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Registry of Toxic Effects of Chemical Substances (RTECS)

Cyclohexane, 1,2,3,4,5,6-hexachloro-, beta-isomer

RTECS #

GV4375000

CAS #

319-85-7

Updated

December 2015

Molecular Weight

290.82

Molecular Formula

C6H6Cl6

Synonyms

1-alpha,2-beta,3-alpha,4-beta,5-alpha,6-beta-Hexachlorocyclohexane
beta-1,2,3,4,5,6-Hexachlorocyclohexane
beta-BHC
beta-HCH
beta-Hexachlorobenzene
beta-Hexachlorocyclohexane
Beta-Hexachlorocyclohexane
beta-Lindane
Cyclohexane, 1,2,3,4,5,6-hexachloro-, beta-
Cyclohexane, 1,2,3,4,5,6-hexachloro-, trans-
Cyclohexane, beta-1,2,3,4,5,6-hexachloro-
ENT 9,233
trans-alpha-Benzenehexachloride

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 672 mg/kg (2W male)Reproductive: Paternal effects: Testes, epididymis, sperm ductBECTA6 41,531,1988
subcutaneous/mouse 100 mg/kg (7D prior to copulation)Reproductive: Maternal effects: Uterus, cervix, vaginaEVHPAZ 108,973,2000

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 18 gm/kg/2Y- continuousTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
FCTXAV 11,433,1973

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, embryonic cells Inhibitor Concentration (50 percent kill): 6.9 nmol/L/1HIn Vitro Toxicity Studies: Other assaysNRTXDN 40,102,2014
In Vitro/jrdInhibitor Concentration Low: 10 µmol/L/5MBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: PhosphokinaseTXAPA9 245,160,2010
In Vitro/jrdInhibitor Concentration Low: 10 µmol/L/24HIn Vitro Toxicity Studies: Other assaysTXAPA9 245,160,2010
intraperitoneal/mouse lowest published toxic dose: 5000 µg/kgLiver: Other changes

Endocrine: Estrogenic

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
TXAPA9 201,137,2004
oral/mouse lowest published lethal dose: 1500 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
PHTXA6 22,273,1959
oral/rat lethal dose (50 percent kill): 6 gm/kgALLVAR 43,-,1955

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/monkey lowest published toxic dose: 2250 mg/kg/90D- intermittentLiver: Fatty liver degeneration

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
NYKZAU 70,85P,1974
oral/mouse lowest published toxic dose: 6048 mg/kg/12W- continuousLiver: Other changes

Liver: Changes in liver weight
CMSHAF 1,153,1972
oral/mouse lowest published toxic dose: 1080 mg/kg/30D- continuousBlood: Changes in spleenHBPTO* 1,771,2001
oral/mouse lowest published toxic dose: 9 gm/kg/30D- continuousEndocrine: Changes in spleen weight

Blood: Changes in other cell count (unspecified)

Immunological Including Allergic: Decrease in cellular immune response
FAATDF 11,293,1988
oral/mouse lowest published toxic dose: 13104 mg/kg/26W- continuousLiver: Other changes

Liver: Tumors

Liver: Changes in liver weight
CMSHAF 1,279,1972
oral/rat lowest published toxic dose: 9 mg/kg/3D- intermittentRelated to Chronic Data: Changes in uterine weightTXAPA9 218,280,2007
oral/rat lowest published toxic dose: 672 mg/kg/2W- continuousLiver: Other changes

Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
BECTA6 41,531,1988
oral/rat lowest published toxic dose: 22750 mg/kg/13W- continuousLiver: Changes in liver weight

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
FAATDF 6,697,1986
oral/rat lowest published toxic dose: 8736 mg/kg/26W- continuousLiver: Other changes

Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JPETAB 100,59,1950
oral/rat lowest published toxic dose: 1989 mg/kg/30D- continuousPeripheral Nerve and Sensation: Recording from peripheral motor nerveBECTA6 27,704,1981
subcutaneous/mouse lowest published toxic dose: 100 mg/kg/1W- continuousEndocrine: Estrogenic

Reproductive: Maternal effects: Uterus, cervix, vagina
EVHPAZ 108,973,2000

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 20,195,1979
TOXICOLOGY REVIEWREPTED 19,209,2004
TOXICOLOGY REVIEWNRTXDN 27,579,2006
TOXICOLOGY REVIEWCLBIAS 39,762,2006
TOXICOLOGY REVIEWENTOX* -,515,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWJTEHD6 7,1,2004
TOXICOLOGY REVIEWJTPAE7 19,111,2006
TOXICOLOGY REVIEWTOLED5 202,36,2011
TOXICOLOGY REVIEWTXCYAC 307,35,2013
TOXICOLOGY REVIEWTXCYAC 307,42,2013
TOXICOLOGY REVIEWTXCYAC 307,74,2013
TOXICOLOGY REVIEWTXCYAC 307,89,2013
TOXICOLOGY REVIEWMUREAV 765,19,2015

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 mg/m3, skin, carc, MAY2011
Occupational Exposure Limit-GERMANYMAK 0.5 mg/m3, inhal, 2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.5 mg/m3, skin, NOV2011
Occupational Exposure Limit-SWITZERLANDMAK-week 0.5 mg/m3, inhal, skin, JAN2011

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/99/166662)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
On EPA IRIS database
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