TXCYAC 301,40,2012

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/jtfInhibitor Concentration Low: 1 µmol/L/48HEndocrine: EstrogenicPYTOEY 22,993,2015
In Vitro/Rat, endocrine cell (tissues) Inhibitor Concentration Low: 0.001 pmol/LIn Vitro Toxicity Studies: Membrane currentsTOLED5 218,137,2013
In Vitro/Rat, testis Inhibitor Concentration Low: 5 µmol/L/6HIn Vitro Toxicity Studies: Apoptosis in vitro

In Vitro Toxicity Studies: Other assays
TIVIEQ 26,1114,2012
In Vitro/Rat, testis Inhibitor Concentration Low: 10 µmol/L/6HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 26,1114,2012
intraperitoneal/non-mammalian species lowest published toxic dose: 2.5 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)TOXID9 72,192,2003
intraperitoneal/rat lowest published toxic dose: 60 mg/kgLiver: Other changesTXCYAC 175,49,2002
oral/mouse lethal dose (50 percent kill): 75.63 mL/kgEESADV 59,123,2004
oral/mouse lethal dose (50 percent kill): 1231 mg/kgNTIS** AD-A067-313
oral/rat lethal dose (50 percent kill): 580 mg/kgNTIS** OTS0573098
parenteral/non-mammalian species lowest published toxic dose: 250 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)REPTED 22,449,2006
skin/rabbit lethal dose (50 percent kill): 2140 µL/kgAIHAAP 30,470,1969
skin/rabbit lethal dose (50 percent kill): 2140 mg/kgVCVGK* -,223,1994

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/frog lowest published toxic dose: 2800 mg/kg/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type field

Endocrine: Other changes
BPBLEO 28,1748,2005
intraperitoneal/rat lowest published toxic dose: 600 mg/kg/10D- intermittentLiver: Other changes

Biochemical: Metabolism (intermediary): Other proteins

Related to Chronic Data: Changes in testicular weight
TXCYAC 175,49,2002
oral/mouse lowest published toxic dose: 525 mg/kg/7D- intermittentLiver: Other changes

Endocrine: Differential effect of sex or castration on observed toxicity

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TXCYAC 256,53,2009
oral/mouse lowest published toxic dose: 350 mg/kg/7D- intermittentLiver: Other changesTXAPA9 252,259,2011
oral/rat lowest published toxic dose: 1400 mg/kg/28D- intermittentEndocrine: Changes in thyroid weight

Blood: Changes in other cell count (unspecified)
ARTODN 81,77,2007
oral/rat lowest published toxic dose: 1400 mg/kg/28D- intermittentEndocrine: Change in LH

Endocrine: Hypoglycemia

Nutritional and Gross Metabolic: Changes in: Ca
ARTODN 81,77,2007
oral/rat lowest published toxic dose: 7000 mg/kg/28D- intermittentLiver: Multiple effects

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Normocytic anemia
ARTODN 81,77,2007
oral/rat lowest published toxic dose: 7000 mg/kg/28D- intermittentLiver: Multiple effects

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
ARTODN 81,77,2007
oral/rat lowest published toxic dose: 1589 mg/kg/29D- continuousNutritional and Gross Metabolic: Other changesNTIS** OTS0573098
oral/rat lowest published toxic dose: 14000 mg/kg/56D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
REPTED 15,293,2001
oral/rat lowest published toxic dose: 3500 mg/kg/2W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
REPTED 15,293,2001
oral/rat lowest published toxic dose: 4200 mg/kg/12W- intermittentKidney, Ureter, and Bladder: Changes in kidney weight

Liver: Changes in liver weight

Brain and Coverings: Changes in brain weight
REPTED 15,293,2001
oral/rat lowest published toxic dose: 168 mg/kg/12W- intermittentEndocrine: Androgenic

Reproductive: Paternal effects: Testes, epididymis, sperm duct
REPTED 15,293,2001
oral/rat lowest published toxic dose: 2800 mg/kg/56D- intermittentKidney, Ureter, and Bladder: Other changes

