Citric acid, trisodium salt

RTECS #
GE8300000
CAS #
68-04-2
See: NMAM or OSHA Methods
Updated
December 2016
Molecular Weight
258.08
Molecular Formula
C6H5O7·3Na
Synonyms
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, trisodium salt (9CI)
Citnatin
Citreme
Citrosodine
Citrosodna
Natrocitral
Trisodium citrate

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisother cell types/rat20 mmol/L/30MMUREAV 794,17,2015

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Rat, bladder Inhibitor Concentration Low: 16.8 mmol/L/24HIn Vitro Toxicity Studies: Cell Viability (cell death), unspecified assayTIVIEQ 3,201,1989
intraperitoneal/mouse lethal dose (50 percent kill): 1364 mg/kgBehavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands
HPV093 -,-,2001
intraperitoneal/mouse lethal dose (50 percent kill): 1364 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Changes in structure or function of salivary glands
JPETAB 94,65,1948
intraperitoneal/rat lethal dose (50 percent kill): 1548 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Changes in structure or function of salivary glands
JPETAB 94,65,1948
intraperitoneal/rat lethal dose (50 percent kill): 1548 mg/kgBehavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands
HPV093 -,-,2001
intravenous/mouse lethal dose (50 percent kill): 170 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Changes in structure or function of salivary glands
JPETAB 94,65,1948
intravenous/mouse lethal dose (50 percent kill): 170 mg/kgBehavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands
HPV093 -,-,2001
intravenous/rabbit lethal dose (50 percent kill): 449 mg/kgBehavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands
HPV093 -,-,2001
intravenous/rabbit lethal dose (50 percent kill): 449 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Changes in structure or function of salivary glands
JPETAB 94,65,1948

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWNBREV* 5,1,1981

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code E0257; Number of Industries 1; Total Number of Facilities 403; Number of Occupations 5; Total Number of Employees Exposed 4029; Total Number of Female Employees Exposed 2015
National Occupational Exposure Survey 1983Hazard Code 68905; Number of Industries 96; Total Number of Facilities 13473; Number of Occupations 105; Total Number of Employees Exposed 301805; Total Number of Female Employees Exposed 163142
National Occupational Hazard Survey 1974Hazard Code 68905; Number of Industries 165; Total Number of Facilities 38675; Number of Occupations 97; Total Number of Employees Exposed 200416

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
Page last reviewed: November 16, 2018