1,6-Octadien-3-ol, 3,7-dimethyl-
RTECS #
RG5775000
CAS #
Updated
December 2018
Molecular Weight
154.28
Molecular Formula
C10H18O
Synonyms
2,6-Dimethylocta-2,7-dien-6-ol
3,7-Dimethyl-1,6-octadien-3-ol
3,7-Dimethylocta-1,6-dien-3-ol
allo-Ocimenol
Linalool
Linalyl alcohol
3,7-Dimethyl-1,6-octadien-3-ol
3,7-Dimethylocta-1,6-dien-3-ol
allo-Ocimenol
Linalool
Linalyl alcohol
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 100 µL | moderate | NTIS** OTS0543729 |
| eye /rabbit | 0.1 mL/1H | moderate | FCTOD7 46,S1,2008 |
| skin /guinea pig | 100 mg/24H | moderate | CTOIDG 94(8),41,1979 |
| skin /human | 32%/72H | mild | FCTOD7 46,S1,2008 |
| skin /human | 10%/2D | CODEDG 61,217,2009 | |
| skin /man | 16 mg/48H | mild | CTOIDG 94(8),41,1979 |
| skin /rabbit | 500 mg/24H | mild | FCTXAV 14,673,1976 |
| skin /rabbit | 100 mg/24H | severe | CTOIDG 94(8),41,1979 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| DNA repair | /Bacillus subtilis | 8622 µg/disc | OIGZDE 34,267,1985 |
| mutation in mammalian somatic cells | other cell types/mouse | 0.1 mL/L (+enzymatic activation step) | HPV397 ,,2001 |
| mutation in microorganisms | /Salmonella typhimurium | 3000 µg/plate (-enzymatic activation step) | HPV397 ,,2001 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | 19500 mg/kg (7D pre-10D after birth) | Reproductive: Other effects on female | HPV397 -,-,2001 |
| oral/rat | 39000 mg/kg (7D pre-10D after birth) | Reproductive: Other effects on female Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) | HPV397 -,-,2001 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Human, leukemia cells | Inhibitor Concentration (25 percent kill): 290.0 mg/L/24H | In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. | TIVIEQ 26,1150,2012 |
| In Vitro/Human, lymphocyte | Inhibitor Concentration (30 percent kill): >200 mg/L/45H | In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. | TIVIEQ 29,901,2015 |
| In Vitro/Human, lymphocyte | Inhibitor Concentration (50 percent kill): 41 mg/L/45H | In Vitro Toxicity Studies: Other assays | TIVIEQ 29,901,2015 |
| In Vitro/Human, monocyte | Inhibitor Concentration Low: 1000 µg/L | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | FCTOD7 50,3079,2012 |
| In Vitro/Human, monocyte | Inhibitor Concentration Low: 333 mg/L/2H | In Vitro Toxicity Studies: Other assays | TIVIEQ 27,1233,2013 |
| In Vitro/Human, neuroblastoma | Inhibitor Concentration (50 percent kill): 1.33 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TOXRE* 2,729,2015 |
| In Vitro/jrd | Inhibitor Concentration (50 percent kill): 76.0 mg/L/24H | In Vitro Toxicity Studies: Other assays | TIVIEQ 28,626,2014 |
| In Vitro/Rat, neurons | Inhibitor Concentration Low: 0.1 mmol/L/24H | In Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM) | TOXRE* 2,729,2015 |
| inhalation/mouse | lowest published toxic concentration: 0.55 pph/10M | Behavioral: Antianxiety | PYTOEY 23,1734,2016 |
| inhalation/mouse | lowest published toxic dose: 1 pph/1H | Behavioral: Altered sleep time (including change in righting reflex) Nutritional and Gross Metabolic: Body temperature decrease | PYTOEY 16,303,2009 |
| inhalation/mouse | lowest published toxic dose: 3 pph/1H | Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Change in motor activity (specific assay) Nutritional and Gross Metabolic: Body temperature decrease | PYTOEY 16,303,2009 |
| intramuscular/mouse | lethal dose (50 percent kill): 8000 mg/kg | FCTOD7 46,S1,2008 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 200 mg/kg | FCTOD7 46,S1,2008 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 340 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Change in motor activity (specific assay) Behavioral: Ataxia | IIFBA4 15,149,1973 |
| intraperitoneal/mouse | lowest published toxic dose: 100 mg/kg | Behavioral: Change in motor activity (specific assay) Behavioral: Alteration of classical conditioning | JOETD7 143,673,2012 |
| intraperitoneal/rat | lowest published toxic dose: 30 mg/kg/5M | Behavioral: Change in psychophysiological tests | JOETD7 212,43,2018 |
