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Registry of Toxic Effects of Chemical Substances (RTECS)

Lactic acid

RTECS #

OD2800000

CAS #

50-21-5

Updated

October 2017

Molecular Weight

90.09

Molecular Formula

C3H6O3

Synonyms

1-Hydroxyethanecarboxylic acid
2-Hydroxypropanoic acid
2-Hydroxypropionic acid
alpha-Hydroxypropionic acid
DL-Lactic acid
Ethylidenelactic acid
Kyselina 2-hydroxypropanova (Czech)
Kyselina mlecna (Czech)
Milchsaure (German)
Milk acid
Ordinary lactic acid
Propanoic acid, 2-hydroxy-
Propel
Propionic acid, 2-hydroxy-
Racemic lactic acid
SY-83

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 750 µg severeAJOPAA 29,1363,1946
eye /rabbit 20%HPV276 -,-,2002
skin /human 10%/48HBJDEAZ 17,294,1987
skin /rabbit 88% severeHPV276 -,-,2002
skin /rabbit 5 mg/24H severe85JCAE -,656,1986
skin /rabbit 100 mg/24H moderateIJTOFN 17(Suppl 1),71,1998

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster10 mmol/LMUREAV 240,195,1990
mutation in microorganisms/Escherichia coli210 ppm/3H (-enzymatic activation step)AMNTA4 85,119,1951

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 5700 mg/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Musculoskeletal system
RCOCB8 77,95,1992

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, leukemia cells Inhibitor Concentration (5 percent kill): 454 mg/L/30MIn Vitro Toxicity Studies: Cell countingTIVIEQ 27,857,2013
In Vitro/Human, leukemia cells Inhibitor Concentration (25 percent kill): 2800 mg/L/24HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.TIVIEQ 26,1150,2012
In Vitro/Human, monocyte Inhibitor Concentration Low: 1300 µmol/L/24HBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationTXAPA9 256,35,2011
In Vitro/Human, skin Inhibitor Concentration (50 percent kill): >2000 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXAPA9 245,281,2010
In Vitro/Human, skin Inhibitor Concentration (20 percent kill): >1000 mg/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,1135,2013
In Vitro/Human, skin Inhibitor Concentration Low: 3.25 pph/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,2175,2013
In Vitro/Human, skin Inhibitor Concentration (50 percent kill): 2.87 pph/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,2175,2013
In Vitro/Human, skin Inhibitor Concentration (20 percent kill): >8300 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 28,13,2014
In Vitro/Human, skin Inhibitor Concentration Low: 0.08 mL/well/1HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 28,616,2014
In Vitro/Human, skin Inhibitor Concentration Low: 0.01 pph/6HIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,2213,2013
In Vitro/Human, skin Inhibitor Concentration Low: 50 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXAPA9 283,147,2015
In Vitro/Human, skin Inhibitor Concentration (20 percent kill): 3.6 mg/L/21HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,314,2013
In Vitro/jdaInhibitor Concentration (50 percent kill): 3485 mg/L/1HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TOLED5 212,198,2012
In Vitro/mraInhibitor Concentration (25 percent kill): 705.9 mg/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TOLED5 216,65,2013
In Vitro/mraInhibitor Concentration Low: 7.059 mg/L/24HBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationTOLED5 216,65,2013
In Vitro/Rabbit, ocular Inhibitor Concentration Low: 5 pph/5MIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 25,1425,2011
inhalation/rat lethal concentration (50 percent kill): >7940 mg/m3/4HHPV276 -,-,2002
oral/guinea pig lethal dose (50 percent kill): 1810 mg/kgJIHTAB 23,259,1941
oral/mouse lethal dose (50 percent kill): 4875 mg/kgFAONAU 40,144,1967
oral/quail lethal dose (50 percent kill): >2250 mg/kgFMCHA2 -,C252,1991
oral/rabbit lowest published lethal dose: 5 gm/kgIECHAD 15,628,1923
oral/rat lethal dose (50 percent kill): 3543 mg/kgHPV276 -,-,2002
rectal/rabbit lowest published lethal dose: 600 mg/kgCRSBAW 83,136,1920
skin/rabbit lethal dose (50 percent kill): >2 gm/kgFMCHA2 -,C252,1991
skin/rabbit lethal dose (50 percent kill): >2000 mg/kgSkin: After topical application: Primary irritationHPV276 -,-,2002

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
skin/rat lowest published toxic dose: 57590 mg/kg/13W- intermittentBrain and Coverings: Changes in brain weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Other changes
IJTOFN 17(Suppl 1),71,1998
skin/rat lowest published toxic dose: 57590 mg/kg/13W- intermittentBrain and Coverings: Changes in brain weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Skin: After topical application: Primary irritation
HPV276 -,-,2002

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 539,77,2003
TOXICOLOGY REVIEWJEADV* 13,14,1999
TOXICOLOGY REVIEWTOPADD 33,517,2005

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESActive registrationRBREV* -,378,1998

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 80595; Number of Industries 39; Total Number of Facilities 10134; Number of Occupations 58; Total Number of Employees Exposed 107962; Total Number of Female Employees Exposed 63436
National Occupational Hazard Survey 1974Hazard Code 80595; Number of Industries 56; Total Number of Facilities 10707; Number of Occupations 50; Total Number of Employees Exposed 68982

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; selected, October 2000
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