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Registry of Toxic Effects of Chemical Substances (RTECS)

9-Octadecenoic acid, (Z)-

RTECS #

RG2275000

CAS #

112-80-1

Updated

October 2017

Molecular Weight

282.52

Molecular Formula

C18H34O2

Synonyms

9-Octadecenoic acid, cis-
Acide oleique (French)
cis-9-Octadecenoic acid
cis-delta(sup 9)-Octadecenoic acid
cis-Octadec-9-enoic acid
Emersol 210
Emersol 213
Emersol 220 white oleic acid
Emersol 221 low titer white oleic acid
Emersol 233LL
Emersol 6321
Glycon RO
Glycon WO
Groco 2
Groco 4
Groco 5L
Groco 6
HY-Phi 1055
HY-Phi 1088
HY-Phi 2066
HY-Phi 2088
HY-Phi 2102
Industrene 105
Industrene 205
Industrene 206
Oleic acid
Oleinic acid
Pamolyn
Tego-oleic 130
Vopcolene 27
Wecoline OO
Wochem No. 320

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg mildJACTDZ 6(3),321,1987
skin /human 15 mg/3D- intermittent moderate85DKA8 -,127,1977
skin /rabbit 500 mg open irritation test mildUCDS** 11/29/1963

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysis/Saccharomyes cerevisiae100 mg/LNATUAS 294,263,1981
Cytogenetic Analysisfibroblast/hamster2500 µg/LCRNGDP 3,499,1982
Unscheduled DNA Synthesisrectal/mouse35 mg/kgCALEDQ 23,253,1984

Tumorigenic Data and References

Route/OrganismDoseEffectReference
skin/mouse lowest published toxic dose: 6 mL/kg/10D- intermittentTumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Facilitates action of known carcinogens
PBBHAU 21,17,1984
subcutaneous/rabbit lowest published toxic dose: 390 mg/kg/17W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
CRSBAW 137,760,1943

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, endothelium Inhibitor Concentration Low: 300 µmol/L/24HIn Vitro Toxicity Studies: Other assays

Biochemical: Metabolism (intermediary): Lipids including transport
TIVIEQ 25,2140,2011
In Vitro/Human, endothelium Inhibitor Concentration Low: 400 µmol/L/1HIn Vitro Toxicity Studies: Other assaysTIVIEQ 25,2140,2011
In Vitro/Human, liver Inhibitor Concentration Low: 62.5 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TOLED5 224,114,2014
In Vitro/Human, liver tumor Inhibitor Concentration Low: 1 mmol/L/24HIn Vitro Toxicity Studies: Other assaysPYTOEY 19,1156,2012
In Vitro/Human, liver tumor Inhibitor Concentration Low: 2 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Other assays

Biochemical: Metabolism (intermediary): Lipids including transport
TIVIEQ 27,945,2013
In Vitro/Human, liver tumor Inhibitor Concentration Low: 1 mmol/L/24HBiochemical: Metabolism (intermediary): Lipids including transportTIVIEQ 26,783,2012
In Vitro/Mouse, macrophage Inhibitor Concentration (50 percent kill): 127.1 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.PYTOEY 22,498,2015
In Vitro/Mouse, macrophage Inhibitor Concentration (50 percent kill): 127.1 µmol/L/48HIn Vitro Toxicity Studies: Cell differentiationPYTOEY 22,498,2015
In Vitro/pkhInhibitor Concentration Low: 0.4 mmol/L/3DIn Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc.TXAPA9 264,274,2012
In Vitro/pthInhibitor Concentration (50 percent kill): 0.85 gm/LAutonomic Nervous System: Smooth muscle relaxant (mechanism undefined, spasmolytic)JOETD7 152,283,2014
In Vitro/Rat, endocrine tumor Inhibitor Concentration Low: 0.1 mmol/L/3DIn Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc.TXAPA9 264,274,2012
In Vitro/Rat, liver Inhibitor Concentration Low: 200 mmol/L/24HBiochemical: Metabolism (intermediary): Lipids including transportTIVIEQ 27,1065,2013
inhalation/rat lowest published toxic concentration: 30 mg/m3/4HBehavioral: Alteration of classical conditioning

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Immunological Including Allergic: Hypersensitivity delayed (multiple organ involvement)
TOVEFN (1),42,2000
intradermal/guinea pig lowest published toxic dose: 400 µg/kgImmunological Including Allergic: Hypersensitivity delayed (multiple organ involvement)TOVEFN (1),42,2000
intraperitoneal/mouse lethal dose (50 percent kill): 282 mg/kgYKKZAJ 104,793,1984
intravenous/Dog lowest published toxic dose: 0.08 mg/kgLung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes

Blood: Other changes
BJMRDK 42,731,2009
intravenous/guinea pig lowest published toxic dose: 15 µL/kgLung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Lung, Thorax, or Respiration: Respiratory depression
BPBLEO 27,1451,2004
intravenous/monkey Lethal dose: >40 µL/kgLung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
LUNGD9 164,259,1986
intravenous/monkey lowest published toxic dose: 0.08 mg/kgImmunological Including Allergic: Increase in humoral response

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 90,347,2006
intravenous/mouse lethal dose (50 percent kill): 230 mg/kgBehavioral: Convulsions or effect on seizure thresholdAPTOA6 18,141,1961
intravenous/rabbit Lethal dose: >55 mg/kgLung, Thorax, or Respiration: Other changesARDSBL 137(Suppl),226,1988
intravenous/rat lowest published toxic dose: 0.25 mL/kgLung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXAPA9 272,895,2013
intravenous/rat lethal dose (50 percent kill): 2400 µg/kgLung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes
AJPAA4 103,376,1981
intravenous/rat lowest published toxic dose: 0.15 mL/kgLung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight
JPETAB 313,379,2005
intravenous/rat lowest published toxic dose: 100 mg/kgLung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes
EJPHAZ 510,135,2005
intravenous/rat lowest published toxic dose: 100 mg/kgBlood: Hemorrhage

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
EJPHAZ 510,135,2005
oral/mouse lethal dose (50 percent kill): 28000 mg/kgTOVEFN (1),42,2000
oral/rat lethal dose (50 percent kill): 25000 mg/kgTOVEFN (1),42,2000

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 2712 mg/kg/6W- intermittentImmunological Including Allergic: Autoimmune (multiple organ involvement)TOXID9 44,187,2005
skin/mouse lowest published toxic dose: 1500 mg/kg/3D- intermittentBlood: Other changesFCTOD7 46,1896,2008

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,336,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 52190; Number of Industries 256; Total Number of Facilities 49332; Number of Occupations 181; Total Number of Employees Exposed 1078478; Total Number of Female Employees Exposed 410362
National Occupational Hazard Survey 1974Hazard Code 52190; Number of Industries 312; Total Number of Facilities 65952; Number of Occupations 196; Total Number of Employees Exposed 796897

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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