1,4:5,8-Dimethanonaphthalene, 1,2,3,4,10,10-hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro,endo,exo-

RTECS #

IO1750000

CAS #

60-57-1; 3039-00-7
See: NMAM or OSHA Methods

Updated

September 2018

Molecular Weight

380.90

Molecular Formula

C₁₂H₈Cl₆O

Synonyms

Aldrin epoxide
Alvit 55
Compound 497
Dieldrex
Dieldrin
Dieldrin (ACGIH:OSHA)
Dieldrine (French)
Dielmoth
Dorytox
ENT 16,225
exo-Dieldrin
HEOD
Hexachloroepoxyoctahydro-endo,exo-dimethanonaphthalene
Illoxol
Insecticide No. 497
Insectlack
Kombi-Albertan
Latka 497 (Czech)
Moth Snub D
NCI-C00124
Octalox
Panoram D-31
RCRA waste number P037
Red Shield
SD 3417
Termitox

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	intraperitoneal/mouse	1200 µg/kg	SOGEBZ 2,80,1966
Cytogenetic Analysis	lymphocyte/duck	100 ppm	34LXAP -,555,1976
DNA Damage	fibroblast/mouse	25 µmol/L/24H	MOCAT* 18,127,2003
DNA Damage	mammary gland/human	2.8 mg/L/24H (-enzymatic activation step)	MUREAV 588,47,2005
DNA inhibition	lymphocyte/human	100 mg/L	ARTODN 45,101,1980
DNA inhibition	HeLa cell/human	400 µmol/L	MUREAV 92,427,1982
DNA inhibition	other cell types/rat	10 mg/L	ARTODN 45,101,1980
DNA inhibition	oral/mouse	50 mg/kg	MUREAV 46,305,1977
morphological transform	oral/rat	15 mg/kg	CNREA8 40,1157,1980
morphological transform	fibroblast/mouse	0.01 mg/L/21D (-enzymatic activation step)	EMMUEG 35,300,2000
mutation in mammalian somatic cells	lung/hamster	10 µmol/L	CBINA8 19,369,1977
mutation in microorganisms	/Salmonella typhimurium	1 mg/L (+/-enzymatic activation step)	JOHEA8 68,184,1977
other mutation test systems	other cell types/mouse	1 ppm/4H	EESADV 3,10,1979
other mutation test systems	fibroblast/mammal (species unspecified)	50 mg/L	AECTCV 15,581,1986
other mutation test systems	oral/mouse	20 mg/kg	MUREAV 343,157,1995
sister chromatid exchange	ovary/hamster	40 mg/L	EMMUEG 10(Suppl 10),1,1987
specific locus test	lymphocyte/mouse	10 mg/L	EMMUEG 17,196,1991
Unscheduled DNA Synthesis	fibroblast/human	1 µmol/L	MUREAV 42,161,1977

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	14 µg/kg (multigenerations)	Reproductive: Effects on newborn: Behavioral	PCBPBS 13,20,1980
oral/mouse	30600 µg/kg (6-14D pregnant)	Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Eye, ear	THERAP 25,907,1970
oral/mouse	15 mg/kg (9D pregnant)	Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)	TJADAB 9,11,1974
oral/mouse	2250 µg/kg (6-14D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	TJADAB 16,57,1977
oral/mouse	12500 µg/kg (1D male)	Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)	FCTXAV 13,317,1975
oral/mouse	4500 µg/kg (6-14D pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system	TJADAB 16,57,1977
oral/mouse	6250 µg/kg (5D male)	Reproductive: Other effects on male	ENVRAL 9,26,1975
oral/Dog	219 mg/kg (44W prior to copulation/1-8W pregnant)	Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)	JAVMA4 123,28,1953
oral/hamster	30 mg/kg (8D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on embryo or fetus: Fetal death	TJADAB 9,11,1974
oral/hamster	30 mg/kg (8D pregnant)	Reproductive: Specific developmental abnormalities: Eye, ear Reproductive: Specific developmental abnormalities: Body wall Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)	TJADAB 9,11,1974
oral/rat	21 mg/kg (14-20D pregnant)	Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Effects on newborn: Delayed effects	ENVRAL 18,437,1979

