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Registry of Toxic Effects of Chemical Substances (RTECS)

Octyl alcohol

RTECS #

RH6550000

CAS #

111-87-5

Updated

July 2016

Molecular Weight

130.26

Molecular Formula

C8H18O

Synonyms

1-Hydroxyoctane
1-Octanol
Alcohol C-8
Alfol 8
Caprylic alcohol
Dytol M-83
EPAL 8
Heptyl carbinol
Lorol 20
n-Octanol
n-Octyl alcohol
Octanol
Octilin
Octyl alcohol, normal-primary
Primary octyl alcohol
Sipol L8

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 0.1 mLHPV112 -,-,2008
skin /rabbit 500 mg/24H mildFCTXAV 11,1079,1973
skin /rabbit 0.5 mL/4H mildHPV112 -,-,2008

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
sex chromosome loss and nondisjunctionlung/hamster800 µmol/LMUREAV 182,135,1987

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 6500 mg/kg (6-15D pregnant)Reproductive: Other effects on femaleHPV112 -,-,2008

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Hamster, lung fibroblast Inhibitor Concentration Low: >5.1 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 1,3,1987
In Vitro/Human, liver tumor Inhibitor Concentration Low: >9.6 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 1,3,1987
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 1.8 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
In Vitro/Human, skin Inhibitor Concentration Low: 60 µL/well/60MIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,1476,2013
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 170 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 17,717,2003
In Vitro/Mouse, fibroblast Inhibitor Concentration Low: >6.4 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 1,3,1987
In Vitro/Mouse, macrophage Inhibitor Concentration Low: >5.1 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 1,3,1987
In Vitro/Rabbit, ocular Inhibitor Concentration Low: 5 pph/5MIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,1855,2013
inhalation/human lowest published toxic concentration: 0.1 ppm/4HCardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Other changes
NRTXDN 24,179,2003
inhalation/mouse lowest published toxic concentration: 4.5 gm/m3/2HTPKVAL 5,51,1963
inhalation/rat Lowest published lethal concentration: 5600 mg/m3/4HLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Blood: Hemorrhage
EPASR* 8EHQ-1088-0762
inhalation/rat lowest published toxic concentration: 1203 ppm/1HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
HPV112 -,-,2008
inhalation/rat Lowest published lethal concentration: 1053 ppm/4HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Acute pulmonary edema

Endocrine: Differential effect of sex or castration on observed toxicity
HPV112 -,-,2008
intraperitoneal/rat lowest published toxic dose: 2000 mg/kgBehavioral: Ataxia

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,115,1984
intravenous/mouse lethal dose (50 percent kill): 69 mg/kgAIPTAK 135,330,1962
ocular/rabbit lowest published toxic dose: 100 pphEye: Conjunctiva irritationTPKVAL 5,51,1963
oral/human lowest published lethal dose: 428.6 mg/kgVCVGK* -,116,1984
oral/mouse lethal dose (50 percent kill): 15000 mg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,115,1984
oral/mouse lethal dose (50 percent kill): 1790 mg/kgHPV112 -,-,2008
oral/mouse lethal dose (50 percent kill): 3.91 gm/kgBrain and Coverings: Changes in circulation

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
TPKVAL 5,51,1963
oral/mouse lowest published lethal dose: 1.95 gm/kgBrain and Coverings: Changes in circulation

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
TPKVAL 5,51,1963
oral/rat lethal dose (50 percent kill): >3200 mg/kgFCTXAV 11,95,1973
oral/rat lethal dose (50 percent kill): 18240 mg/kgVascular: Regional or general arteriolar or venous dilation

Gastrointestinal: Gastritis
HPV112 -,-,2008
oral/rat lethal dose (50 percent kill): 20000 mg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,115,1984
parenteral/frog lowest published lethal dose: 1240 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Somnolence (general depressed activity)
AIPTAK 50,296,1935
skin/guinea pig lethal dose (50 percent kill): >1 gm/kgFCTXAV 11,95,1973
skin/rabbit lowest published lethal dose: 2 gm/kgGastrointestinal: Ulceration or bleeding from stomach

Kidney, Ureter, and Bladder: Hematuria

Skin: After topical application: Corrosive
HPV112 -,-,2008
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 4 gm/kgGISAAA 51(5),61,1986

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 0.27 gm/m3/107D- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerveTPKVAL 5,51,1963
inhalation/rat lowest published toxic concentration: 0.27 gm/m3/137D- intermittentBrain and Coverings: Changes in circulation

Lung, Thorax, or Respiration: Emphysema

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 5,51,1963

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWTOLED5 140-141,261,2003
TOXICOLOGY REVIEWMUREAV 628,67,2007
TOXICOLOGY REVIEWTOLED5 202,36,2011
TOXICOLOGY REVIEWFCTOD7 55,596,2013
TOXICOLOGY REVIEWREPTED 58,252,2015

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,292,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 80235; Number of Industries 133; Total Number of Facilities 9310; Number of Occupations 93; Total Number of Employees Exposed 287737; Total Number of Female Employees Exposed 72792
National Occupational Hazard Survey 1974Hazard Code 80235; Number of Industries 29; Total Number of Facilities 1071; Number of Occupations 32; Total Number of Employees Exposed 13905

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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