Glycine, N,N-bis(carboxymethyl)-, trisodium salt
RTECS #
MB8400000
CAS #
Updated
July 2011
Molecular Weight
257.10
Molecular Formula
C6H6NO6·3Na
Synonyms
Acetic acid, nitrilotri-, trisodium salt
Cheelox nta-14, -Na3
Hampshire NTA
N,N-Bis(carboxymethyl)glycine trisodium salt
Nitrilotriacetic acid, trisodium salt
Trisodium nitrilotriacetate
Trisodium nitrilotriacetic acid
Cheelox nta-14, -Na3
Hampshire NTA
N,N-Bis(carboxymethyl)glycine trisodium salt
Nitrilotriacetic acid, trisodium salt
Trisodium nitrilotriacetate
Trisodium nitrilotriacetic acid
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
Cytogenetic Analysis | lung/hamster | 3 mmol/L | MUREAV 343,1,1995 |
micronucleus test | lung/hamster | 2 mmol/L | MUREAV 343,1,1995 |
morphological transform | embryo/rat | 495 µg/plate | JJATDK 1,190,1981 |
morphological transform | embryo/mouse | 2 mg/L | EMMUEG 12,21,1988 |
other mutation test systems | lung/hamster | 3 mmol/L | MUREAV 343,1,1995 |
specific locus test | oral/Drosophila melanogaster | 5200 µmol/L | MUREAV 262,253,1991 |
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/rat | 39 gm/kg (8W male/8W pre-3W after birth) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | FCTXAV 9,509,1971 |
oral/rat | 8 gm/kg (8W male/8W pre-3W after birth) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | FCTXAV 9,509,1971 |
Tumorigenic Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/rat | lowest published toxic dose: 70300 mg/kg/2Y- continuous | Tumorigenic: Neoplastic by RTECS criteria Liver: Tumors Kidney, Ureter, and Bladder: Kidney tumors | JJIND8 66,869,1981 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
In Vitro/Human, liver tumor | Inhibitor Concentration (50 percent kill): 8.5 mmol/L/24H | In Vitro Toxicity Studies: Cell protein synthesis | TIVIEQ 3,189,1989 |
intraperitoneal/rat | lethal dose (50 percent kill): 254 mg/kg | TXAPA9 18,398,1971 | |
oral/Dog | lethal dose (50 percent kill): >5 gm/kg | Gastrointestinal: Nausea or vomiting | TXAPA9 18,398,1971 |
oral/monkey | lethal dose (50 percent kill): 750 mg/kg | Gastrointestinal: Nausea or vomiting | TXAPA9 18,398,1971 |
oral/mouse | lethal dose (50 percent kill): 681 mg/kg | NCILB* NCI-E-C-72-3252,1973 | |
oral/rat | lethal dose (50 percent kill): 1100 mg/kg | Gastrointestinal: Nausea or vomiting | TXAPA9 18,398,1971 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/rat | lowest published toxic dose: 180 gm/kg/90D- continuous | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Blood: Changes in erythrocyte (RBC) count | TXAPA9 18,398,1971 |
oral/rat | lowest published toxic dose: 56305 mg/kg/30D- intermittent | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | FCTOD7 20,433,1982 |
oral/rat | lowest published toxic dose: 219 gm/kg/2Y- continuous | Kidney, Ureter, and Bladder: Other changes in urine composition Nutritional and Gross Metabolic: Changes in: Other metals Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TXAPA9 21,244,1972 |
oral/rat | lowest published toxic dose: 67200 mg/kg/28D- continuous | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, and Bladder: Other changes | NTIS** OTS0543794 |
Reviews
Organization | Standard | Reference |
---|---|---|
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 48,181,1990 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 73,385,1999 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 73,385,1999 |
International Agency for Research on Cancer (IARC) | Cancer Review:Group 2B | IMEMDT 73,385,1999 |
TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
TOXICOLOGY REVIEW | MUREAV 654,114,2008 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Supported | RBREV* -,298,1998 |
NIOSH Documentation and Surveillance
Status in Federal Agencies
Organization | Reference |
---|---|
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat | |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health