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Registry of Toxic Effects of Chemical Substances (RTECS)

Dibenz(a,h)anthracene

RTECS #

HN2625000

CAS #

53-70-3

Updated

April 2017

Molecular Weight

278.36

Molecular Formula

C22H14

Synonyms

1,2,5,6-Dba
1,2,5,6-Dibenzanthraceen (Dutch)
1,2:5,6-Benzanthracene
1,2:5,6-Dibenz(a)anthracene
1,2:5,6-Dibenzanthracene
1,2:5,6-Dibenzoanthracene
DB(a,h)A
Dibenzo(a,h)anthracene
RCRA waste number U063

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisinhalation/Drosophila melanogaster2700 mg/LGENTAE 33,337,1948
Cytogenetic Analysisfibroblast/hamster1 mmol/LPJACAW 53,46,1977
DNA adductembryo/hamster360 nmol/LCBINA8 22,257,1978
DNA adductlung/hamster1 mg/LCBINA8 4,389,1971/1972
DNA adductoral/mouse6.3 mg/kg/9W- intermittentJJATDK 15,59,1995
DNA adductliver/rat3 µmol/L/24HMUTAEX 22,55,2007
DNA adducttestis/salmon5 µg/1H-continuousBIJOAK 110,159,1968
DNA adduct/Escherichia coli10 µmol/LMUREAV 89,95,1981
DNA adductembryo/human360 nmol/LCBINA8 22,257,1978
DNA adductintratracheal/rat25560 µg/kgMUREAV 312,165,1994
DNA adductliver/mouse6 µmol/LJJIND8 62,947,1979
DNA adductskin/mouse40 µmol/kgIJCNAW 23,201,1979
DNA adductother cell types/mouse1 mg/LCBINA8 4,389,1971/1972
DNA adductembryo/mouse510 nmol/LIJCNAW 9,349,1972
DNA Damagefibroblast/hamster5 mg/L/24HBCPCA6 20,1297,1971
DNA Damageliver/human0.1 µmol/L/24HTXAPA9 259,58,2012
DNA Damageother cell types/human0.01 µmol/L/24HTXAPA9 259,58,2012
DNA Damageovary/human50 µmol/LMUREAV 575,17,2005
DNA Damagefibroblast/human1 µmol/L/24HMUREAV 547,109,2004
DNA Damagefibroblast/hamster10 µmol/L/2H (-enzymatic activation step)MUREAV 650,96,2008
DNA Damagekidney/hamster5 mg/LBCPCA6 20,1297,1971
DNA Damagelymphocyte/mammal (species unspecified)2 nmol/LJMOBAK 5,521,1962
DNA Damage/Escherichia coli1207.1 µg/L/3H (+enzymatic activation step)MUREAV 515,85,2002
DNA repair/Escherichia coli25 µg/wellMUREAV 46,53,1977
gene conversion and mitotic recombination/Drosophila melanogaster2 mmol/LMUREAV 514,193,2002
micronucleus testoral/mouse6.3 mg/kg/9W- intermittentJJATDK 15,59,1995
micronucleus testskin/mouse24 mg/kg/3DMUREAV 588,58,2005
micronucleus testovary/hamster60 µmol/L/24H (-enzymatic activation step)MUREAV 751,1,2013
micronucleus testovary/hamster100 µmol/L/3H (+enzymatic activation step)MUREAV 630,1,2007
micronucleus testintratracheal/rat25500 µg/kg/16H- intermittentMUREAV 326,147,1995
micronucleus testintraperitoneal/mouse500 mg/kgMUREAV 389,3,1997
morphological transformembryo/hamster2500 µg/LCNREA8 32,1391,1972
morphological transformkidney/hamster25 µg/LTOLED5 7,143,1980
morphological transformfibroblast/mouse500 µg/LAETODY 1,133,1980
morphological transformembryo/mouse100 µg/LJNCIAM 52,1167,1974
morphological transformoral/rat200 mg/kgCNREA8 40,1157,1980
morphological transformembryo/rat100 µg/LJNCIAM 51,799,1973
morphological transformembryo/mouse0.03 mg/L/72HMUREAV 702,100,2010
mutation in mammalian somatic cellslung/hamster500 µg/LMUREAV 136,65,1984
mutation in mammalian somatic cellslymphocyte/human54 µg/LMUREAV 371,123,1996
mutation in microorganisms/Neurospora crassa500 ppm (-enzymatic activation step)ANYAA9 71,1072,1958
mutation in microorganisms/Salmonella typhimurium5 µg/plate (-enzymatic activation step)MUREAV 174,247,1986
mutation in microorganismslung/hamster56400 nmol/L (+enzymatic activation step)MUREAV 46,27,1977
mutation in microorganismslymphocyte/mouse4250 µg/L (+enzymatic activation step)MUREAV 106,101,1982
mutation in microorganisms/Salmonella typhimurium39 µg/plate/48H (+enzymatic activation step)MUTAEX 20,217,2005
mutation in microorganisms/Salmonella typhimurium9.8 µg/plate/20M (+enzymatic activation step)MUTAEX 20,217,2005
other mutation test systemslung/hamster1 mg/LCBINA8 4,389,1971/1972
other mutation test systemsother cell types/mouse1 mg/LCBINA8 4,389,1971/1972
other mutation test systemsembryo/mouse510 nmol/LIJCNAW 9,349,1972
phage inhibition capacity/Escherichia coli2 µg/wellMUREAV 260,349,1991
sex chromosome loss and nondisjunctionparenteral/Drosophila melanogaster5 mmol/LEJGCA9 4,400,1975
sex chromosome loss and nondisjunctioninhalation/Drosophila melanogaster2700 mg/LGENTAE 33,337,1948
sister chromatid exchangeintratracheal/rat51150 µg/kgMUREAV 312,165,1994
sister chromatid exchangeintraperitoneal/hamster900 mg/kg/24HMUREAV 66,65,1979
Unscheduled DNA Synthesisoral/mouse6.3 mg/kg/9W- intermittentJJATDK 15,59,1995
Unscheduled DNA Synthesisother cell types/other fish100 µmol/LCBPCEE 86,399,1987
Unscheduled DNA Synthesisfibroblast/human100 µmol/LCBPCEE 86,399,1987
Unscheduled DNA Synthesisother cell types/human10 mg/LCNREA8 38,2091,1978
Unscheduled DNA SynthesisHeLa cell/human100 nmol/LCNREA8 38,2621,1978

