Nitrogen dioxide
RTECS #
QW9800000
CAS #
Updated
March 2019
Molecular Weight
46.01
Molecular Formula
NO2
Synonyms
Azote (French)
Azoto (Italian)
Nitrito
Nitrogen dioxide (ACGIH:OSHA)
Nitrogen peroxide
RCRA waste number P078
Stickstoffdioxid (German)
Stikstofdioxyde (Dutch)
Azoto (Italian)
Nitrito
Nitrogen dioxide (ACGIH:OSHA)
Nitrogen peroxide
RCRA waste number P078
Stickstoffdioxid (German)
Stikstofdioxyde (Dutch)
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | inhalation/rat | 27 ppm/3H-continuous | MUREAV 136,119,1984 |
| Cytogenetic Analysis | fibroblast/hamster | 10 ppm/10M-continuous | MUREAV 89,303,1981 |
| DNA adduct | inhalation/rat | 108 mg/kg/300D- intermittent | CALEDQ 139,189,1999 |
| DNA Damage | other cell types/human | 0.01 ppm/30M | TXAPA9 245,219,2010 |
| DNA Damage | lung/hamster | 10 ppm | CRNGDP 11,37,1990 |
| DNA repair | other cell types/human | 1 ppm/30M | TOLED5 207,89,2011 |
| micronucleus test | other cell types/human | 0.1 ppm/3H | TOLED5 207,89,2011 |
| mutation in mammalian somatic cells | inhalation/rat | 15 ppm/3H-continuous | MUREAV 136,119,1984 |
| mutation in microorganisms | /Salmonella typhimurium | 6 ppm (+enzymatic activation step) | MUREAV 136,119,1984 |
| mutation in microorganisms | /Salmonella typhimurium | 5 ppm (-enzymatic activation step) | EMMUEG 11,65,1988 |
| mutation in microorganisms | /Escherichia coli | 198 µg/L (-enzymatic activation step) | MUREAV 162,1,1986 |
| other mutation test systems | /Escherichia coli | 297 µg/L | MUREAV 162,1,1986 |
| other mutation test systems | /Salmonella typhimurium | 50 ppm | MUREAV 192,239,1987 |
| sister chromatid exchange | lung/hamster | 5 ppm/10M-continuous | MUREAV 89,303,1981 |
| Unscheduled DNA Synthesis | inhalation/rat | 30 ppm/1H | ENVRAL 27,352,1982 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | 10 mg/m3/6H (1-22D pregnant) | Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NTOTDY 7,785,1985 |
| inhalation/rat | 85 µg/m3/24H (1-22D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on embryo or fetus: Fetal death | GISAAA 42(12),22,1977 |
| inhalation/rat | 800 µg/m3/24H (1-22D pregnant) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) | GISAAA 42(12),22,1977 |
| inhalation/rat | 2360 µg/m3/12H (12W prior to copulation) | Reproductive: Maternal effects: Menstrual cycle changes or disorders Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | HYSAAV 36(7-9),178,1971 |
| inhalation/rat | 100 µg/m3/6H (1-22D pregnant) | Reproductive: Effects on newborn: Behavioral | NTOTDY 7,785,1985 |
| inhalation/mouse | 22 ppm (7-18D pregnant) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Behavioral | NRTXDN 9,545,1988 |
| inhalation/rat | 40 pph (8-10D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Other developmental abnormalities | VCVN5* -,37,1989 |
| inhalation/rat | 40 pph (12-16D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Other developmental abnormalities | VCVN5* -,37,1989 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lowest published toxic concentration: 108 mg/kg/300D- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Tumorigenic: Facilitates action of known carcinogens Lung, Thorax, or Respiration: Tumors | CALEDQ 139,189,1999 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/Dog | Lowest published lethal concentration: 123 mg/m3/8H | Olfaction: Other olfaction effects Eye: Other eye effects Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TXAPA9 9,160,1966 |
| inhalation/Dog | lowest published toxic concentration: 19 mg/m3/6H | Blood: Methemoglobinemia- Carboxhemoglobinemia | VCVN5* -,35,1993 |
| inhalation/Dog | lowest published toxic concentration: 37.2 ppm/4H | Lung, Thorax, or Respiration: Acute pulmonary edema | EXMPA6 33,90,1980 |
