Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

The National Institute for Occupational Safety and Health (NIOSH)

Note: Javascript is disabled or is not supported by your browser. For this reason, some items on this page will be unavailable. For more information about this message, please visit this page: About CDC.gov.

Registry of Toxic Effects of Chemical Substances (RTECS)

Citric acid, trisodium salt

RTECS #

GE8300000

CAS #

68-04-2

Updated

July 2011

Molecular Weight

258.08

Molecular Formula

C₆H₅O₇·3Na

Synonyms

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, trisodium salt (9CI)
Citnatin
Citreme
Citrosodine
Citrosodna
Natrocitral
Trisodium citrate

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Rat, bladder	Inhibitor Concentration Low: 16.8 mmol/L/24H	In Vitro Toxicity Studies: Cell Viability (cell death), unspecified assay	TIVIEQ 3,201,1989
intraperitoneal/mouse	lethal dose (50 percent kill): 1364 mg/kg	Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Changes in structure or function of salivary glands	HPV093 -,-,2001
intraperitoneal/mouse	lethal dose (50 percent kill): 1364 mg/kg	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Cyanosis Gastrointestinal: Changes in structure or function of salivary glands	JPETAB 94,65,1948
intraperitoneal/rat	lethal dose (50 percent kill): 1548 mg/kg	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Cyanosis Gastrointestinal: Changes in structure or function of salivary glands	JPETAB 94,65,1948
intraperitoneal/rat	lethal dose (50 percent kill): 1548 mg/kg	Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Changes in structure or function of salivary glands	HPV093 -,-,2001
intravenous/mouse	lethal dose (50 percent kill): 170 mg/kg	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Cyanosis Gastrointestinal: Changes in structure or function of salivary glands	JPETAB 94,65,1948
intravenous/mouse	lethal dose (50 percent kill): 170 mg/kg	Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Changes in structure or function of salivary glands	HPV093 -,-,2001
intravenous/rabbit	lethal dose (50 percent kill): 449 mg/kg	Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Changes in structure or function of salivary glands	HPV093 -,-,2001
intravenous/rabbit	lethal dose (50 percent kill): 449 mg/kg	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Cyanosis Gastrointestinal: Changes in structure or function of salivary glands	JPETAB 94,65,1948

Reviews

Organization	Standard	Reference
TOXICOLOGY REVIEW		NBREV* 5,1,1981

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Occupational Exposure Survey 1983	Hazard Code E0257; Number of Industries 1; Total Number of Facilities 403; Number of Occupations 5; Total Number of Employees Exposed 4029; Total Number of Female Employees Exposed 2015
National Occupational Exposure Survey 1983	Hazard Code 68905; Number of Industries 96; Total Number of Facilities 13473; Number of Occupations 105; Total Number of Employees Exposed 301805; Total Number of Female Employees Exposed 163142
National Occupational Hazard Survey 1974	Hazard Code 68905; Number of Industries 165; Total Number of Facilities 38675; Number of Occupations 97; Total Number of Employees Exposed 200416

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

File Formats Help:

How do I view different file formats (PDF, DOC, PPT, MPEG) on this site?

Page last reviewed:March 7, 2014
Page last updated:February 6, 2017
Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division

TOP