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Registry of Toxic Effects of Chemical Substances (RTECS)

Glycine, N-(phosphonomethyl)-

RTECS #

MC1075000

CAS #

1071-83-6

Updated

October 2017

Molecular Weight

169.09

Molecular Formula

C3H8NO5P

Synonyms

Accord
Glifinox
Gliialka
Glyphosate
MON 0573
MON 2139
N-(Phosphonomethyl)glycine
Rodeo
Sonic
Tornado

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/cattle17 µmol/LMUREAV 403,13,1998
DNA Damagefibroblast/human75 mmol/L/1HTOLED5 147,35,2004
DNA Damageovary/hamster5.5 mmol/LEMMUEG 44,179,2004
DNA Damageother cell types/human5.25 mmol/LEMMUEG 44,179,2004
DNA Damageother cell types/human3 mmol/L/4HETOPFR 28,37,2009
micronucleus testintraperitoneal/mouse400 mg/kg/2D- intermittentETOPFR 28,37,2009
other mutation test systemslymphocyte/cattle17 µmol/LMUREAV 403,13,1998
sister chromatid exchangelymphocyte/cattle17 µmol/LMUREAV 403,13,1998
specific locus test/Drosophila melanogaster2 mmol/LEMMUEG 36,40,2000

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 49 gm/kg (6-19D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
TJADAB 61,446,2000
oral/rat 30 mg/kg (multigeneration)Reproductive: Specific developmental abnormalities: Urogenital systemFEREAC 69,51301,2004
unreported route/mammal (species unspecified) 30 mg/kg (multigenerations)Reproductive: Specific developmental abnormalities: Urogenital systemFEREAC 63,54060,1998

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, embryonic cells Inhibitor Concentration (50 percent kill): 1192 ppm/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXCYAC 313,122,2013
In Vitro/Human, kidney Inhibitor Concentration (50 percent kill): 19323 ppm/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXCYAC 313,122,2013
In Vitro/jrdInhibitor Concentration Low: 1 nmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FCTOD7 59,129,2013
In Vitro/jrdInhibitor Concentration Low: 1 nmol/L/6HIn Vitro Toxicity Studies: Other assaysFCTOD7 59,129,2013
In Vitro/jrdInhibitor Concentration Low: 0.1 µmol/L/24HIn Vitro Toxicity Studies: Other assaysFCTOD7 59,129,2013
In Vitro/Mouse, fibroblast Inhibitor Concentration Low: 0.0096 pph/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 26,1007,2012
In Vitro/Mouse, fibroblast Inhibitor Concentration Low: 0.024 pph/24HIn Vitro Toxicity Studies: Cell counting

In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.

In Vitro Toxicity Studies: Apoptosis in vitro
TIVIEQ 26,1007,2012
In Vitro/Mouse, fibroblast Inhibitor Concentration Low: 0.0096 pph/24HIn Vitro Toxicity Studies: Apoptosis in vitroTIVIEQ 26,1007,2012
In Vitro/Mouse, fibroblast Inhibitor Concentration Low: 0.024 pph/8DIn Vitro Toxicity Studies: Cell differentiationTIVIEQ 26,1007,2012
In Vitro/mtbInhibitor Concentration Low: 30 µmol/L/24HIn Vitro Toxicity Studies: Apoptosis in vitroNRTXDN 33,1499,2012
In Vitro/Rat, endocrine tumor Inhibitor Concentration Low: 20 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.NETEEC 34,344,2012
In Vitro/Rat, endocrine tumor Inhibitor Concentration Low: 10 mmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.NETEEC 34,344,2012
In Vitro/Rat, endocrine tumor Inhibitor Concentration Low: 5 mmol/L/72HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.NETEEC 34,344,2012
In Vitro/Rat, endocrine tumor Inhibitor Concentration Low: 40 mmol/L/24HIn Vitro Toxicity Studies: Apoptosis in vitroNETEEC 34,344,2012
In Vitro/Rat, testis Inhibitor Concentration Low: 0.1 pph/48HIn Vitro Toxicity Studies: Apoptosis in vitroTIVIEQ 26,269,2012
In Vitro/Rat, testis Inhibitor Concentration Low: 0.0001 pph/24HIn Vitro Toxicity Studies: Other assaysTIVIEQ 26,269,2012
inhalation/rat lethal concentration (50 percent kill): >12200 mg/m3/4H85JFAN A222,1984
intraperitoneal/mouse lowest published toxic dose: 400 mg/kgLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
ETOPFR 28,37,2009
intraperitoneal/mouse lethal dose (50 percent kill): 130 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation