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
oral/mouse	lowest published toxic dose: 546 mg/kg/65W- continuous	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	ATSUDG 2,197,1979
oral/mouse	toxic dose: 11 gm/kg/3Y- continuous	Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors Liver: Tumors	FCTXAV 11,415,1973
oral/mouse	toxic dose: 610 mg/kg/73W- continuous	Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors Liver: Tumors	FCTXAV 11,433,1973
oral/mouse	toxic dose: 714 mg/kg/85W- continuous	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	LAINAW 44,392,1981
oral/mouse	toxic dose: 8 mg/kg/2Y- continuous	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Tumors	CRNGDP 3,941,1982
oral/mouse	toxic dose: 4550 mg/kg/65W- continuous	Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors Liver: Tumors	CNREA8 41,3615,1981
oral/rat	lowest published toxic dose: 200 mg/kg/2Y- continuous	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors Skin and Appendages: Tumors	FCTXAV 2,551,1964

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/ctd	Inhibitor Concentration Low: 1 µg/L/72H	Endocrine: Androgenic	TXAPA9 285,23,2015
In Vitro/ctd	Inhibitor Concentration Low: 10 µg/L/72H	Endocrine: Estrogenic	TXAPA9 285,23,2015
In Vitro/cte	Inhibitor Concentration Low: 0.1 µg/L/24H	Reproductive: Other effects on female	TXAPA9 285,23,2015
In Vitro/Human, liver tumor	Inhibitor Concentration Low: 100 µmol/L/24H	In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.	TXCYAC 313,83,2013
In Vitro/Human, melanoma	Inhibitor Concentration Low: 60 µmol/L/15M	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase	NETOX* 32,567,2011
In Vitro/Human, melanoma	Inhibitor Concentration Low: 60 µmol/L/1H	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase In Vitro Toxicity Studies: Apoptosis in vitro	NETOX* 32,567,2011
In Vitro/Human, neuroblastoma	Inhibitor Concentration Low: 10 µmol/L/24H	In Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc.	TIVIEQ 45,81,2017
In Vitro/mtb	Inhibitor Concentration Low: 100 µmol/L/24H	In Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc.	NRTXDN 33,1499,2012
In Vitro/mtb	Inhibitor Concentration Low: 30 µmol/L/24H	In Vitro Toxicity Studies: Apoptosis in vitro	NRTXDN 33,1499,2012
In Vitro/mtb	Inhibitor Concentration Low: 100 µmol/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	NRTXDN 33,1499,2012
In Vitro/mvx	Inhibitor Concentration Low: 0.1 µmol/L/24H	In Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc.	TIVIEQ 45,81,2017
In Vitro/pax	Inhibitor Concentration Low: 250 µmol/L/24H	In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.	NRTXDN ,1,2017
In Vitro/Rat, endocrine tumor	Inhibitor Concentration Low: 10 µmol/L/5D	In Vitro Toxicity Studies: Cell morphology: overgrowth of cell appendixes etc.	TXAPA9 325,25,2017
In Vitro/Rat, endocrine tumor	Inhibitor Concentration Low: 10 µmol/L/24H	In Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc.	TIVIEQ 45,81,2017
In Vitro/Rat, endocrine tumor	Inhibitor Concentration Low: 30 µmol/L/24H	In Vitro Toxicity Studies: Other assays	NETEEC 34,395,2012
In Vitro/Rat, neurons	Inhibitor Concentration Low: 40 µmol/L/1H	In Vitro Toxicity Studies: Other assays	NRTXDN 44,204,2014
In Vitro/Rat, neurons	Inhibitor Concentration Low: 0.1 µmol/L/24H	In Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc.	TIVIEQ 45,81,2017
inhalation/cat	lethal concentration (50 percent kill): 80 mg/m³/4H	Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold Behavioral: Excitement	GTPZAB 8(4),30,1964
inhalation/rat	lethal concentration (50 percent kill): 13 mg/m³/4H		85GMAT -,73,1982