| intraperitoneal/rat | lethal dose (50 percent kill): 307 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Change in motor activity (specific assay) Behavioral: Ataxia | IIFBA4 15,149,1973 |
| intraperitoneal/rat | lethal dose (50 percent kill): 307 mg/kg | FCTOD7 46,S1,2008 | |
| oral/mouse | lethal dose (50 percent kill): 3 gm/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea | NTIS** OTS0543729 |
| oral/mouse | lethal dose (50 percent kill): 2200 mg/kg | FCTOD7 46,S1,2008 | |
| oral/rat | lethal dose (50 percent kill): >2.79 gm/kg | Behavioral: Ataxia | FCTOD7 47,22,2009 |
| oral/rat | lethal dose (50 percent kill): 2790 mg/kg | HPV397 -,-,2001 | |
| skin/rabbit | lethal dose (50 percent kill): 5610 mg/kg | Behavioral: Somnolence (general depressed activity) | HPV397 -,-,2001 |
| skin/rabbit | lethal dose (50 percent kill): 5610 mg/kg | FCTOD7 46,S1,2008 | |
| skin/rat | lethal dose (50 percent kill): 5610 mg/kg | 85JCAE -,202,1986 | |
| subcutaneous/mouse | lethal dose (50 percent kill): 1470 mg/kg | FCTOD7 46,S1,2008 | |
| subcutaneous/mouse | lethal dose (50 percent kill): 1470 mg/kg | Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change | SIZSAR 3,73,1952 |
| subcutaneous/rat | lowest published toxic dose: 25 mg/kg | Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | PYTOEY 9,721,2002 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | lowest published toxic dose: 11200 mg/kg/28D- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation | FCTOD7 46,S1,2008 |
| oral/rat | lowest published toxic dose: 11200 mg/kg/28D- intermittent | Gastrointestinal: Other changes | FCTOD7 46,S1,2008 |
| oral/rat | lowest published toxic dose: 28000 mg/kg/28D- intermittent | Kidney, Ureter, and Bladder: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic: Changes in: Ca | FCTOD7 46,S1,2008 |
| oral/rat | lowest published toxic dose: 28000 mg/kg/28D- intermittent | Liver: Other changes Kidney, Ureter, and Bladder: Changes in kidney weight Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation | FCTOD7 46,S1,2008 |
| oral/rat | lowest published toxic dose: 39000 mg/kg/39D- intermittent | Behavioral: Food intake (animal) Behavioral: Ataxia Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FCTOD7 46,S1,2008 |
| oral/rat | lowest published toxic dose: 11000 mg/kg/11D- intermittent | Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FCTOD7 46,S1,2008 |
| skin/rat | lowest published toxic dose: 92 gm/kg/13W- intermittent | Skin: After topical application: Primary irritation Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FCTOD7 46,S1,2008 |
| skin/rat | lowest published toxic dose: 364 gm/kg/13W- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | FCTOD7 46,S1,2008 |
| skin/rat | lowest published toxic dose: 364 gm/kg/13W- intermittent | Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | FCTOD7 46,S1,2008 |
| skin/rat | lowest published toxic dose: 3625 mg/kg/29D- intermittent | Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia Skin: After topical application: Primary irritation | FCTOD7 46,S1,2008 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| TOXICOLOGY REVIEW | MUREAV 539,77,2003 | |
| TOXICOLOGY REVIEW | FCTOD7 41,919,2003 | |
| TOXICOLOGY REVIEW | FCTOD7 46,S1,2008 | |
| TOXICOLOGY REVIEW | FCTOD7 46,S190,2008 | |
| TOXICOLOGY REVIEW | FCTOD7 84,S76,2015 | |
| TOXICOLOGY REVIEW | FCTOD7 84,S88,2015 | |
| TOXICOLOGY REVIEW | FCTOD7 97,S11,2016 | |
| TOXICOLOGY REVIEW | FCTOD7 97,S110,2016 | |
| TOXICOLOGY REVIEW | FCTOD7 97,S168,2016 | |
| TOXICOLOGY REVIEW | FCTOD7 97,S180,2016 | |
| TOXICOLOGY REVIEW | JOETD7 181,66,2016 | |
| TOXICOLOGY REVIEW | RTOPDW 56,54,2010 | |
| TOXICOLOGY REVIEW | RTOPDW 56,67,2010 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Active registration | RBREV* -,379,1998 |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 5 mg/m3, JUN2003 |
NIOSH Documentation and Surveillance
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health