Nicotinamide
RTECS #
QS3675000
CAS #
Updated
March 2019
Molecular Weight
122.14
Molecular Formula
C6H6N2O
Synonyms
3-Carbamoylpyridine
3-Pyridinecarboxamide
3-Pyridinecarboxylic acid amide
Acid amide
Amid kyseliny nikotinove (Czech)
Amide PP
Aminicotin
Amixicotyn
Amnicotin
Austrovit PP
Benicot
Delonin amide
Dipegyl
Endobion
Factor PP
Hansamid
Inovitan PP
m-(Aminocarbonyl)pyridine
NAM
Niacevit
Niacinamide
Niavit PP
Nicamindon
Nicasir
Nicobion
Nicofort
Nicogen
Nicomidol
Nicosan 2
Nicotamide
Nicotilamide
Nicotinic acid amide
Nicotinic amide
Nicotinsaureamid (German)
Nicotylamide
Nicovit
Nicovitol
Nicozymin
Niko-Tamin
Nikotinsaeureamid (German)
Niocinamide
Niozymin
Pelmine
Pelonin amide
PP-Faktor
Pyridine-3-carboxylic acid amide
Savacotyl
VI-Nicotyl
Vitamin B
Vitamin B3
Vitamin PP
Witamina PP
3-Pyridinecarboxamide
3-Pyridinecarboxylic acid amide
Acid amide
Amid kyseliny nikotinove (Czech)
Amide PP
Aminicotin
Amixicotyn
Amnicotin
Austrovit PP
Benicot
Delonin amide
Dipegyl
Endobion
Factor PP
Hansamid
Inovitan PP
m-(Aminocarbonyl)pyridine
NAM
Niacevit
Niacinamide
Niavit PP
Nicamindon
Nicasir
Nicobion
Nicofort
Nicogen
Nicomidol
Nicosan 2
Nicotamide
Nicotilamide
Nicotinic acid amide
Nicotinic amide
Nicotinsaureamid (German)
Nicotylamide
Nicovit
Nicovitol
Nicozymin
Niko-Tamin
Nikotinsaeureamid (German)
Niocinamide
Niozymin
Pelmine
Pelonin amide
PP-Faktor
Pyridine-3-carboxylic acid amide
Savacotyl
VI-Nicotyl
Vitamin B
Vitamin B3
Vitamin PP
Witamina PP
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
body fluid assay | ovary/rat | 25 mg/kg | MUREAV 143,263,1985 |
Cytogenetic Analysis | intraperitoneal/mouse | 1200 mg/kg | MUTAEX 17,1,2002 |
DNA inhibition | liver/rat | 20 mmol/L | JJIND8 69,1353,1982 |
mutation in microorganisms | /Salmonella typhimurium | 5 mg/plate (+enzymatic activation step) | TRENAF 37,447,1986 |
sister chromatid exchange | lymphocyte/human | 10 mmol/L | NULSAK 28,198,1985 |
sister chromatid exchange | ovary/hamster | 5 mmol/L | MUREAV 126,63,1984 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
In Vitro/Human, endothelium | Inhibitor Concentration (50 percent kill): 50 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 6,493,1992 |
In Vitro/Human, fibroblast | Inhibitor Concentration (50 percent kill): 88 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 6,493,1992 |
In Vitro/Human, liver tumor | Inhibitor Concentration (50 percent kill): 65 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 6,493,1992 |
In Vitro/Human, melanoma | Inhibitor Concentration (50 percent kill): 70 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 6,493,1992 |
In Vitro/Human, skin | Inhibitor Concentration (50 percent kill): 80 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 6,493,1992 |
intraperitoneal/mouse | lowest published lethal dose: 1800 mg/kg | MUTAEX 17,1,2002 | |
intraperitoneal/mouse | lowest published toxic dose: 250 mg/kg | Behavioral: Anticonvulsant | FATOAO 48,21,1985 |
intraperitoneal/mouse | lethal dose (50 percent kill): 2050 mg/kg | RAREAE 109,479,1987 | |
oral/human | lowest published toxic dose: 35.7 mg/kg | Gastrointestinal: Nausea or vomiting Endocrine: Hypoglycemia Nutritional and Gross Metabolic: Changes in: Metabolic acidosis | AEMED3 50,587,2007 |
oral/mouse | lethal dose (50 percent kill): 2500 mg/kg | USXXAM #6365129 | |