Nutritional and Gross Metabolic: Body temperature increase
TOLED5 1000(Sp Iss 1),148,1980
intraperitoneal/rat lethal dose (50 percent kill): 235 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation

Nutritional and Gross Metabolic: Body temperature increase
TOLED5 1000(Sp Iss 1),148,1980
intravenous/pig lowest published toxic dose: 238.47 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)JTCTDW 47,651,2009
multiple/non-mammalian species lethal dose (50 percent kill): 0.59 gm/m3/24HTOVEFN (6),40,2003
oral/human lowest published toxic dose: 1.67 mL/kgCardiac: Arrythmias (indlucing changes in conduction)

Gastrointestinal: Nausea or vomiting

Kidney, Ureter, and Bladder: Renal function tests depressed
AJEMEN 26,275,2008
oral/human lowest published lethal dose: 1.84 mL/kgCardiac: Arrythmias (indlucing changes in conduction)

Gastrointestinal: Nausea or vomiting

Kidney, Ureter, and Bladder: Renal function tests depressed
AJEMEN 26,275,2008
oral/mammal (species unspecified) lethal dose (50 percent kill): >5000 mg/kgFEREAC 69,51301,2004
oral/man lowest published toxic dose: 1.43 mL/kgLung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of exocrine pancreas

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
AJEMEN 26,384.e3,2008
oral/man lowest published lethal dose: 2143 mg/kgVascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Fibrosing alveolitis
JTCTDW 29,91,1991
oral/man lowest published toxic dose: 1214 mg/kgCardiac: Change in rate

Vascular: BP lowering not characterized in autonomic section

Gastrointestinal: Hypermotility, diarrhea
HETOEA 10,103,1991
oral/mouse lethal dose (50 percent kill): 1568 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation

Nutritional and Gross Metabolic: Body temperature increase
TXAPA9 45,319,1978
oral/mouse lethal dose (50 percent kill): 2160 mg/kgMUTAEX 21,375,2006
oral/quail lethal dose (50 percent kill): >4640 mg/kgPEMNDP 9,459,1991
oral/rabbit lethal dose (50 percent kill): 3800 mg/kgPESTC* 7,6,1978
oral/rat lethal dose (50 percent kill): 4873 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation

Nutritional and Gross Metabolic: Body temperature increase
TXAPA9 45,319,1978
oral/rat lethal dose (50 percent kill): >4320 mg/kgJTCTDW 47,651,2009
oral/rat lowest published toxic dose: 250 mg/kgKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)TOLED5 224,192,2014
oral/rat lowest published toxic dose: 500 mg/kgKidney, Ureter, and Bladder: Renal function tests depressed

Kidney, Ureter, and Bladder: Other changes in urine composition
TOLED5 224,192,2014
oral/woman lowest published lethal dose: 4 gm/kgCardiac: Arrythmias (indlucing changes in conduction)

Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Respiratory depression
JTCTDW 29,91,1991
skin/mammal (species unspecified) lethal dose (50 percent kill): >5000 mg/kgFEREAC 69,51301,2004
skin/rabbit lethal dose (50 percent kill): 2000 mg/kgFEREAC 63,54060,1998

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse : 280 µg/kg/7D- intermittentImmunological Including Allergic: Increased immune response

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation

Lung, Thorax, or Respiration: Other changes
TXCYAC 325,42,2014
inhalation/mouse : 280 µg/kg/7D- intermittentBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationTXCYAC 325,42,2014
inhalation/mouse : 360 µg/kg/3W- intermittentLung, Thorax, or Respiration: Other changesTXCYAC 325,42,2014
multiple/non-mammalian species lowest published toxic dose: 0.53 gm/m3/2D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTOVEFN (6),40,2003
multiple/non-mammalian species lowest published toxic dose: 0.033 gm/m3/21D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTOVEFN (6),40,2003
multiple/non-mammalian species lowest published toxic dose: 0.26 gm/m3/21D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainTOVEFN (6),40,2003
oral/mouse lowest published toxic dose: 405000 mg/kg/90D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainFEREAC 69,51301,2004
oral/mouse lowest published toxic dose: 435 gm/kg/13W- continuousGastrointestinal: Changes in structure or function of salivary glands

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
NTPTR* NIH-92-3135
oral/non-mammalian species lowest published toxic dose: 75 mg/kg/15D- intermittentEndocrine: Androgenic

