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Registry of Toxic Effects of Chemical Substances (RTECS)

Copper (II) sulfate (1:1)

RTECS #

GL8800000

CAS #

7758-98-7

Updated

December 2016

Molecular Weight

159.60

Molecular Formula

O4S·Cu

Synonyms

BCS copper fungicide
Blue Copper
Blue stone
Blue vitriol
Copper monosulfate
Copper sulfate
Copper sulfate (1:1)
Copper(2+) sulfate
Copper(2+) sulfate (1:1)
Copper(II) sulfate
Cupric sulfate anhydrous
Cupric sulphate
Griffin super Cu
Incracide 10A
Incracide E 51
Kilcop 53
Kobasic
Phyto-bordeaux
Roman vitriol
Sulfate de cuivre (French)
Sulfuric acid, copper(2+) salt (1:1)
TNCS 53
Trinagle

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA DamageAscites tumor/rat500 µmol/LJBCHA3 261,3370,1986
DNA Damageliver/rat1 mmol/LSinJF# 26OCT1982
DNA Damageoral/mouse1.25 mg/kgFCTOD7 42,1931,2004
DNA Damagemultiple/non-mammalian species7.50 mg/L/2HMUREAV 605,78,2006
DNA inhibitionintraperitoneal/mouse20 gm/kgARGEAR 51,605,1981
micronucleus testmultiple/non-mammalian species3.75 mg/L/24HMUREAV 605,78,2006
micronucleus testoral/mouse8.5 mg/kgMUREAV 577S,1,2005
morphological transformembryo/hamster80 µmol/LCNREA8 39,193,1979
mutation in microorganisms/Escherichia coli7500 ppt/3H (-enzymatic activation step)AMNTA4 85,119,1951
mutation in microorganisms/Bacillus subtilis400 µmol/L (-enzymatic activation step)AMAHA5 21,297,1974
other mutation test systems/Bacillus subtilis400 µmol/LJOBAAY 85,1003,1963
sex chromosome loss and nondisjunctionparenteral/Drosophila melanogaster1000 ppmPNASA6 24,546,1938
sex chromosome loss and nondisjunctionunreported route/Drosophila melanogaster7100 ppmBMAOA3 7,635,1938
Unscheduled DNA Synthesisembryo/hamster200 µmol/LMUREAV 131,173,1984

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 7500 µg/kg (3D pregnant)Reproductive: Effects on fertility: Other measures of fertilityBECTA6 25,702,1980
intratesticular/rat 3192 µg/kg (1D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JRPFA4 7,21,1964
intravenous/mouse 3200 µg/kg (8D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
WRABDT 186,297,1979
intravenous/mouse 3200 µg/kg (7D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)WRABDT 186,297,1979
intravenous/hamster 2130 µg/kg (8D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Body wall
BIREBV 11,97,1974
oral/pig 140 mg/kg (1-15W preg/4W after birth)Reproductive: Effects on newborn: Biochemical and metabolicCNJNAT 71,227,1991
subcutaneous/mouse 12768 µg/kg (30D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductJRPFA4 7,21,1964
subcutaneous/rat 12768 µg/kg (1D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductJRPFA4 7,21,1964

Tumorigenic Data and References

Route/OrganismDoseEffectReference
parenteral/chicken lowest published toxic dose: 10 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Tumors
BEXBAN 9,519,1940

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration Low: 100 µmol/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)

In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.

In Vitro Toxicity Studies: Other assays
FCTOD7 50,415,2012
In Vitro/Human, lung tumor Inhibitor Concentration Low: 100 µmol/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)

In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.

In Vitro Toxicity Studies: Other assays
FCTOD7 50,415,2012
In Vitro/Human, melanoma Inhibitor Concentration (50 percent kill): 70.8 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.FCTOD7 50,2084,2012
In Vitro/Human, neuroblastoma Inhibitor Concentration Low: 500 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Other assays
TIVIEQ 27,844,2013
In Vitro/Human, neuroblastoma Inhibitor Concentration Low: 0.5 µmol/L/24HIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,844,2013
In Vitro/jafInhibitor Concentration Low: 50 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,844,2013
In Vitro/jahInhibitor Concentration Low: 500 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.