| inhalation/Dog | Lowest published lethal concentration: 110 mg/m3 | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea | VCVN5* -,35,1993 |
| inhalation/guinea pig | lethal concentration (50 percent kill): 30 ppm/1H | Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Lung, Thorax, or Respiration: Respiratory stimulation Blood: Methemoglobinemia- Carboxhemoglobinemia | AEHLAU 10,220,1965 |
| inhalation/guinea pig | lethal concentration (50 percent kill): 900 mg/m3/30M | VCVN5* -,28,1993 | |
| inhalation/human | lowest published toxic concentration: 200 mg/m3 | Lung, Thorax, or Respiration: Cough | VCVN5* -,28,1993 |
| inhalation/human | lowest published toxic concentration: 90 mg/m3/15M | Olfaction: Change in sensation of smell Lung, Thorax, or Respiration: Cough Gastrointestinal: Changes in structure or function of salivary glands | VCVN5* -,28,1993 |
| inhalation/human | Lowest published lethal concentration: 200 ppm/1M | AOHYA3 17,159,1974 | |
| inhalation/human | lowest published toxic concentration: 0.5 ppm/2H | Eye: Conjunctiva irritation Behavioral: Headache Lung, Thorax, or Respiration: Dyspnea | TOXID9 44,301,2005 |
| inhalation/human | lowest published toxic concentration: 0.059 mg/m3/5M | Brain and Coverings: Changes in surface EEG | VCVN5* -,36,1993 |
| inhalation/human | lowest published toxic concentration: 14 mg/m3 | Eye: Conjunctiva irritation | VCVN5* -,36,1993 |
| inhalation/human | lowest published toxic concentration: 120 mg/m3 | Lung, Thorax, or Respiration: Dyspnea | VCVN5* -,36,1993 |
| inhalation/human | lowest published toxic concentration: 70 mg/m3 | Behavioral: Muscle weakness | VCVN5* -,36,1993 |
| inhalation/human | lowest published toxic concentration: 38 mg/m3/2H | Blood: Methemoglobinemia- Carboxhemoglobinemia | VCVN5* -,36,1993 |
| inhalation/human | lowest published toxic concentration: 510 mg/m3/5M | Lung, Thorax, or Respiration: Other changes | VCVN5* -,36,1993 |
| inhalation/human | lowest published toxic concentration: 950 mg/m3/5M | Lung, Thorax, or Respiration: Acute pulmonary edema | VCVN5* -,36,1993 |
| inhalation/human | lowest published toxic concentration: 0.2 mg/m3 | Olfaction: Change in sensation of smell Lung, Thorax, or Respiration: Cough | VCVN5* -,36,1993 |
| inhalation/human | lowest published toxic concentration: 0.14 mg/m3/5H | Eye: Other eye effects | VCVN5* -,36,1993 |
| inhalation/man | lowest published toxic concentration: 30 ppm/70M | Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough Lung, Thorax, or Respiration: Dyspnea | TOXID9 44,301,2005 |
| inhalation/man | lowest published toxic concentration: 30 ppm/70M | Lung, Thorax, or Respiration: Sputum | TOXID9 44,301,2005 |
| inhalation/man | lowest published toxic concentration: 2 ppm/4H | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Other changes | INHTE5 11,89,1999 |
| inhalation/man | lowest published toxic concentration: 6200 ppb/10M | Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance | KEKHA7 17,337,1968 |
| inhalation/man | lowest published toxic concentration: 90 ppm/40M | Lung, Thorax, or Respiration: Cough Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Other changes | JOCMA7 8,301,1966 |
| inhalation/monkey | Lowest published lethal concentration: 123 mg/m3/8H | Olfaction: Other olfaction effects Eye: Other eye effects Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TXAPA9 9,160,1966 |
| inhalation/monkey | lowest published toxic concentration: 50 ppm/2H | Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Other changes | TOXID9 44,301,2005 |
| inhalation/monkey | Lowest published lethal concentration: 95 mg/m3/2H | VCVN5* -,36,1993 | |
| inhalation/mouse | lethal concentration (50 percent kill): 800 mg/m3/25M | VCVN5* -,28,1993 | |
