m-Cresol, 4-chloro-

RTECS #
GO7100000
CAS #
59-50-7
See: NMAM or OSHA Methods
Updated
December 2018
Molecular Weight
142.59
Molecular Formula
C7H7ClO
Synonyms
3-Methyl-4-chlorophenol
4-Chloro-3-methylphenol
4-Chloro-m-cresol
Aptal
Baktol
Baktolan
Candaseptic
Chlorocresol
Ottafact
Parol
p-Chlor-m-cresol
p-Chloro-m-cresol
PCMC
Peritonan
Phenol, 4-chloro-3-methyl- (9CI)
Preventol CMK
Raschit
Raschit K
Rasen-Anicon
RCRA waste number U039

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /guinea pig 5 ppmTXCYAC 211,165,2005
skin /mouse 50% severeTOXID9 -,270,2008

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium25 µg/plate (-enzymatic activation step)TECSDY 14,143,1987
other mutation test systems/Escherichia coli100 µmol/LMUREAV 307,141,1994

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, leukemia cells Inhibitor Concentration (25 percent kill): 29 mg/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 30,318,2015
In Vitro/Human, leukemia cells Inhibitor Concentration Low: 29 mg/L/48HImmunological Including Allergic: Increase in cellular immune responseTIVIEQ 30,318,2015
In Vitro/Human, leukemia cells Inhibitor Concentration Low: 29 mg/L/24HBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationTIVIEQ 30,318,2015
intravenous/mouse lethal dose (50 percent kill): 70 mg/kgBehavioral: Coma

Lung, Thorax, or Respiration: Other changes
QJPPAL 12,212,1939
oral/mouse lethal dose (50 percent kill): 600 mg/kgBehavioral: Somnolence (general depressed activity)SRTCAC 36(1-4),10,1989
oral/rat lethal dose (50 percent kill): 1830 mg/kgSchP## 04APR1986
subcutaneous/mouse lethal dose (50 percent kill): 360 mg/kgBehavioral: General anesthetic

Behavioral: Tremor

Lung, Thorax, or Respiration: Other changes
QJPPAL 12,212,1939
subcutaneous/rat lethal dose (50 percent kill): 400 mg/kgQJPPAL 12,212,1939

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 11200 mg/kg/28D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainBECTA6 37,651,1986
oral/rat lowest published toxic dose: 407997 mg/kg/2Y- intermittentKidney, Ureter, and Bladder: Other changesTOXID9 78,151,2004
skin/mouse lowest published toxic dose: 600 mg/kg/3D- intermittentSkin: After topical application: Cutaneous sensitization (experimental)

Immunological Including Allergic: Increase in cellular immune response
TXCYAC 190,259,2003

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWHUTOX* -,259,1996
TOXICOLOGY REVIEWDERCL* 27,289,2009
TOXICOLOGY REVIEWRTOPDW 55,200,2009

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,245,1998
Occupational Exposure Limit-SWEDENtime-weighted average 3 mg/m3;short term exposure limit 6 mg/m3, Sen, JUN2005
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 3 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84772; Number of Industries 65; Total Number of Facilities 5608; Number of Occupations 62; Total Number of Employees Exposed 175929; Total Number of Female Employees Exposed 24335
National Occupational Hazard Survey 1974Hazard Code 84772; Number of Industries 2; Total Number of Facilities 29; Number of Occupations 12; Total Number of Employees Exposed 876

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
Page last reviewed: November 16, 2018