Methane, trichlorofluoro-
RTECS #
PB6125000
CAS #
Updated
September 2013
Molecular Weight
137.36
Molecular Formula
CCl3F
Synonyms
Algofrene type 1
Arcton 9
Electro-CF 11
Eskimon 11
F 11
FC 11
Fluorocarbon No. 11
Fluorotrichloromethane
Fluorotrichloromethane (OSHA)
Fluorotrojchlorometan (Polish)
Freon 11
Freon 11A
Freon 11B
Freon HE
Freon MF
Frigen 11
Genetron 11
Halocarbon 11
Isceon 131
Isotron 11
Ledon 11
Methane, fluorotrichloro-
Monofluorotrichloromethane
NCI-C04637
Refrigerant 11
Trichlorofluoromethane (ACGIH:OSHA)
Trichloromonofluoromethane
Ucon flurocarbon 11
Ucon refrigerant 11
Arcton 9
Electro-CF 11
Eskimon 11
F 11
FC 11
Fluorocarbon No. 11
Fluorotrichloromethane
Fluorotrichloromethane (OSHA)
Fluorotrojchlorometan (Polish)
Freon 11
Freon 11A
Freon 11B
Freon HE
Freon MF
Frigen 11
Genetron 11
Halocarbon 11
Isceon 131
Isotron 11
Ledon 11
Methane, fluorotrichloro-
Monofluorotrichloromethane
NCI-C04637
Refrigerant 11
Trichlorofluoromethane (ACGIH:OSHA)
Trichloromonofluoromethane
Ucon flurocarbon 11
Ucon refrigerant 11
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/Dog | lowest published toxic concentration: 16 pph/10M | Cardiac: Change in rate | AEHLAU 30,353,1975 |
| inhalation/Dog | lowest published toxic concentration: 868500 mg/m3/10M | Cardiac: Change in rate | VCVGH* -,616,1990 |
| inhalation/Dog | Lowest published lethal concentration: 22 pph/10M | Cardiac: Pulse rate decreased with fall in BP Cardiac: Change in conduction velocity | AEHLAU 30,353,1975 |
| inhalation/guinea pig | lowest published toxic concentration: 145000 mg/m3/2H | Behavioral: Tremor Lung, Thorax, or Respiration: Dyspnea | VCVGH* -,616,1990 |
| inhalation/guinea pig | lethal concentration (50 percent kill): 25 pph/30M | EJTXAZ 9,385,1976 | |
| inhalation/human | lowest published toxic concentration: 50000 ppm/30M | Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Fibrosing alveolitis Liver: Other changes | EJTXAZ 9,385,1976 |
| inhalation/mouse | lethal concentration (50 percent kill): 10 pph/30M | EJTXAZ 9,385,1976 | |
| inhalation/mouse | lowest published toxic concentration: 100 pph/10M | Cardiac: EKG changes not diagnostic of above Cardiac: Pulse rate decreased with fall in BP | JAMAAP 214,81,1970 |
| inhalation/mouse | Lowest published lethal concentration: 346700 mg/m3/2H | VCVGH* -,616,1990 | |
| inhalation/rabbit | lowest published toxic concentration: 289500 mg/m3/2M | Cardiac: Cardiac output Vascular: BP lowering not characterized in autonomic section | VCVGH* -,616,1990 |
| inhalation/rabbit | lethal concentration (50 percent kill): 25 pph/30M | EJTXAZ 9,385,1976 | |
| inhalation/rat | lethal concentration (50 percent kill): 13 pph/15M | Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory depression | HUTODJ 1,239,1982 |
| inhalation/rat | lowest published toxic concentration: 520000 mg/m3/30M | Behavioral: General anesthetic | VCVGH* -,616,1990 |
| inhalation/rat | Lowest published lethal concentration: 579000 mg/m3/20M | VCVGH* -,616,1990 | |
| inhalation/rat | Lowest published lethal concentration: 868000 mg/m3/4M | VCVGH* -,616,1990 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 1743 mg/kg | Behavioral: Convulsions or effect on seizure threshold | TOIZAG 18,363,1971 |
| oral/rat | Lethal dose: >352 mg/kg | NTIS** OTS0520424 | |
| oral/rat | lowest published toxic dose: 1.25 mL/kg | Gastrointestinal: Ulceration or bleeding from stomach Blood: Hemorrhage | JTCTDW 46,325,2008 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lowest published toxic concentration: 12000 ppm/4H/10D- intermittent | Brain and Coverings: Other degenerative changes Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion | NTIS** OTS0571425 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-ceiling concentration 1000 ppm | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | FAZMAE 18,365,1974 | |
