4,7-Methanoindene, 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro-

RTECS #

PC0700000

CAS #

76-44-8; 23720-59-4; 37229-06-4
See: NMAM or OSHA Methods

Updated

September 2018

Molecular Weight

373.30

Molecular Formula

C₁₀H₅Cl₇

Synonyms

1(3a),4,5,6,7,8,8-Heptachloro-3a(1),4,7,7a-tetrahydro-4,7-methanoindene
1,4,5,6,7,10,10-Heptachloro-4,7,8,9-tetrahydro-4,7-endomethyleneindene
1,4,5,6,7,10,10-Heptachloro-4,7,8,9-tetrahydro-4,7-methyleneindene
1,4,5,6,7,8,8a-Heptachloro-3a,4,7,7a-tetrahydro-4,7-methanoindane
1,4,5,6,7,8,8-Eptacloro-3a,4,7,7a-tetraidro-4,7-endo-metano-indene (Italian)
1,4,5,6,7,8,8-Heptachloor-3a,4,7,7a-tetrahydro-4,7-endo-methano-indeen (Dutch)
1,4,5,6,7,8,8-Heptachlor-3a,4,7,7,7a-tetrahydro-4,7-endo-methano-inden (German)
1,4,5,6,7,8,8-Heptachloro-3a,4,7,7,7a-tetrahydro-4,7-methylene indene
1,4,5,6,7,8,8-Heptachloro-3a,4,7,7a-tetrahydro-4,7-endomethanoindene
1,4,5,6,7,8,8-Heptachloro-3a,4,7,7a-tetrahydro-4,7-methanoindene
1,4,5,6,7,8,8-Heptachloro-3a,4,7,7a-tetrahydro-4,7-methanol-1H-indene
3,4,5,6,7,8,8a-Heptachlorodicyclopentadiene
3,4,5,6,7,8,8-Heptachlorodicyclopentadiene
3-Chlorochlordene
Aahepta
Agroceres
Analytical grade heptachlor
Arbinex 30TN
Dicyclopentadiene, 3,4,5,6,7,8,8a-heptachloro-
Drinox
E 3314
ENT 15,152
Eptacloro (Italian)
GPKh
H
H-34
H-60
Hepta
Heptachloor (Dutch)
Heptachlor
Heptachlor (ACGIH:OSHA)
Heptachlor (technical grade)
Heptachlorane
Heptachlore (French)
Heptagran
Heptamul
Heptox
Latka 104 (Czech)
NCI-C00180
OMS 193
RCRA waste number P059
Rhodiachlor
Velsicol 104
Velsicol heptachlor
Velsicol104

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	oral/rat	60 µg/kg	34LXAP -,555,1976
Cytogenetic Analysis	intraperitoneal/mouse	5200 µg/kg	SOGEBZ 2,80,1966
Cytogenetic Analysis	fibroblast/hamster	67.0 µmol/L	MUREAV 608,28,2006
Cytogenetic Analysis	/hamster	67.0 µmol/L	MUREAV 608,28,2006
Dominant Lethal Test	oral/rat	60 µg/kg	34LXAP -,555,1976
morphological transform	embryo/hamster	10 mg/L	AETODY 1,241,1980
mutation in mammalian somatic cells	lymphocyte/mouse	25 mg/L	EMMUEG 12,85,1988
other mutation test systems	oral/mouse	35 mg/kg	MUREAV 343,157,1995
other mutation test systems	/Escherichia coli	837 µmol/L	EMMUEG 19,98,1992
Unscheduled DNA Synthesis	fibroblast/human	100 µmol/L	MUREAV 42,161,1977

