Phenethyl alcohol
RTECS #
SG7175000
CAS #
Updated
December 2018
Molecular Weight
122.18
Molecular Formula
C8H10O
Synonyms
2-Phenethyl alcohol
2-Phenylethanol
2-Phenylethyl alcohol
Benzyl carbinol
beta-Fenethylalkohol (Czech)
beta-Fenylethanol (Czech)
beta-Hydroxyethylbenzene
beta-Pea
beta-Phenethyl alcohol
beta-Phenylethanol
beta-Phenylethyl alcohol
Ethanol, 2-phenyl-
Methanol, benzyl-
PEA
Phenethanol
Phenylethyl alcohol
2-Phenylethanol
2-Phenylethyl alcohol
Benzyl carbinol
beta-Fenethylalkohol (Czech)
beta-Fenylethanol (Czech)
beta-Hydroxyethylbenzene
beta-Pea
beta-Phenethyl alcohol
beta-Phenylethanol
beta-Phenylethyl alcohol
Ethanol, 2-phenyl-
Methanol, benzyl-
PEA
Phenethanol
Phenylethyl alcohol
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 12 gm/10M | mild | ARZNAD 9,349,1959 |
| eye /rabbit | 750 µg/24H | severe | 85JCAE -,215,1986 |
| skin /guinea pig | 100% | mild | FCTXAV 13,903,1975 |
| skin /guinea pig | 100 mg/24H | moderate | CTOIDG 94(8),41,1979 |
| skin /rabbit | 100 mg/24H | moderate | CTOIDG 94(8),41,1979 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| mutation in microorganisms | /Saccharomyes cerevisiae | 1000 ppm (-enzymatic activation step) | GENRA8 13,107,1969 |
| other mutation test systems | Ascites tumor/mouse | 8360 µmol/L | BCPCA6 22,2511,1973 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | 43 mg/kg (6-15D pregnant) | Reproductive: Specific developmental abnormalities: Eye, ear Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | JTEHD6 12,235,1983 |
| oral/rat | 430 mg/kg (6-15D pregnant) | Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Urogenital system | JTEHD6 12,235,1983 |
| oral/rat | 43 mg/kg (6-15D pregnant) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | VCVGK* -,135,1994 |
| oral/rat | 430 mg/kg (6-15D pregnant) | Reproductive: Specific developmental abnormalities: Eye, ear Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Urogenital system | VCVGK* -,135,1994 |
| oral/rat | 4300 mg/kg (6-15D pregnant) | Reproductive: Other effects on female Reproductive: Specific developmental abnormalities: Eye, ear Reproductive: Specific developmental abnormalities: Musculoskeletal system | HPV133 -,-,2002 |
| oral/rat | 508 mg/kg (10D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | HPV133 -,-,2002 |
| skin/rat | 14000 mg/kg (6-15D pregnant) | Reproductive: Other effects on female Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | HPV133 -,-,2002 |
| skin/rat | 700 mg/kg (6-15D pregnant) | Reproductive: Other effects on female | HPV133 -,-,2002 |
| skin/rat | 2800 mg/kg (6-15D pregnant) | Reproductive: Other effects on female Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | HPV133 -,-,2002 |
| skin/rat | 14 gm/kg (6-15D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Other developmental abnormalities | EPASR* 8EHQ-0186-0587 |
| skin/rat | 4300 mg/kg (6-15D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | EPASR* 8EHQ-0186-0587 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Human, neuroblastoma | Inhibitor Concentration (50 percent kill): 2.39 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TOXRE* 2,729,2015 |
| In Vitro/Human, skin | Inhibitor Concentration Low: 0.08 mL/well/1H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 28,616,2014 |
| In Vitro/Rat, neurons | Inhibitor Concentration Low: 2.5 mmol/L/24H | In Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM) | TOXRE* 2,729,2015 |
| inhalation/rat | lethal concentration (50 percent kill): >4630 mg/m3/4H | HPV133 -,-,2002 | |
