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Registry of Toxic Effects of Chemical Substances (RTECS)

1,4:5,8-Dimethanonaphthalene, 1,2,3,4,10,10-hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro,endo,exo-

RTECS #

IO1750000

CAS #

60-57-1; 3039-00-7

Updated

April 2017

Molecular Weight

380.90

Molecular Formula

C12H8Cl6O

Synonyms

Aldrin epoxide
Alvit 55
Compound 497
Dieldrex
Dieldrin
Dieldrin (ACGIH:OSHA)
Dieldrine (French)
Dielmoth
Dorytox
ENT 16,225
exo-Dieldrin
HEOD
Hexachloroepoxyoctahydro-endo,exo-dimethanonaphthalene
Illoxol
Insecticide No. 497
Insectlack
Kombi-Albertan
Latka 497 (Czech)
Moth Snub D
NCI-C00124
Octalox
Panoram D-31
RCRA waste number P037
Red Shield
SD 3417
Termitox

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisintraperitoneal/mouse1200 µg/kgSOGEBZ 2,80,1966
Cytogenetic Analysislymphocyte/duck100 ppm34LXAP -,555,1976
DNA Damagefibroblast/mouse25 µmol/L/24HMOCAT* 18,127,2003
DNA Damagemammary gland/human2.8 mg/L/24H (-enzymatic activation step)MUREAV 588,47,2005
DNA inhibitionlymphocyte/human100 mg/LARTODN 45,101,1980
DNA inhibitionHeLa cell/human400 µmol/LMUREAV 92,427,1982
DNA inhibitionother cell types/rat10 mg/LARTODN 45,101,1980
DNA inhibitionoral/mouse50 mg/kgMUREAV 46,305,1977
morphological transformoral/rat15 mg/kgCNREA8 40,1157,1980
morphological transformfibroblast/mouse0.01 mg/L/21D (-enzymatic activation step)EMMUEG 35,300,2000
mutation in mammalian somatic cellslung/hamster10 µmol/LCBINA8 19,369,1977
mutation in microorganisms/Salmonella typhimurium1 mg/L (+/-enzymatic activation step)JOHEA8 68,184,1977
other mutation test systemsother cell types/mouse1 ppm/4HEESADV 3,10,1979
other mutation test systemsfibroblast/mammal (species unspecified)50 mg/LAECTCV 15,581,1986
other mutation test systemsoral/mouse20 mg/kgMUREAV 343,157,1995
sister chromatid exchangeovary/hamster40 mg/LEMMUEG 10(Suppl 10),1,1987
specific locus testlymphocyte/mouse10 mg/LEMMUEG 17,196,1991
Unscheduled DNA Synthesisfibroblast/human1 µmol/LMUREAV 42,161,1977

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 14 µg/kg (multigenerations)Reproductive: Effects on newborn: BehavioralPCBPBS 13,20,1980
oral/mouse 30600 µg/kg (6-14D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear
THERAP 25,907,1970
oral/mouse 15 mg/kg (9D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)TJADAB 9,11,1974
oral/mouse 2250 µg/kg (6-14D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TJADAB 16,57,1977
oral/mouse 12500 µg/kg (1D male)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)FCTXAV 13,317,1975
oral/mouse 4500 µg/kg (6-14D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemTJADAB 16,57,1977
oral/mouse 6250 µg/kg (5D male)Reproductive: Other effects on maleENVRAL 9,26,1975
oral/Dog 219 mg/kg (44W prior to copulation/1-8W pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)JAVMA4 123,28,1953
oral/hamster 30 mg/kg (8D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
TJADAB 9,11,1974
oral/hamster 30 mg/kg (8D pregnant)Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
TJADAB 9,11,1974
oral/rat 21 mg/kg (14-20D pregnant)Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Delayed effects
ENVRAL 18,437,1979

