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Registry of Toxic Effects of Chemical Substances (RTECS)

4,7-Methanoindene, 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro-

RTECS #

PC0700000

CAS #

76-44-8; 23720-59-4; 37229-06-4

Updated

June 2017

Molecular Weight

373.30

Molecular Formula

C10H5Cl7

Synonyms

1(3a),4,5,6,7,8,8-Heptachloro-3a(1),4,7,7a-tetrahydro-4,7-methanoindene
1,4,5,6,7,10,10-Heptachloro-4,7,8,9-tetrahydro-4,7-endomethyleneindene
1,4,5,6,7,10,10-Heptachloro-4,7,8,9-tetrahydro-4,7-methyleneindene
1,4,5,6,7,8,8a-Heptachloro-3a,4,7,7a-tetrahydro-4,7-methanoindane
1,4,5,6,7,8,8-Eptacloro-3a,4,7,7a-tetraidro-4,7-endo-metano-indene (Italian)
1,4,5,6,7,8,8-Heptachloor-3a,4,7,7a-tetrahydro-4,7-endo-methano-indeen (Dutch)
1,4,5,6,7,8,8-Heptachlor-3a,4,7,7,7a-tetrahydro-4,7-endo-methano-inden (German)
1,4,5,6,7,8,8-Heptachloro-3a,4,7,7,7a-tetrahydro-4,7-methylene indene
1,4,5,6,7,8,8-Heptachloro-3a,4,7,7a-tetrahydro-4,7-endomethanoindene
1,4,5,6,7,8,8-Heptachloro-3a,4,7,7a-tetrahydro-4,7-methanoindene
1,4,5,6,7,8,8-Heptachloro-3a,4,7,7a-tetrahydro-4,7-methanol-1H-indene
3,4,5,6,7,8,8a-Heptachlorodicyclopentadiene
3,4,5,6,7,8,8-Heptachlorodicyclopentadiene
3-Chlorochlordene
Aahepta
Agroceres
Analytical grade heptachlor
Arbinex 30TN
Dicyclopentadiene, 3,4,5,6,7,8,8a-heptachloro-
Drinox
E 3314
ENT 15,152
Eptacloro (Italian)
GPKh
H
H-34
H-60
Hepta
Heptachloor (Dutch)
Heptachlor
Heptachlor (ACGIH:OSHA)
Heptachlor (technical grade)
Heptachlorane
Heptachlore (French)
Heptagran
Heptamul
Heptox
Latka 104 (Czech)
NCI-C00180
OMS 193
RCRA waste number P059
Rhodiachlor
Velsicol 104
Velsicol heptachlor
Velsicol104

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisoral/rat60 µg/kg34LXAP -,555,1976
Cytogenetic Analysisintraperitoneal/mouse5200 µg/kgSOGEBZ 2,80,1966
Cytogenetic Analysisfibroblast/hamster67.0 µmol/LMUREAV 608,28,2006
Cytogenetic Analysis/hamster67.0 µmol/LMUREAV 608,28,2006
Dominant Lethal Testoral/rat60 µg/kg34LXAP -,555,1976
morphological transformembryo/hamster10 mg/LAETODY 1,241,1980
mutation in mammalian somatic cellslymphocyte/mouse25 mg/LEMMUEG 12,85,1988
other mutation test systemsoral/mouse35 mg/kgMUREAV 343,157,1995
other mutation test systems/Escherichia coli837 µmol/LEMMUEG 19,98,1992
Unscheduled DNA Synthesisfibroblast/human100 µmol/LMUREAV 42,161,1977

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 350 mg/kg (14D prior to copulation)Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
PHTOEH 76,112,1995
oral/rat 3168 mg/kg (70D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Other effects on male

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
PHTOEH 76,112,1995
oral/rat 0.51 mg/kg (multigenerations)Reproductive: Other developmental abnormalitiesTOSCF2 60,315,2001
oral/rat 51 mg/kg (multigenerations)Reproductive: Specific developmental abnormalities: Central nervous systemTOSCF2 60,315,2001
oral/rat 30 mg/kg (12-22D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)TOSCF2 61,164,2001
oral/rat 510 µg/kg (multigenerations)Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial systemTOSCF2 61,164,2001
oral/rat 51 mg/kg (multigenerations)Reproductive: Specific developmental abnormalities: Hepatobiliary systemTOSCF2 61,164,2001
oral/rat 510 µg/kg (multigenerations)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Other developmental abnormalities
TOSCF2 61,164,2001
oral/rat 45 mg/kg (10D preg-2D after birth)Reproductive: Other developmental abnormalitiesTOXID9 66,131,2002
oral/rat 99 mg/kg (multigeneration)Reproductive: Specific developmental abnormalities: Central nervous systemTOXID9 66,131,2002
oral/rat 50.4 mg/kg (10-21D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Biochemical and metabolic
TOXID9 78,378,2004
oral/mouse 57 mg/kg (2W pre-21D after birth)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Biochemical and metabolic
TOXID9 78,378,2004
oral/mouse 57 mg/kg (14D pre-21D after birth)Reproductive: Effects on newborn: Biochemical and metabolicNETOX* 26,721,2005
oral/rat 25.2 mg/kg (14D prior to copulation)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Other measures of fertility
TOXID9 -,238,2008
subcutaneous/rat 140 mg/kg (14D prior to copulation)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)CBPCBB 110C,221,1995
unreported route/rat 48 mg/kg (multigeneration)Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial systemTOXID9 72,171,2003

