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Registry of Toxic Effects of Chemical Substances (RTECS)

Cobalt(2+) oxide

RTECS #

GG2800000

CAS #

1307-96-6

Updated

December 2016

Molecular Weight

74.93

Molecular Formula

CoO

Synonyms

C.I. 77322
C.I. Pigment Black 13
Cobalt Black
Cobalt monooxide
Cobalt monoxide
Cobaltous oxide
Monocobalt oxide
Zaffre

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/human0.5 µg/well/24HTXAPA9 278,259,2014

Tumorigenic Data and References

Route/OrganismDoseEffectReference
intramuscular/rat lowest published toxic dose: 135 mg/kgTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
CNREA8 22,152,1962
intramuscular/rat toxic dose: 90 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Musculoskeletal: Tumors

Tumorigenic: Tumors at site of application
CNREA8 22,158,1962

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, lung fibroblast Inhibitor Concentration Low: 0.1 µg/cm2/24HIn Vitro Toxicity Studies: Cell growth: Colony formationTXAPA9 278,259,2014
intramuscular/mouse lowest published lethal dose: 400 mg/kgCNREA8 22,152,1962
intratracheal/rat lowest published lethal dose: 50 mg/kgVCVN5* -,452,1989
intratracheal/rat lowest published toxic dose: 25 mg/kgLung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Fibrosing alveolitis
VCVN5* -,452,1989
oral/Dog lowest published lethal dose: 89 mg/kgEQSSDX 1,1,1975
oral/rat lethal dose (50 percent kill): 202 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 20,311,1982
oral/rat lethal dose (50 percent kill): 202 mg/kgKidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Blood: Hemorrhage
VCVN5* -,453,1989
subcutaneous/mouse lethal dose (50 percent kill): 125 mg/kgZVKOA6 19,186,1974

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic dose: 50 mg/m3/8H/35D- intermittentLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0555434
inhalation/rabbit lowest published toxic concentration: 50 mg/m3/8H/35D- intermittentLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0555434
inhalation/rat lowest published toxic concentration: 50 mg/m3/8H/19D- intermittentLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0555434
oral/rat lowest published toxic dose: 783 mg/kg/90D- continuousLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0555434
subcutaneous/mouse lowest published toxic dose: 125 mg/kg/5D- intermittentBehavioral: Tetany

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN5* -,458,1989
subcutaneous/rat lowest published toxic dose: 100 mg/kg/5D- intermittentBehavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)
VCVN5* -,458,1989
subcutaneous/rat lowest published toxic dose: 300 mg/kg/15D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN5* -,458,1989
subcutaneous/rat lowest published toxic dose: 1144 mg/kg/9W- intermittentLung, Thorax, or Respiration: Changes in lung weight

Endocrine: Changes in adrenal weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
GISAAA 26(10),27,1961

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.02 mg(Co)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 52,363,1991
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 52,363,1991
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 52,363,1991
TOXICOLOGY REVIEWFCTXAV 9,105,1971

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-FINLANDtime-weighted average 0.02 mg(Co)/m3, NOV2011
Occupational Exposure Limit-HUNGARYtime-weighted average 0.1 mg(Co)/m3, short term exposure limit 0.4 mg(Co)/m3, SEP2000
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.05 mg(Co)/m3, 2B carc, a1 sen, s2 sen, MAY2012
Occupational Exposure Limit-SWEDENtime-weighted average 0.05 mg(Co)/m3, Sen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.05 mg(Co)/m3, carc 2, inhal, skin, sen, JAN2011
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 mg(Co)/m3, sen, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code A1683; Number of Industries 4; Total Number of Facilities 77; Number of Occupations 12; Total Number of Employees Exposed 3559; Total Number of Female Employees Exposed 1767

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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