Glycine, N-(phosphonomethyl)-
RTECS #
MC1075000
CAS #
Updated
March 2019
Molecular Weight
169.09
Molecular Formula
C3H8NO5P
Synonyms
Accord
Glifinox
Gliialka
Glyphosate
MON 0573
MON 2139
N-(Phosphonomethyl)glycine
Rodeo
Sonic
Tornado
Glifinox
Gliialka
Glyphosate
MON 0573
MON 2139
N-(Phosphonomethyl)glycine
Rodeo
Sonic
Tornado
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | lymphocyte/cattle | 17 µmol/L | MUREAV 403,13,1998 |
| DNA Damage | leukocyte/human | 0.5 mmol/L/24H | FCTOD7 105,93,2017 |
| DNA Damage | fibroblast/human | 75 mmol/L/1H | TOLED5 147,35,2004 |
| DNA Damage | ovary/hamster | 5.5 mmol/L | EMMUEG 44,179,2004 |
| DNA Damage | other cell types/human | 5.25 mmol/L | EMMUEG 44,179,2004 |
| DNA Damage | other cell types/human | 3 mmol/L/4H | ETOPFR 28,37,2009 |
| DNA repair | leukocyte/human | 0.5 mmol/L/24H | FCTOD7 105,93,2017 |
| micronucleus test | intraperitoneal/mouse | 400 mg/kg/2D- intermittent | ETOPFR 28,37,2009 |
| other mutation test systems | lymphocyte/cattle | 17 µmol/L | MUREAV 403,13,1998 |
| sister chromatid exchange | lymphocyte/cattle | 17 µmol/L | MUREAV 403,13,1998 |
| specific locus test | /Drosophila melanogaster | 2 mmol/L | EMMUEG 36,40,2000 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | 49 gm/kg (6-19D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | TJADAB 61,446,2000 |
| oral/rat | 30 mg/kg (multigeneration) | Reproductive: Specific developmental abnormalities: Urogenital system | FEREAC 69,51301,2004 |
| oral/rat | 2700 mg/kg (1D preg-5D after birth) | Reproductive: Effects on newborn: Behavioral | NRTXDN 53,20,2016 |
| oral/rat | 3300 mg/kg (1D preg-11D after birth) | Reproductive: Effects on newborn: Physical | NRTXDN 53,20,2016 |
| oral/rat | 4300 mg/kg (1D preg-21D after birth) | Reproductive: Specific developmental abnormalities: Central nervous system | NRTXDN 53,20,2016 |
| unreported route/mammal (species unspecified) | 30 mg/kg (multigenerations) | Reproductive: Specific developmental abnormalities: Urogenital system | FEREAC 63,54060,1998 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Human, embryonic cells | Inhibitor Concentration (50 percent kill): 1192 ppm/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TXCYAC 313,122,2013 |
| In Vitro/Human, kidney | Inhibitor Concentration (50 percent kill): 19323 ppm/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TXCYAC 313,122,2013 |
| In Vitro/Human, leukemia cells | Inhibitor Concentration Low: 10 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | RTOPDW 85,79,2017 |
| In Vitro/jpc | Inhibitor Concentration Low: 0.25 mmol/L/24H | In Vitro Toxicity Studies: Other assays | FCTOD7 105,93,2017 |
| In Vitro/jrd | Inhibitor Concentration Low: 100 mg/L/6D | Endocrine: Estrogenic | FCTOD7 108,30,2017 |
| In Vitro/jrd | Inhibitor Concentration Low: 1000 mg/L/6D | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | FCTOD7 108,30,2017 |
| In Vitro/jrd | Inhibitor Concentration Low: 1000 µg/L/24H | Endocrine: Estrogenic | FCTOD7 108,30,2017 |
| In Vitro/jrd | Inhibitor Concentration Low: 1 nmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | FCTOD7 59,129,2013 |
| In Vitro/jrd | Inhibitor Concentration Low: 1 nmol/L/6H | In Vitro Toxicity Studies: Other assays | FCTOD7 59,129,2013 |
| In Vitro/jrd | Inhibitor Concentration Low: 0.1 µmol/L/24H | In Vitro Toxicity Studies: Other assays | FCTOD7 59,129,2013 |
| In Vitro/Mouse, fibroblast | Inhibitor Concentration Low: 0.0096 pph/48H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 26,1007,2012 |
| In Vitro/Mouse, fibroblast | Inhibitor Concentration Low: 0.024 pph/24H | In Vitro Toxicity Studies: Cell counting In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. In Vitro Toxicity Studies: Apoptosis in vitro | TIVIEQ 26,1007,2012 |
| In Vitro/Mouse, fibroblast | Inhibitor Concentration Low: 0.0096 pph/24H | In Vitro Toxicity Studies: Apoptosis in vitro | TIVIEQ 26,1007,2012 |
| In Vitro/Mouse, fibroblast | Inhibitor Concentration Low: 0.024 pph/8D | In Vitro Toxicity Studies: Cell differentiation | TIVIEQ 26,1007,2012 |
