Methane, tetranitro-

RTECS #

PB4025000

CAS #

509-14-8
See: NMAM or OSHA Methods

Updated

December 2018

Molecular Weight

196.05

Molecular Formula

CN₄O₈

Synonyms

NCI-C55947
RCRA waste number P112
Tetan
Tetranitromethane
Tetranitromethane (ACGIH:OSHA)
TNM

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	ovary/hamster	20 mg/L	NTPTR* NTP-TR-386,1990
DNA Damage	lung/rat	3.9 µmol/L/20H	MUREAV 605,94,2006
DNA Damage	lung/human	1.95 µmol/L/20H	MUREAV 605,94,2006
DNA Damage	oral/rat	65 mg/kg	MUREAV 605,94,2006
DNA Damage	liver/rat	50 µmol/L/3H	MUREAV 629,49,2007
DNA Damage	liver/rat	70 µmol/L	MUREAV 368,59,1996
mutation in microorganisms	/Salmonella typhimurium	2 µg/plate (+enzymatic activation step)	ENMUDM 9(Suppl 9),1,1987
mutation in microorganisms	/Escherichia coli	500 µg/plate (+enzymatic activation step)	SAIGBL 29,34,1987
sister chromatid exchange	ovary/hamster	1700 µg/L	NTPTR* NTP-TR-386,1990

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lowest published toxic concentration: 500 ppb/6H/2Y- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors Lung, Thorax, or Respiration: Bronchogenic carcinoma	NTPTR* NTP-TR-386,1990
inhalation/mouse	toxic concentration: 500 ppb/6H/2Y- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Bronchogenic carcinoma	CALEDQ 57,95,1991
inhalation/mouse	lowest published toxic concentration: 30.9 mg/kg/103W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors	NTIS** PB91-113373
inhalation/rat	lowest published toxic concentration: 2 ppm/6H/2Y- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors Lung, Thorax, or Respiration: Bronchogenic carcinoma	NTPTR* NTP-TR-386,1990
inhalation/rat	lowest published toxic concentration: 61.8 mg/kg/103W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors	NTIS** PB91-113373
inhalation/rat	lowest published toxic concentration: 51.5 mg/kg/103W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors	NTIS** PB91-113373
inhalation/rat	toxic concentration: 2 ppm/6H/2Y- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Bronchogenic carcinoma	CALEDQ 57,95,1991

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/cat	lethal concentration (50 percent kill): 100 ppm/20M		85JCAE -,403,1986
inhalation/human	lowest published toxic concentration: 0.05 gm/m³	Eye: Lacrimation Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Respiratory depression	TPKVAL 4,134,1962
inhalation/mouse	Lowest published lethal concentration: 0.2 gm/m³	Eye: Lacrimation Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Respiratory depression	TPKVAL 4,134,1962
inhalation/mouse	lethal concentration (50 percent kill): 54.4 ppm		ENTOX* -,159,2005
inhalation/mouse	lowest published toxic concentration: 0.1 gm/m³	Vascular: Other changes Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Acute pulmonary edema	TPKVAL 4,134,1962
inhalation/mouse	lethal concentration (50 percent kill): 54 ppm/4H	Blood: Methemoglobinemia- Carboxhemoglobinemia	NTIS** AD-A051-334
inhalation/mouse	lethal concentration (50 percent kill): 0.6 gm/m³		TPKVAL 4,134,1962
inhalation/rabbit	lowest published toxic concentration: 0.1 gm/m³	Behavioral: Tetany	TPKVAL 4,134,1962
inhalation/rabbit	Lowest published lethal concentration: 0.2 gm/m³	Brain and Coverings: Changes in circulation Brain and Coverings: Other degenerative changes Peripheral Nerve and Sensation: Recording from peripheral motor nerve	TPKVAL 4,134,1962
inhalation/rat	lowest published toxic concentration: 0.1 gm/m³	Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Other	TPKVAL 4,134,1962
inhalation/rat	Lowest published lethal concentration: 0.2 gm/m³	Brain and Coverings: Other degenerative changes	TPKVAL 4,134,1962
inhalation/rat	lethal concentration (50 percent kill): 18 ppm/4H	Blood: Methemoglobinemia- Carboxhemoglobinemia	AMRL** TR-77-25,1977
inhalation/rat	lethal concentration (50 percent kill): 17.5 ppm		ENTOX* -,159,2005
inhalation/rat	Lowest published lethal concentration: 1.5 gm/m³	Brain and Coverings: Changes in circulation Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Emphysema	TPKVAL 4,167,1962
inhalation/rat	Lowest published lethal concentration: 0.6 gm/m³/2H		TPKVAL 4,134,1962
intraperitoneal/mammal (species unspecified)	lowest published lethal dose: 500 mg/kg	Blood: Methemoglobinemia- Carboxhemoglobinemia	COREAF 171,1396,1920
intraperitoneal/mouse	lethal dose (50 percent kill): 53 mg/kg		KHFZAN 10(6),53,1976
intravenous/mouse	lethal dose (50 percent kill): 63100 µg/kg	Blood: Methemoglobinemia- Carboxhemoglobinemia	AMRL** TR-77-25,1977
intravenous/rat	lethal dose (50 percent kill): 12600 µg/kg	Blood: Methemoglobinemia- Carboxhemoglobinemia	AMRL** TR-77-25,1977
oral/mouse	lethal dose (50 percent kill): 375 mg/kg	Olfaction: Other olfaction effects Eye: Other eye effects Behavioral: Somnolence (general depressed activity)	NTIS** AD-A051-334
oral/mouse	lethal dose (50 percent kill): 375 mg/kg		ENTOX* -,159,2005
oral/rat	lethal dose (50 percent kill): 130 mg/kg	Olfaction: Other olfaction effects Eye: Other eye effects Behavioral: Somnolence (general depressed activity)	NTIS** AD-A051-334
oral/rat	lethal dose (50 percent kill): 130 mg/kg		ENTOX* -,159,2005