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 546 mg/kg/65W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
ATSUDG 2,197,1979
oral/mouse toxic dose: 11 gm/kg/3Y- continuousTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
FCTXAV 11,415,1973
oral/mouse toxic dose: 610 mg/kg/73W- continuousTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
FCTXAV 11,433,1973
oral/mouse toxic dose: 714 mg/kg/85W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
LAINAW 44,392,1981
oral/mouse toxic dose: 8 mg/kg/2Y- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
CRNGDP 3,941,1982
oral/mouse toxic dose: 4550 mg/kg/65W- continuousTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
CNREA8 41,3615,1981
oral/rat lowest published toxic dose: 200 mg/kg/2Y- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors
FCTXAV 2,551,1964

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/ctdInhibitor Concentration Low: 1 µg/L/72HEndocrine: AndrogenicTXAPA9 285,23,2015
In Vitro/ctdInhibitor Concentration Low: 10 µg/L/72HEndocrine: EstrogenicTXAPA9 285,23,2015
In Vitro/cteInhibitor Concentration Low: 0.1 µg/L/24HReproductive: Other effects on femaleTXAPA9 285,23,2015
In Vitro/Human, liver tumor Inhibitor Concentration Low: 100 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TXCYAC 313,83,2013
In Vitro/Human, melanoma Inhibitor Concentration Low: 60 µmol/L/15MBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: PhosphokinaseNETOX* 32,567,2011
In Vitro/Human, melanoma Inhibitor Concentration Low: 60 µmol/L/1HBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase

In Vitro Toxicity Studies: Apoptosis in vitro
NETOX* 32,567,2011
In Vitro/mtbInhibitor Concentration Low: 100 µmol/L/24HIn Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc.NRTXDN 33,1499,2012
In Vitro/mtbInhibitor Concentration Low: 30 µmol/L/24HIn Vitro Toxicity Studies: Apoptosis in vitroNRTXDN 33,1499,2012
In Vitro/mtbInhibitor Concentration Low: 100 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.NRTXDN 33,1499,2012
In Vitro/Rat, endocrine tumor Inhibitor Concentration Low: 30 µmol/L/24HIn Vitro Toxicity Studies: Other assaysNETEEC 34,395,2012
In Vitro/Rat, neurons Inhibitor Concentration Low: 40 µmol/L/1HIn Vitro Toxicity Studies: Other assaysNRTXDN 44,204,2014
inhalation/cat lethal concentration (50 percent kill): 80 mg/m3/4HBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement
GTPZAB 8(4),30,1964
inhalation/rat lethal concentration (50 percent kill): 13 mg/m3/4H85GMAT -,73,1982
intracerebral/mouse lethal dose (50 percent kill): 3 mg/kgBehavioral: Convulsions or effect on seizure thresholdTOLED5 60,289,1992
intraperitoneal/mouse lowest published lethal dose: 26 mg/kgTXAPA9 23,288,1972
intraperitoneal/rat lethal dose (50 percent kill): 35 mg/kgCBPCEE 85,437,1986
intraperitoneal/rat lowest published toxic dose: 20 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Metabolism (intermediary): Other
GEPHDP 18,165,1987
intraperitoneal/rat lowest published toxic dose: 3 mg/kgLiver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport

Biochemical: Metabolism (intermediary): Other
FCLPH* 22(Suppl 1),52,2008
intraperitoneal/Sunfish lowest published toxic dose: 10 mg/kgBrain and Coverings: Other degenerative changesNRTXDN 31,356,2010
intravenous/mouse lethal dose (50 percent kill): 10500 µg/kgTXAPA9 23,408,1972
intravenous/pigeon lethal dose (50 percent kill): 1200 mg/kg32ZDAL -,79,1970
intravenous/rat lowest published toxic dose: 45 mg/kgLiver: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
BCPCA6 67,2141,2004
intravenous/rat lethal dose (50 percent kill): 9 mg/kgBJIMAG 21,269,1964
oral/cat lowest published lethal dose: 500 mg/kgLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Other changes
CVETAA 2,71,1958
oral/chicken lethal dose (50 percent kill): 20 mg/kgEye: Miosis (pupilliary constriction)