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 403 mg/kg/80W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NCITR* NCI-TR-9,1977
oral/mouse toxic dose: 930 mg/kg/80W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NCITR* NCI-TR-9,1977
oral/mouse toxic dose: 876 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
ECEBDI 45,147,1977

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 86 µmol/L/72HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FCTOD7 50,3963,2012
In Vitro/Human, liver tumor Inhibitor Concentration Low: 20 µmol/L/72HIn Vitro Toxicity Studies: Cell morphology: overgrowth of cell appendixes etc.FCTOD7 50,3963,2012
In Vitro/Mouse, fibroblast Inhibitor Concentration (10 percent kill): 30 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 2,1,1988
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 59 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 2,1,1988
In Vitro/Mouse, fibroblast Inhibitor Concentration (10 percent kill): 20 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 2,1,1988
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 59 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 2,1,1988
inhalation/cat Lowest published lethal concentration: 150 mg/m3/4H85GMAT -,71,1982
inhalation/mammal (species unspecified) Lowest published lethal concentration: 200 mg/m3/4HBehavioral: Excitement

Behavioral: Muscle contraction or spasticity

Behavioral: Aggression
GTPZAB 2(5),15,1958
intracerebral/mouse lethal dose (50 percent kill): 12 mg/kgBehavioral: Convulsions or effect on seizure thresholdTOLED5 60,289,1992
intraperitoneal/mouse lethal dose (50 percent kill): 130 mg/kgSOGEBZ 2,80,1966
intraperitoneal/rat lethal dose (50 percent kill): 27 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)
FCTXAV 11,63,1973
intraperitoneal/rat lowest published toxic dose: 93.3 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Metabolism (intermediary): Other
GEPHDP 18,165,1987
intraperitoneal/rat lowest published toxic dose: 50 mg/kgBrain and Coverings: Other degenerative changes

Behavioral: Convulsions or effect on seizure threshold

Biochemical: Metabolism (intermediary): Other
TOXID9 60,245,2001
intravenous/mouse lowest published lethal dose: 20 mg/kgJPETAB 107,266,1953
oral/cat lowest published lethal dose: 50 mg/kgBehavioral: Excitement

Behavioral: Muscle contraction or spasticity

Behavioral: Aggression
GTPZAB 2(5),15,1958
oral/cat lethal dose (50 percent kill): 50 mg/kgVCVGH* -,561,1990
oral/guinea pig lethal dose (50 percent kill): 116 mg/kgPCOC** -,576,1966
oral/hamster lethal dose (50 percent kill): 100 mg/kgEJTXAZ 7,159,1974
oral/mouse lethal dose (50 percent kill): 30 mg/kgENTOX* -,502,2005
oral/rat lethal dose (50 percent kill): 40 mg/kgPHJOAV 185,361,1960
oral/rat lowest published toxic dose: 60 mg/kgBrain and Coverings: Other degenerative changesTOXID9 72,304,2003
skin/guinea pig lowest published lethal dose: 1 gm/kgBehavioral: Excitement

Behavioral: Muscle contraction or spasticity

Behavioral: Aggression
GTPZAB 2(5),15,1958
skin/rabbit lethal dose (50 percent kill): 500 mg/kgVCVGH* -,561,1990
skin/rat lethal dose (50 percent kill): 119 mg/kgSPEADM 78-1,12,1978
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 60 mg/kg30ZDA9 -,59,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 1.6 mg/m3/4H/8D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVGH* -,561,1990
intraperitoneal/mouse lowest published toxic dose: 18 mg/kg/2W- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum
NRTXDN 23,537,2002
intraperitoneal/mouse lowest published toxic dose: 9 mg/kg/2W- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
NRTXDN 20,631,1999
intraperitoneal/mouse lowest published toxic dose: 75 mg/kg/3D- intermittentBrain and Coverings: Other degenerative changesTOSCF2 61,100,2001
intraperitoneal/mouse lowest published toxic dose: 6 mg/kg/3D- intermittentBiochemical: Neurotransmitters or modulators (putative): Dopamine in striatumTOSCF2 61,100,2001
intraperitoneal/mouse lowest published toxic dose: 150 mg/kg/3D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTOSCF2 61,100,2001
intraperitoneal/mouse lowest published toxic dose: 18 mg/kg/2W- intermittentBiochemical: Neurotransmitters or modulators (putative): Dopamine in striatumNRTXDN 23,537,2002
intraperitoneal/rat lowest published toxic dose: 70 mg/kg/7D- intermittentLiver: Other changes

