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Registry of Toxic Effects of Chemical Substances (RTECS)

Hydrazine, 1,2-dimethyl-

RTECS #

MV2625000

CAS #

540-73-8

Updated

April 2017

Molecular Weight

60.12

Molecular Formula

C2H8N2

Synonyms

1,2-Dimethylhydrazin (German)
1,2-Dimethylhydrazine
1,2-Dimethyl-hydrazine
Hydrazomethane
N,N'-Dimethylhydrazine
RCRA waste number U099
SDMH
sym-Dimethylhydrazine
Symetryczna dwumetylohydrazyna (Polish)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisoral/mouse12 mg/kgJJIND8 71,133,1983
Cytogenetic Analysissubcutaneous/mouse15 mg/kgVOONC* 43,623,1997
Cytogenetic Analysisintraperitoneal/rat120 mg/kg/6WEMMUEG 44,113,2004
Cytogenetic Analysissubcutaneous/rat160 mg/kg/4D/2W- intermittentEMMUEG 45,8,2005
Cytogenetic Analysissubcutaneous/rat160 mg/kg/4WMUREAV 759,37,2013
DNA adductlung/hamster2 mmol/LMUREAV 173,157,1986
DNA adductlung/human1290 µmol/LCNREA8 37,2309,1977
DNA adductfibroblast/human20 µmolNTIS** AD-A092-249
DNA adductother cell types/rat100 µmol/LTCMUD8 1,3,1980
DNA Damageintraperitoneal/rat10200 µg/kgCNREA8 41,3967,1981
DNA Damageliver/rat300 µmol/LSinJF# 26OCT1982
DNA Damageparenteral/rat210 mg/kgPAACA3 24,82,1983
DNA Damageoral/rat20 mg/kgENMUDM 4,667,1982
DNA Damageoral/mouse5700 µg/kgMUREAV 54,39,1978
DNA Damagesubcutaneous/mouse56200 µg/kgMUREAV 54,39,1978
DNA Damageintraperitoneal/rat120 mg/kg/6WEMMUEG 44,113,2004
DNA Damagesubcutaneous/rat160 mg/kg/2W- intermittentTCMUD8 22,183,2001
DNA Damagesubcutaneous/rat25 mg/kgMUREAV 759,37,2013
DNA Damagesubcutaneous/rat180 mg/kg/6W- intermittentBPBLEO 30,569,2007
DNA Damageintraperitoneal/mouse20 mg/kgMUTAEX 16,39,2001
DNA inhibitionoral/mouse200 mg/kgMUREAV 46,305,1977
DNA inhibitionintraperitoneal/mouse60 mg/kgJTEHD6 13,117,1984
DNA repair/Bacillus subtilis6 mg/discMUREAV 97,1,1982
DNA repair/Escherichia coli250 µg/discJJIND8 62,873,1979
gene conversion and mitotic recombination/Saccharomyes cerevisiae200 mmol/LNATWAY 54,251,1967
host-mediated assayEscherichia coli/mouse50 µmol/kgMUREAV 148,1,1985
host-mediated assayintraperitoneal/mouse30 mg/kgMUREAV 564,1,2004
host-mediated assayintraperitoneal/mouse100 mg/kg/10W- intermittentMUREAV 564,1,2004
micronucleus testoral/rat3320 µg/kgMUREAV 368,115,1996
micronucleus testoral/mouse720 µg/kgMUREAV 368,115,1996
micronucleus testintraperitoneal/mouse10 mg/kgEMMUEG 17,155,1991
morphological transformintraperitoneal/rat500 µmol/kgCALEDQ 20,207,1983
morphological transformoral/rat500 µmol/kgCALEDQ 20,207,1983
morphological transformfibroblast/human230 µmol/LCALEDQ 29,265,1985
morphological transformembryo/hamster100 µg/LIJCNAW 19,642,1977
morphological transformoral/mouse30 mg/kg/8D- intermittentCNREA8 49,1236,1989
mutation in mammalian somatic cellslung/hamster100 µmol/LPAACA3 24,93,1983
mutation in mammalian somatic cellssubcutaneous/rat100 mg/kg/5W- intermittentCRNGDP 22,315,2000
mutation in mammalian somatic cellslymphocyte/mouse5 mmol/L/24HNTIS** AD-A075-605
mutation in microorganisms/Salmonella typhimurium25 µg/plate (+enzymatic activation step)CALEDQ 12,287,1981
mutation in microorganisms/Bacillus subtilis25 µg/plate (-enzymatic activation step)CALEDQ 12,287,1981
mutation in microorganismslymphocyte/mouse10 µL/L (+enzymatic activation step)NTIS** AD-A041-973
other mutation test systemssubcutaneous/mouse560 mg/kg/28W- intermittentCNREA8 43,2545,1983
phage inhibition capacity/Escherichia coli9400 mg/LCNREA8 41,532,1981
sister chromatid exchangeovary/hamster130 µmol/LMUREAV 68,351,1979
sister chromatid exchangeintraperitoneal/mouse270 µmol/kgTCMUD8 9,219,1989
sister chromatid exchangeintraperitoneal/mouse20 mg/kgMUTAEX 2,441,1987
sperm morphologysubcutaneous/mouse15 mg/kgVOONC* 43,623,1997
Unscheduled DNA Synthesissubcutaneous/mouse560 mg/kg/28W- intermittentCNREA8 43,2545,1983
Unscheduled DNA Synthesisintraperitoneal/mouse200 mg/kgJTEHD6 13,117,1984
Unscheduled DNA Synthesislung/human100 µL/LNTIS** AD-A041-973