In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.
TIVIEQ 27,844,2013
In Vitro/mtbInhibitor Concentration (50 percent kill): 0.93 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TOLED5 212,169,2012
In Vitro/mtbInhibitor Concentration (50 percent kill): 1.92 mmol/L/1HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TOLED5 212,169,2012
In Vitro/mtbInhibitor Concentration (50 percent kill): 1.05 mmol/L/21HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TOLED5 212,169,2012
In Vitro/mtbInhibitor Concentration (50 percent kill): 2.71 mmol/L/1HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TOLED5 212,169,2012
In Vitro/mtbInhibitor Concentration (50 percent kill): 0.25 gm/L/1HIn Vitro Toxicity Studies: Other assaysTOLED5 212,169,2012
In Vitro/Non-mammalian species, fibroblast Inhibitor Concentration (50 percent kill): 1.09 mmol/L/24HIn Vitro Toxicity Studies: Cell countingTIVIEQ 7,537,1993
In Vitro/Rat, lung Inhibitor Concentration (10 percent kill): 0.07 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)TIVIEQ 7,111,1993
In Vitro/Rat, lung Inhibitor Concentration (50 percent kill): 0.15 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)TIVIEQ 7,111,1993
In Vitro/Rat, lung Inhibitor Concentration (75 percent kill): 0.24 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)TIVIEQ 7,111,1993
intraperitoneal/mouse lethal dose (50 percent kill): 7182 µg/kgCOREAF 256,1043,1963
intraperitoneal/rat lethal dose (50 percent kill): 20 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
intratracheal/rat lowest published toxic dose: 100 µg/kgLung, Thorax, or Respiration: SputumHBTME* -,529,2007
intravenous/frog lowest published lethal dose: 25 mg/kgHBTXAC 1,76,1955
intravenous/guinea pig lowest published lethal dose: 2 mg/kgEQSSDX 1,1,1975
intravenous/mouse lethal dose (50 percent kill): 23300 µg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
intravenous/rabbit lethal dose (50 percent kill): 10 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Food intake (animal)

Gastrointestinal: Hypermotility, diarrhea
JIHTAB 31,301,1949
intravenous/rat lethal dose (50 percent kill): 48900 µg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
intravenous/rat lowest published toxic dose: 12 mg/kgEndocrine: Change in LHENEXAM 4,37,1970
oral/chicken lowest published toxic dose: 50 mg/kgGastrointestinal: Nausea or vomitingPYTOEY 9,146,2002
oral/child lowest published toxic dose: 150 mg/kgKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Other hemolysis with or without anemia
AJDCAI 131,149,1977
oral/Dog lowest published toxic dose: 37.5 mg/kgGastrointestinal: Nausea or vomitingFATOAO 47,55,1984
oral/human lethal dose (50 percent kill): 50 mg/kgUSXXAM #6770674
oral/human lowest published toxic dose: 0.029 mg/kgKidney, Ureter, and Bladder: Other changes in urine compositionHBTME* -,529,2007
oral/human lowest published lethal dose: 50 mg/kgBehavioral: Somnolence (general depressed activity)

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Hemorrhage
JAMAAP 235,801,1976
oral/human lowest published toxic dose: 11 mg/kgGastrointestinal: Gastritis

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting
LANCAO 2,700,1960
oral/man lowest published lethal dose: 857 mg/kgGastrointestinal: Nausea or vomitingATXKA8 17,20,1958
oral/mouse lethal dose (50 percent kill): 369 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
INJPD2 23,153,1991
oral/mouse lethal dose (50 percent kill): 87 mg/kgHBPTO* 2,1361,2001
oral/rat lethal dose (50 percent kill): 300 mg/kgUSXXAM #6770674
oral/rat lethal dose (50 percent kill): 960 mg/kgBehavioral: Muscle contraction or spasticity

