1-Hexanol, 2-ethyl-

RTECS #
MP0350000
CAS #
104-76-7
See: NMAM or OSHA Methods
Updated
December 2018
Molecular Weight
130.26
Molecular Formula
C8H18O
Synonyms
2-Aethylhexanol (German)
2-Ethyl-1-hexanol
2-Ethylhexanol
2-Ethylhexyl alcohol
Ethylhexanol

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 20 mg severeAJOPAA 29,1363,1946
eye /rabbit 20 mg/24H moderate85JCAE -,200,1986
eye /rabbit 20 µg moderateHPV106 -,-,2002
skin /rabbit 0.5 mL severeHPV106 -,-,2002
skin /rabbit 415 mg open irritation test mildUCDS** 11/11/1969
skin /rabbit 500 mg/24H moderateFCTXAV 17,775,1979

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium500 µmol/L (+enzymatic activation step)EVHPAZ 45,111,1982

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 1628 mg/kg (12D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system
TJADAB 35,41,1987
oral/mouse 12 gm/kg (7-14D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** PB85-220143
oral/mouse 12200 mg/kg (6-13D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TCMUD8 7,29,1987
oral/rat 6500 mg/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
HPV106 -,-,2002
oral/rat 13000 mg/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
HPV106 -,-,2002
oral/mouse 12200 mg/kg (7-14D pregnant)Reproductive: Other effects on female

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
HPV106 -,-,2002

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 270000 mg/kg/72W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HPV341 -,-,2001

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, neuroblastoma Inhibitor Concentration (50 percent kill): 15.1 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TOXRE* 2,729,2015
In Vitro/Human, skin Inhibitor Concentration Low: 60 µL/well/60MIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,1476,2013
In Vitro/Rabbit, ocular Inhibitor Concentration Low: 5 pph/5MIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 25,1425,2011
In Vitro/Rat, neurons Inhibitor Concentration Low: 0.5 mmol/L/24HIn Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)TOXRE* 2,729,2015
inhalation/guinea pig lowest published toxic concentration: 227 ppm/6HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
HPV106 -,-,2002
inhalation/man lowest published toxic concentration: 10 ppm/4HOlfaction: Other olfaction effects

Eye: Conjunctiva irritation

Behavioral: Excitement
NRTXDN 28,347,2007
inhalation/mouse lowest published toxic concentration: 227 ppm/6HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
HPV106 -,-,2002
inhalation/mouse lowest published toxic concentration: 270 mg/m3Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Liver: Other changes
VCVGK* -,115,1984
inhalation/mouse lowest published toxic concentration: 44 ppmLung, Thorax, or Respiration: Respiratory depressionHPV106 -,-,2002
inhalation/rat lowest published toxic concentration: 210 mg/m3Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Liver: Other changes
VCVGK* -,115,1984
inhalation/rat Lethal concentration: >2000 ppm/6HKODAK* 21MAY1971
inhalation/rat lowest published toxic concentration: 227 ppm/6HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
HPV106 -,-,2002
inhalation/rat lowest published toxic concentration: 0.85 mg/m3/4HFEREAC 70,51623,2005
intraperitoneal/mouse lethal dose (50 percent kill): 726 mg/kgHPV106 -,-,2002
intraperitoneal/rat lethal dose (50 percent kill): 650 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
HPV106 -,-,2002
intraperitoneal/rat lethal dose (50 percent kill): 500 mg/kgHYDRDA 3,201,1978
oral/guinea pig lethal dose (50 percent kill): 1860 mg/kgZHYGAM 20,575,1974
oral/guinea pig lethal dose (50 percent kill): 600 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen
HPV106 -,-,2002
oral/human lowest published lethal dose: 428.6 mg/kgVCVGK* -,116,1984
oral/mouse lethal dose (50 percent kill): 2500 mg/kgHPV106 -,-,2002
oral/rabbit lethal dose (50 percent kill): 1180 mg/kgHPV106 -,-,2002
oral/rat lowest published lethal dose: 1516 mg/kgHPV106 -,-,2002
oral/rat lethal dose (50 percent kill): 3730 mg/kgHPV106 -,-,2002
oral/rat lethal dose (50 percent kill): 3730 mg/kgBrain and Coverings: Recordings from specific areas of CNS

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
AIHAAP 34,493,1973
parenteral/mouse lethal dose (50 percent kill): 1670 mg/kgFCTXAV 17,775,1979
parenteral/rat lethal dose (50 percent kill): 4600 mg/kgFCTXAV 17,775,1979
skin/rabbit lethal dose (50 percent kill): 1970 mg/kgNPIRI* 1,61,1974
skin/rat lethal dose (50 percent kill): >3000 mg/kgHPV106 -,-,2002
subcutaneous/rat lowest published lethal dose: 5.54 gm/kgHPV106 -,-,2002
subcutaneous/rat lethal dose (50 percent kill): 650 mg/kgNPIRI* 1,61,1974

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 250 gm/m3/5D- intermittentImmunological Including Allergic: Decreased immune response

