Hypochlorous acid, sodium salt
RTECS #
NH3486300
CAS #
Updated
October 2017
Molecular Weight
74.44
Molecular Formula
ClO·Na
Synonyms
Antiformin
B-K liquid
Carrel-dakin solution
Chloros
Chlorox
Clorox
Dakins solution
Deosan
Hyclorite
Hypochlorite solution containing >7% avaliable chlorine by wt. (UN1791)
Javex
Klorocin
Milton
Neo-cleaner
Neoseptal CL
Parozone
Purin B
Sodium chloride oxide
Sodium hypochlorite
Sodium oxychloride
Surchlor
B-K liquid
Carrel-dakin solution
Chloros
Chlorox
Clorox
Dakins solution
Deosan
Hyclorite
Hypochlorite solution containing >7% avaliable chlorine by wt. (UN1791)
Javex
Klorocin
Milton
Neo-cleaner
Neoseptal CL
Parozone
Purin B
Sodium chloride oxide
Sodium hypochlorite
Sodium oxychloride
Surchlor
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
eye /rabbit | 10 mg | moderate | TXAPA9 55,501,1980 |
eye /rabbit | 1.31 mg | mild | JTPAE7 29,308,2001 |
skin /human | 4%/48H | JIDEAE 11,45,1984 |
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
Cytogenetic Analysis | multiple/non-mammalian species | 120 µg/L | MUREAV 319,223,1993 |
Cytogenetic Analysis | lymphocyte/human | 100 ppm/24H | ARMCAH 21,409,1970 |
Cytogenetic Analysis | lung/hamster | 100 mg/L | ATSUDG 4,41,1980 |
Cytogenetic Analysis | embryo/hamster | 1300 µmol/L/24H | MUREAV 603,111,2006 |
Cytogenetic Analysis | embryo/hamster | 65 µmol/L/3H | MUREAV 603,111,2006 |
DNA Damage | leukocyte/mouse | 160 µmol/L/10M | TXCYAC 221,166,2006 |
DNA Damage | multiple/other fish | 1.24 mg/L/3H | MUREAV 557,119,2004 |
DNA Damage | other cell types/non-mammalian species | 10 mg/L/1H | MUREAV 537,81,2003 |
DNA Damage | /Escherichia coli | 420 µmol/L | AIPAAV 114,595,1968 |
DNA inhibition | fibroblast/human | 0.0005 pph | CBINA8 139,265,2002 |
DNA repair | /Escherichia coli | 20 µg/disc | MUREAV 41,61,1976 |
micronucleus test | multiple/other fish | 0.55 mg/L/20D-continuous | MUREAV 557,119,2004 |
micronucleus test | multiple/non-mammalian species | 200 ppb | MUTAEX 4,170,1989 |
micronucleus test | multiple/other fish | 1.24 mg/L/20D-continuous | MUREAV 729,81,2012 |
mutation in microorganisms | /Salmonella typhimurium | 1 mg/plate (-enzymatic activation step) | AMONDS 3,253,1980 |
phage inhibition capacity | /Escherichia coli | 103 µg/well | MUREAV 260,349,1991 |
sister chromatid exchange | embryo/human | 149 mg/L | SNSHBT (20),574,1980 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
In Vitro/Human, liver tumor | Inhibitor Concentration (50 percent kill): 5.4 mmol/L/24H | In Vitro Toxicity Studies: Cell protein synthesis | TIVIEQ 3,189,1989 |
In Vitro/Human, lung tumor | Inhibitor Concentration Low: 400 µmol/L/24H | In Vitro Toxicity Studies: Cell counting In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TXCYAC 270,112,2010 |
In Vitro/Human, lung tumor | Inhibitor Concentration (25 percent kill): 564.9 µmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TXCYAC 270,112,2010 |
In Vitro/Human, lung tumor | Inhibitor Concentration (25 percent kill): 496.1 µmol/L/24H | In Vitro Toxicity Studies: Cell counting | TXCYAC 270,112,2010 |
In Vitro/Human, lung tumor | Inhibitor Concentration Low: 500 µmol/L/24H | In Vitro Toxicity Studies: Apoptosis in vitro Biochemical: Metabolism (intermediary): Effect on mitochondrial function | TXCYAC 270,112,2010 |