Reproductive: Maternal effects: Ovaries, fallopian tubes
REPTED 15,293,2001
oral/rat lowest published toxic dose: 112 mg/kg/56D- intermittentReproductive: Maternal effects: Uterus, cervix, vaginaREPTED 15,293,2001
oral/rat lowest published toxic dose: 3500 mg/kg/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldREPTED 15,293,2001
oral/rat lowest published toxic dose: 3000 mg/kg/30D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
TOLED5 143,261,2003
oral/rat lowest published toxic dose: 21 gm/kg/6W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type field

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ETOPFR 17,19,2004
oral/rat lowest published toxic dose: 15750 mg/kg/6W- intermittentEndocrine: Changes in thymus weightETOPFR 17,19,2004
oral/rat lowest published toxic dose: 5250 mg/kg/6W- intermittentBiochemical: Metabolism (intermediary): OtherETOPFR 17,19,2004
oral/rat lowest published toxic dose: 2700 mg/kg/18D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainARTODN 78,97,2004
oral/rat lowest published toxic dose: 45 µg/kg/45D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Related to Chronic Data: Changes in testicular weight
ARTODN 76,545,2002
oral/rat lowest published toxic dose: 450 µg/kg/45D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Related to Chronic Data: Changes in testicular weight
ARTODN 76,545,2002
subcutaneous/mouse lowest published toxic dose: 300 mg/kg/3D- intermittentRelated to Chronic Data: Changes in uterine weight

Endocrine: Estrogenic
EVHPAZ 104,1296,1996
subcutaneous/pig lowest published toxic dose: 560 mg/kg/14D- intermittentReproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Uterus, cervix, vagina
REPTED 16,29,2002
subcutaneous/rat lowest published toxic dose: 300 mg/kg/3D- intermittentReproductive: Maternal effects: Uterus, cervix, vaginaREPTED 17,311,2003
unreported route/mouse lowest published toxic dose: 350 mg/kg/7D- intermittentLiver: Other changes

Endocrine: Differential effect of sex or castration on observed toxicity

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TOXID9 90,375,2006
unreported route/mouse lowest published toxic dose: 175 mg/kg/7D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TOXID9 78,72,2004
unreported route/mouse lowest published toxic dose: 10080 mg/kg/32W- intermittentBehavioral: Tolerance

Liver: Other changes
TOXID9 78,72,2004

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWTOLED5 127,225,2002
TOXICOLOGY REVIEWTOLED5 131,75,2002
TOXICOLOGY REVIEWENTOX* -,260,2005
TOXICOLOGY REVIEWARTODN 81,227,2007
TOXICOLOGY REVIEWJTEHD6 7,1,2004
TOXICOLOGY REVIEWREPTED 23,337,2007
TOXICOLOGY REVIEWJTPAE7 17,69,2004
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWMUREAV 681,3,2009
TOXICOLOGY REVIEWTPHSDY 29,116,2008
TOXICOLOGY REVIEWMUREAV 681,51,2009
TOXICOLOGY REVIEWREPTED 38,1,2013
TOXICOLOGY REVIEWMUREAV 764-765,46,2014
TOXICOLOGY REVIEWTOLED5 202,36,2011
TOXICOLOGY REVIEWMUTAEX 30,89,2014
TOXICOLOGY REVIEWFCTOD7 55,596,2013
TOXICOLOGY REVIEWTXCYAC 311,41,2013
TOXICOLOGY REVIEWFCTOD7 86,298,2015
TOXICOLOGY REVIEWTXCYAC 314,51,2013

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83208; Number of Industries 151; Total Number of Facilities 27721; Number of Occupations 108; Total Number of Employees Exposed 306211; Total Number of Female Employees Exposed 42765
National Occupational Hazard Survey 1974Hazard Code 83208; Number of Industries 58; Total Number of Facilities 3891; Number of Occupations 60; Total Number of Employees Exposed 67708

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9019
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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