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Registry of Toxic Effects of Chemical Substances (RTECS)

1-Hexanol, 2-ethyl-

RTECS #

MP0350000

CAS #

104-76-7

Updated

July 2013

Molecular Weight

130.26

Molecular Formula

C8H18O

Synonyms

2-Aethylhexanol (German)
2-Ethyl-1-hexanol
2-Ethylhexanol
2-Ethylhexyl alcohol
Ethylhexanol

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 20 mg severeAJOPAA 29,1363,1946
eye /rabbit 20 mg/24H moderate85JCAE -,200,1986
eye /rabbit 20 µg moderateHPV106 -,-,2002
skin /rabbit 0.5 mL severeHPV106 -,-,2002
skin /rabbit 415 mg open irritation test mildUCDS** 11/11/1969
skin /rabbit 500 mg/24H moderateFCTXAV 17,775,1979

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium500 µmol/L (+enzymatic activation step)EVHPAZ 45,111,1982

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 1628 mg/kg (12D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system		TJADAB 35,41,1987
oral/mouse 12 gm/kg (7-14D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)		NTIS** PB85-220143
oral/mouse 12200 mg/kg (6-13D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)		TCMUD8 7,29,1987
oral/rat 6500 mg/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)		HPV106 -,-,2002
oral/rat 13000 mg/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system		HPV106 -,-,2002
oral/mouse 12200 mg/kg (7-14D pregnant)Reproductive: Other effects on female

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)		HPV106 -,-,2002

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 270000 mg/kg/72W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains		HPV341 -,-,2001

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 227 ppm/6HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea		HPV106 -,-,2002
inhalation/man lowest published toxic concentration: 10 ppm/4HOlfaction: Other olfaction effects

Eye: Conjunctiva irritation

Behavioral: Excitement		NRTXDN 28,347,2007
inhalation/mouse lowest published toxic concentration: 227 ppm/6HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea		HPV106 -,-,2002
inhalation/mouse lowest published toxic concentration: 270 mg/m3Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Liver: Other changes		VCVGK* -,115,1984
inhalation/mouse lowest published toxic concentration: 44 ppmLung, Thorax, or Respiration: Respiratory depressionHPV106 -,-,2002
inhalation/rat lowest published toxic concentration: 210 mg/m3Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Liver: Other changes		VCVGK* -,115,1984
inhalation/rat Lethal concentration: >2000 ppm/6HKODAK* 21MAY1971
inhalation/rat lowest published toxic concentration: 227 ppm/6HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea		HPV106 -,-,2002
inhalation/rat lowest published toxic concentration: 0.85 mg/m3/4HFEREAC 70,51623,2005
intraperitoneal/mouse lethal dose (50 percent kill): 726 mg/kgHPV106 -,-,2002
intraperitoneal/rat lethal dose (50 percent kill): 650 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression		HPV106 -,-,2002
intraperitoneal/rat lethal dose (50 percent kill): 500 mg/kgHYDRDA 3,201,1978
oral/guinea pig lethal dose (50 percent kill): 1860 mg/kgZHYGAM 20,575,1974
oral/guinea pig lethal dose (50 percent kill): 600 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen		HPV106 -,-,2002
oral/human lowest published lethal dose: 428.6 mg/kgVCVGK* -,116,1984
oral/mouse lethal dose (50 percent kill): 2500 mg/kgHPV106 -,-,2002
oral/rabbit lethal dose (50 percent kill): 1180 mg/kgHPV106 -,-,2002
oral/rat lowest published lethal dose: 1516 mg/kgHPV106 -,-,2002
oral/rat lethal dose (50 percent kill): 3730 mg/kgHPV106 -,-,2002
oral/rat lethal dose (50 percent kill): 3730 mg/kgBrain and Coverings: Recordings from specific areas of CNS

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea		AIHAAP 34,493,1973
parenteral/mouse lethal dose (50 percent kill): 1670 mg/kgFCTXAV 17,775,1979
parenteral/rat lethal dose (50 percent kill): 4600 mg/kgFCTXAV 17,775,1979
skin/rabbit lethal dose (50 percent kill): 1970 mg/kgNPIRI* 1,61,1974
skin/rat lethal dose (50 percent kill): >3000 mg/kgHPV106 -,-,2002
subcutaneous/rat lowest published lethal dose: 5.54 gm/kgHPV106 -,-,2002
subcutaneous/rat lethal dose (50 percent kill): 650 mg/kgNPIRI* 1,61,1974

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 250 gm/m3/5D- intermittentImmunological Including Allergic: Decreased immune response

Immunological Including Allergic: Hypersensitivity delayed (multiple organ involvement)		TXAPA9 197,280,2004
inhalation/rat lowest published toxic concentration: 102 mg/m3/4H/137D- intermittentBehavioral: Irritability

