Citric acid, trisodium salt

RTECS #

GE8300000

CAS #

68-04-2
See: NMAM or OSHA Methods

Updated

December 2016

Molecular Weight

258.08

Molecular Formula

C₆H₅O₇·3Na

Synonyms

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, trisodium salt (9CI)
Citnatin
Citreme
Citrosodine
Citrosodna
Natrocitral
Trisodium citrate

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	other cell types/rat	20 mmol/L/30M	MUREAV 794,17,2015

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Rat, bladder	Inhibitor Concentration Low: 16.8 mmol/L/24H	In Vitro Toxicity Studies: Cell Viability (cell death), unspecified assay	TIVIEQ 3,201,1989
intraperitoneal/mouse	lethal dose (50 percent kill): 1364 mg/kg	Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Changes in structure or function of salivary glands	HPV093 -,-,2001
intraperitoneal/mouse	lethal dose (50 percent kill): 1364 mg/kg	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Cyanosis Gastrointestinal: Changes in structure or function of salivary glands	JPETAB 94,65,1948
intraperitoneal/rat	lethal dose (50 percent kill): 1548 mg/kg	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Cyanosis Gastrointestinal: Changes in structure or function of salivary glands	JPETAB 94,65,1948
intraperitoneal/rat	lethal dose (50 percent kill): 1548 mg/kg	Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Changes in structure or function of salivary glands	HPV093 -,-,2001
intravenous/mouse	lethal dose (50 percent kill): 170 mg/kg	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Cyanosis Gastrointestinal: Changes in structure or function of salivary glands	JPETAB 94,65,1948
intravenous/mouse	lethal dose (50 percent kill): 170 mg/kg	Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Changes in structure or function of salivary glands	HPV093 -,-,2001
intravenous/rabbit	lethal dose (50 percent kill): 449 mg/kg	Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Changes in structure or function of salivary glands	HPV093 -,-,2001
intravenous/rabbit	lethal dose (50 percent kill): 449 mg/kg	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Cyanosis Gastrointestinal: Changes in structure or function of salivary glands	JPETAB 94,65,1948

Reviews

Organization	Standard	Reference
TOXICOLOGY REVIEW		NBREV* 5,1,1981

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Occupational Exposure Survey 1983	Hazard Code E0257; Number of Industries 1; Total Number of Facilities 403; Number of Occupations 5; Total Number of Employees Exposed 4029; Total Number of Female Employees Exposed 2015
National Occupational Exposure Survey 1983	Hazard Code 68905; Number of Industries 96; Total Number of Facilities 13473; Number of Occupations 105; Total Number of Employees Exposed 301805; Total Number of Female Employees Exposed 163142
National Occupational Hazard Survey 1974	Hazard Code 68905; Number of Industries 165; Total Number of Facilities 38675; Number of Occupations 97; Total Number of Employees Exposed 200416

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health