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Registry of Toxic Effects of Chemical Substances (RTECS)

Methane, bromodichloro-

RTECS #

PA5310000

CAS #

75-27-4

Updated

April 2017

Molecular Weight

163.83

Molecular Formula

CHBrCl2

Synonyms

BDCM
Bromodichloromethane
Bromo-dichloromethane
Dichlorobromomethane
Dichloromonobromomethane
Monobromodichloromethane
NCI-C55243

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisintraperitoneal/rat164 mg/kgMUREAV 242,111,1990
Cytogenetic Analysislung/hamster10 µmol/LTECSDY 13,205,1987
DNA Damagelung/human10 µmol/L/3HMUREAV 538,41,2003
DNA Damagekidney/rat0.5 mmol/L/20HTXCYAC 204,187,2004
DNA Damageoral/rat458 mg/kgTXCYAC 204,187,2004
DNA Damagekidney/human0.5 mmol/L/20HTXCYAC 204,187,2004
DNA Damageother cell types/human1 µmol/L/4HMUREAV 741,89,2012
micronucleus testkidney/human2 mmol/L/48HTXCYAC 204,187,2004
micronucleus testkidney/rat1 mmol/L/48HTXCYAC 204,187,2004
micronucleus testoral/rat458 mg/kgTXCYAC 204,187,2004
micronucleus testinhalation/mouse100 ppm/6H/7DMUREAV 520,171,2002
micronucleus testinhalation/mouse15 ppm/6H/13WMUREAV 520,171,2002
mutation in mammalian somatic cellslymphocyte/mouse180 mg/LEMMUEG 11,91,1988
mutation in microorganismslymphocyte/mouse180 mg/L (+enzymatic activation step)EMMUEG 11,91,1988
mutation in microorganisms/Salmonella typhimurium50 mg/plate (+enzymatic activation step)DHEFDK FDA-78-1046,1978
mutation in microorganisms/Salmonella typhimurium10 µg/plate (-enzymatic activation step)TECSDY 13,205,1987
sister chromatid exchangelymphocyte/human400 µmol/LENVRAL 32,72,1983
sister chromatid exchangeleukocyte/rat200 µmol/LMUREAV 300,241,1993
sister chromatid exchangeoral/mouse200 mg/kg/4D- intermittentENVRAL 32,72,1983

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 750 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)FAATDF 40,30,1997
oral/rat 200 mg/kg (6-10D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)TOXID9 72,77,2003
oral/rat 1627.6 mg/kg (multigeneration)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects
IJTOFN 21,115,2002
oral/rat 4247 mg/kg (multigeneration)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Other postnatal measures or effects
IJTOFN 21,115,2002
oral/rat 375 mg/kg (6-10D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
TOSCF2 77,101,2004
oral/rat 1890 mg/kg (1-21D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemTOXID9 60,216,2001

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 25500 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
NTPTR* NTP-TR-321,1987
oral/mouse toxic dose: 38250 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTPTR* NTP-TR-321,1987
oral/mouse lowest published toxic dose: 12875 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
NTIS** PB88-168687
oral/mouse lowest published toxic dose: 38625 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** PB88-168687
oral/rat lowest published toxic dose: 8400 mg/kg/16W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
TXCYAC 187,1,2003
oral/rat lowest published toxic dose: 6500 mg/kg/26W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Colon tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
JTEHF8 67,23,2004
oral/rat lowest published toxic dose: 51500 mg/kg/13W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Colon tumors

Kidney, Ureter, and Bladder: Kidney tumors
NTIS** PB88-168687
oral/rat toxic dose: 51 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Kidney, Ureter, and Bladder: Kidney tumors
NTPTR* NTP-TR-321,1987
oral/rat lowest published toxic dose: 25500 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Kidney, Ureter, and Bladder: Kidney tumors
NTPTR* NTP-TR-321,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse Lowest published lethal concentration: 450 mg/m3VCVGH* -,629,1990
inhalation/rat lowest published toxic concentration: 100 ppm/4HLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXCYAC 161,67,2001
oral/mouse lethal dose (50 percent kill): 450 mg/kgBrain and Coverings: Changes in circulation