Behavioral: Excitement

Behavioral: Food intake (animal)
JEENAI 44,1013,1951
oral/Dog lethal dose (50 percent kill): 65 mg/kgGUCHAZ 6,198,1973
oral/duck lethal dose (50 percent kill): 381 mg/kgTXAPA9 20,57,1971
oral/guinea pig lethal dose (50 percent kill): 49 mg/kgPCOC** -,377,1966
oral/hamster lethal dose (50 percent kill): 60 mg/kgTJADAB 9,11,1974
oral/mammal (species unspecified) lethal dose (50 percent kill): 94 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold
NTIS** PB288-416
oral/man lowest published lethal dose: 65 mg/kg34ZIAG -,215,1969
oral/monkey lethal dose (50 percent kill): 3 mg/kg32ZDAL -,79,1970
oral/mouse lethal dose (50 percent kill): 38 mg/kgSPEADM 78-1,13,1978
oral/pig lethal dose (50 percent kill): 38 mg/kgEJTXAZ 7,159,1974
oral/pigeon lethal dose (50 percent kill): 23700 µg/kgASTTA8 (680),157,1979
oral/quail lethal dose (50 percent kill): 10780 µg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Behavioral: Irritability
ETOCDK 1,157,1982
oral/rabbit lethal dose (50 percent kill): 45 mg/kgPCOC** -,377,1966
oral/rat lowest published toxic dose: 30 mg/kgLiver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
ENPBBC 5,119,1975
oral/rat lethal dose (50 percent kill): 38300 µg/kgJAFCAU 3,402,1955
oral/wild bird lethal dose (50 percent kill): 13300 µg/kgASTTA8 (680),157,1979
skin/cat lowest published lethal dose: 750 mg/kgBehavioral: Food intake (animal)

Behavioral: Withdrawal

Gastrointestinal: Nausea or vomiting
CVETAA 2,71,1958
skin/rabbit lethal dose (50 percent kill): 250 mg/kgSPEADM 78-1,13,1978
skin/rat lethal dose (50 percent kill): 56 mg/kgRPZHAW 18,161,1967
subcutaneous/rabbit lowest published lethal dose: 150 mg/kg85GMAT -,73,1982
subcutaneous/rat lethal dose (50 percent kill): 49 mg/kg85GMAT -,73,1982
unreported route/Dog lowest published lethal dose: 65 mg/kgAMIHBC 3,64,1951
unreported route/human lowest published lethal dose: 28 mg/kgCardiac: Other changes

Lung, Thorax, or Respiration: Acute pulmonary edema
ATXKA8 22,115,1966
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 25 mg/kg30ZDA9 -,63,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 21 mg/kg/7D- intermittentLiver: Other changes

Biochemical: Metabolism (intermediary): Other
TXAPA9 19,234,1971
oral/cat lowest published toxic dose: 51 mg/kg/17D- intermittentPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Convulsions or effect on seizure threshold

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
CVETAA 2,71,1958
oral/Dog lowest published toxic dose: 27200 µg/kg/68W- intermittentLiver: Changes in liver weightJAFCAU 3,402,1955
oral/domestic bird lowest published toxic dose: 68 mg/kg/8W- continuousAutonomic Nervous System: Sympathomimetic

Liver: Changes in liver weight

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
TXAPA9 53,75,1980
oral/mammal (species unspecified) lowest published toxic dose: 239 mg/kg/30D- continuousBehavioral: Convulsions or effect on seizure threshold

Skin and Appendages: Other: Hair

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** PB288-416
oral/mouse lowest published toxic dose: 25 mg/kg/10D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Endocrine: Androgenic

