Pentyl alcohol
RTECS #
SB9800000
CAS #
Updated
March 2019
Molecular Weight
88.17
Molecular Formula
C5H12O
Synonyms
1-Pentanol
Alcool amylique (French)
Amyl alcohol
Amyl alcohol, normal
Amylol
n-Amyl alcohol
n-Amylalkohol (Czech)
n-Butylcarbinol
n-Pentanol
Pentan-1-ol
Pentanol
Pentanol-1
Primary amyl alcohol
Alcool amylique (French)
Amyl alcohol
Amyl alcohol, normal
Amylol
n-Amyl alcohol
n-Amylalkohol (Czech)
n-Butylcarbinol
n-Pentanol
Pentan-1-ol
Pentanol
Pentanol-1
Primary amyl alcohol
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
eye /rabbit | 81 mg | severe | AIHAAP 34,493,1973 |
eye /rabbit | 5 µL/24H | severe | NTIS** OTS0534716 |
skin /rabbit | 3200 mg/24H | severe | AIHAAP 34,493,1973 |
skin /rabbit | 20 mg/24H | moderate | 85JCAE -,196,1986 |
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
mutation in microorganisms | /Escherichia coli | 7000 ppm (-enzymatic activation step) | ABMGAJ 23,843,1969 |
sex chromosome loss and nondisjunction | lung/hamster | 25 mmol/L | MUREAV 182,135,1987 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
In Vitro/Hamster, lung fibroblast | Inhibitor Concentration Low: >36.8 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 1,3,1987 |
In Vitro/Human, liver tumor | Inhibitor Concentration Low: >50.6 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 1,3,1987 |
In Vitro/Human, liver tumor | Inhibitor Concentration (50 percent kill): 37 mmol/L/24H | In Vitro Toxicity Studies: Cell protein synthesis | TIVIEQ 3,189,1989 |
In Vitro/Mouse, fibroblast | Inhibitor Concentration Low: >12.9 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 1,3,1987 |
In Vitro/Mouse, macrophage | Inhibitor Concentration Low: >23.9 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 1,3,1987 |
In Vitro/Rat, myocard | Inhibitor Concentration Low: 150 mmol/L/6H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 26,849,2012 |
inhalation/guinea pig | Lethal concentration: >14 gm/m3/6H | Brain and Coverings: Recordings from specific areas of CNS Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea | AIHAAP 34,493,1973 |
inhalation/human | lowest published toxic concentration: 0.061 mg/m3 | Brain and Coverings: Changes in surface EEG | VCVGK* -,108,1984 |
inhalation/human | lowest published toxic concentration: 0.4 mg/m3 | Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough | VCVGK* -,108,1984 |
inhalation/mouse | Lowest published lethal concentration: 14000 mg/m3 | VCVGK* -,107,1984 | |
inhalation/mouse | Lowest published lethal concentration: 14000 mg/m3/6H | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Acute pulmonary edema Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | AIHAAP 34,493,1973 |
inhalation/rat | Lowest published lethal concentration: 14000 mg/m3/6H | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Acute pulmonary edema Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | AIHAAP 34,493,1973 |
inhalation/rat | Lowest published lethal concentration: 14000 mg/m3 | VCVGK* -,108,1984 | |
intraperitoneal/guinea pig | lethal dose (50 percent kill): 615 mg/kg | EVHPAZ 61,321,1985 | |
intraperitoneal/hamster | lethal dose (50 percent kill): 626 mg/kg | EVHPAZ 61,321,1985 | |
intraperitoneal/mouse | lethal dose (50 percent kill): 970 mg/kg | EVHPAZ 61,321,1985 | |
intraperitoneal/rabbit | lethal dose (50 percent kill): 140 mg/kg | EVHPAZ 61,321,1985 | |
intraperitoneal/rat | lethal dose (50 percent kill): 579 mg/kg | EVHPAZ 61,321,1985 | |
intraperitoneal/rat | lowest published lethal dose: 450 mg/kg | VCVGK* -,108,1984 | |
intravenous/cat | lowest published lethal dose: 15 mg/kg | VCVGK* -,108,1984 | |
intravenous/mouse | lethal dose (50 percent kill): 184 mg/kg | AIPTAK 135,330,1962 | |
intravenous/rat | lethal dose (50 percent kill): 196 mg/kg | EVHPAZ 61,321,1985 | |
oral/Dog | lowest published lethal dose: 1400 mg/kg | Gastrointestinal: Other changes Blood: Hemorrhage | COREAF 81,192,1875 |
oral/human | lowest published lethal dose: 142.8 mg/kg | Brain and Coverings: Other degenerative changes Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,108,1984 |
oral/mouse | lethal dose (50 percent kill): 200 mg/kg | Behavioral: General anesthetic | GISAAA 35(9),88,1970 |
oral/mouse | lethal dose (50 percent kill): 200 mg/kg | VCVGK* -,107,1984 | |
oral/rat | lethal dose (50 percent kill): 5660 µL/kg | Behavioral: Somnolence (general depressed activity) | NTIS** OTS0534716 |
oral/rat | lethal dose (50 percent kill): 370 mg/kg | VCVGK* -,107,1984 | |
parenteral/frog | lowest published lethal dose: 2 gm/kg | Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Behavioral: Somnolence (general depressed activity) | AIPTAK 50,296,1935 |
skin/rabbit | lethal dose (50 percent kill): 2830 µL/kg | Liver: Other changes Kidney, Ureter, and Bladder: Other changes | NTIS** OTS0534716 |
skin/rabbit | lowest published lethal dose: 4490 mg/kg | VCVGK* -,108,1984 | |
subcutaneous/Dog | lowest published lethal dose: 1800 mg/kg | Gastrointestinal: Other changes Blood: Hemorrhage | COREAF 81,192,1875 |
unreported route/mammal (species unspecified) | lethal dose (50 percent kill): 1174 mg/kg | GISAAA 51(5),61,1986 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/mammal (species unspecified) | lowest published toxic concentration: 10 mg/m3/24H/90D- continuous | Brain and Coverings: Other degenerative changes Liver: Other changes Lung, Thorax, or Respiration: Other changes | VCVGK* -,108,1994 |
inhalation/mammal (species unspecified) | lowest published toxic concentration: 0.09 mg/m3/60D- intermittent | Eye: Other eye effects | VCVGK* -,108,1994 |
inhalation/rat | lowest published toxic concentration: 0.08 mg/m3/24H/30D- continuous | Eye: Optic nerve neuropathy Olfaction: Change in olfactory nerve | VCVGK* -,108,1994 |
Reviews
Organization | Standard | Reference |
---|---|---|
TOXICOLOGY REVIEW | MUREAV 628,67,2007 | |
TOXICOLOGY REVIEW | REPTED 58,252,2015 | |
TOXICOLOGY REVIEW | RTOPDW 59,364,2011 | |
TOXICOLOGY REVIEW | RTOPDW 60,120,2011 |
Standards and Regulations
NIOSH Documentation and Surveillance
Status in Federal Agencies
Organization | Reference |
---|---|
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health