Hypochlorous acid, sodium salt

RTECS #

NH3486300

CAS #

7681-52-9; 8007-59-8
See: NMAM or OSHA Methods

Updated

October 2017

Molecular Weight

74.44

Molecular Formula

ClO·Na

Synonyms

Antiformin
B-K liquid
Carrel-dakin solution
Chloros
Chlorox
Clorox
Dakins solution
Deosan
Hyclorite
Hypochlorite solution containing >7% avaliable chlorine by wt. (UN1791)
Javex
Klorocin
Milton
Neo-cleaner
Neoseptal CL
Parozone
Purin B
Sodium chloride oxide
Sodium hypochlorite
Sodium oxychloride
Surchlor

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	10 mg	moderate	TXAPA9 55,501,1980
eye /rabbit	1.31 mg	mild	JTPAE7 29,308,2001
skin /human	4%/48H		JIDEAE 11,45,1984

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	multiple/non-mammalian species	120 µg/L	MUREAV 319,223,1993
Cytogenetic Analysis	lymphocyte/human	100 ppm/24H	ARMCAH 21,409,1970
Cytogenetic Analysis	lung/hamster	100 mg/L	ATSUDG 4,41,1980
Cytogenetic Analysis	embryo/hamster	1300 µmol/L/24H	MUREAV 603,111,2006
Cytogenetic Analysis	embryo/hamster	65 µmol/L/3H	MUREAV 603,111,2006
DNA Damage	leukocyte/mouse	160 µmol/L/10M	TXCYAC 221,166,2006
DNA Damage	multiple/other fish	1.24 mg/L/3H	MUREAV 557,119,2004
DNA Damage	other cell types/non-mammalian species	10 mg/L/1H	MUREAV 537,81,2003
DNA Damage	/Escherichia coli	420 µmol/L	AIPAAV 114,595,1968
DNA inhibition	fibroblast/human	0.0005 pph	CBINA8 139,265,2002
DNA repair	/Escherichia coli	20 µg/disc	MUREAV 41,61,1976
micronucleus test	multiple/other fish	0.55 mg/L/20D-continuous	MUREAV 557,119,2004
micronucleus test	multiple/non-mammalian species	200 ppb	MUTAEX 4,170,1989
micronucleus test	multiple/other fish	1.24 mg/L/20D-continuous	MUREAV 729,81,2012
mutation in microorganisms	/Salmonella typhimurium	1 mg/plate (-enzymatic activation step)	AMONDS 3,253,1980
phage inhibition capacity	/Escherichia coli	103 µg/well	MUREAV 260,349,1991
sister chromatid exchange	embryo/human	149 mg/L	SNSHBT (20),574,1980