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	350 mg/kg (14D prior to copulation)	Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	PHTOEH 76,112,1995
oral/rat	3168 mg/kg (70D male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Other effects on male Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	PHTOEH 76,112,1995
oral/rat	0.51 mg/kg (multigenerations)	Reproductive: Other developmental abnormalities	TOSCF2 60,315,2001
oral/rat	51 mg/kg (multigenerations)	Reproductive: Specific developmental abnormalities: Central nervous system	TOSCF2 60,315,2001
oral/rat	30 mg/kg (12-22D pregnant)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	TOSCF2 61,164,2001
oral/rat	510 µg/kg (multigenerations)	Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system	TOSCF2 61,164,2001
oral/rat	51 mg/kg (multigenerations)	Reproductive: Specific developmental abnormalities: Hepatobiliary system	TOSCF2 61,164,2001
oral/rat	510 µg/kg (multigenerations)	Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Other developmental abnormalities	TOSCF2 61,164,2001
oral/rat	45 mg/kg (10D preg-2D after birth)	Reproductive: Other developmental abnormalities	TOXID9 66,131,2002
oral/rat	99 mg/kg (multigeneration)	Reproductive: Specific developmental abnormalities: Central nervous system	TOXID9 66,131,2002
oral/rat	50.4 mg/kg (10-21D pregnant)	Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Effects on newborn: Biochemical and metabolic	TOXID9 78,378,2004
oral/mouse	57 mg/kg (2W pre-21D after birth)	Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Effects on newborn: Biochemical and metabolic	TOXID9 78,378,2004
oral/mouse	57 mg/kg (14D pre-21D after birth)	Reproductive: Effects on newborn: Biochemical and metabolic	NETOX* 26,721,2005
oral/rat	25.2 mg/kg (14D prior to copulation)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Other measures of fertility	TOXID9 -,238,2008
subcutaneous/rat	140 mg/kg (14D prior to copulation)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)	CBPCBB 110C,221,1995
unreported route/rat	48 mg/kg (multigeneration)	Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system	TOXID9 72,171,2003

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
oral/mouse	lowest published toxic dose: 403 mg/kg/80W- continuous	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	NCITR* NCI-TR-9,1977
oral/mouse	toxic dose: 930 mg/kg/80W- continuous	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	NCITR* NCI-TR-9,1977
oral/mouse	toxic dose: 876 mg/kg/2Y- continuous	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	ECEBDI 45,147,1977

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, liver tumor	Inhibitor Concentration (50 percent kill): 86 µmol/L/72H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	FCTOD7 50,3963,2012
In Vitro/Human, liver tumor	Inhibitor Concentration Low: 20 µmol/L/72H	In Vitro Toxicity Studies: Cell morphology: overgrowth of cell appendixes etc.	FCTOD7 50,3963,2012
In Vitro/Mouse, fibroblast	Inhibitor Concentration (10 percent kill): 30 µmol/L/24H	In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.	TIVIEQ 2,1,1988
In Vitro/Mouse, fibroblast	Inhibitor Concentration (50 percent kill): 59 µmol/L/24H	In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.	TIVIEQ 2,1,1988
In Vitro/Mouse, fibroblast	Inhibitor Concentration (10 percent kill): 20 µmol/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 2,1,1988
In Vitro/Mouse, fibroblast	Inhibitor Concentration (50 percent kill): 59 µmol/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 2,1,1988
In Vitro/Rat, endocrine tumor	Inhibitor Concentration Low: 10 µmol/L/5D	In Vitro Toxicity Studies: Cell morphology: overgrowth of cell appendixes etc.	TXAPA9 325,25,2017
inhalation/cat	Lowest published lethal concentration: 150 mg/m³/4H		85GMAT -,71,1982
inhalation/mammal (species unspecified)	Lowest published lethal concentration: 200 mg/m³/4H	Behavioral: Excitement Behavioral: Muscle contraction or spasticity Behavioral: Aggression	GTPZAB 2(5),15,1958
intracerebral/mouse	lethal dose (50 percent kill): 12 mg/kg	Behavioral: Convulsions or effect on seizure threshold	TOLED5 60,289,1992
intraperitoneal/mouse	lethal dose (50 percent kill): 130 mg/kg		SOGEBZ 2,80,1966
intraperitoneal/rat	lethal dose (50 percent kill): 27 mg/kg	Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Behavioral: Change in motor activity (specific assay)	FCTXAV 11,63,1973
intraperitoneal/rat	lowest published toxic dose: 93.3 mg/kg	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Metabolism (intermediary): Other	GEPHDP 18,165,1987
intraperitoneal/rat	lowest published toxic dose: 50 mg/kg	Brain and Coverings: Other degenerative changes Behavioral: Convulsions or effect on seizure threshold Biochemical: Metabolism (intermediary): Other	TOXID9 60,245,2001
intravenous/mouse	lowest published lethal dose: 20 mg/kg		JPETAB 107,266,1953
oral/cat	lowest published lethal dose: 50 mg/kg	Behavioral: Excitement Behavioral: Muscle contraction or spasticity Behavioral: Aggression	GTPZAB 2(5),15,1958
oral/cat	lethal dose (50 percent kill): 50 mg/kg		VCVGH* -,561,1990
oral/guinea pig	lethal dose (50 percent kill): 116 mg/kg		PCOC** -,576,1966
oral/hamster	lethal dose (50 percent kill): 100 mg/kg		EJTXAZ 7,159,1974
oral/mouse	lethal dose (50 percent kill): 30 mg/kg		ENTOX* -,502,2005
oral/rat	lethal dose (50 percent kill): 40 mg/kg		PHJOAV 185,361,1960
oral/rat	lowest published toxic dose: 60 mg/kg	Brain and Coverings: Other degenerative changes	TOXID9 72,304,2003
skin/guinea pig	lowest published lethal dose: 1 gm/kg	Behavioral: Excitement Behavioral: Muscle contraction or spasticity Behavioral: Aggression	GTPZAB 2(5),15,1958
skin/rabbit	lethal dose (50 percent kill): 500 mg/kg		VCVGH* -,561,1990
skin/rat	lethal dose (50 percent kill): 119 mg/kg		SPEADM 78-1,12,1978
unreported route/mammal (species unspecified)	lethal dose (50 percent kill): 60 mg/kg		30ZDA9 -,59,1971