Liver: Fatty liver degeneration

Blood: Hemorrhage
TXAPA9 44,213,1978
oral/mouse lowest published toxic dose: 50 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
TOXID9 72(Suppl 1),234,2003
oral/rat lowest published toxic dose: 35 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
TOXID9 72(Suppl 1),234,2003
oral/rat lowest published toxic dose: 20.5 mg/kgLiver: Liver function tests impairedTOXID9 66,49,2002
oral/rat lowest published toxic dose: 400 mg/kgLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TOXID9 60,236,2001
oral/rat lethal dose (50 percent kill): 430 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Liver: Other changes
SRTCAC 36(1-4),10,1989
oral/rat lowest published toxic dose: 40 mg/kgNutritional and Gross Metabolic: Weight loss or decreased weight gainTOXID9 72,77,2003

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 10 ppm/6H/3W- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes
TOXID9 54,221,2000
inhalation/mouse lowest published toxic concentration: 30 ppm/3W- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 60,279,2001
inhalation/mouse lowest published toxic concentration: 30 ppm/3W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTOXID9 60,279,2001
inhalation/mouse lowest published toxic concentration: 150 ppm/1W- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 60,279,2001
inhalation/mouse lowest published toxic concentration: 150 ppm/1W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTOXID9 60,279,2001
oral/mouse lowest published toxic dose: 3500 mg/kg/14D- intermittentLiver: Changes in liver weight

Endocrine: Changes in spleen weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
EVHPAZ 46,117,1982
oral/mouse lowest published toxic dose: 750 mg/kg/5D- intermittentLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TXCYAC 94,3,1994
oral/mouse lowest published toxic dose: 1400 mg/kg/28D- intermittentKidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other
TOXID9 44,365,2005
oral/mouse lowest published toxic dose: 4550 mg/kg/26W- intermittentLiver: Other changes

Liver: Changes in liver weight
TOXID9 66,184,2002
oral/mouse lowest published toxic dose: 4550 mg/kg/26W- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in kidney weight
TOXID9 66,184,2002
oral/mouse lowest published toxic dose: 6500 mg/kg/13W- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NTP-TR-321,1987
oral/mouse lowest published toxic dose: 19.04 gm/kg/100W- continuousKidney, Ureter, and Bladder: Changes in kidney weightIJTOFN 21,219,2002
oral/mouse lowest published toxic dose: 1000 mg/kg/4W- intermittentKidney, Ureter, and Bladder: Renal function tests depressed

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
ARTODN 78,410,2004
oral/mouse : 336 mg/kg/3W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTPTR* NTP-TR-532
oral/mouse : 672 mg/kg/21D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in thymus weight
NTPTR* NTP-TR-532
oral/mouse : 672 mg/kg/21D- intermittentLung, Thorax, or Respiration: Changes in lung weightNTPTR* NTP-TR-532
oral/mouse lowest published toxic dose: 1960 mg/kg/28D- continuousKidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other
TOXID9 44,365,2005
oral/mouse lowest published toxic dose: 1960 mg/kg/28D- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
TOXID9 66,62,2002
oral/mouse : 252 mg/kg/4W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTPTR* NTP-TR-532
oral/mouse lowest published toxic dose: 2548 mg/kg/0.5Y- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes
TOXID9 60,152,2001
oral/rabbit lowest published toxic dose: 59.5 mg/kg/24D- continuousBehavioral: Fluid intakeTOXID9 60,216,2001
oral/rabbit lowest published toxic dose: 1783.2 mg/kg/24D- continuousBehavioral: Food intake (animal)TOXID9 60,216,2001
oral/rat lowest published toxic dose: 105 mg/kg/21D- continuousBehavioral: Food intake (animal)

Behavioral: Fluid intake
TOXID9 60,216,2001
oral/rat : 8760 mg/kg/730D- intermittentLiver: Other changesNTPTR* NTP-TR-532
oral/rat lowest published toxic dose: 6000 mg/kg/12W- intermittentGastrointestinal: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TOLED5 223,162,2013
oral/rat lowest published toxic dose: 1225 mg/kg/28D- continuousLiver: Other changesTOXID9 66,62,2002
oral/rat lowest published toxic dose: 2.84 gm/kg/104W- continuousLiver: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
IJTOFN 21,219,2002
oral/rat lowest published toxic dose: 26.43 gm/kg/104W- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in kidney weight
IJTOFN 21,219,2002
oral/rat lowest published toxic dose: 375 mg/kg/5D- intermittentEndocrine: Change in LH

Endocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOSCF2 77,101,2004
oral/rat lowest published toxic dose: 1000 mg/kg/28D- intermittentKidney, Ureter, and Bladder: Other changes in urine compositionTOXID9 78,91,2004
oral/rat lowest published toxic dose: 2000 mg/kg/28D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Other changes
TOXID9 78,91,2004
oral/rat lowest published toxic dose: 1400 mg/kg/28D- intermittentKidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other
TOXID9 44,365,2005
oral/rat lowest published toxic dose: 750 mg/kg/5D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TXCYAC 94,3,1994
oral/rat lowest published toxic dose: 5670 mg/kg/4W- continuousLiver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTSCDR 17,119,1992
oral/rat lowest published toxic dose: 19500 mg/kg/13W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-321,1987
oral/rat lowest published toxic dose: 9828 mg/kg/9W- intermittentBlood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
GISAAA 50(4),80,1985
oral/rat lowest published toxic dose: 20075 mg/kg/2Y- continuousLiver: Fatty liver degeneration

Liver: Other changes

Liver: Changes in liver weight
JTSCDR 17,51,1992
oral/rat lowest published toxic dose: 742 mg/kg/14D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Behavioral: Food intake (animal)
NTIS** PB97-111728
oral/rat lowest published toxic dose: 1232 mg/kg/14D- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymesNTIS** PB97-111728
oral/rat lowest published toxic dose: 742 mg/kg/14D- continuousLiver: Other changesNTIS** PB97-111728
oral/rat lowest published toxic dose: 2904.6 mg/kg/118D- continuousBehavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Dehydration
IJTOFN 21,115,2002
oral/rat lowest published toxic dose: 5366.9 mg/kg/118D- continuousKidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in adrenal weight

Skin and Appendages: Other: Hair
IJTOFN 21,115,2002
oral/rat lowest published toxic dose: 3127 mg/kg/106D- continuousBehavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
IJTOFN 21,115,2002
oral/rat lowest published toxic dose: 200 mg/kg/4D- intermittentKidney, Ureter, and Bladder: Other changes in urine compositionARTODN 78,410,2004
oral/rat lowest published toxic dose: 2000 mg/kg/4W- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Other changes
ARTODN 78,410,2004
oral/rat lowest published toxic dose: 980 mg/kg/28D- continuousKidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other
TOXID9 44,365,2005
oral/rat lowest published toxic dose: 375 mg/kg/5D- intermittentEndocrine: Change in LH

Endocrine: Estrogenic

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOXID9 66,374,2002
oral/rat lowest published toxic dose: 1000 mg/kg/5D- intermittentEndocrine: Change in LH

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOXID9 66,374,2002
oral/rat lowest published toxic dose: 742 mg/kg/14D- intermittentBehavioral: Food intake (animal)

Behavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* RDGT94017
oral/rat lowest published toxic dose: 1232 mg/kg/14D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymesNTPTR* RDGT94017
oral/rat lowest published toxic dose: 742 mg/kg/14D- intermittentLiver: Other changesNTPTR* RDGT94017
oral/rat lowest published toxic dose: 1232 mg/kg/14D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
NTPTR* RDGT94017
oral/rat : 798 mg/kg/3W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTPTR* NTP-TR-532
oral/rat : 420 mg/kg/3W- intermittentKidney, Ureter, and Bladder: Changes in kidney weightNTPTR* NTP-TR-532
oral/rat : 126 mg/kg/3W- intermittentBehavioral: Fluid intakeNTPTR* NTP-TR-532

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 52,179,1991
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 71,1295,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 52,179,1991
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,1295,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 71,1295,1999
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWMUTAEX 14,5,1999
TOXICOLOGY REVIEWTXCYAC 198,239,2004
TOXICOLOGY REVIEWENTOX* -,546,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWBCLPT* 96,131,2005
TOXICOLOGY REVIEWMUREAV 636,242,2007
TOXICOLOGY REVIEWMUREAV 659,248,2008
TOXICOLOGY REVIEWMUREAV 659,202,2008
TOXICOLOGY REVIEWMUREAV 608,157,2006
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWTXAPA9 254,100,2011
TOXICOLOGY REVIEWMUREAV 769,34,2014
TOXICOLOGY REVIEWMUREAV 802,1,2016

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-JAPAN2B carc, MAY2012

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X5772; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 1; Total Number of Employees Exposed 3266; Total Number of Female Employees Exposed 502

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/90/167461/AS)
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:mouse,rat
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
NTP Carcinogenesis studies; on test (prechronic studies), October 2000
NTP Carcinogenesis studies; on test (two year studies), October 2000
On EPA IRIS database
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