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, liver tumor	Inhibitor Concentration (50 percent kill): 5.4 mmol/L/24H	In Vitro Toxicity Studies: Cell protein synthesis	TIVIEQ 3,189,1989
In Vitro/Human, lung tumor	Inhibitor Concentration Low: 400 µmol/L/24H	In Vitro Toxicity Studies: Cell counting In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TXCYAC 270,112,2010
In Vitro/Human, lung tumor	Inhibitor Concentration (25 percent kill): 564.9 µmol/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TXCYAC 270,112,2010
In Vitro/Human, lung tumor	Inhibitor Concentration (25 percent kill): 496.1 µmol/L/24H	In Vitro Toxicity Studies: Cell counting	TXCYAC 270,112,2010
In Vitro/Human, lung tumor	Inhibitor Concentration Low: 500 µmol/L/24H	In Vitro Toxicity Studies: Apoptosis in vitro Biochemical: Metabolism (intermediary): Effect on mitochondrial function	TXCYAC 270,112,2010
In Vitro/Human, lung tumor	Inhibitor Concentration Low: 500 µmol/L/6H	Biochemical: Metabolism (intermediary): Effect on mitochondrial function	TXCYAC 270,112,2010
In Vitro/Human, lung tumor	Inhibitor Concentration Low: 100 µmol/L/24H	In Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc.	TXCYAC 270,112,2010
In Vitro/Human, lung tumor	Inhibitor Concentration Low: 250 µmol/L/1H	In Vitro Toxicity Studies: Other assays	TXCYAC 270,112,2010
In Vitro/jzx	Inhibitor Concentration (50 percent kill): 1601.40 mg/L/48H	In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.	TIVIEQ 25,1989,2011
intraperitoneal/rat	lowest published toxic dose: 65.12 µg/kg	Lung, Thorax, or Respiration: Respiratory depression Skin: After topical application: Cutaneous sensitization (experimental) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases	JJATDK 20,431,2000
intravenous/man	lowest published toxic dose: 45 mg/kg	Lung, Thorax, or Respiration: Other changes Gastrointestinal: Nausea or vomiting	AEMED3 21,1394,1992
oral/mouse	lethal dose (50 percent kill): 5800 mg/kg	Behavioral: Change in motor activity (specific assay) Gastrointestinal: Other changes	SKEZAP 27,553,1986
oral/woman	lowest published toxic dose: 1 gm/kg	Behavioral: Somnolence (general depressed activity) Vascular: BP lowering not characterized in autonomic section Skin: After topical application: Corrosive	HUTODJ 7,37,1988
Tank with water/other fish	Inhibitor Concentration Low: 1.24 mg/L/10D	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes	MUREAV 729,81,2012

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/rat	lowest published toxic dose: 47.96 mg/kg/11D- intermittent	Blood: Tumors Immunological Including Allergic: Autoimmune (multiple organ involvement)	JJATDK 20,431,2000
intraperitoneal/rat	lowest published toxic dose: 26.05 mg/kg/7D- intermittent	Blood: Tumors Immunological Including Allergic: Autoimmune (multiple organ involvement)	JJATDK 20,431,2000
intraperitoneal/rat	lowest published toxic dose: 26.05 mg/kg/9D- intermittent	Blood: Tumors Immunological Including Allergic: Autoimmune (multiple organ involvement)	JJATDK 20,431,2000
oral/rat	lowest published toxic dose: 140 mg/kg/9W- continuous	Endocrine: Changes in spleen weight Immunological Including Allergic: Decrease in cellular immune response Biochemical: Metabolism (intermediary): Lipids including transport	TXCYAC 44,257,1987

Reviews

Organization	Standard	Reference
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Inadequate Evidence	IMEMDT 52,159,1991
International Agency for Research on Cancer (IARC)	Cancer Review:Human No Available Data	IMEMDT 52,159,1991
International Agency for Research on Cancer (IARC)	Cancer Review:Group 3	IMEMDT 52,159,1991
TOXICOLOGY REVIEW		MUREAV 564,179,2004
TOXICOLOGY REVIEW		CHHSA* 8,24,2001
TOXICOLOGY REVIEW		ENTOX* -,317,2005
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		HUTOX* -,671,1996
TOXICOLOGY REVIEW		HUTOX* -,683,1996
TOXICOLOGY REVIEW		MUREAV 681,80,2009
TOXICOLOGY REVIEW		MUREAV 723,108,2011
TOXICOLOGY REVIEW		MUREAV 751,15,2012
TOXICOLOGY REVIEW		MUREAV 802,1,2016

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	RED Completed	RBREV* -,148,1998

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Occupational Exposure Survey 1983	Hazard Code 69090; Number of Industries 168; Total Number of Facilities 23747; Number of Occupations 132; Total Number of Employees Exposed 562423; Total Number of Female Employees Exposed 265913
National Occupational Hazard Survey 1974	Hazard Code 69090; Number of Industries 202; Total Number of Facilities 70228; Number of Occupations 111; Total Number of Employees Exposed 556864

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro cytogenetics-human lymphocyte
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro cytogenetics-nonhuman
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health