Biochemical: Metabolism (intermediary): Other
ENVRAL 13,441,1977
oral/mouse lowest published toxic dose: 75600 µg/kg/18W- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation
EVHPAZ 39,79,1981
oral/mouse lowest published toxic dose: 840 µg/kg/2W- continuousImmunological Including Allergic: Decrease in humoral immune responseEVHPAZ 39,79,1981
oral/quail lowest published toxic dose: 14 mg/kg/14D- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
POSCAL 53,54,1974
oral/rabbit lowest published toxic dose: 751 µg/kg/13W- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Immunological Including Allergic: Decrease in humoral immune response

Biochemical: Metabolism (intermediary): Other proteins
BECTA6 10,42,1973
oral/rat lowest published toxic dose: 75 mg/kg/15D- continuousLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
TOLED5 11,131,1982
oral/rat lowest published toxic dose: 88 mg/kg/88D- continuousBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
JTEHD6 25,461,1988
oral/rat lowest published toxic dose: 140 mg/kg/8W- intermittentLiver: Other changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
TXAPA9 37,29,1976
oral/rat lowest published toxic dose: 109 mg/kg/2Y- continuousLiver: Changes in liver weightJAFCAU 3,402,1955
oral/rat lowest published toxic dose: 410 mg/kg/39W- continuousLiver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMPLAO 64,614,1957
oral/rat lowest published toxic dose: 120 mg/kg/30D- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Alteration of classical conditioning

Behavioral: Aggression
TOXID9 44,432,2005
oral/rat lowest published toxic dose: 120 mg/kg/30D- intermittentGastrointestinal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 44,432,2005
oral/rat lowest published toxic dose: 60 mg/kg/30D- intermittentLiver: Changes in liver weightTOXID9 44,432,2005
oral/rat lowest published toxic dose: 30 mg/kg/30D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)TOXID9 44,432,2005
oral/rat lowest published toxic dose: 32.5 mg/kg/13D- intermittentLiver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOXID9 90,143,2006
oral/rat lowest published toxic dose: 28 mg/kg/7D- intermittentBehavioral: Food intake (animal)TOXID9 44,432,2005
unreported route/mouse lowest published toxic dose: 30 mg/kg/30D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum
TOXID9 90,227,2006