| In Vitro/mtb | Inhibitor Concentration Low: 30 µmol/L/24H | In Vitro Toxicity Studies: Apoptosis in vitro | NRTXDN 33,1499,2012 |
| In Vitro/Rat, endocrine tumor | Inhibitor Concentration Low: 20 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | NETEEC 34,344,2012 |
| In Vitro/Rat, endocrine tumor | Inhibitor Concentration Low: 10 mmol/L/48H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | NETEEC 34,344,2012 |
| In Vitro/Rat, endocrine tumor | Inhibitor Concentration Low: 5 mmol/L/72H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | NETEEC 34,344,2012 |
| In Vitro/Rat, endocrine tumor | Inhibitor Concentration Low: 40 mmol/L/24H | In Vitro Toxicity Studies: Apoptosis in vitro | NETEEC 34,344,2012 |
| In Vitro/Rat, neurons | Inhibitor Concentration Low: 6 gm/L/4D | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | NRTXDN 52,150,2016 |
| In Vitro/Rat, neurons | Inhibitor Concentration Low: 4 gm/L/24H | In Vitro Toxicity Studies: Cell differentiation | NRTXDN 52,150,2016 |
| In Vitro/Rat, testis | Inhibitor Concentration Low: 0.1 pph/48H | In Vitro Toxicity Studies: Apoptosis in vitro | TIVIEQ 26,269,2012 |
| In Vitro/Rat, testis | Inhibitor Concentration Low: 0.0001 pph/24H | In Vitro Toxicity Studies: Other assays | TIVIEQ 26,269,2012 |
| inhalation/rat | lethal concentration (50 percent kill): >12200 mg/m3/4H | 85JFAN A222,1984 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 130 mg/kg | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory stimulation Nutritional and Gross Metabolic: Body temperature increase | TOLED5 1000(Sp Iss 1),148,1980 |
| intraperitoneal/mouse | lowest published toxic dose: 400 mg/kg | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases | ETOPFR 28,37,2009 |
| intraperitoneal/rat | lethal dose (50 percent kill): 235 mg/kg | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory stimulation Nutritional and Gross Metabolic: Body temperature increase | TOLED5 1000(Sp Iss 1),148,1980 |
| intravenous/pig | lowest published toxic dose: 238.47 mg/kg | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | JTCTDW 47,651,2009 |
| multiple/non-mammalian species | lethal dose (50 percent kill): 0.59 gm/m3/24H | TOVEFN (6),40,2003 | |
| oral/human | lowest published toxic dose: 1.67 mL/kg | Cardiac: Arrythmias (indlucing changes in conduction) Gastrointestinal: Nausea or vomiting Kidney, Ureter, and Bladder: Renal function tests depressed | AJEMEN 26,275,2008 |
| oral/human | lowest published lethal dose: 1.84 mL/kg | Cardiac: Arrythmias (indlucing changes in conduction) Gastrointestinal: Nausea or vomiting Kidney, Ureter, and Bladder: Renal function tests depressed | AJEMEN 26,275,2008 |
| oral/mammal (species unspecified) | lethal dose (50 percent kill): >5000 mg/kg | FEREAC 69,51301,2004 | |
| oral/man | lowest published lethal dose: 2143 mg/kg | Vascular: BP lowering not characterized in autonomic section Lung, Thorax, or Respiration: Fibrosis (interstitial) Lung, Thorax, or Respiration: Fibrosing alveolitis | JTCTDW 29,91,1991 |
| oral/man | lowest published toxic dose: 1214 mg/kg | Cardiac: Change in rate Vascular: BP lowering not characterized in autonomic section Gastrointestinal: Hypermotility, diarrhea | HETOEA 10,103,1991 |
| oral/man | lowest published toxic dose: 1.43 mL/kg | Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Changes in structure or function of exocrine pancreas Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | AJEMEN 26,384.e3,2008 |
| oral/mouse | lethal dose (50 percent kill): 1568 mg/kg | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory stimulation Nutritional and Gross Metabolic: Body temperature increase | TXAPA9 45,319,1978 |
| oral/mouse | lethal dose (50 percent kill): 2160 mg/kg | MUTAEX 21,375,2006 | |
| oral/quail | lethal dose (50 percent kill): >4640 mg/kg | PEMNDP 9,459,1991 | |
| oral/rabbit | lethal dose (50 percent kill): 3800 mg/kg | PESTC* 7,6,1978 | |
| oral/rat | lethal dose (50 percent kill): >4320 mg/kg | JTCTDW 47,651,2009 | |