Vascular: Shock

Gastrointestinal: Nausea or vomiting
HBPTO* 2,1361,2001
oral/woman lowest published toxic dose: 2100 µg/kg/5W- intermittentGastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting

Gastrointestinal: Other changes
TOXID9 54,73,2000
oral/woman lowest published lethal dose: 47320 µL/kgGastrointestinal: Hypermotility, diarrhea

Liver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
NPRNAY 15,74,1975
oral/woman lowest published toxic dose: 24 µg/kgGastrointestinal: Nausea or vomitingTOXID9 66,102,2002
oral/woman lowest published toxic dose: 0.024 mg/kgReproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Menstrual cycle changes or disorders
TOXID9 60,436,2001
oral/woman lowest published lethal dose: 50 mg/kgKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)JTCTDW 39,161,2001
subcutaneous/mouse lowest published lethal dose: 500 µg/kgTJIZAF 48,313,1978
subcutaneous/rat lethal dose (50 percent kill): 43 mg/kgPESTD5 16,252,1975
Tank with water/Catfish Lowest published lethal concentration: 354 µmol/L/7DTIVIEQ 37,327,1997
Tank with water/Zebrafish lethal concentration (50 percent kill): 0.121 mg/L/24HNETEEC 50,33,2015
Tank with water/Zebrafish lethal concentration (50 percent kill): 0.124 mg/L/48HNETEEC 50,33,2015
Tank with water/Zebrafish lethal concentration (50 percent kill): 0.125 mg/L/72HNETEEC 50,33,2015
Tank with water/Zebrafish lowest published toxic concentration: 0.01 mg/L/72HReproductive: Other developmental abnormalitiesNETEEC 50,33,2015
Tank with water/Zebrafish lowest published toxic concentration: 0.024 mg/L/72HReproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Behavioral
NETEEC 50,33,2015
Tank with water/Zebrafish lowest published toxic concentration: 0.152 mg/L/72HReproductive: Effects on embryo or fetus: Fetal deathNETEEC 50,33,2015
unreported route/rat lethal dose (50 percent kill): 520 mg/kgGTPZAB 26(6),21,1982

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 791 mg/kg/18W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTXAPA9 18,562,1971
multiple/non-mammalian species lowest published toxic dose: 0.002 gm/m3/30D- continuousLiver: Other changes

Immunological Including Allergic: Decrease in humoral immune response

Biochemical: Metabolism (intermediary): Lipids including transport
TOVEFN -,13,2009
multiple/non-mammalian species lowest published toxic dose: 0.02 gm/m3/45D- continuousLiver: Other changes

Liver: Changes in liver weight

Immunological Including Allergic: Decrease in humoral immune response
TOVEFN -,13,2009
multiple/non-mammalian species lowest published toxic dose: 0.002 gm/m3/60D- continuousLiver: Other changes

Liver: Changes in liver weight

Immunological Including Allergic: Decrease in humoral immune response
TOVEFN -,13,2009
oral/human lowest published toxic dose: 598.5 mg/kg/5W- intermittentGastrointestinal: Nausea or vomitingRTOPDW 34,137,2001
oral/mouse lowest published toxic dose: 3 gm/kg/8W- continuousBlood: Changes in spleen

Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response
FAATDF 16,249,1991
oral/mouse lowest published toxic dose: 2 gm/kg/3W- continuousBlood: Changes in spleen

Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response
FAATDF 16,249,1991
oral/mouse lowest published toxic dose: 240 mg/kg/3D- intermittentLiver: Other changes

Liver: Changes in liver weight
TXCYAC 249,176,2008
oral/rat lowest published toxic dose: 14 mg/kg/7D- intermittentNutritional and Gross Metabolic: Changes in: Ca