intracerebral/mouse	lethal dose (50 percent kill): 3 mg/kg	Behavioral: Convulsions or effect on seizure threshold	TOLED5 60,289,1992
intraperitoneal/mouse	lowest published lethal dose: 26 mg/kg		TXAPA9 23,288,1972
intraperitoneal/rat	lethal dose (50 percent kill): 35 mg/kg		CBPCEE 85,437,1986
intraperitoneal/rat	lowest published toxic dose: 20 mg/kg	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Metabolism (intermediary): Other	GEPHDP 18,165,1987
intraperitoneal/rat	lowest published toxic dose: 3 mg/kg	Liver: Other changes Biochemical: Metabolism (intermediary): Lipids including transport Biochemical: Metabolism (intermediary): Other	FCLPH* 22(Suppl 1),52,2008
intraperitoneal/Sunfish	lowest published toxic dose: 10 mg/kg	Brain and Coverings: Other degenerative changes	NRTXDN 31,356,2010
intravenous/mouse	lethal dose (50 percent kill): 10500 µg/kg		TXAPA9 23,408,1972
intravenous/pigeon	lethal dose (50 percent kill): 1200 mg/kg		32ZDAL -,79,1970
intravenous/rat	lowest published toxic dose: 45 mg/kg	Liver: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	BCPCA6 67,2141,2004
intravenous/rat	lethal dose (50 percent kill): 9 mg/kg		BJIMAG 21,269,1964
oral/cat	lowest published lethal dose: 500 mg/kg	Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Liver: Fatty liver degeneration Kidney, Ureter, and Bladder: Other changes	CVETAA 2,71,1958
oral/chicken	lethal dose (50 percent kill): 20 mg/kg	Eye: Miosis (pupilliary constriction) Behavioral: Excitement Behavioral: Food intake (animal)	JEENAI 44,1013,1951
oral/Dog	lethal dose (50 percent kill): 65 mg/kg		GUCHAZ 6,198,1973
oral/duck	lethal dose (50 percent kill): 381 mg/kg		TXAPA9 20,57,1971
oral/guinea pig	lethal dose (50 percent kill): 49 mg/kg		PCOC** -,377,1966
oral/hamster	lethal dose (50 percent kill): 60 mg/kg		TJADAB 9,11,1974
oral/mammal (species unspecified)	lethal dose (50 percent kill): 94 mg/kg	Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold	NTIS** PB288-416
oral/man	lowest published lethal dose: 65 mg/kg		34ZIAG -,215,1969
oral/monkey	lethal dose (50 percent kill): 3 mg/kg		32ZDAL -,79,1970
oral/mouse	lethal dose (50 percent kill): 38 mg/kg		SPEADM 78-1,13,1978
oral/pig	lethal dose (50 percent kill): 38 mg/kg		EJTXAZ 7,159,1974
oral/pigeon	lethal dose (50 percent kill): 23700 µg/kg		ASTTA8 (680),157,1979
oral/quail	lethal dose (50 percent kill): 10780 µg/kg	Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Somnolence (general depressed activity) Behavioral: Irritability	ETOCDK 1,157,1982
oral/rabbit	lethal dose (50 percent kill): 45 mg/kg		PCOC** -,377,1966
oral/rat	lowest published toxic dose: 30 mg/kg	Liver: Other changes Biochemical: Metabolism (intermediary): Lipids including transport	ENPBBC 5,119,1975
oral/rat	lethal dose (50 percent kill): 38300 µg/kg		JAFCAU 3,402,1955
oral/wild bird	lethal dose (50 percent kill): 13300 µg/kg		ASTTA8 (680),157,1979
skin/cat	lowest published lethal dose: 750 mg/kg	Behavioral: Food intake (animal) Behavioral: Withdrawal Gastrointestinal: Nausea or vomiting	CVETAA 2,71,1958
skin/rabbit	lethal dose (50 percent kill): 250 mg/kg		SPEADM 78-1,13,1978
skin/rat	lethal dose (50 percent kill): 56 mg/kg		RPZHAW 18,161,1967
subcutaneous/rabbit	lowest published lethal dose: 150 mg/kg		85GMAT -,73,1982
subcutaneous/rat	lethal dose (50 percent kill): 49 mg/kg		85GMAT -,73,1982
unreported route/Dog	lowest published lethal dose: 65 mg/kg		AMIHBC 3,64,1951
unreported route/human	lowest published lethal dose: 28 mg/kg	Cardiac: Other changes Lung, Thorax, or Respiration: Acute pulmonary edema	ATXKA8 22,115,1966
unreported route/mammal (species unspecified)	lethal dose (50 percent kill): 25 mg/kg		30ZDA9 -,63,1971