| oral/rat | lethal dose (50 percent kill): 4873 mg/kg | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory stimulation Nutritional and Gross Metabolic: Body temperature increase | TXAPA9 45,319,1978 |
| oral/rat | lowest published toxic dose: 250 mg/kg | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | TOLED5 224,192,2014 |
| oral/rat | lowest published toxic dose: 500 mg/kg | Kidney, Ureter, and Bladder: Renal function tests depressed Kidney, Ureter, and Bladder: Other changes in urine composition | TOLED5 224,192,2014 |
| oral/woman | lowest published lethal dose: 4 gm/kg | Cardiac: Arrythmias (indlucing changes in conduction) Vascular: BP lowering not characterized in autonomic section Lung, Thorax, or Respiration: Respiratory depression | JTCTDW 29,91,1991 |
| skin/mammal (species unspecified) | lethal dose (50 percent kill): >5000 mg/kg | FEREAC 69,51301,2004 | |
| skin/rabbit | lethal dose (50 percent kill): 2000 mg/kg | FEREAC 63,54060,1998 | |
| Tank with water/Catfish | lethal concentration (50 percent kill): 0.0072 mL/L/96H | Behavioral: Somnolence (general depressed activity) | TOXIA6 3,513,2016 |
| Tank with water/frog | toxic concentration: 1 mg/L/96H | Skin: After systemic exposure: Dermatitis, other | CMSHAF 156,37,2016 |
| Tank with water/other fish | lethal concentration (50 percent kill): 41.4 mg/L/96H | CMSHAF 155,429,2016 | |
| Tank with water/Zebrafish | toxic concentration: 0.01 mg/L/96H | Behavioral: Somnolence (general depressed activity) Behavioral: Change in psychophysiological tests | TXCYAC 392,32,2017 |
| Tank with water/Zebrafish | toxic concentration: 0.5 mg/L/96H | Aquatic organism effects: Growth retardation | TXCYAC 392,32,2017 |
| Tank with water/Zebrafish | toxic concentration: 50 mg/L/37D | Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system | ETOPFR 46,292,2016 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | lowest published toxic concentration: 280 µg/kg/7D- intermittent | Immunological Including Allergic: Increased immune response Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation Lung, Thorax, or Respiration: Other changes | TXCYAC 325,42,2014 |
| inhalation/mouse | lowest published toxic concentration: 280 µg/kg/7D- intermittent | Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TXCYAC 325,42,2014 |
| inhalation/mouse | lowest published toxic concentration: 360 µg/kg/3W- intermittent | Lung, Thorax, or Respiration: Other changes | TXCYAC 325,42,2014 |
| multiple/non-mammalian species | lowest published toxic dose: 0.53 gm/m3/2D- continuous | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TOVEFN (6),40,2003 |
| multiple/non-mammalian species | lowest published toxic dose: 0.033 gm/m3/21D- continuous | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TOVEFN (6),40,2003 |
| multiple/non-mammalian species | lowest published toxic dose: 0.26 gm/m3/21D- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TOVEFN (6),40,2003 |
| oral/mouse | lowest published toxic dose: 405000 mg/kg/90D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FEREAC 69,51301,2004 |
| oral/mouse | lowest published toxic dose: 435 gm/kg/13W- continuous | Gastrointestinal: Changes in structure or function of salivary glands Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight | NTPTR* NIH-92-3135 |
| oral/non-mammalian species | lowest published toxic dose: 75 mg/kg/15D- intermittent | Endocrine: Androgenic Endocrine: Estrogenic Reproductive: Paternal effects: Testes, epididymis, sperm duct | REPTED 23,182,2007 |
| oral/non-mammalian species | lowest published toxic dose: 75 mg/kg/15D- intermittent | Biochemical: Metabolism (intermediary): Lipids including transport Biochemical: Metabolism (intermediary): Other proteins | REPTED 23,182,2007 |
| oral/rat | lowest published toxic dose: 375 mg/kg/5D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites | TOXID9 12,471,2008 |
| oral/rat | lowest published toxic dose: 4000 mg/kg/5D- intermittent | Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites | TOLED5 180S,S164,2008 |
| oral/rat | lowest published toxic dose: 4500 mg/kg/90D- intermittent | Nutritional and Gross Metabolic: Changes in: P Nutritional and Gross Metabolic: Changes in: K | FEREAC 69,51301,2004 |
