Ethylene glycol, dinitrate

RTECS #

KW5600000

CAS #

628-96-6
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

152.08

Molecular Formula

C₂H₄N₂O₆

Synonyms

Dinitroglicol (Italian)
Dinitroglycol
EGDN
Ethanediol dinitrate
Ethylene dinitrate
Ethylene glycol dinitrate (ACGIH:OSHA)
Ethylene nitrate
Ethylenglykoldinitrat (Czech)
Glycol (dinitrate de) (French)
Glycol dinitrate
Glycoldinitraat (Dutch)
Glykoldinitrat (German)
Nitroglycol
Nitroglykol (Czech)

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
oral/mouse	lethal dose (50 percent kill): 540 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold Cardiac: Other changes	STGNBT -,96,1999
oral/rat	lethal dose (50 percent kill): 460 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold Cardiac: Other changes	STGNBT -,96,1999
skin/rat	lethal dose (50 percent kill): 3800 mg/kg		STGNBT -,96,1999
subcutaneous/cat	lowest published lethal dose: 75 mg/kg	Blood: Normocytic anemia	AEPPAE 200,271,1942
subcutaneous/rabbit	lowest published lethal dose: 300 mg/kg	Vascular: Other changes Blood: Normocytic anemia	AEPPAE 200,271,1942

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 10 mg/m³/17W- intermittent	Cardiac: Other changes Kidney, Ureter, and Bladder: Other changes Blood: Pigmented or nucleated red blood cells	STGNBT -,96,1999
oral/rat	lowest published toxic dose: 3067 mg/kg/20D- intermittent	Kidney, Ureter, and Bladder: Changes in kidney weight Blood: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain	STGNBT -,96,1999
subcutaneous/rat	lowest published toxic dose: 1 gm/kg/10D- intermittent	Behavioral: Tolerance Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS	PHTOEH 61,172,1987

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.05 ppm (skin)	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		NTIS** AD778-725
TOXICOLOGY REVIEW		AJMEAZ 38,409,1965

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.05 ppm (0.31 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.05 ppm (0.3 mg/m³);KZW 0.2 ppm (1.2 mg/m³), skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.05 ppm (0.31 mg/m³), Skin, MAR2002
Occupational Exposure Limit-DENMARK	ceiling concentration 0.02 ppm (0.12 mg/m³), skin, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 0.03 ppm (0.2 mg/m³), short term exposure limit 0.1 ppm (0.6 mg/m³), skin, NOV2011
Occupational Exposure Limit-FRANCE	VME 0.17 ppm (1 mg/m³), Skin, FEB2006
Occupational Exposure Limit-GERMANY	MAK 0.05 ppm (0.32 mg/m³), skin, 2011
Occupational Exposure Limit-ICELAND	short term exposure limit 0.02 ppm (0.12 mg/m³), skin, NOV2011
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 0.05 ppm (0.31 mg/m³), skin, MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 0.05 ppm (0.3 mg/m³), skin, 2006
Occupational Exposure Limit-KOREA	time-weighted average 0.5 ppm (1.2 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.05 ppm (0.3 mg/m³);short term exposure limit 0.1 ppm (skin), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.05 ppm (0.31 mg/m³), skin, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 0.03 ppm (0.18 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 0,05 ppm (0,3 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	time-weighted average 0.3 mg/m³, short term exposure limit 0.4 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	time-weighted average 0.05 mg/m³, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 0.03 ppm (0.2 mg/m³);short term exposure limit 0.1 ppm (0.6 mg/m³), Skin, JUN2005
Occupational Exposure Limit-SWITZERLAND	ceiling concentration 0.05 ppm (0.3 mg/m³), skin, JAN2011
Occupational Exposure Limit-THAILAND	time-weighted average 0.2 ppm (1 mg/m³), JAN1993
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.3 mg/m³, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 0.2 ppm (1.2 mg/m³), Skin, JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 0.2 ppm (1 mg/m³), Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	ceiling concentration 0.2 ppm (1 mg/m³) (skin)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	ceiling concentration 0.2 ppm (1 mg/m³) (skin)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	ceiling concentration 0.2 ppm (1 mg/m³) (skin)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	ceiling concentration 0.2 ppm (1 mg/m³) (skin)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYLENE GLYCOL DINITRATE-air	short term exposure limit 0.1 mg/m³ (Sk)	NIOSH* DHHS #92-100,1992

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ethylene glycol dinitrate, 2507
OSHA ANALYTICAL METHOD #43

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health