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 mg/m3 (inhal, vapor, skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 5,125,1974
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 5,125,1974
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,196,1987
TOXICOLOGY REVIEWENVRAL 7,243,1974
TOXICOLOGY REVIEWJSIRAC 34,462,1975
TOXICOLOGY REVIEWDTTIAF 80,485,1973
TOXICOLOGY REVIEWRREVAH 56,107,1975
TOXICOLOGY REVIEWECMAAI 14,141,1973
TOXICOLOGY REVIEWBNYMAM 54,413,1978
TOXICOLOGY REVIEW85CVA2 5,250,1970
TOXICOLOGY REVIEW26UZAB 6,149,1968/1970
TOXICOLOGY REVIEWCTOXAO 13,231,1978
TOXICOLOGY REVIEWEESADV 1,89,1977
TOXICOLOGY REVIEWTXAPA9 10,613,1967
TOXICOLOGY REVIEWEVHPAZ 109(Suppl 1),113,2001
TOXICOLOGY REVIEWEVHPAZ 109(Suppl 1),35,2001
TOXICOLOGY REVIEWTOLED5 127,101,2002
TOXICOLOGY REVIEWMUREAV 567,109,2004
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWNETOX* 26,701,2005
TOXICOLOGY REVIEWNRTXDN 27,579,2006
TOXICOLOGY REVIEWBPCEM* 16,105,2002
TOXICOLOGY REVIEWENTOX* -,15,2005
TOXICOLOGY REVIEWENTOX* -,334,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWHETOEA 25,413,2006
TOXICOLOGY REVIEWJTEHD6 7,1,2004
TOXICOLOGY REVIEWREPTED 23,457,2007
TOXICOLOGY REVIEWJTPAE7 17,69,2004
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWTPHSDY 29,322,2008
TOXICOLOGY REVIEWFCTOD7 46,813,2008
TOXICOLOGY REVIEWMUREAV 674,3,2009
TOXICOLOGY REVIEWMUREAV 674,36,2009
TOXICOLOGY REVIEWMUREAV 674,73,2009
TOXICOLOGY REVIEWMUTAEX 22,161,2007
TOXICOLOGY REVIEWFESTAS 90,911,2008
TOXICOLOGY REVIEWNEUCL* 23,485,2005
TOXICOLOGY REVIEWMUREAV 705,184,2010
TOXICOLOGY REVIEWNRTXDN 31,555,2010
TOXICOLOGY REVIEWMUREAV 728,98,2011
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWNRTXDN 32,383,2011
TOXICOLOGY REVIEWREPTED 38,1,2013
TOXICOLOGY REVIEWNRTXDN 33,833,2012
TOXICOLOGY REVIEWTXAPA9 254,86,2011
TOXICOLOGY REVIEWMUREAV 760,1,2014
TOXICOLOGY REVIEWTOLED5 201,152,2011
TOXICOLOGY REVIEWTOLED5 202,36,2011
TOXICOLOGY REVIEWMUREAV 769,34,2014
TOXICOLOGY REVIEWTXCYAC 307,24,2013
TOXICOLOGY REVIEWTXCYAC 307,35,2013
TOXICOLOGY REVIEWTXCYAC 307,42,2013
TOXICOLOGY REVIEWTXCYAC 307,74,2013
TOXICOLOGY REVIEWTXCYAC 307,89,2013
TOXICOLOGY REVIEWTXCYAC 307,123,2013
TOXICOLOGY REVIEWMUREAV 764,31,2015
TOXICOLOGY REVIEWTOLED5 230,85,2014
TOXICOLOGY REVIEWTXAPA9 268,157,2013
TOXICOLOGY REVIEWMUREAV 802,1,2016
TOXICOLOGY REVIEWFCTOD7 86,298,2015

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.25 mg/m3 (skin)DTLVS* 3,84,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.25 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.25 mg/m3;KZW 2.5 mg/m3, inhal, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.25 mg/m3, Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.25 mg/m3, skin, carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.25 mg/m3, short term exposure limit 0.75 mg/m3, skin, NOV2011
Occupational Exposure Limit-FRANCEVME 0.25 mg/m3, Skin, C3 Carcinogen, FEB2006
Occupational Exposure Limit-GERMANYMAK 0.25 mg/m3, inhal, 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 0.25 mg/m3 (resp), short term exposure limit 1 mg/m3 (resp), SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.25 mg/m3, skin, NOV2011
Occupational Exposure Limit-INDIAtime-weighted average 0.25 mg/m3, Skin, JAN1993
Occupational Exposure Limit-KOREAtime-weighted average 0.25 mg/m3, skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.25 mg/m3;short term exposure limit 0.75 mg/m3 (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.25 mg/m3, skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.25 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0.25 mg/m3, JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.5 mg/m3, short term exposure limit 1.5 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.01 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.25 mg/m3, carc 3, inhal, skin, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.25 mg/m3, JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.25 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.25 mg/m3, Skin, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.25 mg/m3, Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.25 mg/m3 (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.25 mg/m3 (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.25 mg/m3 (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.25 mg/m3 (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIELDRIN-airCarcinogen time-weighted average 0.25 mg/m3 (Sk) (0.15 mg/m3 LOQ)NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974Hazard Code M2830; Number of Industries 2; Total Number of Facilities 56; Number of Occupations 3; Total Number of Employees Exposed 760

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/182368/AS)
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal; Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);equivocal evidence:mouseNCITR* NCI-TR-21,1978
NCI Carcinogenesis Bioassay (feed);no evidence:ratNCITR* NCI-TR-22,1978
NCI Carcinogenesis Bioassay (feed);no evidence:ratNCITR* NCI-TR-21,1978
On EPA IRIS database
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