| oral/rat | lowest published toxic dose: 49000 mg/kg/14D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TJADAB 61,446,2000 |
| oral/rat | lowest published toxic dose: 153 gm/kg/13W- continuous | Liver: Changes in liver weight Blood: Changes in erythrocyte (RBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | NTPTR* NIH-92-3135 |
| oral/rat | lowest published toxic dose: 22500 mg/kg/90D- intermittent | Behavioral: Somnolence (general depressed activity) Behavioral: Food intake (animal) Gastrointestinal: Hypermotility, diarrhea | HCKHDV 5(2),52,1984 |
| oral/rat | lowest published toxic dose: 420 mg/kg/21D- intermittent | Behavioral: Food intake (animal) Behavioral: Fluid intake Liver: Changes in liver weight | REPTED 19,501,2005 |
| oral/rat | lowest published toxic dose: 420 mg/kg/21D- intermittent | Liver: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | REPTED 19,501,2005 |
| oral/rat | lowest published toxic dose: 1750 mg/kg/35D- intermittent | Reproductive: Paternal effects: Testes, epididymis, sperm duct | FCTOD7 100,247,2017 |
| oral/rat | lowest published toxic dose: 3500 mg/kg/35D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | FCTOD7 100,247,2017 |
| oral/rat | lowest published toxic dose: 2.808 mL/kg/10D- intermittent | Biochemical: Metabolism (intermediary): Other proteins | TXCYAC 387,67,2017 |
| oral/rat | lowest published toxic dose: 17500 mg/kg/5W- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands | AHISA9 118,519,2016 |
| skin/rabbit | lowest published toxic dose: 105000 mg/kg/21D- intermittent | Skin: After systemic exposure: Dermatitis, irritative | FEREAC 67,60934,2002 |
| skin/rabbit | lowest published toxic dose: 105000 mg/kg/21D- intermittent | Behavioral: Food intake (animal) Skin: After systemic exposure: Dermatitis, irritative | FEREAC 67,60934,2002 |
| skin/rabbit | lowest published toxic dose: 105000 mg/kg/21D- intermittent | Skin: After topical application: Primary irritation | FEREAC 69,51301,2004 |
| skin/rabbit | lowest published toxic dose: 105000 mg/kg/21D- intermittent | Behavioral: Food intake (animal) Skin: After topical application: Primary irritation | FEREAC 69,51301,2004 |
| subcutaneous/rat | lowest published toxic dose: 8 mg/kg/8D- intermittent | Reproductive: Effects on newborn: Other postnatal measures or effects | FCTOD7 118,111,2018 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 112,78,2015 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human Limited Evidence | IMEMDT 112,78,2015 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 2A | IMEMDT 112,78,2015 |
| TOXICOLOGY REVIEW | MUREAV 557,109,2004 | |
| TOXICOLOGY REVIEW | TOLED5 128,45,2002 | |
| TOXICOLOGY REVIEW | MUTAEX 21,93,2006 | |
| TOXICOLOGY REVIEW | ENTOX* -,455,2005 | |
| TOXICOLOGY REVIEW | JTEHD6 7,267,2004 | |
| TOXICOLOGY REVIEW | FEREAC 71,32899,2006 | |
| TOXICOLOGY REVIEW | FEREAC 71,56392,2006 | |
| TOXICOLOGY REVIEW | FEREAC 71,76180,2006 | |
| TOXICOLOGY REVIEW | FEREAC 73,29456,2008 | |
| TOXICOLOGY REVIEW | JTPAE7 19,1,2006 | |
| TOXICOLOGY REVIEW | ITODC* -,355,2004 | |
| TOXICOLOGY REVIEW | HUTOX* -,551,1996 | |
| TOXICOLOGY REVIEW | MUREAV 681,80,2009 | |
| TOXICOLOGY REVIEW | FEREAC 73,73586,2008 | |
| TOXICOLOGY REVIEW | FEREAC 73,52607,2008 | |
| TOXICOLOGY REVIEW | FEREAC 74,29963,2009 | |
| TOXICOLOGY REVIEW | FEREAC 74,67129,2009 | |
| TOXICOLOGY REVIEW | TXCYAC 307,3,2013 | |
| TOXICOLOGY REVIEW | TXCYAC 307,123,2013 | |
| TOXICOLOGY REVIEW | TXAPA9 268,157,2013 | |
| TOXICOLOGY REVIEW | FCTOD7 84,133,2015 | |
| TOXICOLOGY REVIEW | MUREAV 770,183,2016 | |
| TOXICOLOGY REVIEW | REPTED 71,71,2017 | |
| TOXICOLOGY REVIEW | RTOPDW 61,172,2011 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Occupational Exposure Limit-RUSSIA | short term exposure limit 1 mg/m3, JUN2003 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| NTP Toxicity studies, RPT# TOX-16, October 2000 | |
| On EPA IRIS database |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health