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 100 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)JTEHD6 13,125,1984

Tumorigenic Data and References

Route/OrganismDoseEffectReference
implant/rabbit lowest published toxic dose: 2 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors

Tumorigenic: Tumors at site of application
CNREA8 35,2292,1975
intraperitoneal/mouse lowest published toxic dose: 25 mg/kg/24W- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
TXAPA9 72,313,1984
intraperitoneal/mouse lowest published toxic dose: 360 mg/kg/12W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors

Gastrointestinal: Colon tumors
FCTOD7 50,1405,2012
intraperitoneal/rat lowest published toxic dose: 260 mg/kg/13W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors
CALEDQ 19,1,1983
oral/mouse lowest published toxic dose: 12500 µg/kg/24W- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
TXAPA9 72,313,1984
oral/rat lowest published toxic dose: 160 mg/kg/2W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
CALEDQ 168,23,2001
oral/rat lowest published toxic dose: 120 mg/kg/4W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors

Eye: Other eye effects
AJCNAC 30,176,1977
oral/rat lowest published toxic dose: 1750 mg/kg/2W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Endocrine: Thyroid tumors
CALEDQ 168,23,2001
parenteral/rat lowest published toxic dose: 160 mg/kg/16W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Colon tumors
PAACA3 21,67,1980
rectal/mouse lowest published toxic dose: 360 mg/kg/18W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Colon tumors
FEPRA7 34,827,1975
subcutaneous/hamster lowest published toxic dose: 340 mg/kg/17W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Behavioral: Ataxia

Gastrointestinal: Hypermotility, diarrhea
EXMPA6 27,19,1977
subcutaneous/monkey lowest published toxic dose: 400 mg/kg/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Colon tumors
JJCREP 83,584,1992
subcutaneous/monkey lowest published toxic dose: 608 mg/kg/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Tumorigenic effects: Uterine tumors
JJCREP 83,584,1992
subcutaneous/mouse lowest published toxic dose: 200 mg/kg/10W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Gastrointestinal: Colon tumors
JJIND8 63,1081,1979
subcutaneous/mouse toxic dose: 300 mg/kg/20W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Colon tumors

Reproductive: Tumorigenic effects: Uterine tumors
JNCIAM 52,999,1974
subcutaneous/mouse lowest published toxic dose: 160 mg/kg/20W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Colon tumors

Reproductive: Other reproductive system tumors
VOONC* 43,321,1997
subcutaneous/rat lowest published toxic dose: 160 mg/kg/2W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors
TCMUD8 22,183,2001
subcutaneous/rat lowest published toxic dose: 80 mg/kg/3W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Colon tumors

Liver: Tumors
JTSCDR 27,57,2002
subcutaneous/rat lowest published toxic dose: 300 mg/kg/15W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Colon tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
PHMREP 47,133,2003
subcutaneous/rat lowest published toxic dose: 160 mg/kg/2W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
TXAPA9 194,132,2004
subcutaneous/rat lowest published toxic dose: 80 mg/kg/4W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Colon tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
CALEDQ 202,11,2003
subcutaneous/rat lowest published toxic dose: 260 mg/kg/21D- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Colon tumors

