Registry of Toxic Effects of Chemical Substances (RTECS)

Pentyl alcohol

RTECS #

SB9800000

CAS #

71-41-0

Updated

July 2013

Molecular Weight

88.17

Molecular Formula

C₅H₁₂O

Synonyms

1-Pentanol
Alcool amylique (French)
Amyl alcohol
Amyl alcohol, normal
Amylol
n-Amyl alcohol
n-Amylalkohol (Czech)
n-Butylcarbinol
n-Pentanol
Pentan-1-ol
Pentanol
Pentanol-1
Primary amyl alcohol

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	81 mg	severe	AIHAAP 34,493,1973
eye /rabbit	5 µL/24H	severe	NTIS** OTS0534716
skin /rabbit	3200 mg/24H	severe	AIHAAP 34,493,1973
skin /rabbit	20 mg/24H	moderate	85JCAE -,196,1986

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
mutation in microorganisms	/Escherichia coli	7000 ppm (-enzymatic activation step)	ABMGAJ 23,843,1969
sex chromosome loss and nondisjunction	lung/hamster	25 mmol/L	MUREAV 182,135,1987

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Hamster, lung fibroblast	Inhibitor Concentration Low: >36.8 mmol/L/24H	In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.	TIVIEQ 1,3,1987
In Vitro/Human, liver tumor	Inhibitor Concentration Low: >50.6 mmol/L/24H	In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.	TIVIEQ 1,3,1987
In Vitro/Human, liver tumor	Inhibitor Concentration (50 percent kill): 37 mmol/L/24H	In Vitro Toxicity Studies: Cell protein synthesis	TIVIEQ 3,189,1989
In Vitro/Mouse, fibroblast	Inhibitor Concentration Low: >12.9 mmol/L/24H	In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.	TIVIEQ 1,3,1987
In Vitro/Mouse, macrophage	Inhibitor Concentration Low: >23.9 mmol/L/24H	In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.	TIVIEQ 1,3,1987
inhalation/guinea pig	Lethal concentration: >14 gm/m³/6H	Brain and Coverings: Recordings from specific areas of CNS Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea	AIHAAP 34,493,1973
inhalation/human	lowest published toxic concentration: 0.061 mg/m³	Brain and Coverings: Changes in surface EEG	VCVGK* -,108,1984
inhalation/human	lowest published toxic concentration: 0.4 mg/m³	Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough	VCVGK* -,108,1984
inhalation/mouse	Lowest published lethal concentration: 14000 mg/m³		VCVGK* -,107,1984
inhalation/mouse	Lowest published lethal concentration: 14000 mg/m³/6H	Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Acute pulmonary edema Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)	AIHAAP 34,493,1973
inhalation/rat	Lowest published lethal concentration: 14000 mg/m³/6H	Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Acute pulmonary edema Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)	AIHAAP 34,493,1973
inhalation/rat	Lowest published lethal concentration: 14000 mg/m³		VCVGK* -,108,1984
intraperitoneal/guinea pig	lethal dose (50 percent kill): 615 mg/kg		EVHPAZ 61,321,1985
intraperitoneal/hamster	lethal dose (50 percent kill): 626 mg/kg		EVHPAZ 61,321,1985
intraperitoneal/mouse	lethal dose (50 percent kill): 970 mg/kg		EVHPAZ 61,321,1985
intraperitoneal/rabbit	lethal dose (50 percent kill): 140 mg/kg		EVHPAZ 61,321,1985
intraperitoneal/rat	lethal dose (50 percent kill): 579 mg/kg		EVHPAZ 61,321,1985
intraperitoneal/rat	lowest published lethal dose: 450 mg/kg		VCVGK* -,108,1984
intravenous/cat	lowest published lethal dose: 15 mg/kg		VCVGK* -,108,1984
intravenous/mouse	lethal dose (50 percent kill): 184 mg/kg		AIPTAK 135,330,1962
intravenous/rat	lethal dose (50 percent kill): 196 mg/kg		EVHPAZ 61,321,1985
oral/Dog	lowest published lethal dose: 1400 mg/kg	Gastrointestinal: Other changes Blood: Hemorrhage	COREAF 81,192,1875
oral/human	lowest published lethal dose: 142.8 mg/kg	Brain and Coverings: Other degenerative changes Liver: Other changes Kidney, Ureter, and Bladder: Other changes	VCVGK* -,108,1984
oral/mouse	lethal dose (50 percent kill): 200 mg/kg	Behavioral: General anesthetic	GISAAA 35(9),88,1970
oral/mouse	lethal dose (50 percent kill): 200 mg/kg		VCVGK* -,107,1984
oral/rat	lethal dose (50 percent kill): 5660 µL/kg	Behavioral: Somnolence (general depressed activity)	NTIS** OTS0534716
oral/rat	lethal dose (50 percent kill): 370 mg/kg		VCVGK* -,107,1984
parenteral/frog	lowest published lethal dose: 2 gm/kg	Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Behavioral: Somnolence (general depressed activity)	AIPTAK 50,296,1935
skin/rabbit	lethal dose (50 percent kill): 2830 µL/kg	Liver: Other changes Kidney, Ureter, and Bladder: Other changes	NTIS** OTS0534716
skin/rabbit	lowest published lethal dose: 4490 mg/kg		VCVGK* -,108,1984
subcutaneous/Dog	lowest published lethal dose: 1800 mg/kg	Gastrointestinal: Other changes Blood: Hemorrhage	COREAF 81,192,1875
unreported route/mammal (species unspecified)	lethal dose (50 percent kill): 1174 mg/kg		GISAAA 51(5),61,1986

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mammal (species unspecified)	lowest published toxic concentration: 10 mg/m³/24H/90D- continuous	Brain and Coverings: Other degenerative changes Liver: Other changes Lung, Thorax, or Respiration: Other changes	VCVGK* -,108,1994
inhalation/mammal (species unspecified)	lowest published toxic concentration: 0.09 mg/m³/60D- intermittent	Eye: Other eye effects	VCVGK* -,108,1994
inhalation/rat	lowest published toxic concentration: 0.08 mg/m³/24H/30D- continuous	Eye: Optic nerve neuropathy Olfaction: Change in olfactory nerve	VCVGK* -,108,1994

Reviews

Organization	Standard	Reference
TOXICOLOGY REVIEW		MUREAV 628,67,2007

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit-DENMARK	time-weighted average 100 ppm (360 mg/m³), MAY2011
Occupational Exposure Limit-GERMANY	MAK 20 ppm (73 mg/m³), 2011
Occupational Exposure Limit-ICELAND	time-weighted average 100 ppm (360 mg/m³), NOV2011
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 100 mg/m³, MAC(short term exposure limit) 450 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	short term exposure limit 10 mg/m³, Skin, JUN2003
Occupational Exposure Limit-SWITZERLAND	MAK-week 20 ppm (73 mg/m³), KZG-week 80 ppm (292 mg/m³), JAN2011
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 100 ppm (525 mg/m³), JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 100 ppm (525 mg/m³), JAN1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Occupational Exposure Survey 1983	Hazard Code M0264; Number of Industries 21; Total Number of Facilities 3107; Number of Occupations 31; Total Number of Employees Exposed 23891; Total Number of Female Employees Exposed 10257
National Occupational Hazard Survey 1974	Hazard Code M0264; Number of Industries 32; Total Number of Facilities 892; Number of Occupations 42; Total Number of Employees Exposed 17247

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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Page last reviewed:March 7, 2014
Page last updated:February 6, 2017
Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division

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