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/rat	lowest published toxic dose: 21 mg/kg/7D- intermittent	Liver: Other changes Biochemical: Metabolism (intermediary): Other	TXAPA9 19,234,1971
oral/cat	lowest published toxic dose: 51 mg/kg/17D- intermittent	Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Behavioral: Convulsions or effect on seizure threshold Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	CVETAA 2,71,1958
oral/Dog	lowest published toxic dose: 27200 µg/kg/68W- intermittent	Liver: Changes in liver weight	JAFCAU 3,402,1955
oral/domestic bird	lowest published toxic dose: 68 mg/kg/8W- continuous	Autonomic Nervous System: Sympathomimetic Liver: Changes in liver weight Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites	TXAPA9 53,75,1980
oral/mammal (species unspecified)	lowest published toxic dose: 239 mg/kg/30D- continuous	Behavioral: Convulsions or effect on seizure threshold Skin and Appendages: Other: Hair Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTIS** PB288-416
oral/mouse	lowest published toxic dose: 25 mg/kg/10D- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Endocrine: Androgenic Biochemical: Metabolism (intermediary): Other	ENVRAL 13,441,1977
oral/mouse	lowest published toxic dose: 75600 µg/kg/18W- continuous	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation	EVHPAZ 39,79,1981
oral/mouse	lowest published toxic dose: 840 µg/kg/2W- continuous	Immunological Including Allergic: Decrease in humoral immune response	EVHPAZ 39,79,1981
oral/quail	lowest published toxic dose: 14 mg/kg/14D- continuous	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Lipids including transport	POSCAL 53,54,1974
oral/rabbit	lowest published toxic dose: 751 µg/kg/13W- continuous	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Immunological Including Allergic: Decrease in humoral immune response Biochemical: Metabolism (intermediary): Other proteins	BECTA6 10,42,1973
oral/rat	lowest published toxic dose: 75 mg/kg/15D- continuous	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases	TOLED5 11,131,1982
oral/rat	lowest published toxic dose: 88 mg/kg/88D- continuous	Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases	JTEHD6 25,461,1988
oral/rat	lowest published toxic dose: 140 mg/kg/8W- intermittent	Liver: Other changes Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases	TXAPA9 37,29,1976
oral/rat	lowest published toxic dose: 109 mg/kg/2Y- continuous	Liver: Changes in liver weight	JAFCAU 3,402,1955
oral/rat	lowest published toxic dose: 410 mg/kg/39W- continuous	Liver: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	AMPLAO 64,614,1957
oral/rat	lowest published toxic dose: 120 mg/kg/30D- intermittent	Brain and Coverings: Other degenerative changes Behavioral: Alteration of classical conditioning Behavioral: Aggression	TOXID9 44,432,2005
oral/rat	lowest published toxic dose: 120 mg/kg/30D- intermittent	Gastrointestinal: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TOXID9 44,432,2005
oral/rat	lowest published toxic dose: 60 mg/kg/30D- intermittent	Liver: Changes in liver weight	TOXID9 44,432,2005
oral/rat	lowest published toxic dose: 30 mg/kg/30D- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	TOXID9 44,432,2005
oral/rat	lowest published toxic dose: 28 mg/kg/7D- intermittent	Behavioral: Food intake (animal)	TOXID9 44,432,2005
oral/rat	lowest published toxic dose: 32.5 mg/kg/13D- intermittent	Liver: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects	TOXID9 90,143,2006
unreported route/mouse	lowest published toxic dose: 30 mg/kg/30D- intermittent	Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Other proteins Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum	TOXID9 90,227,2006