In Vitro/Human, lung tumor | Inhibitor Concentration Low: 500 µmol/L/6H | Biochemical: Metabolism (intermediary): Effect on mitochondrial function | TXCYAC 270,112,2010 |
In Vitro/Human, lung tumor | Inhibitor Concentration Low: 100 µmol/L/24H | In Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc. | TXCYAC 270,112,2010 |
In Vitro/Human, lung tumor | Inhibitor Concentration Low: 250 µmol/L/1H | In Vitro Toxicity Studies: Other assays | TXCYAC 270,112,2010 |
In Vitro/jzx | Inhibitor Concentration (50 percent kill): 1601.40 mg/L/48H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 25,1989,2011 |
intraperitoneal/rat | lowest published toxic dose: 65.12 µg/kg | Lung, Thorax, or Respiration: Respiratory depression Skin: After topical application: Cutaneous sensitization (experimental) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | JJATDK 20,431,2000 |
intravenous/man | lowest published toxic dose: 45 mg/kg | Lung, Thorax, or Respiration: Other changes Gastrointestinal: Nausea or vomiting | AEMED3 21,1394,1992 |
oral/mouse | lethal dose (50 percent kill): 5800 mg/kg | Behavioral: Change in motor activity (specific assay) Gastrointestinal: Other changes | SKEZAP 27,553,1986 |
oral/woman | lowest published toxic dose: 1 gm/kg | Behavioral: Somnolence (general depressed activity) Vascular: BP lowering not characterized in autonomic section Skin: After topical application: Corrosive | HUTODJ 7,37,1988 |
Tank with water/other fish | Inhibitor Concentration Low: 1.24 mg/L/10D | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | MUREAV 729,81,2012 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
intraperitoneal/rat | lowest published toxic dose: 47.96 mg/kg/11D- intermittent | Blood: Tumors Immunological Including Allergic: Autoimmune (multiple organ involvement) | JJATDK 20,431,2000 |
intraperitoneal/rat | lowest published toxic dose: 26.05 mg/kg/7D- intermittent | Blood: Tumors Immunological Including Allergic: Autoimmune (multiple organ involvement) | JJATDK 20,431,2000 |
intraperitoneal/rat | lowest published toxic dose: 26.05 mg/kg/9D- intermittent | Blood: Tumors Immunological Including Allergic: Autoimmune (multiple organ involvement) | JJATDK 20,431,2000 |
oral/rat | lowest published toxic dose: 140 mg/kg/9W- continuous | Endocrine: Changes in spleen weight Immunological Including Allergic: Decrease in cellular immune response Biochemical: Metabolism (intermediary): Lipids including transport | TXCYAC 44,257,1987 |
Reviews
Organization | Standard | Reference |
---|---|---|
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Inadequate Evidence | IMEMDT 52,159,1991 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human No Available Data | IMEMDT 52,159,1991 |
International Agency for Research on Cancer (IARC) | Cancer Review:Group 3 | IMEMDT 52,159,1991 |
TOXICOLOGY REVIEW | MUREAV 564,179,2004 | |
TOXICOLOGY REVIEW | CHHSA* 8,24,2001 | |
TOXICOLOGY REVIEW | ENTOX* -,317,2005 | |
TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
TOXICOLOGY REVIEW | HUTOX* -,671,1996 | |
TOXICOLOGY REVIEW | HUTOX* -,683,1996 | |
TOXICOLOGY REVIEW | MUREAV 681,80,2009 | |
TOXICOLOGY REVIEW | MUREAV 723,108,2011 | |
TOXICOLOGY REVIEW | MUREAV 751,15,2012 | |
TOXICOLOGY REVIEW | MUREAV 802,1,2016 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | RED Completed | RBREV* -,148,1998 |
NIOSH Documentation and Surveillance
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health