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Registry of Toxic Effects of Chemical Substances (RTECS)

Maleic acid

RTECS #

OM9625000

CAS #

110-16-7

Updated

April 2015

Molecular Weight

116.08

Molecular Formula

C4H4O4

Synonyms

1,2-Ethylenedicarboxylic acid, (Z)
Butenedioic acid, (Z)-
cis-1,2-Ethylenedicarboxylic acid
cis-Butenedioic acid
Kyselina maleinova (Czech)
Maleinic acid
Malenic acid
Toxilic acid

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 1%/2M severeAJOPAA 33,387,1950

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA inhibitionfibroblast/human20 mmol/LMUREAV 183,89,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 10 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
In Vitro/Human, melanoma Inhibitor Concentration (50 percent kill): 967 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.FCTOD7 50,2084,2012
In Vitro/Human, skin Inhibitor Concentration (20 percent kill): 464.3 mg/L/21HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,314,2013
In Vitro/Human, skin Inhibitor Concentration Low: 464.3 mg/L/4HIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,314,2013
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 3.83 mmol/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 27,1357,2013
In Vitro/paaInhibitor Concentration Low: 1.04 mmol/L/44HIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,1416,2013
oral/mouse lethal dose (50 percent kill): 2400 mg/kgTumorigenic: Active as anti-cancer agentBIJOAK 34,1196,1940

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
skin/mouse lowest published toxic dose: 600 mg/kg/3D- intermittentBlood: Other changesFCTOD7 46,1896,2008

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84505; Number of Industries 36; Total Number of Facilities 2076; Number of Occupations 45; Total Number of Employees Exposed 30064; Total Number of Female Employees Exposed 11590
National Occupational Hazard Survey 1974Hazard Code 84505; Number of Industries 22; Total Number of Facilities 1840; Number of Occupations 27; Total Number of Employees Exposed 17036

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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