Ether, 1-chloro-2,2,2-trifluoroethyl difluoromethyl
RTECS #
KN6799000
CAS #
Updated
March 2019
Molecular Weight
184.50
Molecular Formula
C3H2ClF5O
Synonyms
(+-)-Isoflurane
2-Chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane
Ethane, 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro- (9CI)
Forane
ISF
Isoflurane
Pentafluoran
R-E 235dal
2-Chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane
Ethane, 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro- (9CI)
Forane
ISF
Isoflurane
Pentafluoran
R-E 235dal
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
DNA Damage | inhalation/human | 1 pph/2H | MUREAV 492,99,2001 |
DNA Damage | inhalation/rat | 1 pph/30M | TXCYAC 220,169,2006 |
micronucleus test | oral/rat | 4 mmol/kg | MUREAV 413,1,1998 |
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rat | 10500 ppm/6H (14-16D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | ANESAV 64,339,1986 |
inhalation/rat | 4000 ppm/3H (7-17D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | KSRNAM 21,3091,1987 |
inhalation/rat | 12000 ppm/3H (17-20D preg/21D after birth) | Reproductive: Effects on newborn: Physical | KSRNAM 21,3109,1987 |
inhalation/mouse | 6000 ppm/4H (6-15D pregnant) | Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Urogenital system | TJADAB 29(2),54A,1984 |
inhalation/rat | 1.3 pph (21D pregnant) | Reproductive: Other effects to embryo or fetus | NEPHBW 53,942,2007 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
In Vitro/Human, lymphocyte | Inhibitor Concentration Low: 0.5 pph/4H | Immunological Including Allergic: Decrease in cellular immune response | TOLED5 266,23,2017 |
In Vitro/Human, neuroblastoma | Inhibitor Concentration Low: 0.56 mmol/l/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | NETEEC 65,19,2018 |
In Vitro/maa | Inhibitor Concentration Low: 0.8 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. In Vitro Toxicity Studies: Other assays | TXAPA9 250,291,2011 |
In Vitro/maa | Inhibitor Concentration Low: 0.8 mmol/L/12.5M | Nutritional and Gross Metabolic: Changes in: Ca | TXAPA9 250,291,2011 |
In Vitro/maa | Inhibitor Concentration Low: 0.8 mmol/L/4.2M | Nutritional and Gross Metabolic: Changes in: Ca | TXAPA9 250,291,2011 |
In Vitro/maa | Inhibitor Concentration Low: 0.8 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TXAPA9 250,291,2011 |
In Vitro/pax | Inhibitor Concentration Low: 1.5 pph/6H | In Vitro Toxicity Studies: Apoptosis in vitro In Vitro Toxicity Studies: Other assays | TOLED5 233,102,2015 |
inhalation/human | lowest published toxic concentration: 1.8 pph | Cardiac: Change in rate Vascular: BP lowering not characterized in autonomic section Vascular: Other changes | AANEAB 45,971,2001 |
inhalation/monkey | lowest published toxic concentration: 1.9 pph/5H | Brain and Coverings: Other degenerative changes | NETEEC 60,63,2017 |
inhalation/mouse | lowest published toxic concentration: 1.30 pph/80M | Behavioral: General anesthetic | NETEEC 60,69,2017 |
inhalation/mouse | lowest published toxic concentration: 0.73 pph/80M | Behavioral: Altered sleep time (including change in righting reflex) | NETEEC 60,69,2017 |
inhalation/mouse | lowest published toxic concentration: 2 pph/1H | Behavioral: Alteration of classical conditioning | NETEEC 61,92,2017 |
inhalation/mouse | lowest published toxic concentration: 1.5 pph/12M | Behavioral: General anesthetic | JPETAB 323,924,2007 |
inhalation/mouse | lethal concentration (50 percent kill): 16800 ppm/3H | Behavioral: Somnolence (general depressed activity) Behavioral: Excitement Lung, Thorax, or Respiration: Respiratory depression | KSRNAM 21,3031,1987 |
inhalation/mouse | lethal concentration (16 percent kill): 35.3 gm/m3/2H | Behavioral: General anesthetic Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory depression | TOVEFN (5),12,1998 |
inhalation/mouse | lethal concentration (50 percent kill): 50.5 gm/m3/2H | Behavioral: General anesthetic Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory depression | TOVEFN (5),12,1998 |
inhalation/mouse | lowest published toxic concentration: 1.27 pph/6M | Behavioral: Analgesia | JPETAB 317,615,2006 |
inhalation/rat | lowest published toxic concentration: 1.5 pph/5H | Vascular: BP lowering not characterized in autonomic section Kidney, Ureter, and Bladder: Hematuria Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | FCTOD7 46,3550,2008 |
inhalation/rat | Lowest published lethal concentration: 1.5 pph/2H | Lung, Thorax, or Respiration: Acute pulmonary edema Lung, Thorax, or Respiration: Pleural effusion | FCTOD7 46,3550,2008 |
inhalation/rat | lowest published toxic concentration: 1.5 pph/1H | Vascular: BP lowering not characterized in autonomic section | FCTOD7 46,3550,2008 |
inhalation/rat | lowest published toxic concentration: 1 pph/30M | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes Biochemical: Metabolism (intermediary): Other | AANEAB 46,378,2002 |