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 1.6 mg/m³/4H/8D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVGH* -,561,1990
intraperitoneal/mouse	lowest published toxic dose: 18 mg/kg/2W- intermittent	Brain and Coverings: Other degenerative changes Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum	NRTXDN 23,537,2002
intraperitoneal/mouse	lowest published toxic dose: 9 mg/kg/2W- intermittent	Brain and Coverings: Other degenerative changes Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites	NRTXDN 20,631,1999
intraperitoneal/mouse	lowest published toxic dose: 75 mg/kg/3D- intermittent	Brain and Coverings: Other degenerative changes	TOSCF2 61,100,2001
intraperitoneal/mouse	lowest published toxic dose: 6 mg/kg/3D- intermittent	Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum	TOSCF2 61,100,2001
intraperitoneal/mouse	lowest published toxic dose: 150 mg/kg/3D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TOSCF2 61,100,2001
intraperitoneal/mouse	lowest published toxic dose: 18 mg/kg/2W- intermittent	Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum	NRTXDN 23,537,2002
intraperitoneal/rat	lowest published toxic dose: 70 mg/kg/7D- intermittent	Liver: Other changes Biochemical: Metabolism (intermediary): Other	TXAPA9 19,234,1971
oral/mammal (species unspecified)	lowest published toxic dose: 2800 mg/kg/28D- continuous	Kidney, Ureter, and Bladder: Changes in bladder weight Endocrine: Changes in adrenal weight Endocrine: Changes in spleen weight	AECTCV 19,913,1990
oral/rabbit	lowest published toxic dose: 0.63 mg/kg/3W- continuous	Immunological Including Allergic: Decreased immune response	HBPTO* 1,771,2001
oral/rat	lowest published toxic dose: 22750 mg/kg/26W- intermittent	Blood: Pigmented or nucleated red blood cells Blood: Changes in erythrocyte (RBC) count Biochemical: Metabolism (intermediary): Lipids including transport	GISAAA 30(3),13,1965
skin/rabbit	lowest published toxic dose: 475 mg/kg/19D- intermittent	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory depression Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	GTPZAB 2(5)15,1958
subcutaneous/rat	lowest published toxic dose: 45 mg/kg/18D- intermittent	Endocrine: Estrogenic Endocrine: Other changes	CBPCEE 111C,191,1995
subcutaneous/rat	lowest published toxic dose: 225 mg/kg/18D- intermittent	Endocrine: Effect on menstrual cycle	CBPCEE 111C,191,1995
subcutaneous/rat	lowest published toxic dose: 180 mg/kg/18D- intermittent	Endocrine: Effect on menstrual cycle Nutritional and Gross Metabolic: Weight loss or decreased weight gain	CBCPAI 110C,221,1995
subcutaneous/rat	lowest published toxic dose: 140 mg/kg/14D- intermittent	Reproductive: Maternal effects: Parturition Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)	CBCPAI 110C,221,1995