oral/rat | lethal dose (50 percent kill): 3500 mg/kg | USXXAM #6365129 | |
skin/mouse | lowest published toxic dose: 5128 µg/kg | Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | WOPOF* #2004000333 |
subcutaneous/mouse | lethal dose (50 percent kill): 2 gm/kg | QJPPAL 19,48,1946 | |
subcutaneous/mouse | lowest published toxic dose: 62.5 mg/kg | Endocrine: Hypoglycemia Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases | FATOAO 51,51,1988 |
subcutaneous/rabbit | lowest published toxic dose: 62.5 mg/kg | Endocrine: Hypoglycemia | FATOAO 51,51,1988 |
subcutaneous/rat | lethal dose (50 percent kill): 1680 mg/kg | Lung, Thorax, or Respiration: Other changes | PSEBAA 62,19,1946 |
unreported route/mammal (species unspecified) | lethal dose (50 percent kill): 2500 mg/kg | PCJOAU 20,29,1986 | |
unreported route/mouse | lowest published toxic dose: 820 mg/kg | Behavioral: Anticonvulsant | FATOAO 55,27,1992 |
unreported route/mouse | lowest published toxic dose: 1600 mg/kg | Behavioral: Ataxia | FATOAO 55,27,1992 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
intraperitoneal/mouse | lowest published toxic dose: 480 mg/kg/2D- intermittent | Endocrine: Other changes | BPBLEO 29,1167,2006 |
intraperitoneal/mouse | lowest published toxic dose: 960 mg/kg/2D- intermittent | Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | BPBLEO 29,1167,2006 |
intraperitoneal/rat | lowest published toxic dose: 4200 mg/kg/2W- intermittent | Vascular: BP elevation not characterized in autonomic section Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JPETAB 320,458,2007 |
intraperitoneal/rat | lowest published toxic dose: 2800 mg/kg/2W- intermittent | Vascular: BP elevation not characterized in autonomic section | JPETAB 320,458,2007 |
intraperitoneal/rat | lowest published toxic dose: 5600 mg/kg/2W- intermittent | Vascular: BP elevation not characterized in autonomic section Behavioral: Analgesia | JPETAB 320,458,2007 |
oral/human | lowest published toxic dose: 150 mg/kg/7D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Immunological Including Allergic: Increased immune response | CRNGDP 30,101,2009 |
oral/rat | lowest published toxic dose: 0.56 mg/kg/40D- intermittent | Liver: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | TOVEFN (3),36,1997 |
oral/rat | lowest published toxic dose: 16.8 mg/kg/5W- continuous | Gastrointestinal: Other changes | CRNGDP 24,81,2003 |
skin/mouse | lowest published toxic dose: 6400 mg/kg/16W- intermittent | TXAPA9 278,148,2014 |
Reviews
Organization | Standard | Reference |
---|---|---|
TOXICOLOGY REVIEW | MUREAV 539,77,2003 | |
TOXICOLOGY REVIEW | TPHSDY 24,228,2003 | |
TOXICOLOGY REVIEW | IJTOFN 24,1,2005 | |
TOXICOLOGY REVIEW | JCLIP* (1),191,2007 | |
TOXICOLOGY REVIEW | TXCYAC 278,27,2010 | |
TOXICOLOGY REVIEW | MUREAV 760,36,2014 | |
TOXICOLOGY REVIEW | MUREAV 803-804,1,2016 | |
TOXICOLOGY REVIEW | MUREAV 827,1,2018 | |
TOXICOLOGY REVIEW | SFDRA* 38,469,2016 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Occupational Exposure Limit-RUSSIA | short term exposure limit 1 mg/m3, JUN2003 |
NIOSH Documentation and Surveillance
Status in Federal Agencies
Organization | Reference |
---|---|
EPA TSCA Section 8(b) CHEMICAL INVENTORY |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health