| inhalation/mouse | lethal concentration (50 percent kill): 1000 ppm/10M | Behavioral: Convulsions or effect on seizure threshold Behavioral: Change in motor activity (specific assay) | JCTODH 4,246,1977 |
| inhalation/mouse | lethal concentration (50 percent kill): 900 mg/m3/2H | VCVN5* -,35,1993 | |
| inhalation/mouse | lowest published toxic concentration: 9.5 mg/m3/1H | Blood: Normocytic anemia Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | VCVN5* -,35,1993 |
| inhalation/rabbit | lethal concentration (50 percent kill): 315 ppm/15M | Lung, Thorax, or Respiration: Respiratory depression Eye: Conjunctiva irritation | AIHAAP 23,457,1962 |
| inhalation/rabbit | lethal concentration (50 percent kill): 60 mg/m3/15M | VCVN5* -,35,1993 | |
| inhalation/rabbit | lethal concentration (50 percent kill): 12 mg/m3/15M | Eye: Conjunctiva irritation | VCVN5* -,35,1993 |
| inhalation/rabbit | lowest published toxic concentration: 28 mg/m3/3H | Immunological Including Allergic: Decrease in cellular immune response | VCVN5* -,35,1993 |
| inhalation/rat | lethal concentration (50 percent kill): 220 mg/m3/1H | Lung, Thorax, or Respiration: Acute pulmonary edema | VCVN5* -,35,1993 |
| inhalation/rat | lethal concentration (50 percent kill): 310 mg/m3/30M | Lung, Thorax, or Respiration: Acute pulmonary edema | VCVN5* -,35,1993 |
| inhalation/rat | lethal concentration (50 percent kill): 790 mg/m3/5M | Lung, Thorax, or Respiration: Acute pulmonary edema | VCVN5* -,35,1993 |
| inhalation/rat | lowest published toxic concentration: 4 mg/m3/17H | Lung, Thorax, or Respiration: Other changes | VCVN5* -,35,1993 |
| inhalation/rat | lowest published toxic concentration: 32 mg/m3/2H | Lung, Thorax, or Respiration: Ciliary function changes Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi | VCVN5* -,35,1993 |
| inhalation/rat | lowest published toxic concentration: 25 mg/m3/2H | Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough | VCVN5* -,35,1993 |
| inhalation/rat | lowest published toxic concentration: 22.7 mg/m3/4H | Brain and Coverings: Other degenerative changes Lung, Thorax, or Respiration: Other changes Endocrine: Other changes | VCVN5* -,35,1993 |
| inhalation/rat | lowest published toxic concentration: 1.9 mg/m3/4H | Lung, Thorax, or Respiration: Other changes | VCVN5* -,35,1993 |
| inhalation/rat | lethal concentration (50 percent kill): 200 ppm/30M | ENTOX* -,639,2005 | |
| inhalation/rat | lethal concentration (50 percent kill): 88 ppm/4H | ENTOX* -,244,2005 | |
| inhalation/rat | lowest published toxic concentration: 58 mg/m3/4H | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Other changes in urine composition Endocrine: Changes in adrenal weight | TPKVAL 15,53,1979 |
| inhalation/rat | lowest published toxic concentration: 20 mg/m3/4H | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | TPKVAL 15,53,1979 |
| inhalation/rat | lowest published toxic concentration: 0.00475 gm/m3/4H | Behavioral: Alteration of classical conditioning | TPKVAL 9,37,1967 |
| inhalation/rat | lowest published toxic concentration: 44.93 mg/m3/4H | Kidney, Ureter, and Bladder: Other changes Blood: Changes in bone marrow not included in above | TOVEFN (4),23,2006 |
| inhalation/rat | lowest published toxic concentration: 10.1 mg/m3/48H | Lung, Thorax, or Respiration: Other changes Kidney, Ureter, and Bladder: Other changes Blood: Changes in bone marrow not included in above | TOVEFN (4),23,2006 |
| inhalation/rat | lowest published toxic concentration: 20 ppm/20H | Lung, Thorax, or Respiration: Other changes Liver: Other changes Biochemical: Metabolism (intermediary): Lipids including transport | TOLED5 6,149,1980 |