Skin and Appendages: Tumors
FCTOD7 44,271,2006
subcutaneous/rat lowest published toxic dose: 180 mg/kg/6W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Colon tumors
BPBLEO K61
subcutaneous/rat lowest published toxic dose: 360 mg/kg/18W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Colon tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
FCTOD7 48,390,2010
subcutaneous/rat lowest published toxic dose: 300 mg/kg/15W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Colon tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
FCTOD7 47,2594,2009
subcutaneous/rat lowest published toxic dose: 300 mg/kg/15WTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Colon tumors
FCTOD7 49,887,2011
subcutaneous/rat toxic dose: 120 mg/kg/12W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Colon tumors
NASDA6 32,270,1981
subcutaneous/rat toxic dose: 20 mg/kgTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Gastrointestinal: Colon tumors
GANNA2 74,493,1983
subcutaneous/rat toxic dose: 200 mg/kg/10W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Colon tumors

Kidney, Ureter, and Bladder: Kidney tumors
CRNGDP 3,1097,1982
subcutaneous/rat lowest published toxic dose: 60 mg/kg/7D- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Colon tumors
CRNGDP 21,2255,2000
subcutaneous/rat lowest published toxic dose: 100 mg/kg/5W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Colon tumors
CRNGDP 22,315,2000
subcutaneous/rat lowest published toxic dose: 105 mg/kg/5W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Colon tumors
CALEDQ 138,27,1999
subcutaneous/rat lowest published toxic dose: 160 mg/kg/4W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Colon tumors
MUREAV 506-507,129,2002
subcutaneous/rat lowest published toxic dose: 420 mg/kg/20W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
CALEDQ 147,125,1999
subcutaneous/rat toxic dose: 80 mg/kg/4W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Colon tumors
CRNGDP 6,637,1985
subcutaneous/rat toxic dose: 300 mg/kg/11W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Colon tumors
GASTAB 81,475,1981
subcutaneous/rat toxic dose: 42 mg/kg/28W- intermittentTumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors

Gastrointestinal: Tumors
BIMDB3 32,41,1980
subcutaneous/rat toxic dose: 420 mg/kg/28W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Kidney, Ureter, and Bladder: Kidney tumors
CRNGDP 4,1175,1983
subcutaneous/rat toxic dose: 200 mg/kg/20W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors

Gastrointestinal: Colon tumors
DICRAG 23,137,1980
subcutaneous/rat toxic dose: 400 mg/kg/10W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Colon tumors
LANCAO 2,1030,1980
subcutaneous/rat lowest published toxic dose: 105 mg/kg/24W- continuousTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Other changes
CALEDQ 148,215,2000
subcutaneous/rat toxic dose: 160 mg/kg/2WTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Other changes
CALEDQ 154,121,2000
subcutaneous/rat lowest published toxic dose: 90 mg/kg/28W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Eye: Other eye effects

Gastrointestinal: Colon tumors
BIMDB3 32,41,1980
subcutaneous/rat lowest published toxic dose: 80 mg/kg/4W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Colon tumors
CRNGDP 21,173,2000
subcutaneous/rat lowest published toxic dose: 160 mg/kg/2W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Colon tumors
FCTOD7 50,2902,2012

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 280 ppm/4HEye: Other eye effects

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
AMIHAB 12,609,1955
intramuscular/hamster lethal dose (50 percent kill): 95 mg/kgARZNAD 19,1891,1969
intraperitoneal/mouse lethal dose (50 percent kill): 35 mg/kgMEPAAX 24,71,1973
intraperitoneal/rat lethal dose (50 percent kill): 163 mg/kgMEPAAX 24,71,1973
intraperitoneal/rat lowest published toxic dose: 125 mg/kgGastrointestinal: Other changes

Biochemical: Metabolism (intermediary): Other
TXCYAC 312,123,2013
intravenous/Dog lethal dose (50 percent kill): 100 mg/kgMEPAAX 24,71,1973
intravenous/mouse lethal dose (50 percent kill): 29 mg/kgMEPAAX 24,71,1973
intravenous/rat lethal dose (50 percent kill): 176 mg/kgMEPAAX 24,71,1973
oral/mouse lethal dose (50 percent kill): 36 mg/kgMEPAAX 24,71,1973
oral/rat lethal dose (50 percent kill): 100 mg/kgNATWAY 54,285,1967
oral/rat lowest published toxic dose: 10 mg/kgGastrointestinal: Necrotic changesFCTOD7 40,801,2002
oral/rat lowest published toxic dose: 25 mg/kgNutritional and Gross Metabolic: Weight loss or decreased weight gainFCTOD7 40,801,2002
subcutaneous/mouse lowest published toxic dose: 80 mg/kgGastrointestinal: Other changesJJIND8 93,1534,2001
subcutaneous/mouse lethal dose (50 percent kill): 24 mg/kgTOLED5 8,87,1981
subcutaneous/rat lethal dose (50 percent kill): 220 mg/kgXENOBH 3,271,1973
subcutaneous/rat lowest published toxic dose: 40 mg/kgLiver: Tumors