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.05 mg/m³ (skin)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Confirmed animal carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 20,129,1979
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Limited Evidence	IMSUDL 7,146,1987
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 53,115,1991
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Inadequate Evidence	IMEMDT 5,173,1974
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 20,129,1979
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 53,115,1991
International Agency for Research on Cancer (IARC)	Cancer Review:Group 2B	IMEMDT 53,115,1991
TOXICOLOGY REVIEW		CRTXB2 1(1),93,1971
TOXICOLOGY REVIEW		CNDQA8 10(3),43,1975
TOXICOLOGY REVIEW		RREVAH 56,107,1975
TOXICOLOGY REVIEW		BNYMAM 54,413,1978
TOXICOLOGY REVIEW		CTOXAO 13,231,1978
TOXICOLOGY REVIEW		85CVA2 5,250,1970
TOXICOLOGY REVIEW		TOLED5 127,101,2002
TOXICOLOGY REVIEW		MUTAEX 21,93,2006
TOXICOLOGY REVIEW		NETOX* 26,531,2005
TOXICOLOGY REVIEW		ENTOX* -,502,2005
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		JTEHD6 7,1,2004
TOXICOLOGY REVIEW		REPTED 23,457,2007
TOXICOLOGY REVIEW		ITODC* -,327,2004
TOXICOLOGY REVIEW		HTOPA* 1,501,2002
TOXICOLOGY REVIEW		MUREAV 590,1,2005
TOXICOLOGY REVIEW		IMEMDT 79,411,
TOXICOLOGY REVIEW		TOLED5 201,152,2011
TOXICOLOGY REVIEW		TOLED5 202,36,2011
TOXICOLOGY REVIEW		MUREAV 769,34,2014
TOXICOLOGY REVIEW		TXCYAC 307,24,2013
TOXICOLOGY REVIEW		TXCYAC 307,123,2013
TOXICOLOGY REVIEW		TXAPA9 268,157,2013
TOXICOLOGY REVIEW		MUREAV 802,1,2016
TOXICOLOGY REVIEW		NETEEC 52,25,2015
TOXICOLOGY REVIEW		FCTOD7 105,456,2017

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	RED Completed	RBREV* -,123,1998
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 0.5 mg/m³ (skin)	DTLVS* 3,123,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.5 mg/m³, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.5 mg/m³;KZW 5 mg/m³, inhal, skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.05 mg/m³, Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.05 mg/m³, skin, carc, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 0.05 mg/m³, short term exposure limit 0.15 mg/m³, skin, NOV2011
Occupational Exposure Limit-FRANCE	VME 0.03 ppm (0.5 mg/m³), C3 Carcinogen, FEB2006
Occupational Exposure Limit-GERMANY	MAK 0.05 mg/m³, inhal, skin, 2011
Occupational Exposure Limit-HUNGARY	Skin, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 0.05 mg/m³, skin, NOV2011
Occupational Exposure Limit-JAPAN	2B carc, MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 0.5 mg/m³, skin, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.5 mg/m³;short term exposure limit 2 mg/m³ (skin), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.5 mg/m³, skin, JAN2002
Occupational Exposure Limit-PERU	time-weighted average 0,05 mg/m³, JUL2005
Occupational Exposure Limit-RUSSIA	short term exposure limit 0.01 mg/m³, JUN2003
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.05 mg/m³, KZG-week 0.4 mg/m³, carc 3, inhal, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.05 mg/m³, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 0.5 mg/m³, Skin, JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 1 mg/m³, Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 0.5 mg/m³ (skin)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 0.5 mg/m³ (skin)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 0.5 mg/m³ (skin)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 0.5 mg/m³ (skin)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HEPTACHLOR-air	10H Carcinogen time-weighted average 0.5 mg/m³ (Sk)	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 35960; Number of Industries 2; Total Number of Facilities 120; Number of Occupations 2; Total Number of Employees Exposed 1034
National Occupational Hazard Survey 1974	Hazard Code 35960; Number of Industries 2; Total Number of Facilities 346; Number of Occupations 8; Total Number of Employees Exposed 907

Status in Federal Agencies

Organization	Reference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/182467/AS)
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);clear evidence:mouse	NCITR* NCI-TR-9,1977
NCI Carcinogenesis Bioassay (feed);no evidence:rat	NCITR* NCI-TR-9,1977
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health