| inhalation/rat | lowest published toxic concentration: 200 ppm/15M | Lung, Thorax, or Respiration: Respiratory obstruction Lung, Thorax, or Respiration: Changes in lung weight Biochemical: Metabolism (intermediary): Lipids including transport | TXAPA9 184,1,2002 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/guinea pig | lowest published toxic concentration: 15 ppm/24H/10W- continuous | Kidney, Ureter, and Bladder: Other changes Blood: Changes in spleen Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases | AEHLAU 10,220,1965 |
| inhalation/guinea pig | lowest published toxic concentration: 3284 µg/m3/8H/26W- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | BCTKAG 8,241,1975 |
| inhalation/guinea pig | lowest published toxic concentration: 68 mg/m3/8H/6W- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVN5* -,37,1989 |
| inhalation/guinea pig | lowest published toxic concentration: 17 mg/m3/24H/4W- continuous | Lung, Thorax, or Respiration: Other changes Liver: Other changes Biochemical: Effect on specific coenzyme: Proportion of isoenzymes | VCVN5* -,37,1989 |
| inhalation/guinea pig | lowest published toxic concentration: 22 mg/m3/24H/90D- continuous | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVN5* -,37,1989 |
| inhalation/guinea pig | lowest published toxic concentration: 0.9 mg/m3/6H/13W- intermittent | Immunological Including Allergic: Decreased immune response | VCVN5* -,38,1989 |
| inhalation/guinea pig | lowest published toxic concentration: 5 ppm/2H/35D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Lipids including transport | JPFCD2 B27,53,1992 |
| inhalation/guinea pig | lowest published toxic concentration: 5800 µg/m3/4H/91D- intermittent | Olfaction: Change in sensation of smell Behavioral: Change in motor activity (specific assay) Lung, Thorax, or Respiration: Respiratory depression | TPKVAL 15,53,1979 |
| inhalation/guinea pig | lowest published toxic concentration: 5800 µg/m3/4H/8D- intermittent | Lung, Thorax, or Respiration: Other changes | TPKVAL 15,53,1979 |
| inhalation/guinea pig | lowest published toxic concentration: 5800 µg/m3/4H/17W- intermittent | Behavioral: Change in motor activity (specific assay) Lung, Thorax, or Respiration: Respiratory depression Lung, Thorax, or Respiration: Other changes | TPKVAL 15,53,1979 |
| inhalation/hamster | lowest published toxic concentration: 30 ppm/22H/36W- intermittent | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi | EXLRDA 11,179,1986 |
| inhalation/human | lowest published toxic concentration: 1.9 mg/m3/2H/3D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases | VCVN5* -,36,1989 |
| inhalation/human | lowest published toxic concentration: 0.8 mg/m3/3Y- intermittent | Lung, Thorax, or Respiration: Emphysema Lung, Thorax, or Respiration: Fibrosis (interstitial) Blood: Change in clotting factors | VCVN5* -,38,1989 |
| inhalation/mammal (species unspecified) | lowest published toxic concentration: 10 ppm/4H/15W- intermittent | Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) Lung, Thorax, or Respiration: Other changes | TOLED5 73,241,1994 |
| inhalation/monkey | lowest published toxic concentration: 68 mg/m3/8H/6W- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVN5* -,37,1989 |
| inhalation/monkey | lowest published toxic concentration: 22 mg/m3/24H/90D- continuous | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVN5* -,37,1989 |
| inhalation/monkey | lowest published toxic concentration: 9.5 mg/m3/24H/8W- continuous | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVN5* -,36,1989 |
| inhalation/mouse | lowest published toxic concentration: 0.9 mg/m3/6H/13W- intermittent | Immunological Including Allergic: Decreased immune response | VCVN5* -,38,1989 |
| inhalation/mouse | lowest published toxic concentration: 0.7 ppm/2H/3D- intermittent | Lung, Thorax, or Respiration: Other changes | JTEHD6 65,1999,2002 |