Gastrointestinal: Colon tumors
TXAPA9 227,136,2008

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 136 mg/kg/20W- intermittentGastrointestinal: Colon tumorsCRNGDP 24,527,2003
intraperitoneal/mouse lowest published toxic dose: 360 mg/kg/12W- intermittentGastrointestinal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
FCTOD7 50,1405,2012
intraperitoneal/rat lowest published toxic dose: 120 mg/kg/6W- intermittentGastrointestinal: Colon tumors

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
EMMUEG 44,113,2004
intraperitoneal/rat lowest published toxic dose: 120 mg/kg/6W- intermittentGastrointestinal: Other changesEMMUEG 44,113,2004
subcutaneous/rat : 160 mg/kg/2W- intermittentGastrointestinal: Colon tumorsFCTOD7 44,877,2006
subcutaneous/rat lowest published toxic dose: 80 mg/kg/4W- intermittentGastrointestinal: Other changes

Gastrointestinal: Colon tumors

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXAPA9 214,290,2006
subcutaneous/rat lowest published toxic dose: 180 mg/kg/6W- intermittentGastrointestinal: Colon tumorsBPBLEO 30,569,2007
subcutaneous/rat lowest published toxic dose: 60 mg/kg/5D- intermittentGastrointestinal: Other changesCRNGDP 24,491,2003
subcutaneous/rat lowest published toxic dose: 300 mg/kg/15W- intermittentGastrointestinal: Tumors

Gastrointestinal: Colon tumors

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 47,309,2009
subcutaneous/rat lowest published toxic dose: 300 mg/kg/15W- intermittentGastrointestinal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
FCTOD7 49,887,2011
subcutaneous/rat lowest published toxic dose: 480 mg/kg/16W- intermittentGastrointestinal: Colon tumors

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOLED5 171,10,2007
subcutaneous/rat lowest published toxic dose: 200 mg/kg/10D- intermittentGastrointestinal: Other changesFCTOD7 64,200,2014
subcutaneous/rat lowest published toxic dose: 160 mg/kg/2W- intermittentGastrointestinal: Other changesFCTOD7 50,3719,2012
subcutaneous/rat lowest published toxic dose: 300 mg/kg/15W- intermittentGastrointestinal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport
PHMREP 47,133,2003

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 4,145,1974
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 71,947,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 4,145,1974
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,947,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 2AIMEMDT 71,947,1999
TOXICOLOGY REVIEWMUREAV 39,111,1977
TOXICOLOGY REVIEWMUTAEX 15,431,2000
TOXICOLOGY REVIEWMUREAV 588,88,2005
TOXICOLOGY REVIEWEMMUEG 44,26,2004
TOXICOLOGY REVIEWFCTOD7 44,1699,2006
TOXICOLOGY REVIEWMUREAV 627,10,2007
TOXICOLOGY REVIEWBCLPT* 96,131,2005
TOXICOLOGY REVIEWJTPAE7 19,1,2006
TOXICOLOGY REVIEWMUREAV 658,68,2008
TOXICOLOGY REVIEWMUREAV 566,191,2004
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWMUREAV 705,40,2010
TOXICOLOGY REVIEWMUREAV 678,76,2009
TOXICOLOGY REVIEWMUTAEX 26,223,2011
TOXICOLOGY REVIEWEMMUEG 49,9,2008
TOXICOLOGY REVIEWMUREAV 591,276,2005
TOXICOLOGY REVIEWMUREAV 723,108,2011
TOXICOLOGY REVIEWMUREAV 783,19,2015
TOXICOLOGY REVIEWMUREAV 733,61,2012
TOXICOLOGY REVIEWMUREAV 783,66,2015

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-HUNGARYceiling concentration 1.2 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit-SWEDENGroup B Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.5 ppm (1.2 mg/m3), carc 2, skin, sen, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HYDRAZINES-airCarcinogen ceiling concentration 0.03 ppm/120MNIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/98/101025/AS)
EPA GENETOX PROGRAM 1988, Inconclusive: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: SHE-clonal assay; Mammalian micronucleus
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9
On EPA IRIS database
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