Biochemical: Metabolism (intermediary): Other
TXAPA9 19,234,1971
oral/mammal (species unspecified) lowest published toxic dose: 2800 mg/kg/28D- continuousKidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in adrenal weight

Endocrine: Changes in spleen weight
AECTCV 19,913,1990
oral/rabbit lowest published toxic dose: 0.63 mg/kg/3W- continuousImmunological Including Allergic: Decreased immune responseHBPTO* 1,771,2001
oral/rat lowest published toxic dose: 22750 mg/kg/26W- intermittentBlood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count

Biochemical: Metabolism (intermediary): Lipids including transport
GISAAA 30(3),13,1965
skin/rabbit lowest published toxic dose: 475 mg/kg/19D- intermittentBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
GTPZAB 2(5)15,1958
subcutaneous/rat lowest published toxic dose: 45 mg/kg/18D- intermittentEndocrine: Estrogenic

Endocrine: Other changes
CBPCEE 111C,191,1995
subcutaneous/rat lowest published toxic dose: 225 mg/kg/18D- intermittentEndocrine: Effect on menstrual cycleCBPCEE 111C,191,1995
subcutaneous/rat lowest published toxic dose: 180 mg/kg/18D- intermittentEndocrine: Effect on menstrual cycle

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
CBCPAI 110C,221,1995
subcutaneous/rat lowest published toxic dose: 140 mg/kg/14D- intermittentReproductive: Maternal effects: Parturition

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)
CBCPAI 110C,221,1995

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.05 mg/m3 (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 20,129,1979
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMSUDL 7,146,1987
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 53,115,1991
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 5,173,1974
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 20,129,1979
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 53,115,1991
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 53,115,1991
TOXICOLOGY REVIEWCRTXB2 1(1),93,1971
TOXICOLOGY REVIEWCNDQA8 10(3),43,1975
TOXICOLOGY REVIEWRREVAH 56,107,1975
TOXICOLOGY REVIEWBNYMAM 54,413,1978
TOXICOLOGY REVIEWCTOXAO 13,231,1978
TOXICOLOGY REVIEW85CVA2 5,250,1970
TOXICOLOGY REVIEWTOLED5 127,101,2002
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWNETOX* 26,531,2005
TOXICOLOGY REVIEWENTOX* -,502,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWJTEHD6 7,1,2004
TOXICOLOGY REVIEWREPTED 23,457,2007
TOXICOLOGY REVIEWITODC* -,327,2004
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWMUREAV 590,1,2005
TOXICOLOGY REVIEWIMEMDT 79,411,
TOXICOLOGY REVIEWTOLED5 201,152,2011
TOXICOLOGY REVIEWTOLED5 202,36,2011
TOXICOLOGY REVIEWMUREAV 769,34,2014
TOXICOLOGY REVIEWTXCYAC 307,24,2013
TOXICOLOGY REVIEWTXCYAC 307,123,2013
TOXICOLOGY REVIEWTXAPA9 268,157,2013
TOXICOLOGY REVIEWMUREAV 802,1,2016

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,123,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.5 mg/m3 (skin)DTLVS* 3,123,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.5 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.5 mg/m3;KZW 5 mg/m3, inhal, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.05 mg/m3, Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.05 mg/m3, skin, carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.05 mg/m3, short term exposure limit 0.15 mg/m3, skin, NOV2011
Occupational Exposure Limit-FRANCEVME 0.03 ppm (0.5 mg/m3), C3 Carcinogen, FEB2006
Occupational Exposure Limit-GERMANYMAK 0.05 mg/m3, inhal, skin, 2011
Occupational Exposure Limit-HUNGARYSkin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.05 mg/m3, skin, NOV2011
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.5 mg/m3, skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.5 mg/m3;short term exposure limit 2 mg/m3 (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.5 mg/m3, skin, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0,05 mg/m3, JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.01 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.05 mg/m3, KZG-week 0.4 mg/m3, carc 3, inhal, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.05 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 1 mg/m3, Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.5 mg/m3 (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.5 mg/m3 (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.5 mg/m3 (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.5 mg/m3 (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HEPTACHLOR-air10H Carcinogen time-weighted average 0.5 mg/m3 (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 35960; Number of Industries 2; Total Number of Facilities 120; Number of Occupations 2; Total Number of Employees Exposed 1034
National Occupational Hazard Survey 1974Hazard Code 35960; Number of Industries 2; Total Number of Facilities 346; Number of Occupations 8; Total Number of Employees Exposed 907

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/182467/AS)
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);clear evidence:mouseNCITR* NCI-TR-9,1977
NCI Carcinogenesis Bioassay (feed);no evidence:ratNCITR* NCI-TR-9,1977
On EPA IRIS database
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