| inhalation/mouse | lowest published toxic concentration: 0.7 ppm/3D- intermittent | Biochemical: Metabolism (intermediary): Other Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TOXID9 1,71,2001 |
| inhalation/mouse | lowest published toxic concentration: 5 ppm/4H/3D- intermittent | Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TOXID9 -,295,2008 |
| inhalation/mouse | lowest published toxic concentration: 25 ppm/4H/3D- intermittent | Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Other proteins Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TOXID9 -,295,2008 |
| inhalation/mouse | lowest published toxic concentration: 9.5 mg/m3/6H/1Y- intermittent | Lung, Thorax, or Respiration: Tumors | VCVN5* -,37,1989 |
| inhalation/mouse | lowest published toxic concentration: 5.7 mg/m3/2H/15W- intermittent | Blood: Normocytic anemia Immunological Including Allergic: Decrease in cellular immune response | VCVN5* -,37,1989 |
| inhalation/mouse | lowest published toxic concentration: 5.7 mg/m3/2H/1Y- intermittent | Lung, Thorax, or Respiration: Other changes | VCVN5* -,37,1989 |
| inhalation/mouse | lowest published toxic concentration: 250 ppb/7H/7W- intermittent | Blood: Changes in spleen Immunological Including Allergic: Decrease in cellular immune response | JTEHD6 25,247,1988 |
| inhalation/mouse | lowest published toxic concentration: 20 ppm/24H/4D- continuous | Endocrine: Changes in spleen weight Endocrine: Changes in thymus weight Immunological Including Allergic: Decrease in humoral immune response | ENVRAL 42,446,1987 |
| inhalation/mouse | lowest published toxic concentration: 10 ppm/2H/30W- intermittent | Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) Blood: Pigmented or nucleated red blood cells | ENVRAL 19,154,1979 |
| inhalation/mouse | lowest published toxic concentration: 500 ppb/30D- continuous | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi | NKYZA2 10,16,1972 |
| inhalation/rabbit | lowest published toxic concentration: 68 mg/m3/8H/6W- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVN5* -,37,1989 |
| inhalation/rabbit | lowest published toxic concentration: 22 mg/m3/24H/90D- continuous | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVN5* -,37,1989 |
| inhalation/rat | lowest published toxic concentration: 50 mg/m3/24H/2W- continuous | Behavioral: Change in motor activity (specific assay) Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Emphysema | VCVN5* -,37,1989 |
| inhalation/rat | lowest published toxic concentration: 17 mg/m3/4H/10D- intermittent | Lung, Thorax, or Respiration: Other changes | VCVN5* -,37,1989 |
| inhalation/rat | lowest published toxic concentration: 5 mg/m3/5D/39W- continuous | Lung, Thorax, or Respiration: Changes in lung weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | VCVN5* -,38,1989 |
| inhalation/rat | lowest published toxic concentration: 5 mg/m3/5H/13W- intermittent | Lung, Thorax, or Respiration: Changes in lung weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | VCVN5* -,38,1989 |
| inhalation/rat | lowest published toxic concentration: 3.8 mg/m3/24H/2Y- continuous | Lung, Thorax, or Respiration: Ciliary function changes | VCVN5* -,38,1989 |
| inhalation/rat | lowest published toxic concentration: 2.4 mg/m3/12H/13W- intermittent | Endocrine: Effect on menstrual cycle | VCVN5* -,38,1989 |
| inhalation/rat | lowest published toxic concentration: 0.9 mg/m3/6H/13W- intermittent | Immunological Including Allergic: Decreased immune response | VCVN5* -,38,1989 |
| inhalation/rat | lowest published toxic concentration: 68 mg/m3/8H/6W- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVN5* -,37,1989 |
| inhalation/rat | lowest published toxic concentration: 22 mg/m3/24H/90D- continuous | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVN5* -,37,1989 |
