Cyanogen chloride

RTECS #

GT2275000

CAS #

506-77-4
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

61.47

Molecular Formula

CClN

Synonyms

Chlorcyan
Chlorine cyanide
Chlorocyan
Chlorocyanide
Chlorocyanogen
Chlorure de cyanogene (French)
Cyanogen chloride (ACGIH)
RCRA waste number P033

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/human	lowest published toxic concentration: 10 mg/m³	Eye: Lacrimation Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion	WHOTAC -,31,1970
inhalation/human	lowest published toxic concentration: 2 mg/m³	Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi	TOVEFN (2),39,2001
inhalation/human	lowest published toxic concentration: 60 mg/m³	Eye: Lacrimation Eye: Change in extra- ocular muscles	TOVEFN (2),39,2001
inhalation/human	Lowest published lethal concentration: 400 mg/m³/10M	Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)	TOVEFN (2),39,2001
inhalation/man	lowest published toxic concentration: 2 gm/m³	Skin: After topical application: Primary irritation	NTIS** PB158-508
inhalation/rat	lethal concentration (50 percent kill): 600 mg/m³/4H		TOVEFN (2),39,2001
oral/cat	lethal dose (50 percent kill): 6 mg/kg		ENTOX* -,701,2005
subcutaneous/Dog	lowest published lethal dose: 5 mg/kg		HBAMAK 4,1341,1935
subcutaneous/pigeon	lowest published lethal dose: 8700 µg/kg		HBAMAK 4,1341,1935
subcutaneous/rabbit	lowest published lethal dose: 20 mg/kg		HBAMAK 4,1341,1935
unreported route/Dog	lethal dose (50 percent kill): 3300 µg/kg		NTIS** PB158-508
unreported route/domestic animal	lethal dose (50 percent kill): 2970 µg/kg		NTIS** PB158-508
unreported route/rabbit	lethal dose (50 percent kill): 3150 µg/kg		NTIS** PB158-508

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-ceiling concentration 0.3 ppm	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		MUREAV 539,77,2003
TOXICOLOGY REVIEW		CPEMM* 3,239,2002
TOXICOLOGY REVIEW		ENTOX* -,701,2005
TOXICOLOGY REVIEW		CCACL* 21,691,2005

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	ceiling concentration 0.3 ppm (0.75 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.3 ppm (0.6 mg/m³);KZW 0.3 ppm (0.6 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.3 ppm (0.76 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.1 ppm (0.3 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	short term exposure limit 0.1 ppm (0.26 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VLE 0.3 ppm (0.6 mg/m³), FEB2006
Occupational Exposure Limit-GERMANY	MAK 2 mg(CN)/m³, inhal, 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 5 mg(CN)/m³, short term exposure limit 20 mg(CN)/m³, Skin, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 0.1 ppm (0.3 mg/m³), NOV2011
Occupational Exposure Limit-KOREA	ceiling concentration 0.3 ppm (0.6 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 5 mg(CN)/m³, 2004
Occupational Exposure Limit-NEW ZEALAND	ceiling concentration 0.3 ppm (0.75 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 0.25 ppm (0.6 mg/m³), JAN1999
Occupational Exposure Limit-PERU	short term exposure limit 0.3 ppm (0.75 mg/m³), JUL2005
Occupational Exposure Limit-RUSSIA	short term exposure limit 0.2 mg/m³, Skin, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 0.1 ppm (0.3 mg/m³);short term exposure limit 0.3 ppm (0.8 mg/m³), JUN2005
Occupational Exposure Limit-SWITZERLAND	ceiling concentration 2 mg(CN)/m³, inhal, skin, JAN2011
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.3 ppm (0.8 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-C 0.6 mg/m³, 2003
Occupational Exposure Limit-UNITED KINGDOM	short term exposure limit 0.3 ppm (0.77 mg/m³), OCT2007

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYANOGEN CHLORIDE-air	ceiling concentration 0.3 ppm	NIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983	Hazard Code 84337; Number of Industries 1; Total Number of Facilities 4; Number of Occupations 16; Total Number of Employees Exposed 1391
National Occupational Hazard Survey 1974	Hazard Code 84337; Number of Industries 1; Total Number of Facilities 34; Number of Occupations 1; Total Number of Employees Exposed 134

Status in Federal Agencies

Organization	Reference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/98/101207/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9033
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; selected, October 2000
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health