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Registry of Toxic Effects of Chemical Substances (RTECS)

Glutaronitrile, 2-bromo-2-(bromomethyl)-

RTECS #

MA5599000

CAS #

35691-65-7

Updated

October 2017

Molecular Weight

265.96

Molecular Formula

C6H6Br2N2

Synonyms

1,2-Dibromo-2,4-dicyanobutane
1-Bromo-1-(bromomethyl)-1,3-propanedicarbonitrile
2-Bromo-2-(bromomethyl)glutaronitrile
Methyldibromoglutaronitrile
Pentanedinitrile, 2-bromo-2-(bromomethyl)-

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg severeJACTDZ 15,140,1996
skin /guinea pig 1%/24HCODEDG 28,149,1993
skin /rabbit 500 mg moderateJACTDZ 15,140,1996

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 1750 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)TOLED5 18(Suppl 1),158,1983

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, leukemia cells Inhibitor Concentration (5 percent kill): 102 mg/L/30MIn Vitro Toxicity Studies: Cell countingTIVIEQ 27,857,2013
In Vitro/Human, leukemia cells Inhibitor Concentration Low: 8.80 mg/L/30MIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,857,2013
In Vitro/Human, leukemia cells Inhibitor Concentration Low: 200 mg/L/30MIn Vitro Toxicity Studies: Cell counting

In Vitro Toxicity Studies: Other assays
TIVIEQ 27,857,2013
In Vitro/Human, leukemia cells Inhibitor Concentration (25 percent kill): 9.9 mg/L/24HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.TIVIEQ 26,1150,2012
In Vitro/Human, leukemia cells Inhibitor Concentration (50 percent kill): 10.8 mg/L/24HIn Vitro Toxicity Studies: Other assaysTIVIEQ 26,1150,2012
In Vitro/Human, monocyte Inhibitor Concentration Low: 11.4 mg/L/2HIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,1233,2013
In Vitro/Human, skin Inhibitor Concentration Low: 0.01 pph/6HIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,2213,2013
In Vitro/Human, skin Inhibitor Concentration (20 percent kill): 0.93 mg/L/24HIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,1127,2013
In Vitro/Human, skin Inhibitor Concentration (50 percent kill): 25.6 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXAPA9 245,281,2010
In Vitro/Human, skin Inhibitor Concentration (50 percent kill): 7.8 µmol/L/48HIn Vitro Toxicity Studies: Other assaysTXAPA9 245,281,2010
In Vitro/jrdInhibitor Concentration (50 percent kill): 2.5 mg/L/24HIn Vitro Toxicity Studies: Other assaysTIVIEQ 28,626,2014
inhalation/rat lethal concentration (50 percent kill): >13 gm/m3/4HJACTDZ 15,140,1996
oral/rat lethal dose (50 percent kill): 515 mg/kgJACTDZ 15,140,1996
skin/rabbit lethal dose (50 percent kill): >5 gm/kgJACTDZ 15,140,1996

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 380 mg/kg/13W- continuousEndocrine: Changes in thyroid weightJACTDZ 15,140,1996
skin/rabbit lowest published toxic dose: 120 mg/kg/4W- intermittentBlood: Pigmented or nucleated red blood cellsJACTDZ 15,140,1996
skin/rat lowest published toxic dose: 84 gm/kg/3W- intermittentBlood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count

Skin: After systemic exposure: Dermatitis, other
JACTDZ 15,140,1996

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 539,77,2003

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,172,1998

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X1017; Number of Industries 9; Total Number of Facilities 512; Number of Occupations 10; Total Number of Employees Exposed 17713; Total Number of Female Employees Exposed 3345

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NTP Carcinogenesis studies; on test (prechronic studies), October 2000
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