Lung, Thorax, or Respiration: Other changes		VCVGK* -,116,1994
inhalation/rat lowest published toxic concentration: 1.5 mg/m3/90D- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		VCVGK* -,116,1994
oral/mouse lowest published toxic dose: 3247 mg/kg/17D- continuousBehavioral: Food intake (animal)NTIS** #PB91-185900
oral/mouse lowest published toxic dose: 22500 mg/kg/90D- intermittentGastrointestinal: Other changesFEREAC 70,51623,2005
oral/mouse lowest published toxic dose: 9 gm/kg/11D- intermittentGastrointestinal: Other changes

Liver: Changes in liver weight		FAATDF 29,31,1996
oral/mouse lowest published toxic dose: 16250 mg/kg/13W- intermittentLiver: Other changes

Liver: Changes in liver weight		FAATDF 29,31,1996
oral/mouse lowest published toxic dose: 29150 mg/kg/11D- intermittentEndocrine: Differential effect of sex or castration on observed toxicity

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		HPV106 -,-,2002
oral/rat lowest published toxic dose: 16250 mg/kg/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases		HPV098 -,-,2004
oral/rat lowest published toxic dose: 24.5 gm/kg/14D- intermittentLiver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport		ATSUDG 12,274,1988
oral/rat lowest published toxic dose: 2100 mg/kg/3W- continuousLiver: Other changesVCVGK* -,116,1994
oral/rat lowest published toxic dose: 24000 mg/kg/60D- continuousBrain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		VCVGK* -,116,1994
oral/rat lowest published toxic dose: 2970 mg/kg/9D- intermittentBehavioral: Change in motor activity (specific assay)

Behavioral: Ataxia

Behavioral: Muscle contraction or spasticity		NTIS** OTS0540989
oral/rat lowest published toxic dose: 9 gm/kg/11D- intermittentGastrointestinal: Ulceration or bleeding from stomach

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight		FAATDF 29,31,1996
oral/rat lowest published toxic dose: 16250 mg/kg/13W- intermittentGastrointestinal: Other changes

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight		FAATDF 29,31,1996
oral/rat lowest published toxic dose: 14 gm/kg/17D- intermittentLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases		BCSTB5 2,322,1974
oral/rat lowest published toxic dose: 25200 mg/kg/3W- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)TOLED5 10,379,1982
oral/rat lowest published toxic dose: 260 gm/kg/2Y- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTOXID9 13,70,1993
oral/rat lowest published toxic dose: 16250 mg/kg/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight		HPV046 -,-,2004
oral/rat lowest published toxic dose: 32500 mg/kg/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		HPV046 -,-,2004
oral/rat lowest published toxic dose: 5500 mg/kg/11D- intermittentGastrointestinal: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport		HPV106 -,-,2002
oral/rat lowest published toxic dose: 10780 mg/kg/11D- intermittentLiver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport		HPV106 -,-,2002
oral/rat lowest published toxic dose: 25380 mg/kg/90D- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Other changes		FEREAC 70,51623,2005
oral/rat lowest published toxic dose: 22500 mg/kg/90D- intermittentLiver: Other changes

Biochemical: Effect on specific coenzyme: CoA		FEREAC 70,51623,2005
skin/rat lowest published toxic dose: 20 mL/kg/16D- intermittentCardiac: Cardiomyopathy including infarction

Liver: Fatty liver degeneration

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)		HPV106 -,-,2002
skin/rat lowest published toxic dose: 7506 mg/kg/11D- intermittentEndocrine: Changes in spleen weight

Blood: Changes in other cell count (unspecified)

Skin: After systemic exposure: Dermatitis, other		NTIS** OTS0536344

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 539,77,2003
TOXICOLOGY REVIEWTOLED5 140-141,261,2003
TOXICOLOGY REVIEWREPTED 25,192,2008
TOXICOLOGY REVIEWREPTED 22,291,2006
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWMUREAV 750,141,2012

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIAMAK-TMW 50 ppm (270 mg/m3);KZW 100 ppm (540 mg/m3), skin, 2007
Occupational Exposure Limit-GERMANYMAK 10 ppm (54 mg/m3), 2011
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDceiling concentration 20 ppm (110 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 270 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M0262; Number of Industries 97; Total Number of Facilities 11356; Number of Occupations 74; Total Number of Employees Exposed 117564; Total Number of Female Employees Exposed 11656
National Occupational Hazard Survey 1974Hazard Code M0262; Number of Industries 67; Total Number of Facilities 3280; Number of Occupations 62; Total Number of Employees Exposed 45342

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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