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Registry of Toxic Effects of Chemical Substances (RTECS)

Ether, bis(2-chloro-1-methylethyl)

RTECS #

KN1750000

CAS #

108-60-1; 52438-91-2

Updated

April 2017

Molecular Weight

171.08

Molecular Formula

C6H12Cl2O

Synonyms

(2-Chloro-1-methylethyl) ether
2-(1-Methyl-2-chloroethoxy)-1-chloropropane
2-(1-Methyl-2-chloroethoxy)-1-chloropropane, fume
2,2'-Dichloroisopropyl ether
2,2'-Oxybis(1-chloropropane)
beta,beta'-Dichlorodiisopropyl ether
Bis(1-chloro-2-propyl) ether
Bis(2-chloro-1-methylethyl) ether
Bis(2-chloroisopropyl) ether
Bis(beta-chloroisopropyl)ether
DCIP
DCIP (nematocide)
Dichlorodiisopropyl ether
Dichloroisopropyl ether
Isopropylchlorex
NCI-C50044
Nemamol
Nemamort
Nemamorte
Propane, 2,2'-oxybis(1-chloro-
RCRA waste number U027

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster124 mg/LEMMUEG 10(Suppl 10),1,1987
mutation in mammalian somatic cellslymphocyte/mouse250 mg/LEMMUEG 12,85,1988
mutation in microorganisms/Salmonella typhimurium1000 mg/L/2H (+/-enzymatic activation step)EMMUEG 44,329,2004
mutation in microorganisms/Salmonella typhimurium1 gm/plate (+enzymatic activation step)DHEFDK FDA-78-1046,1978
mutation in microorganisms/Salmonella typhimurium333 µg/plate (-enzymatic activation step)ENMUDM 8(Suppl 7),1,1986
sister chromatid exchangeovary/hamster11300 µg/LEMMUEG 10(Suppl 10),1,1987

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 103000 mg/kg/180D- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
NTIS** PB83-169615
oral/mouse lowest published toxic dose: 103000 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
NTIS** PB83-169615

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 700 ppm/5HEye: Iritis

Lung, Thorax, or Respiration: Dyspnea

Liver: Other changes
BJIMAG 27,1,1970
inhalation/rat Lowest published lethal concentration: 5700 mg/m3/1HEye: Conjunctiva irritation

Behavioral: Ataxia
VCVGK* -,284,1994
inhalation/rat Lowest published lethal concentration: 700 mg/m3/5HLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,284,1994
inhalation/rat Lowest published lethal concentration: 400 mg/m3/6HLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,284,1994
inhalation/rat Lowest published lethal concentration: 240 mg/m3/8HLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,284,1994
oral/mouse lethal dose (50 percent kill): 1400 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Liver: Hepatitis (hepatocellular necrosis), zonal
VCVGK* -,284,1994
oral/mouse lethal dose (50 percent kill): 296 mg/kgYKYUA6 37,597,1986
oral/rat lethal dose (50 percent kill): 1300 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Liver: Hepatitis (hepatocellular necrosis), zonal
VCVGK* -,284,1994
oral/rat lethal dose (50 percent kill): 240 mg/kgAMIHBC 4,119,1951
skin/rabbit lethal dose (50 percent kill): 3 mL/kgAMIHBC 4,119,1951
skin/rat lethal dose (50 percent kill): >2 gm/kgPEMNDP 9,83,1991

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 4424 mg/kg/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-239,1982
oral/mouse lowest published toxic dose: 876 gm/kg/2Y- continuousBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTSCDR 2,295,1977
oral/mouse lowest published toxic dose: 873600 mg/kg/104W- continuousBlood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
VCVGK* -,285,1994
oral/rat lowest published toxic dose: 11250 mg/kg/45D- intermittentBlood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count
GISAAA 50(5),69,1985
oral/rat lowest published toxic dose: 2340 mg/kg/26W- intermittentBlood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
GISAAA 50(5),69,1985
oral/rat lowest published toxic dose: 364 gm/kg/2Y- continuousBehavioral: Food intake (animal)

Blood: Changes in spleen

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTSCDR 2,296,1977
oral/rat lowest published toxic dose: 11250 mg/kg/45D- intermittentBrain and Coverings: Changes in brain weight

Liver: Multiple effects

Kidney, Ureter, and Bladder: Changes in kidney weight
VCVGK* -,284,1994
oral/rat lowest published toxic dose: 2250 mg/kg/45D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
VCVGK* -,284,1994
oral/rat lowest published toxic dose: 660 mg/kg/152D- intermittentCardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,284,1994
oral/rat lowest published toxic dose: 228 mg/kg/152D- intermittentBehavioral: Alteration of classical conditioningVCVGK* -,285,1994

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 41,149,1986
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 71,1275,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 41,149,1986
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,1275,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 71,1275,1999
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 763,36,2014
TOXICOLOGY REVIEWMUREAV 769,34,2014
TOXICOLOGY REVIEWMUREAV 802,1,2016

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (gavage);no evidence:ratNCITR* NCI-TR-191,1979
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