| inhalation/rat | lowest published toxic concentration: 10 ppm/3D- continuous | Lung, Thorax, or Respiration: Other changes Immunological Including Allergic: Decrease in cellular immune response | TOLED5 121,135,2001 |
| inhalation/rat | lowest published toxic concentration: 2 ppm/24H/14D- continuous | Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | JTEHD6 15,23,1985 |
| inhalation/rat | lowest published toxic concentration: 16 ppm/23H/74W- continuous | Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma Lung, Thorax, or Respiration: Emphysema Lung, Thorax, or Respiration: Changes in lung weight | ARDSBL 121,541,1980 |
| inhalation/rat | lowest published toxic concentration: 5700 µg/m3/6H/26W- intermittent | Endocrine: Other changes | GISAAA 26(12),79,1961 |
| inhalation/rat | lowest published toxic concentration: 3 ppm/24H/39W- continuous | Lung, Thorax, or Respiration: Other changes Lung, Thorax, or Respiration: Changes in lung weight Biochemical: Metabolism (intermediary): Lipids including transport | AEHLAU 26,156,1973 |
| inhalation/rat | lowest published toxic concentration: 2 ppm/24H/1Y- continuous | Lung, Thorax, or Respiration: Changes in lung weight | AEHLAU 17,181,1968 |
| inhalation/rat | lowest published toxic concentration: 4 ppm/24H/14W- continuous | Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) | ENVRAL 41,184,1986 |
| inhalation/rat | lowest published toxic concentration: 8 ppm/24H/7D- continuous | Lung, Thorax, or Respiration: Other changes Immunological Including Allergic: Decrease in cellular immune response Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases | AECTCV 15,733,1986 |
| inhalation/rat | lowest published toxic concentration: 5 ppm/24H/4W- continuous | Liver: Other changes Biochemical: Metabolism (intermediary): Other proteins | BECTA6 40,139,1988 |
| inhalation/rat | lowest published toxic concentration: 5 mg/m3/6H/7D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TOLED5 214,120,2012 |
| inhalation/rat | lowest published toxic concentration: 5800 µg/m3/4H/91D- intermittent | Olfaction: Change in sensation of smell Behavioral: Change in motor activity (specific assay) Lung, Thorax, or Respiration: Respiratory depression | TPKVAL 15,53,1979 |
| inhalation/rat | lowest published toxic concentration: 5800 µg/m3/4H/8D- intermittent | Lung, Thorax, or Respiration: Other changes | TPKVAL 15,53,1979 |
| inhalation/rat | lowest published toxic concentration: 5800 µg/m3/4H/17W- intermittent | Behavioral: Change in motor activity (specific assay) Lung, Thorax, or Respiration: Respiratory depression Lung, Thorax, or Respiration: Other changes | TPKVAL 15,53,1979 |
| inhalation/rat | lowest published toxic concentration: 0.6 mg/m3/24H/13W- continuous | Peripheral Nerve and Sensation: Recording from peripheral motor nerve Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Fibrosis (interstitial) | VCVN5* -,38,1989 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.2 ppm | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | ANAEA3 35,165,1975 | |
| TOXICOLOGY REVIEW | FEPRA7 35,89,1976 | |
| TOXICOLOGY REVIEW | NTIS** PB228-002 | |
| TOXICOLOGY REVIEW | CTOXAO 7,145,1974 | |
| TOXICOLOGY REVIEW | AEHLAU 16,903,1968 | |
| TOXICOLOGY REVIEW | NTIS** CONF-691001 | |
| TOXICOLOGY REVIEW | AEHLAU 12,522,1966 | |
| TOXICOLOGY REVIEW | XPHBAO 272,1,1941 | |
| TOXICOLOGY REVIEW | MUREAV 558,7,2004 | |
| TOXICOLOGY REVIEW | DIMON* 46,551,2000 | |
| TOXICOLOGY REVIEW | ENTOX* -,639,2005 | |
| TOXICOLOGY REVIEW | ENTOX* -,244,2005 | |
| TOXICOLOGY REVIEW | HUTOX* -,661,1996 | |
| TOXICOLOGY REVIEW | MUREAV 543,195,2003 | |
| TOXICOLOGY REVIEW | MUREAV 674,45,2009 | |
| TOXICOLOGY REVIEW | MUREAV 674,62,2009 | |
