p-Cymene
RTECS #
GZ5950000
CAS #
Updated
December 2017
Molecular Weight
134.24
Molecular Formula
C10H14
Synonyms
1-Methyl-4-isopropylbenzene
4-Isopropyl-1-methylbenzene
Benzene, 1-isopropyl-4-methyl-
Camphogen
Cumene, p-methyl-
Cymene
Cymol
Dolcymene
Paracymene
Paracymol
p-Isopropylmethylbenzene
p-Isopropyltoluene
p-Methylisopropyl benzene
4-Isopropyl-1-methylbenzene
Benzene, 1-isopropyl-4-methyl-
Camphogen
Cumene, p-methyl-
Cymene
Cymol
Dolcymene
Paracymene
Paracymol
p-Isopropylmethylbenzene
p-Isopropyltoluene
p-Methylisopropyl benzene
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
skin /rabbit | 500 mg/24H | moderate | FCTXAV 12,401,1974 |
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
micronucleus test | intraperitoneal/rat | 1250 mg/kg | HPV121 -,-,2002 |
morphological transform | fibroblast/mouse | 60000 µg/L | HPV121 -,-,2002 |
Unscheduled DNA Synthesis | liver/rat | 16000 µg/L | HPV121 -,-,2002 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
In Vitro/Hamster, ovary | Inhibitor Concentration (50 percent kill): >50 mg/L | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | JOETD7 151,652,2014 |
In Vitro/Human, fibroblast | Inhibitor Concentration (50 percent kill): >50 mg/L | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | JOETD7 151,652,2014 |
In Vitro/Human, monocyte | Inhibitor Concentration Low: 1000 µg/L | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | FCTOD7 50,3079,2012 |
In Vitro/mvb | Inhibitor Concentration (50 percent kill): 20.06 mg/L/72H | In Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc. | PYTOEY 20,615,2013 |
inhalation/guinea pig | lowest published toxic concentration: 9700 mg/m3/5H | Behavioral: Convulsions or effect on seizure threshold | HPV121 -,-,2002 |
inhalation/mouse | Lowest published lethal concentration: 9700 mg/m3/5H | Behavioral: Coma Lung, Thorax, or Respiration: Other changes Liver: Other changes | HPV121 -,-,2002 |
inhalation/mouse | lethal concentration (50 percent kill): 19500 mg/m3 | VCVGH* -,180,1990 | |
inhalation/mouse | lethal concentration (50 percent kill): 24000 mg/m3/2H | TOVEFN (1),41,2006 | |
inhalation/rat | Lowest published lethal concentration: 8000 ppm/4H | HPV121 -,-,2002 | |
inhalation/rat | lowest published toxic concentration: 9700 mg/m3/5H | Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Changes in structure or function of salivary glands | HPV121 -,-,2002 |
inhalation/rat | lowest published toxic concentration: 500 ppm/6H | Behavioral: Change in motor activity (specific assay) | HPV121 -,-,2002 |
inhalation/rat | lowest published toxic concentration: 1200 ppm/6H | Behavioral: Change in motor activity (specific assay) Nutritional and Gross Metabolic: Body temperature decrease | HPV121 -,-,2002 |
intraperitoneal/Dog | lowest published toxic dose: 2 gm/kg | Gastrointestinal: Hypermotility, diarrhea | VCVGH* -,180,1990 |
intraperitoneal/guinea pig | lowest published lethal dose: 2.162 mg/kg | VCVGH* -,180,1990 | |
intraperitoneal/mouse | lethal dose (50 percent kill): 1125 mg/kg | VCVGH* -,180,1990 | |
oral/human | lowest published toxic dose: 42.86 mg/kg | Behavioral: Headache Gastrointestinal: Nausea or vomiting | TOVEFN (1),41,2006 |
oral/human | lowest published toxic dose: 3 gm/kg | Gastrointestinal: Nausea or vomiting | VCVGH* -,181,1990 |
oral/mouse | lethal dose (50 percent kill): 1695 mg/kg | VCVGH* -,180,1990 | |
oral/mouse | lowest published toxic dose: 40 mg/kg/2H | Behavioral: Analgesia | PYTOEY 20,436,2013 |
oral/mouse | lowest published toxic dose: 40 mg/kg/1H | Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | PYTOEY 20,436,2013 |
oral/rat | lethal dose (50 percent kill): 4750 mg/kg | Eye: Chromodacryorrhea Behavioral: Somnolence (general depressed activity) Gastrointestinal: Hypermotility, diarrhea | FCTXAV 2,327,1964 |
oral/rat | lethal dose (50 percent kill): 3200 mg/kg | Behavioral: Tremor Liver: Other changes Blood: Hemorrhage | HPV121 -,-,2002 |
oral/rat | lethal dose (50 percent kill): 4750 mg/kg | Behavioral: Coma Gastrointestinal: Hypermotility, diarrhea Blood: Hemorrhage | HPV121 -,-,2002 |
oral/rat | lethal dose (50 percent kill): 1400 mg/kg | HPV121 -,-,2002 | |
oral/rat | lethal dose (90 percent kill): 5 mL/kg | VCVGH* -,180,1990 | |
skin/rabbit | lethal dose (50 percent kill): >5000 mg/kg | Skin: After topical application: Primary irritation | HPV121 -,-,2002 |
skin/rabbit | lethal dose (50 percent kill): 10545 mg/kg | HPV121 -,-,2002 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rat | lowest published toxic concentration: 250 ppm/4W- intermittent | Brain and Coverings: Other degenerative changes | HPV121 -,-,2002 |
Reviews
Organization | Standard | Reference |
---|---|---|
TOXICOLOGY REVIEW | JOETD7 174,540,2015 |
Standards and Regulations
NIOSH Documentation and Surveillance
Status in Federal Agencies
Organization | Reference |
---|---|
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health