Tumorigenic Data and References

Route/OrganismDoseEffectReference
implant/mouse lowest published toxic dose: 80 mg/kgTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
BJCAAI 11,212,1957
implant/mouse toxic dose: 14 mg/kgTumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application
AJPAA4 16,287,1940
implant/mouse toxic dose: 200 mg/kgTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma

Tumorigenic: Tumors at site of application
AJCAA7 36,201,1939
implant/mouse toxic dose: 100 mg/kgTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Tumorigenic: Tumors at site of application
BMBUAQ 14,147,1958
intramuscular/pigeon lowest published toxic dose: 6 mg/kgTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Tumorigenic: Tumors at site of application
JNCIAM 32,905,1964
intrarenal/frog lowest published toxic dose: 12 mg/kgTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Kidney, Ureter, and Bladder: Kidney tumors
CNREA8 24,1969,1964
intratracheal/rat lowest published toxic dose: 100 mg/kgTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
GISAAA 31(7),12,1966
intravenous/guinea pig lowest published toxic dose: 30 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumors at site of application
JNCIAM 13,705,1952
intravenous/mouse lowest published toxic dose: 40 mg/kgTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
PHRPA6 54,1158,1939
multiple/mouse lowest published toxic dose: 40 mg/kg/12D- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumors at site of application
PHRPA6 52,637,1937
oral/mouse lowest published toxic dose: 4160 mg/kg/26W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
JPBAA7 49,21,1939
oral/mouse toxic dose: 4520 mg/kg/36W- continuousTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Gastrointestinal: Tumors
JNCIAM 1,17,1940
skin/mouse toxic dose: 400 mg/kg/40W- intermittentTumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors
CNREA8 22,78,1962
skin/mouse toxic dose: 6 µg/kgTumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors
CNREA8 20,1179,1960
skin/mouse lowest published toxic dose: 1200 mg/kg/50W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
14JTAF -,275,1965
subcutaneous/guinea pig lowest published toxic dose: 250 mg/kg/24D- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumors at site of application
AKBNAE 51,112,1938
subcutaneous/mouse lowest published toxic dose: 445 µg/kgTumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
CRNGDP 11,1721,1990
subcutaneous/mouse toxic dose: 6 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
IJCNAW 32,765,1983
subcutaneous/mouse toxic dose: 78 µg/kgTumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application
JNCIAM 3,503,1943
subcutaneous/mouse toxic dose: 400 mg/kg/10W- intermittentTumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application
IJCNAW 2,500,1967
subcutaneous/rat toxic dose: 135 mg/kg/9W- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumors at site of application
PSEBAA 68,330,1948