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.1 mg/m³ (inhal, vapor, skin)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Limited Evidence	IMEMDT 5,125,1974
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 5,125,1974
International Agency for Research on Cancer (IARC)	Cancer Review:Group 3	IMSUDL 7,196,1987
TOXICOLOGY REVIEW		ENVRAL 7,243,1974
TOXICOLOGY REVIEW		JSIRAC 34,462,1975
TOXICOLOGY REVIEW		DTTIAF 80,485,1973
TOXICOLOGY REVIEW		RREVAH 56,107,1975
TOXICOLOGY REVIEW		ECMAAI 14,141,1973
TOXICOLOGY REVIEW		BNYMAM 54,413,1978
TOXICOLOGY REVIEW		85CVA2 5,250,1970
TOXICOLOGY REVIEW		26UZAB 6,149,1968/1970
TOXICOLOGY REVIEW		CTOXAO 13,231,1978
TOXICOLOGY REVIEW		EESADV 1,89,1977
TOXICOLOGY REVIEW		TXAPA9 10,613,1967
TOXICOLOGY REVIEW		EVHPAZ 109(Suppl 1),113,2001
TOXICOLOGY REVIEW		EVHPAZ 109(Suppl 1),35,2001
TOXICOLOGY REVIEW		TOLED5 127,101,2002
TOXICOLOGY REVIEW		MUREAV 567,109,2004
TOXICOLOGY REVIEW		MUTAEX 21,93,2006
TOXICOLOGY REVIEW		NETOX* 26,701,2005
TOXICOLOGY REVIEW		NRTXDN 27,579,2006
TOXICOLOGY REVIEW		BPCEM* 16,105,2002
TOXICOLOGY REVIEW		ENTOX* -,15,2005
TOXICOLOGY REVIEW		ENTOX* -,334,2005
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		HETOEA 25,413,2006
TOXICOLOGY REVIEW		JTEHD6 7,1,2004
TOXICOLOGY REVIEW		REPTED 23,457,2007
TOXICOLOGY REVIEW		JTPAE7 17,69,2004
TOXICOLOGY REVIEW		HTOPA* 1,501,2002
TOXICOLOGY REVIEW		TPHSDY 29,322,2008
TOXICOLOGY REVIEW		FCTOD7 46,813,2008
TOXICOLOGY REVIEW		MUREAV 674,3,2009
TOXICOLOGY REVIEW		MUREAV 674,36,2009
TOXICOLOGY REVIEW		MUREAV 674,73,2009
TOXICOLOGY REVIEW		MUTAEX 22,161,2007
TOXICOLOGY REVIEW		FESTAS 90,911,2008
TOXICOLOGY REVIEW		NEUCL* 23,485,2005
TOXICOLOGY REVIEW		MUREAV 705,184,2010
TOXICOLOGY REVIEW		NRTXDN 31,555,2010
TOXICOLOGY REVIEW		MUREAV 728,98,2011
TOXICOLOGY REVIEW		MUREAV 721,27,2011
TOXICOLOGY REVIEW		NRTXDN 32,383,2011
TOXICOLOGY REVIEW		REPTED 38,1,2013
TOXICOLOGY REVIEW		NRTXDN 33,833,2012
TOXICOLOGY REVIEW		TXAPA9 254,86,2011
TOXICOLOGY REVIEW		MUREAV 760,1,2014
TOXICOLOGY REVIEW		TOLED5 201,152,2011
TOXICOLOGY REVIEW		TOLED5 202,36,2011
TOXICOLOGY REVIEW		MUREAV 769,34,2014
TOXICOLOGY REVIEW		TXCYAC 307,24,2013
TOXICOLOGY REVIEW		TXCYAC 307,35,2013
TOXICOLOGY REVIEW		TXCYAC 307,42,2013
TOXICOLOGY REVIEW		TXCYAC 307,74,2013
TOXICOLOGY REVIEW		TXCYAC 307,89,2013
TOXICOLOGY REVIEW		TXCYAC 307,123,2013
TOXICOLOGY REVIEW		MUREAV 764,31,2015
TOXICOLOGY REVIEW		TOLED5 230,85,2014
TOXICOLOGY REVIEW		TXAPA9 268,157,2013
TOXICOLOGY REVIEW		MUREAV 802,1,2016
TOXICOLOGY REVIEW		FCTOD7 86,298,2015
TOXICOLOGY REVIEW		NETEEC 52,25,2015
TOXICOLOGY REVIEW		FCTOD7 105,456,2017

