Nicotinamide

RTECS #

QS3675000

CAS #

98-92-0
See: NMAM or OSHA Methods

Updated

March 2019

Molecular Weight

122.14

Molecular Formula

C₆H₆N₂O

Synonyms

3-Carbamoylpyridine
3-Pyridinecarboxamide
3-Pyridinecarboxylic acid amide
Acid amide
Amid kyseliny nikotinove (Czech)
Amide PP
Aminicotin
Amixicotyn
Amnicotin
Austrovit PP
Benicot
Delonin amide
Dipegyl
Endobion
Factor PP
Hansamid
Inovitan PP
m-(Aminocarbonyl)pyridine
NAM
Niacevit
Niacinamide
Niavit PP
Nicamindon
Nicasir
Nicobion
Nicofort
Nicogen
Nicomidol
Nicosan 2
Nicotamide
Nicotilamide
Nicotinic acid amide
Nicotinic amide
Nicotinsaureamid (German)
Nicotylamide
Nicovit
Nicovitol
Nicozymin
Niko-Tamin
Nikotinsaeureamid (German)
Niocinamide
Niozymin
Pelmine
Pelonin amide
PP-Faktor
Pyridine-3-carboxylic acid amide
Savacotyl
VI-Nicotyl
Vitamin B
Vitamin B3
Vitamin PP
Witamina PP

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
body fluid assay	ovary/rat	25 mg/kg	MUREAV 143,263,1985
Cytogenetic Analysis	intraperitoneal/mouse	1200 mg/kg	MUTAEX 17,1,2002
DNA inhibition	liver/rat	20 mmol/L	JJIND8 69,1353,1982
mutation in microorganisms	/Salmonella typhimurium	5 mg/plate (+enzymatic activation step)	TRENAF 37,447,1986
sister chromatid exchange	lymphocyte/human	10 mmol/L	NULSAK 28,198,1985
sister chromatid exchange	ovary/hamster	5 mmol/L	MUREAV 126,63,1984

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, endothelium	Inhibitor Concentration (50 percent kill): 50 mmol/L/24H	In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.	TIVIEQ 6,493,1992
In Vitro/Human, fibroblast	Inhibitor Concentration (50 percent kill): 88 mmol/L/24H	In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.	TIVIEQ 6,493,1992
In Vitro/Human, liver tumor	Inhibitor Concentration (50 percent kill): 65 mmol/L/24H	In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.	TIVIEQ 6,493,1992
In Vitro/Human, melanoma	Inhibitor Concentration (50 percent kill): 70 mmol/L/24H	In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.	TIVIEQ 6,493,1992
In Vitro/Human, skin	Inhibitor Concentration (50 percent kill): 80 mmol/L/24H	In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.	TIVIEQ 6,493,1992
intraperitoneal/mouse	lowest published lethal dose: 1800 mg/kg		MUTAEX 17,1,2002
intraperitoneal/mouse	lowest published toxic dose: 250 mg/kg	Behavioral: Anticonvulsant	FATOAO 48,21,1985
intraperitoneal/mouse	lethal dose (50 percent kill): 2050 mg/kg		RAREAE 109,479,1987
oral/human	lowest published toxic dose: 35.7 mg/kg	Gastrointestinal: Nausea or vomiting Endocrine: Hypoglycemia Nutritional and Gross Metabolic: Changes in: Metabolic acidosis	AEMED3 50,587,2007
oral/mouse	lethal dose (50 percent kill): 2500 mg/kg		USXXAM #6365129
oral/rat	lethal dose (50 percent kill): 3500 mg/kg		USXXAM #6365129
skin/mouse	lowest published toxic dose: 5128 µg/kg	Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	WOPOF* #2004000333
subcutaneous/mouse	lethal dose (50 percent kill): 2 gm/kg		QJPPAL 19,48,1946
subcutaneous/mouse	lowest published toxic dose: 62.5 mg/kg	Endocrine: Hypoglycemia Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases	FATOAO 51,51,1988
subcutaneous/rabbit	lowest published toxic dose: 62.5 mg/kg	Endocrine: Hypoglycemia	FATOAO 51,51,1988
subcutaneous/rat	lethal dose (50 percent kill): 1680 mg/kg	Lung, Thorax, or Respiration: Other changes	PSEBAA 62,19,1946
unreported route/mammal (species unspecified)	lethal dose (50 percent kill): 2500 mg/kg		PCJOAU 20,29,1986
unreported route/mouse	lowest published toxic dose: 820 mg/kg	Behavioral: Anticonvulsant	FATOAO 55,27,1992
unreported route/mouse	lowest published toxic dose: 1600 mg/kg	Behavioral: Ataxia	FATOAO 55,27,1992

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/mouse	lowest published toxic dose: 480 mg/kg/2D- intermittent	Endocrine: Other changes	BPBLEO 29,1167,2006
intraperitoneal/mouse	lowest published toxic dose: 960 mg/kg/2D- intermittent	Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	BPBLEO 29,1167,2006
intraperitoneal/rat	lowest published toxic dose: 4200 mg/kg/2W- intermittent	Vascular: BP elevation not characterized in autonomic section Nutritional and Gross Metabolic: Weight loss or decreased weight gain	JPETAB 320,458,2007
intraperitoneal/rat	lowest published toxic dose: 2800 mg/kg/2W- intermittent	Vascular: BP elevation not characterized in autonomic section	JPETAB 320,458,2007
intraperitoneal/rat	lowest published toxic dose: 5600 mg/kg/2W- intermittent	Vascular: BP elevation not characterized in autonomic section Behavioral: Analgesia	JPETAB 320,458,2007
oral/human	lowest published toxic dose: 150 mg/kg/7D- intermittent	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Immunological Including Allergic: Increased immune response	CRNGDP 30,101,2009
oral/rat	lowest published toxic dose: 0.56 mg/kg/40D- intermittent	Liver: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects	TOVEFN (3),36,1997
oral/rat	lowest published toxic dose: 16.8 mg/kg/5W- continuous	Gastrointestinal: Other changes	CRNGDP 24,81,2003
skin/mouse	lowest published toxic dose: 6400 mg/kg/16W- intermittent		TXAPA9 278,148,2014

Reviews

Organization	Standard	Reference
TOXICOLOGY REVIEW		MUREAV 539,77,2003
TOXICOLOGY REVIEW		TPHSDY 24,228,2003
TOXICOLOGY REVIEW		IJTOFN 24,1,2005
TOXICOLOGY REVIEW		JCLIP* (1),191,2007
TOXICOLOGY REVIEW		TXCYAC 278,27,2010
TOXICOLOGY REVIEW		MUREAV 760,36,2014
TOXICOLOGY REVIEW		MUREAV 803-804,1,2016
TOXICOLOGY REVIEW		MUREAV 827,1,2018
TOXICOLOGY REVIEW		SFDRA* 38,469,2016

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit-RUSSIA	short term exposure limit 1 mg/m³, JUN2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Occupational Exposure Survey 1983	Hazard Code M0321; Number of Industries 8; Total Number of Facilities 2791; Number of Occupations 34; Total Number of Employees Exposed 64950; Total Number of Female Employees Exposed 44524
National Occupational Hazard Survey 1974	Hazard Code M0321; Number of Industries 6; Total Number of Facilities 1142; Number of Occupations 15; Total Number of Employees Exposed 17336

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health