Phenethyl alcohol

RTECS #

SG7175000

CAS #

60-12-8
See: NMAM or OSHA Methods

Updated

July 2016

Molecular Weight

122.18

Molecular Formula

C₈H₁₀O

Synonyms

2-Phenethyl alcohol
2-Phenylethanol
2-Phenylethyl alcohol
Benzyl carbinol
beta-Fenethylalkohol (Czech)
beta-Fenylethanol (Czech)
beta-Hydroxyethylbenzene
beta-Pea
beta-Phenethyl alcohol
beta-Phenylethanol
beta-Phenylethyl alcohol
Ethanol, 2-phenyl-
Methanol, benzyl-
PEA
Phenethanol
Phenylethyl alcohol

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	12 gm/10M	mild	ARZNAD 9,349,1959
eye /rabbit	750 µg/24H	severe	85JCAE -,215,1986
skin /guinea pig	100%	mild	FCTXAV 13,903,1975
skin /guinea pig	100 mg/24H	moderate	CTOIDG 94(8),41,1979
skin /rabbit	100 mg/24H	moderate	CTOIDG 94(8),41,1979

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
mutation in microorganisms	/Saccharomyes cerevisiae	1000 ppm (-enzymatic activation step)	GENRA8 13,107,1969
other mutation test systems	Ascites tumor/mouse	8360 µmol/L	BCPCA6 22,2511,1973

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	43 mg/kg (6-15D pregnant)	Reproductive: Specific developmental abnormalities: Eye, ear Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	JTEHD6 12,235,1983
oral/rat	430 mg/kg (6-15D pregnant)	Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Urogenital system	JTEHD6 12,235,1983
oral/rat	43 mg/kg (6-15D pregnant)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	VCVGK* -,135,1994
oral/rat	430 mg/kg (6-15D pregnant)	Reproductive: Specific developmental abnormalities: Eye, ear Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Urogenital system	VCVGK* -,135,1994
oral/rat	4300 mg/kg (6-15D pregnant)	Reproductive: Other effects on female Reproductive: Specific developmental abnormalities: Eye, ear Reproductive: Specific developmental abnormalities: Musculoskeletal system	HPV133 -,-,2002
oral/rat	508 mg/kg (10D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	HPV133 -,-,2002
skin/rat	14000 mg/kg (6-15D pregnant)	Reproductive: Other effects on female Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	HPV133 -,-,2002
skin/rat	700 mg/kg (6-15D pregnant)	Reproductive: Other effects on female	HPV133 -,-,2002
skin/rat	2800 mg/kg (6-15D pregnant)	Reproductive: Other effects on female Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	HPV133 -,-,2002
skin/rat	14 gm/kg (6-15D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Other developmental abnormalities	EPASR* 8EHQ-0186-0587
skin/rat	4300 mg/kg (6-15D pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system	EPASR* 8EHQ-0186-0587

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, skin	Inhibitor Concentration Low: 0.08 mL/well/1H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 28,616,2014
inhalation/rat	lethal concentration (50 percent kill): >4630 mg/m³/4H		HPV133 -,-,2002
inhalation/rat	lethal concentration (50 percent kill): >500 mg/m³	Behavioral: Somnolence (general depressed activity) Blood: Normocytic anemia Nutritional and Gross Metabolic: Body temperature decrease	GISAAA 52(10),83,1987
inhalation/rat	lethal concentration (50 percent kill): >500 mg/m³		VCVGK* -,135,1984
inhalation/rat	lowest published toxic concentration: 120 mg/m³/4H	Behavioral: Somnolence (general depressed activity) Blood: Normocytic anemia Nutritional and Gross Metabolic: Body temperature decrease	VCVGK* -,135,1984
intraperitoneal/guinea pig	lethal dose (50 percent kill): 200 mg/kg		38MKAJ 2C,4642,1982
intraperitoneal/mouse	lowest published toxic dose: 200 mg/kg	Behavioral: Antianxiety	LIFSAK 72,91,2002
intraperitoneal/mouse	lethal dose (50 percent kill): 200 mg/kg		HPV133 -,-,2002
oral/guinea pig	lethal dose (50 percent kill): 2540 mg/kg		HPV133 -,-,2002
oral/guinea pig	lethal dose (50 percent kill): 400 mg/kg	Brain and Coverings: Other degenerative changes	VCVGK* -,135,1984
oral/mouse	lethal dose (50 percent kill): 2540 mg/kg		HPV133 -,-,2002
oral/mouse	lethal dose (50 percent kill): 800 mg/kg	Brain and Coverings: Other degenerative changes	VCVGK* -,135,1984
oral/rabbit	lowest published lethal dose: 2 gm/kg		JEENAI 48,139,1955
oral/rat	lethal dose (50 percent kill): 1800 mg/kg	Brain and Coverings: Other degenerative changes	VCVGK* -,135,1984
oral/rat	lethal dose (50 percent kill): 1790 mg/kg	Behavioral: Coma Gastrointestinal: Gastritis	HPV133 -,-,2002
oral/rat	lethal dose (50 percent kill): 1500 mg/kg		HPV133 -,-,2002
skin/rabbit	lethal dose (50 percent kill): 805 mg/kg		HPV133 -,-,2002
skin/rabbit	lethal dose (50 percent kill): 790 µL/kg		TXAPA9 28,313,1974
skin/rat	lethal dose (50 percent kill): >5000 mg/kg		HPV133 -,-,2002
subcutaneous/mouse	lowest published lethal dose: 1640 mg/kg	Behavioral: General anesthetic Behavioral: Ataxia Behavioral: Coma	JPETAB 14,211,1920

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	lowest published toxic dose: 6120 mg/kg/16W- intermittent	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects	HPV133 -,-,2002
oral/rat	lowest published toxic dose: 90 mL/kg/90D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	HPV133 -,-,2002
oral/rat	lowest published toxic dose: 180 mL/kg/90D- intermittent	Blood: Normocytic anemia Blood: Luekopenia Nutritional and Gross Metabolic: Weight loss or decreased weight gain	HPV133 -,-,2002
oral/rat	lowest published toxic dose: 6 gm/kg/30D- intermittent	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood: Changes in leukocyte (WBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	GISAAA 50(2),70,1985
oral/rat	lowest published toxic dose: 6052 mg/kg/17W- intermittent	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	VPITAR 33(5),48,1974
skin/rat	lowest published toxic dose: 90 mL/kg/90D- intermittent	Blood: Normocytic anemia Blood: Changes in leukocyte (WBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain	VCVGK* -,135,1994
skin/rat	lowest published toxic dose: 14000 mg/kg/10D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	HPV133 -,-,2002

Reviews

Organization	Standard	Reference
TOXICOLOGY REVIEW		TOLED5 140-141,239,2003
TOXICOLOGY REVIEW		REPTED 58,252,2015

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit-RUSSIA	short term exposure limit 5 mg/m³, Skin, JUN2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Occupational Exposure Survey 1983	Hazard Code 80836; Number of Industries 44; Total Number of Facilities 10505; Number of Occupations 77; Total Number of Employees Exposed 161595; Total Number of Female Employees Exposed 92702
National Occupational Hazard Survey 1974	Hazard Code 80836; Number of Industries 22; Total Number of Facilities 873; Number of Occupations 41; Total Number of Employees Exposed 34310

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health