Immunological Including Allergic: Hypersensitivity delayed (multiple organ involvement)
TXAPA9 197,280,2004
inhalation/rat lowest published toxic concentration: 102 mg/m3/4H/137D- intermittentBehavioral: Irritability

Lung, Thorax, or Respiration: Other changes
VCVGK* -,116,1994
inhalation/rat lowest published toxic concentration: 1.5 mg/m3/90D- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,116,1994
oral/mouse lowest published toxic dose: 3247 mg/kg/17D- continuousBehavioral: Food intake (animal)NTIS** #PB91-185900
oral/mouse lowest published toxic dose: 22500 mg/kg/90D- intermittentGastrointestinal: Other changesFEREAC 70,51623,2005
oral/mouse lowest published toxic dose: 9 gm/kg/11D- intermittentGastrointestinal: Other changes

Liver: Changes in liver weight
FAATDF 29,31,1996
oral/mouse lowest published toxic dose: 16250 mg/kg/13W- intermittentLiver: Other changes

Liver: Changes in liver weight
FAATDF 29,31,1996
oral/mouse lowest published toxic dose: 29150 mg/kg/11D- intermittentEndocrine: Differential effect of sex or castration on observed toxicity

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV106 -,-,2002
oral/rat lowest published toxic dose: 16250 mg/kg/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
HPV098 -,-,2004
oral/rat lowest published toxic dose: 24.5 gm/kg/14D- intermittentLiver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
ATSUDG 12,274,1988
oral/rat lowest published toxic dose: 2100 mg/kg/3W- continuousLiver: Other changesVCVGK* -,116,1994
oral/rat lowest published toxic dose: 24000 mg/kg/60D- continuousBrain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,116,1994
oral/rat lowest published toxic dose: 2970 mg/kg/9D- intermittentBehavioral: Change in motor activity (specific assay)

Behavioral: Ataxia

Behavioral: Muscle contraction or spasticity
NTIS** OTS0540989
oral/rat lowest published toxic dose: 9 gm/kg/11D- intermittentGastrointestinal: Ulceration or bleeding from stomach

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
FAATDF 29,31,1996
oral/rat lowest published toxic dose: 16250 mg/kg/13W- intermittentGastrointestinal: Other changes

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
FAATDF 29,31,1996
oral/rat lowest published toxic dose: 14 gm/kg/17D- intermittentLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases
BCSTB5 2,322,1974
oral/rat lowest published toxic dose: 25200 mg/kg/3W- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)TOLED5 10,379,1982
oral/rat lowest published toxic dose: 260 gm/kg/2Y- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTOXID9 13,70,1993
oral/rat lowest published toxic dose: 16250 mg/kg/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
HPV046 -,-,2004
oral/rat lowest published toxic dose: 32500 mg/kg/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV046 -,-,2004
oral/rat lowest published toxic dose: 5500 mg/kg/11D- intermittentGastrointestinal: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
HPV106 -,-,2002
oral/rat lowest published toxic dose: 10780 mg/kg/11D- intermittentLiver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
HPV106 -,-,2002
oral/rat lowest published toxic dose: 25380 mg/kg/90D- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
FEREAC 70,51623,2005
oral/rat lowest published toxic dose: 22500 mg/kg/90D- intermittentLiver: Other changes

Biochemical: Effect on specific coenzyme: CoA
FEREAC 70,51623,2005
skin/rat lowest published toxic dose: 20 mL/kg/16D- intermittentCardiac: Cardiomyopathy including infarction

Liver: Fatty liver degeneration

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
HPV106 -,-,2002
skin/rat lowest published toxic dose: 7506 mg/kg/11D- intermittentEndocrine: Changes in spleen weight

Blood: Changes in other cell count (unspecified)

Skin: After systemic exposure: Dermatitis, other
NTIS** OTS0536344

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 539,77,2003
TOXICOLOGY REVIEWTOLED5 140-141,261,2003
TOXICOLOGY REVIEWREPTED 25,192,2008
TOXICOLOGY REVIEWREPTED 22,291,2006
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWMUREAV 750,141,2012
TOXICOLOGY REVIEWTOLED5 199,203,2010
TOXICOLOGY REVIEWREPTED 58,252,2015
TOXICOLOGY REVIEWFCTOD7 97,S119,2016
TOXICOLOGY REVIEWFCTOD7 97,S147,2016
TOXICOLOGY REVIEWFCTOD7 97,S157,2016

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIAMAK-TMW 50 ppm (270 mg/m3);KZW 100 ppm (540 mg/m3), skin, 2007
Occupational Exposure Limit-GERMANYMAK 10 ppm (54 mg/m3), 2011
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDceiling concentration 20 ppm (110 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 270 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M0262; Number of Industries 97; Total Number of Facilities 11356; Number of Occupations 74; Total Number of Employees Exposed 117564; Total Number of Female Employees Exposed 11656
National Occupational Hazard Survey 1974Hazard Code M0262; Number of Industries 67; Total Number of Facilities 3280; Number of Occupations 62; Total Number of Employees Exposed 45342

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
Page last reviewed: November 16, 2018