| inhalation/rat | lethal concentration (50 percent kill): >500 mg/m3 | Behavioral: Somnolence (general depressed activity) Blood: Normocytic anemia Nutritional and Gross Metabolic: Body temperature decrease | GISAAA 52(10),83,1987 |
| inhalation/rat | lethal concentration (50 percent kill): >500 mg/m3 | VCVGK* -,135,1984 | |
| inhalation/rat | lowest published toxic concentration: 120 mg/m3/4H | Behavioral: Somnolence (general depressed activity) Blood: Normocytic anemia Nutritional and Gross Metabolic: Body temperature decrease | VCVGK* -,135,1984 |
| intraperitoneal/guinea pig | lethal dose (50 percent kill): 200 mg/kg | 38MKAJ 2C,4642,1982 | |
| intraperitoneal/mouse | lowest published toxic dose: 200 mg/kg | Behavioral: Antianxiety | LIFSAK 72,91,2002 |
| intraperitoneal/mouse | lethal dose (50 percent kill): 200 mg/kg | HPV133 -,-,2002 | |
| oral/guinea pig | lethal dose (50 percent kill): 2540 mg/kg | HPV133 -,-,2002 | |
| oral/guinea pig | lethal dose (50 percent kill): 400 mg/kg | Brain and Coverings: Other degenerative changes | VCVGK* -,135,1984 |
| oral/mouse | lethal dose (50 percent kill): 2540 mg/kg | HPV133 -,-,2002 | |
| oral/mouse | lethal dose (50 percent kill): 800 mg/kg | Brain and Coverings: Other degenerative changes | VCVGK* -,135,1984 |
| oral/rabbit | lowest published lethal dose: 2 gm/kg | JEENAI 48,139,1955 | |
| oral/rat | lethal dose (50 percent kill): 1800 mg/kg | Brain and Coverings: Other degenerative changes | VCVGK* -,135,1984 |
| oral/rat | lethal dose (50 percent kill): 1790 mg/kg | Behavioral: Coma Gastrointestinal: Gastritis | HPV133 -,-,2002 |
| oral/rat | lethal dose (50 percent kill): 1500 mg/kg | HPV133 -,-,2002 | |
| skin/rabbit | lethal dose (50 percent kill): 805 mg/kg | HPV133 -,-,2002 | |
| skin/rabbit | lethal dose (50 percent kill): 790 µL/kg | TXAPA9 28,313,1974 | |
| skin/rat | lethal dose (50 percent kill): >5000 mg/kg | HPV133 -,-,2002 | |
| subcutaneous/mouse | lowest published lethal dose: 1640 mg/kg | Behavioral: General anesthetic Behavioral: Ataxia Behavioral: Coma | JPETAB 14,211,1920 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | lowest published toxic dose: 6120 mg/kg/16W- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | HPV133 -,-,2002 |
| oral/rat | lowest published toxic dose: 90 mL/kg/90D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV133 -,-,2002 |
| oral/rat | lowest published toxic dose: 180 mL/kg/90D- intermittent | Blood: Normocytic anemia Blood: Luekopenia Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV133 -,-,2002 |
| oral/rat | lowest published toxic dose: 6 gm/kg/30D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood: Changes in leukocyte (WBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | GISAAA 50(2),70,1985 |
| oral/rat | lowest published toxic dose: 6052 mg/kg/17W- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | VPITAR 33(5),48,1974 |
| skin/rat | lowest published toxic dose: 90 mL/kg/90D- intermittent | Blood: Normocytic anemia Blood: Changes in leukocyte (WBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain | VCVGK* -,135,1994 |
| skin/rat | lowest published toxic dose: 14000 mg/kg/10D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV133 -,-,2002 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| TOXICOLOGY REVIEW | TOLED5 140-141,239,2003 | |
| TOXICOLOGY REVIEW | REPTED 58,252,2015 | |
| TOXICOLOGY REVIEW | RTOPDW 55,205,2009 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Occupational Exposure Limit-RUSSIA | short term exposure limit 5 mg/m3, Skin, JUN2003 |
NIOSH Documentation and Surveillance
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health