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 0.25 mg/m³ (skin)	DTLVS* 3,84,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.25 mg/m³, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.25 mg/m³;KZW 2.5 mg/m³, inhal, skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.25 mg/m³, Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.25 mg/m³, skin, carc, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 0.25 mg/m³, short term exposure limit 0.75 mg/m³, skin, NOV2011
Occupational Exposure Limit-FRANCE	VME 0.25 mg/m³, Skin, C3 Carcinogen, FEB2006
Occupational Exposure Limit-GERMANY	MAK 0.25 mg/m³, inhal, 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 0.25 mg/m³ (resp), short term exposure limit 1 mg/m³ (resp), SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 0.25 mg/m³, skin, NOV2011
Occupational Exposure Limit-INDIA	time-weighted average 0.25 mg/m³, Skin, JAN1993
Occupational Exposure Limit-KOREA	time-weighted average 0.25 mg/m³, skin, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.25 mg/m³;short term exposure limit 0.75 mg/m³ (skin), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.25 mg/m³, skin, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 0.25 mg/m³, JAN1999
Occupational Exposure Limit-PERU	time-weighted average 0.25 mg/m³, JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 0.5 mg/m³, short term exposure limit 1.5 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	short term exposure limit 0.01 mg/m³, JUN2003
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.25 mg/m³, carc 3, inhal, skin, JAN2011
Occupational Exposure Limit-THAILAND	time-weighted average 0.25 mg/m³, JAN1993
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.25 mg/m³, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 0.25 mg/m³, Skin, JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 0.25 mg/m³, Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 0.25 mg/m³ (skin)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 0.25 mg/m³ (skin)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 0.25 mg/m³ (skin)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 0.25 mg/m³ (skin)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIELDRIN-air	Carcinogen time-weighted average 0.25 mg/m³ (Sk) (0.15 mg/m³ LOQ)	NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974	Hazard Code M2830; Number of Industries 2; Total Number of Facilities 56; Number of Occupations 3; Total Number of Employees Exposed 760

Status in Federal Agencies

Organization	Reference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/182368/AS)
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal; Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);equivocal evidence:mouse	NCITR* NCI-TR-21,1978
NCI Carcinogenesis Bioassay (feed);no evidence:rat	NCITR* NCI-TR-22,1978
NCI Carcinogenesis Bioassay (feed);no evidence:rat	NCITR* NCI-TR-21,1978
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health