Endocrine: Estrogenic

Reproductive: Paternal effects: Testes, epididymis, sperm duct
REPTED 23,182,2007
oral/non-mammalian species lowest published toxic dose: 75 mg/kg/15D- intermittentBiochemical: Metabolism (intermediary): Lipids including transport

Biochemical: Metabolism (intermediary): Other proteins
REPTED 23,182,2007
oral/rat lowest published toxic dose: 375 mg/kg/5D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
TOXID9 12,471,2008
oral/rat lowest published toxic dose: 4000 mg/kg/5D- intermittentBiochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
TOLED5 180S,S164,2008
oral/rat lowest published toxic dose: 4500 mg/kg/90D- intermittentNutritional and Gross Metabolic: Changes in: P

Nutritional and Gross Metabolic: Changes in: K
FEREAC 69,51301,2004
oral/rat lowest published toxic dose: 49000 mg/kg/14D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TJADAB 61,446,2000
oral/rat lowest published toxic dose: 153 gm/kg/13W- continuousLiver: Changes in liver weight

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
NTPTR* NIH-92-3135
oral/rat lowest published toxic dose: 22500 mg/kg/90D- intermittentBehavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Gastrointestinal: Hypermotility, diarrhea
HCKHDV 5(2),52,1984
oral/rat lowest published toxic dose: 420 mg/kg/21D- intermittentBehavioral: Food intake (animal)

Behavioral: Fluid intake

Liver: Changes in liver weight
REPTED 19,501,2005
oral/rat lowest published toxic dose: 420 mg/kg/21D- intermittentLiver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
REPTED 19,501,2005
oral/rat lowest published toxic dose: 1750 mg/kg/35D- intermittentReproductive: Paternal effects: Testes, epididymis, sperm ductFCTOD7 100,247,2017
oral/rat lowest published toxic dose: 3500 mg/kg/35D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)FCTOD7 100,247,2017
skin/rabbit lowest published toxic dose: 105000 mg/kg/21D- intermittentSkin: After systemic exposure: Dermatitis, irritativeFEREAC 67,60934,2002
skin/rabbit lowest published toxic dose: 105000 mg/kg/21D- intermittentBehavioral: Food intake (animal)

Skin: After systemic exposure: Dermatitis, irritative
FEREAC 67,60934,2002
skin/rabbit lowest published toxic dose: 105000 mg/kg/21D- intermittentSkin: After topical application: Primary irritationFEREAC 69,51301,2004
skin/rabbit lowest published toxic dose: 105000 mg/kg/21D- intermittentBehavioral: Food intake (animal)

Skin: After topical application: Primary irritation
FEREAC 69,51301,2004

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 112,78,2015
International Agency for Research on Cancer (IARC)Cancer Review:Human Limited EvidenceIMEMDT 112,78,2015
International Agency for Research on Cancer (IARC)Cancer Review:Group 2AIMEMDT 112,78,2015
TOXICOLOGY REVIEWMUREAV 557,109,2004
TOXICOLOGY REVIEWTOLED5 128,45,2002
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWENTOX* -,455,2005
TOXICOLOGY REVIEWJTEHD6 7,267,2004
TOXICOLOGY REVIEWFEREAC 71,32899,2006
TOXICOLOGY REVIEWFEREAC 71,56392,2006
TOXICOLOGY REVIEWFEREAC 71,76180,2006
TOXICOLOGY REVIEWFEREAC 73,29456,2008
TOXICOLOGY REVIEWJTPAE7 19,1,2006
TOXICOLOGY REVIEWITODC* -,355,2004
TOXICOLOGY REVIEWHUTOX* -,551,1996
TOXICOLOGY REVIEWMUREAV 681,80,2009
TOXICOLOGY REVIEWFEREAC 73,73586,2008
TOXICOLOGY REVIEWFEREAC 73,52607,2008
TOXICOLOGY REVIEWFEREAC 74,29963,2009
TOXICOLOGY REVIEWFEREAC 74,67129,2009
TOXICOLOGY REVIEWTXCYAC 307,3,2013
TOXICOLOGY REVIEWTXCYAC 307,123,2013
TOXICOLOGY REVIEWTXAPA9 268,157,2013
TOXICOLOGY REVIEWFCTOD7 84,133,2015

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, JUN2003

Status in Federal Agencies

OrganizationReference
NTP Toxicity studies, RPT# TOX-16, October 2000
On EPA IRIS database
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