inhalation/rat | lowest published toxic concentration: 1.2 pph/30M | Behavioral: Analgesia | AANEAB 46,451,2002 |
inhalation/rat | lowest published toxic concentration: 1 pph/90M | Brain and Coverings: Other degenerative changes | EJPHAZ 503,49,2004 |
inhalation/rat | lethal concentration (50 percent kill): 15300 ppm/3H | Behavioral: Somnolence (general depressed activity) Behavioral: Excitement Lung, Thorax, or Respiration: Respiratory depression | KSRNAM 21,3031,1987 |
inhalation/rat | lethal concentration (16 percent kill): 35.2 gm/m3/4H | Behavioral: General anesthetic Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory depression | TOVEFN (5),12,1998 |
inhalation/rat | lethal concentration (50 percent kill): 58.5 gm/m3/4H | Behavioral: General anesthetic Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory depression | TOVEFN (5),12,1998 |
inhalation/rat | lowest published toxic concentration: 1.5 pph/6H | Brain and Coverings: Other degenerative changes Behavioral: Alteration of classical conditioning | TOLED5 233,102,2015 |
intraperitoneal/mouse | lowest published lethal dose: 60000 mg/kg | TOVEFN (5),12,1998 | |
intraperitoneal/mouse | lethal dose (50 percent kill): 3030 µL/kg | Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory depression Nutritional and Gross Metabolic: Body temperature decrease | KSRNAM 21,3031,1987 |
intraperitoneal/mouse | lowest published toxic dose: 5.5 gm/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | TOLED5 228,13,2014 |
intraperitoneal/mouse | lowest published toxic dose: 0.729 mL/kg | Behavioral: Altered sleep time (including change in righting reflex) | BCLPT* 103,31,2008 |
intraperitoneal/mouse | lowest published toxic dose: 0.4 mL/kg | Behavioral: Analgesia | BCLPT* 105,120,2009 |
intraperitoneal/rat | lethal dose (50 percent kill): 4280 µL/kg | Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory depression Nutritional and Gross Metabolic: Body temperature decrease | KSRNAM 21,3031,1987 |
intraperitoneal/rat | lethal dose (16 percent kill): 10250 mg/kg | TOVEFN (5),12,1998 | |
intraperitoneal/rat | lethal dose (50 percent kill): 14400 mg/kg | TOVEFN (5),12,1998 | |
intraperitoneal/rat | lowest published lethal dose: 20200 mg/kg | TOVEFN (5),12,1998 | |
oral/man | lowest published lethal dose: 1143 µL/kg | Brain and Coverings: Changes in surface EEG Behavioral: Muscle weakness Blood: Changes in leukocyte (WBC) count | NLJMAV 33,74,1988 |
oral/man | lowest published lethal dose: 1071 µL/kg | JFSCAS 38,968,1993 | |
oral/mouse | lethal dose (50 percent kill): 5080 µL/kg | Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory depression Nutritional and Gross Metabolic: Body temperature decrease | KSRNAM 21,3031,1987 |
oral/rat | lethal dose (50 percent kill): 4770 µL/kg | Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory depression Nutritional and Gross Metabolic: Body temperature decrease | KSRNAM 21,3031,1987 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/guinea pig | lowest published toxic concentration: 1500 ppm/24H/5W- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | ANESAV 42,408,1975 |
inhalation/mouse | lowest published toxic concentration: 150 ppm/24H/5W- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | ANESAV 42,408,1975 |
inhalation/rat | lowest published toxic concentration: 12000 ppm/3H/10W- intermittent | Endocrine: Changes in adrenal weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | KSRNAM 21,3037,1987 |
inhalation/rat | lowest published toxic concentration: 24 gm/m3/3D- intermittent | Biochemical: Metabolism (intermediary): Other | TOVEFN (5),12,1998 |
Reviews
Organization | Standard | Reference |
---|---|---|
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Inadequate Evidence | IMSUDL 7,93,1987 |
TOXICOLOGY REVIEW | TPHSDY 23,519,2002 | |
TOXICOLOGY REVIEW | TPHSDY 24,648,2003 | |
TOXICOLOGY REVIEW | MUREAV 566,209,2004 | |
TOXICOLOGY REVIEW | DIMON* 39,678,1993 | |
TOXICOLOGY REVIEW | ENTOX* -,125,2005 | |
TOXICOLOGY REVIEW | HUTOX* -,577,1996 | |
TOXICOLOGY REVIEW | NCLNA* 16,503,1998 | |
TOXICOLOGY REVIEW | MUREAV 721,27,2011 | |
TOXICOLOGY REVIEW | MUTAEX 30,459,2015 | |
TOXICOLOGY REVIEW | MUREAV 770,26,2016 | |
TOXICOLOGY REVIEW | NETEEC 60,102,2017 | |
TOXICOLOGY REVIEW | NETEEC 60,117,2017 | |
TOXICOLOGY REVIEW | NETEEC 60,2,2017 | |
TOXICOLOGY REVIEW | NETEEC 60,24,2017 | |
TOXICOLOGY REVIEW | NETEEC 60,33,2017 | |
TOXICOLOGY REVIEW | NETEEC 60,50,2017 | |
TOXICOLOGY REVIEW | NETEEC 60,59,2017 | |
TOXICOLOGY REVIEW | NETEEC 60,95,2017 | |
TOXICOLOGY REVIEW | RTOPDW 59,364,2011 |
Standards and Regulations
NIOSH Documentation and Surveillance
Status in Federal Agencies
Organization | Reference |
---|---|
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test | |
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse | |
OSHA ANALYTICAL METHOD #103 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health