| TOXICOLOGY REVIEW | MUREAV 636,144,2007 | |
| TOXICOLOGY REVIEW | MUREAV 636,36,2007 | |
| TOXICOLOGY REVIEW | MUREAV 690,3,2010 | |
| TOXICOLOGY REVIEW | REPTED 31,363,2011 | |
| TOXICOLOGY REVIEW | MUREAV 717,38,2011 | |
| TOXICOLOGY REVIEW | MUREAV 721,27,2011 | |
| TOXICOLOGY REVIEW | MUTAEX 28,485,2013 | |
| TOXICOLOGY REVIEW | MUREAV 762,133,2014 | |
| TOXICOLOGY REVIEW | TXCYAC 313,3,2013 | |
| TOXICOLOGY REVIEW | MUREAV 770,170,2016 | |
| TOXICOLOGY REVIEW | NETEEC 60,2,2017 | |
| TOXICOLOGY REVIEW | VETODR ,215,2018 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD | air-ceiling concentration 5 ppm (9 mg/m3) | DTLVS* 3,185,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-ARAB Republic of Egypt | time-weighted average 3 ppm (6 mg/m3), JAN1993 | |
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 3 ppm (5.6 mg/m3), short term exposure limit 5 ppm (9.4 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 3 ppm (6 mg/m3);KZW 6 ppm (12 mg/m3), 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 3 ppm (5.7 mg/m3), short term exposure limit 5 ppm (9.5 mg/m3), MAR2002 | |
| Occupational Exposure Limit-DENMARK | ceiling concentration 2 ppm (4 mg/m3), MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 3 ppm (5.7 mg/m3), short term exposure limit 6 ppm (11 mg/m3), NOV2011 | |
| Occupational Exposure Limit-FRANCE | VLE 3 ppm (6 mg/m3), FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 0.5 ppm (0.95 mg/m3), 2011 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 9 mg/m3, short term exposure limit 9 mg/m3, SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 3 ppm (5.5 mg/m3), short term exposure limit 5 ppm (9 mg/m3), NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 3 ppm (6 mg/m3), short term exposure limit 5 ppm (10 mg/m3), 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 3 ppm (6 mg/m3);short term exposure limit 5 ppm (10 mg/m3), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 3 ppm (5.6 mg/m3), short term exposure limit 5 ppm (9.4 mg/m3), JAN2002 | |
| Occupational Exposure Limit-PERU | time-weighted average 3 ppm (5,6 mg/m3); short term exposure limit 5 ppm (9,4 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 5 mg/m3, MAC(short term exposure limit) 10 mg/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 2 mg/m3, JUN2003 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 2 ppm (4 mg/m3), ceiling concentration 5 ppm (10 mg/m3), JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | ceiling concentration 3 ppm (6 mg/m3), JAN2011 | |
| Occupational Exposure Limit-THAILAND | time-weighted average 5 ppm (9 mg/m3), JAN1993 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 4 mg/m3, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 5 ppm (9 mg/m3), JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 5 ppm (9 mg/m3), JAN1993 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | ceiling concentration 5 ppm (9 mg/m3) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | ceiling concentration 5 ppm (9 mg/m3) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | ceiling concentration 5 ppm (9 mg/m3) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | ceiling concentration 5 ppm (9 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NITROGEN DIOXIDE-air | short term exposure limit 1 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 50870; Number of Industries 5; Total Number of Facilities 94; Number of Occupations 24; Total Number of Employees Exposed 18737; Total Number of Female Employees Exposed 1773 | |
| National Occupational Hazard Survey 1974 | Hazard Code 50870; Number of Industries 16; Total Number of Facilities 424; Number of Occupations 19; Total Number of Employees Exposed 11419 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health