| TOXICOLOGY REVIEW | TXCYAC 3,311,1975 | |
| TOXICOLOGY REVIEW | NYSJAM 74,1939,1974 | |
| TOXICOLOGY REVIEW | AIHAAP 29,517,1968 | |
| TOXICOLOGY REVIEW | MUREAV 543,201,2003 | |
| TOXICOLOGY REVIEW | HUTOX* -,577,1996 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Cancelled | RBREV* -,312,1998 |
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 1000 ppm (5600 mg/m3) | DTLVS* 3,118,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | ceiling concentration 1000 ppm (5620 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 1000 ppm (5600 mg/m3);KZW 2000 ppm (11200 mg/m3), 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 1000 ppm (5702 mg/m3), MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 500 ppm (2810 mg/m3), MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 1000 ppm (5600 mg/m3), short term exposure limit 1300 ppm (7000 mg/m3), NOV2011 | |
| Occupational Exposure Limit-FRANCE | VLE 1000 ppm (5600 mg/m3), FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 1000 ppm (5700 mg/m3), 2011 | |
| Occupational Exposure Limit-HUNGARY | Prohibited in Hungary, SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 500 ppm (2810 mg/m3), NOV2011 | |
| Occupational Exposure Limit-JAPAN | ceiling concentration 1000 ppm (5600 mg/m3), MAY2012 | |
| Occupational Exposure Limit-KOREA | ceiling concentration 1,000 ppm (5,600 mg/m3), 2006 | |
| Occupational Exposure Limit-MEXICO | peak 1000 ppm (5600 mg/m3), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | ceiling concentration 1000 ppm (5620 mg/m3), JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 500 ppm (2800 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | short term exposure limit 1000 ppm (5619 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 500 mg/m3, MAC(C) 5600 mg/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 1000 mg/m3, JUN2003 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 500 ppm (3000 mg/m3);short term exposure limit 750 ppm (4500 mg/m3), JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 1000 ppm (5600 mg/m3), JAN2011 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 1000 ppm (5600 mg/m3), JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 1000 ppm (5600 mg/m3), JAN1993 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 1000 ppm (5600 mg/m3) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 1000 ppm (5600 mg/m3) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 1000 ppm (5600 mg/m3) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 1000 ppm (5600 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FLUOROTRICHLOROMETHANE-air | ceiling concentration 1000 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 33565; Number of Industries 142; Total Number of Facilities 15107; Number of Occupations 119; Total Number of Employees Exposed 267742; Total Number of Female Employees Exposed 95886 | |
| National Occupational Hazard Survey 1974 | Hazard Code 33565; Number of Industries 304; Total Number of Facilities 68187; Number of Occupations 173; Total Number of Employees Exposed 785337 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NCI Carcinogenesis Bioassay (gavage);inadequate studies:rat | NCITR* NCI-TR-106,1978 |
| NCI Carcinogenesis Bioassay (gavage);no evidence:mouse | NCITR* NCI-TR-106,1978 |
| NIOSH Analytical Method, 1994: Fluorotrichloromethane, 1006 | |
| NIOSH Analytical Method, 1994: Trichlorofluoromethane, 1006 | |
| On EPA IRIS database |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health