Musculoskeletal: Other changes
BPBLEO 28,2296,2005
oral/rat lowest published toxic dose: 675 mg/kg/45D- intermittentLiver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Liver: Jaundice, cholestatic

Liver: Liver function tests impaired
TXAPA9 250,54,2011
oral/rat lowest published toxic dose: 10.4 gm/kg/18W- continuousLiver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Liver function tests impaired
JTCTDW 38,709,2000
oral/rat lowest published toxic dose: 50.4 gm/kg/16W- continuousLiver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Liver function tests impaired
JTCTDW 38,709,2000
oral/rat lowest published toxic dose: 9.45 gm/kg/18W- intermittentLiver: Hepatitis (hepatocellular necrosis), diffuse

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
JTCTDW 38,709,2000
oral/rat lowest published toxic dose: 37.8 gm/kg/12W- intermittentLiver: Hepatitis (hepatocellular necrosis), diffuse

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
JTCTDW 38,709,2000
oral/rat lowest published toxic dose: 915 mg/kg/1Y- intermittentCardiac: Changes in coronary arteries

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
GISAAA 54(2),64,1989
oral/rat lowest published toxic dose: 157 mg/kg/6W- intermittentEndocrine: Changes in adrenal weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
TXAPA9 28,395,1974
oral/rat lowest published toxic dose: 7530 mg/kg/30D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOLED5 38,275,1987
oral/rat lowest published toxic dose: 2 gm/kg/20D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOLED5 6,163,1980
oral/woman lowest published toxic dose: 0.7 mg/kg/7D- continuousGastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting

Gastrointestinal: Other changes
EVHPAZ 109,949,2001

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWADTEAS 5,51,1972
TOXICOLOGY REVIEWAJMEAZ 38,409,1965
TOXICOLOGY REVIEW85DHAX Cu,23,1977
TOXICOLOGY REVIEWTOLED5 128,45,2002
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWDIMON* 39,678,1993
TOXICOLOGY REVIEWENTOX* -,665,2005
TOXICOLOGY REVIEWENTOX* -,110,2005
TOXICOLOGY REVIEWHUTOX* -,561,1996
TOXICOLOGY REVIEWHTOPA* 1,595,2002
TOXICOLOGY REVIEWMUREAV 681,80,2009
TOXICOLOGY REVIEWNBREV* 5,1,1981
TOXICOLOGY REVIEWNBREV* 11,107,1987
TOXICOLOGY REVIEWMUTAEX 21,343,2006
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWMUREAV 767,67,2016
TOXICOLOGY REVIEWTXAPA9 268,157,2013

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,105,1998
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.1 mg(Cu)/m3 (fume), JAN1993
Occupational Exposure Limit-FINLANDtime-weighted average 1 mg(Cu)/m3, NOV2011
Occupational Exposure Limit-GERMANYMAK 0.1 mg(Cu)/m3, inhal, 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 1 mg(Cu)/m3, short term exposure limit 4 mg(Cu)/m3, SEP2000
Occupational Exposure Limit-INDIAtime-weighted average 0.2 mg(Cu)/m3 (fume), JAN1993
Occupational Exposure Limit-RUSSIAtime-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 1 mg(Cu)/m3;time-weighted average 0.2 mg(Cu)/m3 (resp. dust), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg(Cu)/m3, KZG-week 0.2 mg(Cu)/m3, inhal, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 1 mg(Cu)/m3, JAN1993
Occupational Exposure Limit-THAILANDtime-weighted average 0.1 mg(Cu)/m3 (fume), JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 1.0 mg(Cu)/m3 (fume), JAN1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 20900; Number of Industries 114; Total Number of Facilities 9321; Number of Occupations 94; Total Number of Employees Exposed 227496; Total Number of Female Employees Exposed 105906
National Occupational Hazard Survey 1974Hazard Code 20900; Number of Industries 76; Total Number of Facilities 4642; Number of Occupations 58; Total Number of Employees Exposed 57558

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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