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Registry of Toxic Effects of Chemical Substances (RTECS)

1,6-Octadien-3-ol, 3,7-dimethyl-

RTECS #

RG5775000

CAS #

78-70-6

Updated

September 201

Molecular Weight

154.28

Molecular Formula

C₁₀H₁₈O

Synonyms

2,6-Dimethylocta-2,7-dien-6-ol
3,7-Dimethyl-1,6-octadien-3-ol
3,7-Dimethylocta-1,6-dien-3-ol
allo-Ocimenol
Linalool
Linalyl alcohol

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	100 µL	moderate	NTIS** OTS0543729
eye /rabbit	0.1 mL/1H	moderate	FCTOD7 46,S1,2008
skin /guinea pig	100 mg/24H	moderate	CTOIDG 94(8),41,1979
skin /human	32%/72H	mild	FCTOD7 46,S1,2008
skin /human	10%/2D		CODEDG 61,217,2009
skin /man	16 mg/48H	mild	CTOIDG 94(8),41,1979
skin /rabbit	500 mg/24H	mild	FCTXAV 14,673,1976
skin /rabbit	100 mg/24H	severe	CTOIDG 94(8),41,1979

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
DNA repair	/Bacillus subtilis	8622 µg/disc	OIGZDE 34,267,1985
mutation in mammalian somatic cells	other cell types/mouse	0.1 mL/L (+enzymatic activation step)	HPV397 ,,2001
mutation in microorganisms	/Salmonella typhimurium	3000 µg/plate (-enzymatic activation step)	HPV397 ,,2001

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	19500 mg/kg (7D pre-10D after birth)	Reproductive: Other effects on female	HPV397 -,-,2001
oral/rat	39000 mg/kg (7D pre-10D after birth)	Reproductive: Other effects on female Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)	HPV397 -,-,2001

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, monocyte	Inhibitor Concentration Low: 1000 µg/L	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	FCTOD7 50,3079,2012
inhalation/mouse	lowest published toxic dose: 1 pph/1H	Behavioral: Altered sleep time (including change in righting reflex) Nutritional and Gross Metabolic: Body temperature decrease	PYTOEY 16,303,2009
inhalation/mouse	lowest published toxic dose: 3 pph/1H	Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Change in motor activity (specific assay) Nutritional and Gross Metabolic: Body temperature decrease	PYTOEY 16,303,2009
intramuscular/mouse	lethal dose (50 percent kill): 8000 mg/kg		FCTOD7 46,S1,2008
intraperitoneal/mouse	lethal dose (50 percent kill): 200 mg/kg		FCTOD7 46,S1,2008
intraperitoneal/mouse	lethal dose (50 percent kill): 340 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Change in motor activity (specific assay) Behavioral: Ataxia	IIFBA4 15,149,1973
intraperitoneal/rat	lethal dose (50 percent kill): 307 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Change in motor activity (specific assay) Behavioral: Ataxia	IIFBA4 15,149,1973
intraperitoneal/rat	lethal dose (50 percent kill): 307 mg/kg		FCTOD7 46,S1,2008
oral/mouse	lethal dose (50 percent kill): 3 gm/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea	NTIS** OTS0543729
oral/mouse	lethal dose (50 percent kill): 2200 mg/kg		FCTOD7 46,S1,2008
oral/rat	lethal dose (50 percent kill): >2.79 gm/kg	Behavioral: Ataxia	FCTOD7 47,22,2009
oral/rat	lethal dose (50 percent kill): 2790 mg/kg		HPV397 -,-,2001
skin/rabbit	lethal dose (50 percent kill): 5610 mg/kg	Behavioral: Somnolence (general depressed activity)	HPV397 -,-,2001
skin/rabbit	lethal dose (50 percent kill): 5610 mg/kg		FCTOD7 46,S1,2008
skin/rat	lethal dose (50 percent kill): 5610 mg/kg		85JCAE -,202,1986
subcutaneous/mouse	lethal dose (50 percent kill): 1470 mg/kg		FCTOD7 46,S1,2008
subcutaneous/mouse	lethal dose (50 percent kill): 1470 mg/kg	Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change	SIZSAR 3,73,1952
subcutaneous/rat	lowest published toxic dose: 25 mg/kg	Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	PYTOEY 9,721,2002

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	lowest published toxic dose: 11200 mg/kg/28D- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation	FCTOD7 46,S1,2008
oral/rat	lowest published toxic dose: 11200 mg/kg/28D- intermittent	Gastrointestinal: Other changes	FCTOD7 46,S1,2008
oral/rat	lowest published toxic dose: 28000 mg/kg/28D- intermittent	Kidney, Ureter, and Bladder: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic: Changes in: Ca	FCTOD7 46,S1,2008
oral/rat	lowest published toxic dose: 28000 mg/kg/28D- intermittent	Liver: Other changes Kidney, Ureter, and Bladder: Changes in kidney weight Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation	FCTOD7 46,S1,2008
oral/rat	lowest published toxic dose: 39000 mg/kg/39D- intermittent	Behavioral: Food intake (animal) Behavioral: Ataxia Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FCTOD7 46,S1,2008
oral/rat	lowest published toxic dose: 11000 mg/kg/11D- intermittent	Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FCTOD7 46,S1,2008
skin/rat	lowest published toxic dose: 92 gm/kg/13W- intermittent	Skin: After topical application: Primary irritation Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FCTOD7 46,S1,2008
skin/rat	lowest published toxic dose: 364 gm/kg/13W- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	FCTOD7 46,S1,2008
skin/rat	lowest published toxic dose: 364 gm/kg/13W- intermittent	Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	FCTOD7 46,S1,2008
skin/rat	lowest published toxic dose: 3625 mg/kg/29D- intermittent	Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia Skin: After topical application: Primary irritation	FCTOD7 46,S1,2008

Reviews

Organization	Standard	Reference
TOXICOLOGY REVIEW		MUREAV 539,77,2003
TOXICOLOGY REVIEW		FCTOD7 41,919,2003
TOXICOLOGY REVIEW		FCTOD7 46,S1,2008
TOXICOLOGY REVIEW		FCTOD7 46,S190,2008

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Active registration	RBREV* -,379,1998
Occupational Exposure Limit-RUSSIA	short term exposure limit 5 mg/m³, JUN2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Occupational Exposure Survey 1983	Hazard Code M4982; Number of Industries 106; Total Number of Facilities 16058; Number of Occupations 118; Total Number of Employees Exposed 245476; Total Number of Female Employees Exposed 109311
National Occupational Hazard Survey 1974	Hazard Code M4982; Number of Industries 2; Total Number of Facilities 37; Number of Occupations 16; Total Number of Employees Exposed 2301

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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Page last reviewed:March 7, 2014
Page last updated:February 6, 2017
Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division

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