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration Low: 1 µmol/L/14HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXCYAC 279,36,2011
In Vitro/Human, liver tumor Inhibitor Concentration (20 percent kill): 3.79 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TOLED5 212,18,2012
intratracheal/mouse lowest published toxic dose: 3 mg/kgLung, Thorax, or Respiration: Other changes

Immunological Including Allergic: Decreased immune response

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 12,439,2008
intravenous/mouse lowest published lethal dose: 10 mg/kgJNCIAM 1,225,1940
oral/mouse lowest published toxic dose: 8351 µg/kgImmunological Including Allergic: Decrease in humoral immune response

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TOXID9 44,182,2005

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 58.5 mg/kg/7D- intermittentEndocrine: Changes in spleen weight

Endocrine: Changes in thymus weight

Blood: Changes in spleen
TOXID9 44,182,2005
oral/mouse lowest published toxic dose: 58.5 mg/kg/7D- intermittentImmunological Including Allergic: Decrease in cellular immune responseTOXID9 44,182,2005
subcutaneous/mouse lowest published toxic dose: 14000 µg/kg/28D- intermittentImmunological Including Allergic: Decrease in humoral immune responseTOXID9 44,182,2005
subcutaneous/mouse lowest published toxic dose: 1120 mg/kg/28D- intermittentImmunological Including Allergic: Hypersensitivity delayed (multiple organ involvement)TOXID9 44,182,2005
subcutaneous/mouse lowest published toxic dose: 140000 µg/kg/28D- intermittentImmunological Including Allergic: Decrease in cellular immune responseTOXID9 44,182,2005
unreported route/mouse lowest published toxic dose: 180 mg/kg/12D- intermittentImmunological Including Allergic: Uncharacterized (multiple organ involvement)TOXID9 48,13,1999

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 3,178,1973
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 32,299,1983
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 32,299,1983
International Agency for Research on Cancer (IARC)Cancer Review:Group 2AIMSUDL 7,56,1987
TOXICOLOGY REVIEWAEHLAU 23,6,1971
TOXICOLOGY REVIEWMUREAV 39,257,1977
TOXICOLOGY REVIEWBLFSBY 24,129,1983
TOXICOLOGY REVIEWMUREAV 544,397,2003
TOXICOLOGY REVIEWMUREAV 540,89,2003
TOXICOLOGY REVIEWMUREAV 558,155,2004
TOXICOLOGY REVIEWMUREAV 558,7,2004
TOXICOLOGY REVIEWTOLED5 140-141,353,2003
TOXICOLOGY REVIEWMUREAV 567,227,2004
TOXICOLOGY REVIEWMUREAV 567,109,2004
TOXICOLOGY REVIEWMUREAV 567,401,2004
TOXICOLOGY REVIEWMUREAV 567,151,2004
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWMUREAV 613,103,2006
TOXICOLOGY REVIEWFCTOD7 44,1699,2006
TOXICOLOGY REVIEWMUREAV 627,10,2007
TOXICOLOGY REVIEWENTOX* -,790,2005
TOXICOLOGY REVIEWMUREAV 547,1,2004
TOXICOLOGY REVIEWMUREAV 705,184,2010
TOXICOLOGY REVIEWMUTAEX 26,223,2011
TOXICOLOGY REVIEWMUREAV 727,1,2011
TOXICOLOGY REVIEWTOLED5 205,279,2011
TOXICOLOGY REVIEWMUTAEX 31,17,2016
TOXICOLOGY REVIEWMUREAV 764,64,2015
TOXICOLOGY REVIEWMUTAEX 31,117,2016
TOXICOLOGY REVIEWMUREAV 802,1,2016
TOXICOLOGY REVIEWFCTOD7 86,144,2015

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-NORWAYtime-weighted average 0.04 mg/m3, JAN1999
Occupational Exposure Limit-POLANDtime-weighted average 0.004 mg/m3, JAN1999

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264370)
EPA GENETOX PROGRAM 1988, Inconclusive: Cell transform.-mouse prostate; In vivo SCE-nonhuman
EPA GENETOX PROGRAM 1988, Inconclusive: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Positive/dose response: SHE-clonal assay
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; Cell transform.-SA7/F344 rat
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-BALB/c-3T3; SHE-focus assay
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-C3H/10T1/2; Cell transform.-mouse embryo
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; N crassa-forward mutation
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Polynuclear aromatic hydrocarbons by HPLC, 5506; by GC, 5515
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
On EPA IRIS database
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