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lowest published toxic concentration: 25 ppm/6H/14D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTPTR* NTP-TR-386,1990
inhalation/mouse	lowest published toxic concentration: 10 ppm/6H/13W- intermittent	Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Other changes Liver: Changes in liver weight	NTPTR* NTP-TR-386,1990
inhalation/rat	lowest published toxic concentration: 0.002 gm/m³/7D- intermittent	Behavioral: Alteration of classical conditioning	TPKVAL 4,134,1962
inhalation/rat	lowest published toxic concentration: 6350 ppb/6H/26W- intermittent	Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	AMIHBC 10,213,1954
inhalation/rat	lowest published toxic concentration: 25 ppm/6H/14D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTPTR* NTP-TR-386,1990
inhalation/rat	lowest published toxic concentration: 10 ppm/6H/13W- intermittent	Lung, Thorax, or Respiration: Other changes Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTPTR* NTP-TR-386,1990

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.005 ppm	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Confirmed animal carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 65,437,1996
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 65,437,1996
International Agency for Research on Cancer (IARC)	Cancer Review:Group 2B	IMEMDT 65,437,1996
TOXICOLOGY REVIEW		ENTOX* -,159,2005
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		MUREAV 769,34,2014
TOXICOLOGY REVIEW		MUREAV 802,1,2016
TOXICOLOGY REVIEW		RTOPDW 54,247,2009

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 1 ppm (8 mg/m³)	DTLVS* 3,254,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 1 ppm (8 mg/m³), JUL2008
Occupational Exposure Limit-BELGIUM	time-weighted average 0.005 ppm (0.04 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.005 ppm (0.04 mg/m³), carc, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 0.05 ppm (0.41 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 1 ppm (8 mg/m³), FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 0.005 ppm (0.04 mg/m³), NOV2011
Occupational Exposure Limit-JAPAN	2B carc, MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 1 ppm (8 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 1 ppm (8 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 1 ppm (8 mg/m³), skin, JAN2002
Occupational Exposure Limit-PERU	time-weighted average 0,005 ppm (0,04 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 0.04 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	short term exposure limit 0.3 mg/m³, Skin, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 0.05 ppm (0.4 mg/m³);short term exposure limit 0.1 ppm (0.8 mg/m³), JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 1 ppm (8 mg/m³), carc 2, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.04 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 1 ppm (8 mg/m³), JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 1 ppm (8 mg/m³), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 1 ppm (8 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 1 ppm (8 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 1 ppm (8 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 1 ppm (8 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TETRANITROMETHANE-air	10H time-weighted average 1 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code X7237; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 1; Total Number of Employees Exposed 1445; Total Number of Female Employees Exposed 230

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);clear evidence:mouse,rat
NIOSH Analytical Method, 1994: Tetranitromethane, 3513
NTP 14th Report on Carcinogens,2016:Reasonably anticipated to be human carcinogen
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health