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Registry of Toxic Effects of Chemical Substances (RTECS)

Glycine, N,N-bis(carboxymethyl)-, trisodium salt

RTECS #

MB8400000

CAS #

5064-31-3; 37291-81-9

Updated

July 2011

Molecular Weight

257.10

Molecular Formula

C6H6NO6·3Na

Synonyms

Acetic acid, nitrilotri-, trisodium salt
Cheelox nta-14, -Na3
Hampshire NTA
N,N-Bis(carboxymethyl)glycine trisodium salt
Nitrilotriacetic acid, trisodium salt
Trisodium nitrilotriacetate
Trisodium nitrilotriacetic acid

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster3 mmol/LMUREAV 343,1,1995
micronucleus testlung/hamster2 mmol/LMUREAV 343,1,1995
morphological transformembryo/rat495 µg/plateJJATDK 1,190,1981
morphological transformembryo/mouse2 mg/LEMMUEG 12,21,1988
other mutation test systemslung/hamster3 mmol/LMUREAV 343,1,1995
specific locus testoral/Drosophila melanogaster5200 µmol/LMUREAV 262,253,1991

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 39 gm/kg (8W male/8W pre-3W after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)FCTXAV 9,509,1971
oral/rat 8 gm/kg (8W male/8W pre-3W after birth)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)FCTXAV 9,509,1971

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 70300 mg/kg/2Y- continuousTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Kidney tumors		JJIND8 66,869,1981

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 8.5 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
intraperitoneal/rat lethal dose (50 percent kill): 254 mg/kgTXAPA9 18,398,1971
oral/Dog lethal dose (50 percent kill): >5 gm/kgGastrointestinal: Nausea or vomitingTXAPA9 18,398,1971
oral/monkey lethal dose (50 percent kill): 750 mg/kgGastrointestinal: Nausea or vomitingTXAPA9 18,398,1971
oral/mouse lethal dose (50 percent kill): 681 mg/kgNCILB* NCI-E-C-72-3252,1973
oral/rat lethal dose (50 percent kill): 1100 mg/kgGastrointestinal: Nausea or vomitingTXAPA9 18,398,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 180 gm/kg/90D- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in erythrocyte (RBC) count		TXAPA9 18,398,1971
oral/rat lowest published toxic dose: 56305 mg/kg/30D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)FCTOD7 20,433,1982
oral/rat lowest published toxic dose: 219 gm/kg/2Y- continuousKidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Changes in: Other metals

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		TXAPA9 21,244,1972
oral/rat lowest published toxic dose: 67200 mg/kg/28D- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes		NTIS** OTS0543794

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 48,181,1990
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 73,385,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 73,385,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 73,385,1999
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 654,114,2008

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,298,1998

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M0951; Number of Industries 95; Total Number of Facilities 11433; Number of Occupations 97; Total Number of Employees Exposed 224263; Total Number of Female Employees Exposed 60818
National Occupational Hazard Survey 1974Hazard Code M0951; Number of Industries 82; Total Number of Facilities 7988; Number of Occupations 64; Total Number of Employees Exposed 77882

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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