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Registry of Toxic Effects of Chemical Substances (RTECS)

Morpholine, 4-ethyl-

RTECS #

QE4025000

CAS #

100-74-3

Updated

September 2013

Molecular Weight

115.20

Molecular Formula

C6H13NO

Synonyms

4-Ethylmorpholine
NEM
N-Ethylmorfolin (Czech)
N-Ethylmorpholine
N-Ethylmorpholine (ACGIH:OSHA)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 453 mg open irritation test mildUCDS** 11/3/1971

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium6667 µg/plate (-enzymatic activation step)ENMUDM 9(Suppl 9),1,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/pzxInhibitor Concentration Low: 100 µmol/L/2HIn Vitro Toxicity Studies: Other assaysTXCYAC 276,27,2010
inhalation/mouse lethal concentration (50 percent kill): 18000 mg/m3/2HTPKVAL 15,116,1979
inhalation/rat Lowest published lethal concentration: 2000 ppm/4HAMIHBC 10,61,1954
intravenous/mouse lethal dose (50 percent kill): 180 mg/kgCSLNX* NX#04778
oral/mammal (species unspecified) lethal dose (50 percent kill): 1200 mg/kgGISAAA 39(4),86,1974
oral/mouse lethal dose (50 percent kill): 1200 mg/kgLung, Thorax, or Respiration: Other changes

Liver: Liver function tests impaired

Blood: Other changes
TPKVAL 15,116,1979
oral/rat lethal dose (50 percent kill): 1780 mg/kgDTLWS* 4,190,1982

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 5 ppm (skin)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWCHHSA* 9,6,2002

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 20 ppm (94 mg/m3) (skin)DTLVS* 3,113,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit-AUSTRALIAtime-weighted average 5 ppm (24 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 5 ppm (23 mg/m3);KZW 10 ppm (46 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 5 ppm (24 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 ppm (23.5 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 5 ppm (24 mg/m3), short term exposure limit 10 ppm (48 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 5 ppm (23 mg/m3), Skin, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 5 ppm (23.5 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 5 ppm (23 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 20 ppm (95 mg/m3) (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 5 ppm (24 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 5 ppm (23 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 5 ppm (24 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAtime-weighted average 5 mg/m3, short term exposure limit 15 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 5 ppm (25 mg/m3);short term exposure limit 10 ppm (50 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 5 ppm (25 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 23 mg/m3, Skin, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 5 ppm (24 mg/m3);short term exposure limit 20 ppm (96 mg/m3), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 20 ppm (94 mg/m3) (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 20 ppm (94 mg/m3) (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 20 ppm (94 mg/m3) (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 20 ppm (94 mg/m3) (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO N-ETHYLMORPHOLINE-air10H time-weighted average 5 ppm (Sk)NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974Hazard Code 32840; Number of Industries 3; Total Number of Facilities 37; Number of Occupations 3; Total Number of Employees Exposed 967

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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